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View article: Supplementary Table S1 from miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer
Supplementary Table S1 from miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer Open
Gleason scores of the cancer from which the TMA cores were obtained and the miR-409 intensity counts by ISH-QD. None of the TMA cores had any treatment.
View article: Supplementary Table S1 from miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer
Supplementary Table S1 from miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer Open
Gleason scores of the cancer from which the TMA cores were obtained and the miR-409 intensity counts by ISH-QD. None of the TMA cores had any treatment.
View article: Supplementary Tables from A Collagen-Remodeling Gene Signature Regulated by TGF-β Signaling Is Associated with Metastasis and Poor Survival in Serous Ovarian Cancer
Supplementary Tables from A Collagen-Remodeling Gene Signature Regulated by TGF-β Signaling Is Associated with Metastasis and Poor Survival in Serous Ovarian Cancer Open
XLS file 139K, Supplementary Tables. Supplementary Table 1A-C. Poor prognosis genes identified from 3 different datasets (A) TCGA, (B) GSE26712, (C) Karlan. Supplementary Table 2. Functional annotation of poor prognosis genes in three data…
View article: Supplementary Figure S2 from miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer
Supplementary Figure S2 from miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer Open
Effect of miR-409 overexpression in LNCaP cells. A, miR-409-5p and miR-409-3p levels in LNCaP control cells (LNCaP-C) and LNCaP miR-409 expressing cells (LNCaP-409) measured by qRT-PCR. B, Protein expression of RSU1 in LNCaP-C and LNCaP-40…
View article: Supplementary Figure S4 from miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer
Supplementary Figure S4 from miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer Open
A, miR-409-5p and miR-409-3p in exosomes from ARCaPE and ARCaPM PCa cells measured by qRT-PCR. B, miR-409-5p levels in exosomes from ARCaPM-C and ARCaPM-409-5pi PCa cells measured by qRT-PCR.
View article: Supplementary Figure S1 from miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer
Supplementary Figure S1 from miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer Open
A, miR-409-5p and miR-409-3p binding sties in 3`UTR of RSU1 mRNA. B, Effect miR-409-5p mimic binding on 3` UTR of RSU1 luciferase construct, both wild type and mutated construct. Effect of miR-409-5p mimic and miR-409-3p mimic on STAG2 3`U…
View article: Supplementary Figure S2 from miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer
Supplementary Figure S2 from miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer Open
Effect of miR-409 overexpression in LNCaP cells. A, miR-409-5p and miR-409-3p levels in LNCaP control cells (LNCaP-C) and LNCaP miR-409 expressing cells (LNCaP-409) measured by qRT-PCR. B, Protein expression of RSU1 in LNCaP-C and LNCaP-40…
View article: Supplementary Figure S3 from miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer
Supplementary Figure S3 from miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer Open
A, Nanog and Oct-3/4 expression in tumor and stromal areas of prostates expressing miR-409 compared to control normal prostates, using IHC analysis. B, IHC staining of cytokeratin 8 (CK-8) and cytokeratin 5 (CK-5) in normal control prostat…
View article: Data from miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer
Data from miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer Open
Purpose: miR-409-3p/-5p is a miRNA expressed by embryonic stem cells, and its role in cancer biology and metastasis is unknown. Our pilot studies demonstrated elevated miR-409-3p/-5p expression in human prostate cancer bone metastatic cell…
View article: Data from miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer
Data from miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer Open
Purpose: miR-409-3p/-5p is a miRNA expressed by embryonic stem cells, and its role in cancer biology and metastasis is unknown. Our pilot studies demonstrated elevated miR-409-3p/-5p expression in human prostate cancer bone metastatic cell…
View article: Supplementary Table S3 from miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer
Supplementary Table S3 from miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer Open
miRNA differentially expressed in metastatic ARCaPM prostate cancer cells and non-metastatic ARCaPE prostate cancer cells by multiplexed real time PCR analysis. miRNA in bold are in the DLK1-DIO3 mega-cluster.
View article: Supplementary Table S2 from miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer
Supplementary Table S2 from miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer Open
Global miRNA expression, represented as Ct values assayed by multiplexed qRT-PCR analysis in ARCaPE and ARCaPM PCa EMT bone metastatic model.
View article: Supplementary Table S3 from miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer
Supplementary Table S3 from miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer Open
miRNA differentially expressed in metastatic ARCaPM prostate cancer cells and non-metastatic ARCaPE prostate cancer cells by multiplexed real time PCR analysis. miRNA in bold are in the DLK1-DIO3 mega-cluster.
View article: Supplementary Methods, Figure Legends from miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer
Supplementary Methods, Figure Legends from miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer Open
Supplementary Methods, Figure Legends from miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer
View article: Supplementary Table S2 from miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer
Supplementary Table S2 from miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer Open
Global miRNA expression, represented as Ct values assayed by multiplexed qRT-PCR analysis in ARCaPE and ARCaPM PCa EMT bone metastatic model.
View article: Supplementary Methods, Figure Legends from miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer
Supplementary Methods, Figure Legends from miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer Open
Supplementary Methods, Figure Legends from miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer
View article: Data from A Collagen-Remodeling Gene Signature Regulated by TGF-β Signaling Is Associated with Metastasis and Poor Survival in Serous Ovarian Cancer
Data from A Collagen-Remodeling Gene Signature Regulated by TGF-β Signaling Is Associated with Metastasis and Poor Survival in Serous Ovarian Cancer Open
Purpose: To elucidate molecular pathways contributing to metastatic cancer progression and poor clinical outcome in serous ovarian cancer.Experimental Design: Poor survival signatures from three different serous ovarian cancer datasets wer…
View article: Supplementary Figure S3 from miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer
Supplementary Figure S3 from miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer Open
A, Nanog and Oct-3/4 expression in tumor and stromal areas of prostates expressing miR-409 compared to control normal prostates, using IHC analysis. B, IHC staining of cytokeratin 8 (CK-8) and cytokeratin 5 (CK-5) in normal control prostat…
View article: Supplementary Figures from A Collagen-Remodeling Gene Signature Regulated by TGF-β Signaling Is Associated with Metastasis and Poor Survival in Serous Ovarian Cancer
Supplementary Figures from A Collagen-Remodeling Gene Signature Regulated by TGF-β Signaling Is Associated with Metastasis and Poor Survival in Serous Ovarian Cancer Open
PDF file 831K, Supplementary Figures. Supplementary Fig. 1. A schematic diagram of the methods, datasets and patient samples used in this study. Supplementary Fig. 2. Correlogram of the 10 poor outcome. signature genes. Supplementary Fig. …
View article: Supplementary Figure S1 from miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer
Supplementary Figure S1 from miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer Open
A, miR-409-5p and miR-409-3p binding sties in 3`UTR of RSU1 mRNA. B, Effect miR-409-5p mimic binding on 3` UTR of RSU1 luciferase construct, both wild type and mutated construct. Effect of miR-409-5p mimic and miR-409-3p mimic on STAG2 3`U…
View article: Supplementary Figure S4 from miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer
Supplementary Figure S4 from miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer Open
A, miR-409-5p and miR-409-3p in exosomes from ARCaPE and ARCaPM PCa cells measured by qRT-PCR. B, miR-409-5p levels in exosomes from ARCaPM-C and ARCaPM-409-5pi PCa cells measured by qRT-PCR.
View article: Supplementary Figures from A Collagen-Remodeling Gene Signature Regulated by TGF-β Signaling Is Associated with Metastasis and Poor Survival in Serous Ovarian Cancer
Supplementary Figures from A Collagen-Remodeling Gene Signature Regulated by TGF-β Signaling Is Associated with Metastasis and Poor Survival in Serous Ovarian Cancer Open
PDF file 831K, Supplementary Figures. Supplementary Fig. 1. A schematic diagram of the methods, datasets and patient samples used in this study. Supplementary Fig. 2. Correlogram of the 10 poor outcome. signature genes. Supplementary Fig. …
View article: Data from A Collagen-Remodeling Gene Signature Regulated by TGF-β Signaling Is Associated with Metastasis and Poor Survival in Serous Ovarian Cancer
Data from A Collagen-Remodeling Gene Signature Regulated by TGF-β Signaling Is Associated with Metastasis and Poor Survival in Serous Ovarian Cancer Open
Purpose: To elucidate molecular pathways contributing to metastatic cancer progression and poor clinical outcome in serous ovarian cancer.Experimental Design: Poor survival signatures from three different serous ovarian cancer datasets wer…
View article: Supplementary Tables from A Collagen-Remodeling Gene Signature Regulated by TGF-β Signaling Is Associated with Metastasis and Poor Survival in Serous Ovarian Cancer
Supplementary Tables from A Collagen-Remodeling Gene Signature Regulated by TGF-β Signaling Is Associated with Metastasis and Poor Survival in Serous Ovarian Cancer Open
XLS file 139K, Supplementary Tables. Supplementary Table 1A-C. Poor prognosis genes identified from 3 different datasets (A) TCGA, (B) GSE26712, (C) Karlan. Supplementary Table 2. Functional annotation of poor prognosis genes in three data…
View article: A composite immune signature parallels disease progression across T1D subjects
A composite immune signature parallels disease progression across T1D subjects Open
At diagnosis, most people with type 1 diabetes (T1D) produce measurable levels of endogenous insulin, but the rate at which insulin secretion declines is heterogeneous. To explain this heterogeneity, we sought to identify a composite signa…
View article: ZEB1 Is a Transcription Factor That Is Prognostic and Predictive in Diffuse Gliomas
ZEB1 Is a Transcription Factor That Is Prognostic and Predictive in Diffuse Gliomas Open
Objective: To address the unmet medical need to better prognosticate patients with diffuse gliomas and to predict responses to chemotherapy regimens. Methods: ZEB1 alterations were retrospectively identified from a cohort of 1,160 diffuse …
View article: Perianal Crohnʼs Disease is Associated with Distal Colonic Disease, Stricturing Disease Behavior, IBD-Associated Serologies and Genetic Variation in the JAK-STAT Pathway
Perianal Crohnʼs Disease is Associated with Distal Colonic Disease, Stricturing Disease Behavior, IBD-Associated Serologies and Genetic Variation in the JAK-STAT Pathway Open
We have identified associations between pCD, more distal colonic inflammation, Crohn's disease-associated serologies, and genetic variation in the JAK-Stat pathway.
View article: Combined Immunosuppression Impairs Immunogenicity to Tetanus and Pertussis Vaccination Among Patients with Inflammatory Bowel Disease
Combined Immunosuppression Impairs Immunogenicity to Tetanus and Pertussis Vaccination Among Patients with Inflammatory Bowel Disease Open
Antibody responses to tetanus and pertussis vaccination may be affected by therapeutic drug regimen. Patients with IBD should optimally receive Tdap before starting immunomodulators, particularly when used in combination with anti-tumor ne…
View article: TOX3 is expressed in mammary ER+ epithelial cells and regulates ER target genes in luminal breast cancer
TOX3 is expressed in mammary ER+ epithelial cells and regulates ER target genes in luminal breast cancer Open
These results demonstrate that high expression of this protein likely plays a crucial role in breast cancer progression. This is in sharp contrast to previous studies that indicated breast cancer susceptibility is associated with lower exp…