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View article: Cold and lithium delay forgetting of olfactory memories in Caenorhabditis elegans
Cold and lithium delay forgetting of olfactory memories in Caenorhabditis elegans Open
The persistence of memory reflects not only how it is formed but also how forgetting is delayed. The mechanisms controlling forgetting remain obscure, and in particular it is unclear to what degree this process is actively regulated. We di…
View article: A Tunable and Druggable Mechanism to Delay Forgetting of Olfactory Memories in<i>C. elegans</i>
A Tunable and Druggable Mechanism to Delay Forgetting of Olfactory Memories in<i>C. elegans</i> Open
The poet W.B Yeats wrote that “All that is personal soon rots, it must be packed in ice or salt” . Here we show that in Caenorhabditis elegans nematodes, simple animals with just 302 neurons, memories are preserved on ice and in lithium sa…
View article: A decline in avian cytokine expression with age revealed by commercially available cytokine array
A decline in avian cytokine expression with age revealed by commercially available cytokine array Open
Cytokines are secreted immunomodulators that are key regulators of the avian immune response. Currently, the most commonly used method to follow cytokine expression is qPCR, which measures cellular levels of mRNA, rather their extracellula…
View article: Time-Restricted Feeding in Commercial Layer Chickens Improves Egg Quality in Old Age and Points to Lack of Adipostat Activity in Chickens
Time-Restricted Feeding in Commercial Layer Chickens Improves Egg Quality in Old Age and Points to Lack of Adipostat Activity in Chickens Open
In mammals, time-restricted feeding (TRF) with no caloric restriction provides health benefits and extends longevity, usually with a minor (∼3%) or no reduction in total food consumption. In the current study, a TRF regimen of 6 h free acc…
View article: Increased LOH Due to Defective Sister Chromatid Cohesion Is Due Primarily to Chromosomal Aneuploidy and Not Recombination
Increased LOH Due to Defective Sister Chromatid Cohesion Is Due Primarily to Chromosomal Aneuploidy and Not Recombination Open
Loss of heterozygosity (LOH) is an important factor in cancer, pathogenic fungi, and adaptation to changing environments. The sister chromatid cohesion process (SCC) suppresses aneuploidy and therefore whole chromosome LOH. SCC is also imp…
View article: The addition of a developmental factor, <i>unc-62</i>, to already long-lived worms increases lifespan and healthspan
The addition of a developmental factor, <i>unc-62</i>, to already long-lived worms increases lifespan and healthspan Open
Aging is a complex trait that is affected by multiple genetic pathways. A relatively unexplored approach is to manipulate multiple independent aging pathways simultaneously in order to observe their cumulative effect on lifespan. Here, we …
View article: Tissue- and Time-Specific Expression of Otherwise Identical tRNA Genes
Tissue- and Time-Specific Expression of Otherwise Identical tRNA Genes Open
Codon usage bias affects protein translation because tRNAs that recognize synonymous codons differ in their abundance. Although the current dogma states that tRNA expression is exclusively regulated by intrinsic control elements (A- and B-…