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View article: Molecular Profile and Dynamics of Commensal Viruses in Brazilian Patients Who Underwent Allogeneic Hematopoietic Stem Cell Transplantation
Molecular Profile and Dynamics of Commensal Viruses in Brazilian Patients Who Underwent Allogeneic Hematopoietic Stem Cell Transplantation Open
Background Commensal viruses are typically well‐tolerated by healthy individuals, but their behavior in immunocompromised patients is not fully understood. Methods This study investigated the prevalence, molecular dynamics, and circulating…
View article: Neurologic manifestations of COVID-19 and viral test in cerebrospinal fluid
Neurologic manifestations of COVID-19 and viral test in cerebrospinal fluid Open
Background Neurological manifestations are present in about one-third of COVID-19 cases, ranging from mild symptoms, such as anosmia, to more severe forms like demyelinating syndromes. Although direct invasion of the CNS has been demonstra…
View article: Viral Metagenomics in Patients Who Underwent Allogeneic Hematopoietic Stem Cell Transplantation (HSCT): A Brazilian Experience
Viral Metagenomics in Patients Who Underwent Allogeneic Hematopoietic Stem Cell Transplantation (HSCT): A Brazilian Experience Open
Viral infections are one of the most important causes of morbidity and mortality among patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT). Immunosuppression may lead to the reactivation of latent viruses or the a…
View article: Impact of SARS-CoV-2 variants on COVID-19 symptomatology and severity during five waves
Impact of SARS-CoV-2 variants on COVID-19 symptomatology and severity during five waves Open
View article: DESENVOLVIMENTO DE UM ENSAIO SNAPSHOT MULTIPLEX PARA IDENTIFICAÇÃO DE ALELOS RHD VARIANTES
DESENVOLVIMENTO DE UM ENSAIO SNAPSHOT MULTIPLEX PARA IDENTIFICAÇÃO DE ALELOS RHD VARIANTES Open
Introdução: A identificação de variantes do sistema de grupo sanguíneo Rh é uma preocupação essencial nos serviços de bancos de sangue, pois impacta diretamente na segurança das transfusões e na gestão dos estoques de unidades transfusiona…
View article: ALELOS VARIANTES DO GENE RHD: UM DESAFIO PARA OS BANCOS DE SANGUE BRASILEIROS
ALELOS VARIANTES DO GENE RHD: UM DESAFIO PARA OS BANCOS DE SANGUE BRASILEIROS Open
Introdução: Um dos desafios dos bancos de sangue e hospitais é fornecer unidades de hemácias compatíveis, especialmente para os pacientes com hemoglobinopatias ou outros distúrbios que necessitam de transfusões de sangue regulares. A ocorr…
View article: DESENVOLVIMENTO E AVALIAÇÃO DE VETORES EPISSOMAIS NÃO-TRANSIENTES PARA USO EM TERAPIA GÊNICA NA DOENÇA FALCIFORME
DESENVOLVIMENTO E AVALIAÇÃO DE VETORES EPISSOMAIS NÃO-TRANSIENTES PARA USO EM TERAPIA GÊNICA NA DOENÇA FALCIFORME Open
As Doenças Falciformes (DF) são hemoglobinopatias hereditárias que ocasionam dor aguda e danos progressivos em múltiplos órgãos e tecidos do corpo devido à expressão da Hemoglobina S (HbS). A HbS no estado desoxigenado acarreta deformação …
View article: INVESTIGAÇÃO DO ESTRESSE E DA DIFERENCIAÇÃO ATÍPICA DAS CÉLULAS-TRONCO HEMATOPOIÉTICAS PROMOVIDOS PELA HIDROXIUREIA EM PACIENTES COM ANEMIA FALCIFORME
INVESTIGAÇÃO DO ESTRESSE E DA DIFERENCIAÇÃO ATÍPICA DAS CÉLULAS-TRONCO HEMATOPOIÉTICAS PROMOVIDOS PELA HIDROXIUREIA EM PACIENTES COM ANEMIA FALCIFORME Open
A hidroxiureia (HU) é usada para aumentar os níveis de hemoglobina fetal, reduzindo complicações como vasoclusão, hemólise e inflamação na anemia falciforme (AF). No entanto, a HU interfere na função das células-tronco e progenitoras hemat…
View article: DESENVOLVIMENTO E IMPLEMENTAÇÃO DO BIOBANCO HEMOCENTRO-RP
DESENVOLVIMENTO E IMPLEMENTAÇÃO DO BIOBANCO HEMOCENTRO-RP Open
Objetivos: O sucesso no desenvolvimento de novas abordagens de medicina de precisão depende diretamente da disponibilidade de grandes coortes que possuam qualidade excepcional das amostras biológicas. Neste contexto, a automação permite qu…
View article: Dynamic clade transitions and the influence of vaccination on the spatiotemporal circulation of SARS-CoV-2 variants
Dynamic clade transitions and the influence of vaccination on the spatiotemporal circulation of SARS-CoV-2 variants Open
Since 2021, the emergence of variants of concern (VOC) has led Brazil to experience record numbers of in COVID-19 cases and deaths. The expanded spread of the SARS-CoV-2 combined with a low vaccination rate has contributed to the emergence…
View article: Rh D-positive genotypes in Brazilian blood donors with D-negative phenotype
Rh D-positive genotypes in Brazilian blood donors with D-negative phenotype Open
View article: The Brazilian association of hematology, hemotherapy, and cell therapy (ABHH) and its absolute commitment to ethics and absence of conflicts of interest
The Brazilian association of hematology, hemotherapy, and cell therapy (ABHH) and its absolute commitment to ethics and absence of conflicts of interest Open
View article: Exploring the Chikungunya virus landscape in a dengue-endemic Brazilian area
Exploring the Chikungunya virus landscape in a dengue-endemic Brazilian area Open
View article: Simultaneous Dengue and Chikungunya Coinfection in Endemic Area in Brazil: Clinical Presentation and Implications for Public Health
Simultaneous Dengue and Chikungunya Coinfection in Endemic Area in Brazil: Clinical Presentation and Implications for Public Health Open
Background Dengue virus (DENV) and Chikungunya virus (CHIKV) pose significant public health threats in Brazil, where favorable conditions facilitated the proliferation of Aedes mosquitoes. Since the mid-1980s, Brazil has experienced annual…
View article: Age-related Morphofunctional Changes in Sickle Cell Mice Bone Marrow Mesenchymal Stromal Cells
Age-related Morphofunctional Changes in Sickle Cell Mice Bone Marrow Mesenchymal Stromal Cells Open
Background and objectives: Bone marrow mesenchymal stromal cells (BM-MSCs) are key elements of the hematopoietic niche and participate in the regulatory mechanisms of hematopoietic stem cells (HSCs). Hematological diseases can affect MSCs …
View article: Epidemiology of the SARS-CoV-2 Omicron Variant Emergence in the Southeast Brazilian Population
Epidemiology of the SARS-CoV-2 Omicron Variant Emergence in the Southeast Brazilian Population Open
The aim of this study was to describe epidemiological characteristics and perform SARS-CoV-2 genomic surveillance in the southeastern region of São Paulo State. During the first months of 2022, we compared weekly SARS-CoV-2 infection preva…
View article: Dynamic clade transitions and the influence of vaccine rollout on the spatiotemporal circulation of SARS-CoV-2 variants in São Paulo, Brazil
Dynamic clade transitions and the influence of vaccine rollout on the spatiotemporal circulation of SARS-CoV-2 variants in São Paulo, Brazil Open
Since 2021, the emergence of variants of concern (VOC) has led Brazil to experience record numbers of in COVID-19 cases and deaths. The expanded spread of the SARS-CoV-2 combined with a low vaccination rate has contributed to the emergence…
View article: Chimeric antigen-receptor (CAR) engineered natural killer cells in a chronic myeloid leukemia (CML) blast crisis model
Chimeric antigen-receptor (CAR) engineered natural killer cells in a chronic myeloid leukemia (CML) blast crisis model Open
During the last two decades, the introduction of tyrosine kinase inhibitors (TKIs) to the therapy has changed the natural history of CML but progression into accelerated and blast phase (AP/BP) occurs in 3-5% of cases, especially in patien…
View article: The Epidemiological Scenario of the SARS-CoV-2 Omicron Emergence in the Southeast Brazilian Population
The Epidemiological Scenario of the SARS-CoV-2 Omicron Emergence in the Southeast Brazilian Population Open
Background: To describe epidemiological characteristics and perform a SARS-CoV-2 genomic surveillance in the southeastern region of São Paulo state. Methods: During the first months of 2022, we compared weekly SARS-CoV-2 infection prevalen…
View article: PARP1 Characterization as a Potential Biomarker for BCR::ABL1 p190+ Acute Lymphoblastic Leukemia
PARP1 Characterization as a Potential Biomarker for BCR::ABL1 p190+ Acute Lymphoblastic Leukemia Open
Detection of t(9;22), and consequent BCR::ABL1 fusion, is still a marker of worse prognosis for acute lymphoblastic leukemia (ALL), with resistance to tyrosine-kinase inhibitor therapy being a major obstacle in the clinical practice for th…
View article: Exploring Viral Metagenomics in Pediatric Patients with Acute Respiratory Infections: Unveiling Pathogens beyond SARS-CoV-2
Exploring Viral Metagenomics in Pediatric Patients with Acute Respiratory Infections: Unveiling Pathogens beyond SARS-CoV-2 Open
The emergence of SARS-CoV-2 and the subsequent pandemic have prompted extensive diagnostic and clinical efforts to mitigate viral spread. However, these strategies have largely overlooked the presence of other respiratory viruses. Acute re…
View article: AVALIAÇÃO DA EXPRESSÃO DE CITOCINAS INFLAMATÓRIAS EM PLASMA E SALIVA DE PACIENTES COM DOENÇA DO ENXERTO CONTRA O HOSPEDEIRO CRÔNICA
AVALIAÇÃO DA EXPRESSÃO DE CITOCINAS INFLAMATÓRIAS EM PLASMA E SALIVA DE PACIENTES COM DOENÇA DO ENXERTO CONTRA O HOSPEDEIRO CRÔNICA Open
A doença do enxerto contra o hospedeiro crônica (DECHc) é uma importante complicação tardia do transplante alogênico de células-tronco hematopoiéticas (alo-TCTH). A identificação de marcadores que possibilitem o diagnóstico precoce, prediz…
View article: ANTI-CD19 CARS ARMED WITH NK RECEPTOR-DERIVED ACTIVATION DOMAINS DEMONSTRATE TO IMPROVE CAR-NK ANTITUMOR EFFECTOR FUNCTION AND ARE DIFFERENTIALLY ENHANCED BY DASATINIB
ANTI-CD19 CARS ARMED WITH NK RECEPTOR-DERIVED ACTIVATION DOMAINS DEMONSTRATE TO IMPROVE CAR-NK ANTITUMOR EFFECTOR FUNCTION AND ARE DIFFERENTIALLY ENHANCED BY DASATINIB Open
Natural Killer (NK) cells represent a cytotoxic group of cells that play important roles in immune surveillance and antitumor activities. They mediate the death of target cells through activating receptors in a Human Leukocyte Antigen (HLA…
View article: POTENTIAL CLINICAL APPLICATION OF A FLOW CYTOMETRY METHOD FOR QUANTIFICATION OF FETAL HEMOGLOBIN (HBF) CONTENT IN RED BLOOD CELLS (RBCS) IN SICKLE CELL DISEASE (SCD)
POTENTIAL CLINICAL APPLICATION OF A FLOW CYTOMETRY METHOD FOR QUANTIFICATION OF FETAL HEMOGLOBIN (HBF) CONTENT IN RED BLOOD CELLS (RBCS) IN SICKLE CELL DISEASE (SCD) Open
Introduction: Hydroxyurea, the 1st line treatment for SCD, induces HbF, inhibiting polymerization of mutant HbS and cell sickling. However, laboratory tests that assess HbF induction do not quantify the % of effectively protected RBCs (%pR…
View article: EMPOWERING CAR-T CELL THERAPY: GITRL COSTIMULATION FOR ENHANCED ANTITUMOR RESPONSE AND IMMUNOSSUPPRESSION RESISTANCE IN SOLID TUMORS
EMPOWERING CAR-T CELL THERAPY: GITRL COSTIMULATION FOR ENHANCED ANTITUMOR RESPONSE AND IMMUNOSSUPPRESSION RESISTANCE IN SOLID TUMORS Open
The treatment of solid tumors with CAR-T cells is challenging due to the complex tumor microenvironment that impairs infiltration and persistence of injected cells. Thus, enhancing persistence and resistance to exhaustion of CAR-T cells is…
View article: CÉLULAS CAR-T EXPRESSANDO UMA NOVA CONSTRUÇÃO CONTRA O ANTÍGENO INTRACELULAR MAGE-A4 INDUZEM REGRESSÃO TUMORAL COMPLETA EM MODELO DE MIELOMA MÚLTIPLO
CÉLULAS CAR-T EXPRESSANDO UMA NOVA CONSTRUÇÃO CONTRA O ANTÍGENO INTRACELULAR MAGE-A4 INDUZEM REGRESSÃO TUMORAL COMPLETA EM MODELO DE MIELOMA MÚLTIPLO Open
Introdução/Objetivo: Os receptores de antígenos quiméricos (CARs) convencionais reconhecem apenas antígenos de superfície celular em sua conformação nativa. Isto limita a aplicação da terapia, já que a maioria dos antígenos associados a tu…
View article: PRODUCTION OF “UNIVERSAL” CHIMERIC ANTIGEN RECEPTOR (CAR) T CELLS THROUGH A HIGHLY EFFICIENT CRISPR/CAS9-INDUCED KNOCKOUT OF THE ENDOGENOUS TRAC GENE
PRODUCTION OF “UNIVERSAL” CHIMERIC ANTIGEN RECEPTOR (CAR) T CELLS THROUGH A HIGHLY EFFICIENT CRISPR/CAS9-INDUCED KNOCKOUT OF THE ENDOGENOUS TRAC GENE Open
Allogeneic Chimeric Antigen Receptor (CAR) T cell therapy represents a promising approach to overcome the accessibility limitations of conventional autologous treatment. Some advantages of such allogeneic therapy include the availability o…
View article: ENHANCED ANTI-TUMOR ACTIVITY OF CD19.CAR-NK CELLS BY INCORPORATING IL-27
ENHANCED ANTI-TUMOR ACTIVITY OF CD19.CAR-NK CELLS BY INCORPORATING IL-27 Open
Autologous T-cells expressing Chimeric Antigen Receptor (CAR) have shown great efficacy against hematologic malignancies, however, severe side effects limit their clinical use. Natural Killer (NK) cells are an attractive alternative to T-c…
View article: DIVERSITY OF β-GLOBIN HAPLOTYPES IN SICKLE CELL DISEASE PATIENTS FROM BRAZIL
DIVERSITY OF β-GLOBIN HAPLOTYPES IN SICKLE CELL DISEASE PATIENTS FROM BRAZIL Open
The characterization of beta globin (β-Hbb) gene haplotypes in sickle cell anemia patients continues to be a valuable source of information for understanding the heterogeneity of the clinical manifestations of this disease and for the regi…
View article: CIRCULATING HEMATOPOIETIC STEM AND PROGENITOR CELLS AND ERYTHROBLASTS COUNTING IS INCREASED IN PATIENTS WITH SICKLE CELL ANEMIA
CIRCULATING HEMATOPOIETIC STEM AND PROGENITOR CELLS AND ERYTHROBLASTS COUNTING IS INCREASED IN PATIENTS WITH SICKLE CELL ANEMIA Open
Due to the challenges associated with accessing bone marrow samples from individuals with sickle cell anemia (SCA), hematopoiesis in the context of this disease remains less studied compared to other pathologies. However, characterizing th…