Fengwei Yu
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View article: Rosiglitazone Ameliorates Phenotypes of Drosophila Parkinson's Disease Model via Decomposing Lipid Droplets and Elevating dCTP
Rosiglitazone Ameliorates Phenotypes of Drosophila Parkinson's Disease Model via Decomposing Lipid Droplets and Elevating dCTP Open
View article: Rosiglitazone Ameliorates Phenotypes of Drosophila Parkinson's Disease Model via Decomposing Lipid Droplets and Elevating dCTP
Rosiglitazone Ameliorates Phenotypes of Drosophila Parkinson's Disease Model via Decomposing Lipid Droplets and Elevating dCTP Open
View article: Exploring novel MYH7 gene variants using in silico analyses in Korean patients with cardiomyopathy
Exploring novel MYH7 gene variants using in silico analyses in Korean patients with cardiomyopathy Open
Overall, our study identified the distribution of MYH7 variants among patients with cardiomyopathy in Korea, offering new insights for improved diagnosis by enriching the data on the pathogenicity of novel variants using in silico tools an…
View article: Interplay between autophagy and CncC regulates dendrite pruning in <i>Drosophila</i>
Interplay between autophagy and CncC regulates dendrite pruning in <i>Drosophila</i> Open
Autophagy is essential for the turnover of damaged organelles and long-lived proteins. It is responsible for many biological processes such as maintaining brain functions and aging. Impaired autophagy is often linked to neurodevelopmental …
View article: Data from PPARδ Reprograms Glutamine Metabolism in Sorafenib-Resistant HCC
Data from PPARδ Reprograms Glutamine Metabolism in Sorafenib-Resistant HCC Open
The tyrosine kinase inhibitor sorafenib is the only therapeutic agent approved for the treatment of advanced hepatocellular carcinoma (HCC), but acquired resistance to sorafenib is high. Here, we report metabolic reprogramming in sorafenib…
View article: Figure S2 from PPARδ Reprograms Glutamine Metabolism in Sorafenib-Resistant HCC
Figure S2 from PPARδ Reprograms Glutamine Metabolism in Sorafenib-Resistant HCC Open
Figure S2 shows relative amount of intracellular glutamine level and abundance of indicated protein levels in sorafenib-sensitive and -resistant HCC cells.
View article: Figure S3 from PPARδ Reprograms Glutamine Metabolism in Sorafenib-Resistant HCC
Figure S3 from PPARδ Reprograms Glutamine Metabolism in Sorafenib-Resistant HCC Open
Figure S3 shows relative amount of intracellular glutamine level and abundance of indicated protein levels in sorafenib-sensitive and -resistant HCC cells.
View article: Polycomb group genes are required for neuronal pruning in Drosophila
Polycomb group genes are required for neuronal pruning in Drosophila Open
View article: Additional file 11 of Polycomb group genes are required for neuronal pruning in Drosophila
Additional file 11 of Polycomb group genes are required for neuronal pruning in Drosophila Open
Additional file 11: Table S1. Source data for all the figures.
View article: <i>Drosophila</i> GSK3β promotes microtubule disassembly and dendrite pruning in sensory neurons
<i>Drosophila</i> GSK3β promotes microtubule disassembly and dendrite pruning in sensory neurons Open
The evolutionarily conserved Glycogen Synthase Kinase 3β (GSK3β), a negative regulator of microtubules, is crucial for neuronal polarization, growth and migration during animal development. However, it remains unknown whether GSK3β regulat…
View article: Decision letter: Inter-organ Wingless/Ror/Akt signaling regulates nutrient-dependent hyperarborization of somatosensory neurons
Decision letter: Inter-organ Wingless/Ror/Akt signaling regulates nutrient-dependent hyperarborization of somatosensory neurons Open
View article: AMPK activates the Nrf2-Keap1 pathway to govern dendrite pruning via the insulin pathway in <i>Drosophila</i>
AMPK activates the Nrf2-Keap1 pathway to govern dendrite pruning via the insulin pathway in <i>Drosophila</i> Open
During Drosophila metamorphosis, the ddaC dendritic arborisation sensory neurons selectively prune their larval dendrites in response to steroid hormone ecdysone signalling. The Nrf2-Keap1 pathway acts downstream of ecdysone signalling to …
View article: Drosophila CLASP regulates microtubule orientation and dendrite pruning by suppressing Par-1 kinase
Drosophila CLASP regulates microtubule orientation and dendrite pruning by suppressing Par-1 kinase Open
The evolutionarily conserved CLASPs (cytoplasmic linker-associated proteins) are microtubule-associated proteins that inhibit microtubule catastrophe and promote rescue. CLASPs can regulate axonal elongation and dendrite branching in growi…
View article: Histone Demethylase KDM7A Contributes to the Development of Hepatic Steatosis by Targeting Diacylglycerol Acyltransferase 2
Histone Demethylase KDM7A Contributes to the Development of Hepatic Steatosis by Targeting Diacylglycerol Acyltransferase 2 Open
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. While the development of NAFLD is correlated with aberrant histone methylation, modifiers of histone methylation involved in this event remain poorly unders…
View article: Decision letter: Glial Nrf2 signaling mediates the neuroprotection exerted by Gastrodia elata Blume in Lrrk2-G2019S Parkinson’s disease
Decision letter: Glial Nrf2 signaling mediates the neuroprotection exerted by Gastrodia elata Blume in Lrrk2-G2019S Parkinson’s disease Open
Article Figures and data Abstract Editor's evaluation eLife digest Introduction Results Discussion Materials and methods Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstrac…
View article: Cannabinoids differentially modulate behavioral and developmental responses to ethanol in <i>Drosophila</i>
Cannabinoids differentially modulate behavioral and developmental responses to ethanol in <i>Drosophila</i> Open
Prolonged prenatal or adult exposure to ethanol is detrimental to mental and physical well-being, resulting in developmental abnormalities, progressive addiction and ultimate death. A growing number of studies have shown the therapeutic po…
View article: A systematic analysis of microtubule‐destabilizing factors during dendrite pruning in <i>Drosophila</i>
A systematic analysis of microtubule‐destabilizing factors during dendrite pruning in <i>Drosophila</i> Open
View article: The Nrf2-Keap1 pathway is activated by steroid hormone signaling to govern neuronal remodeling
The Nrf2-Keap1 pathway is activated by steroid hormone signaling to govern neuronal remodeling Open
The evolutionarily conserved Nrf2-Keap1 pathway is a key antioxidant response pathway that protects cells/organisms against detrimental effects of oxidative stress. Impaired Nrf2 function is associated with cancer and neurodegenerative dis…
View article: Decision letter: Activity-dependent Golgi satellite formation in dendrites reshapes the neuronal surface glycoproteome
Decision letter: Activity-dependent Golgi satellite formation in dendrites reshapes the neuronal surface glycoproteome Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Activity-driven changes in the neuronal su…
View article: Cannabinoids modulate food preference and consumption in Drosophila melanogaster
Cannabinoids modulate food preference and consumption in Drosophila melanogaster Open
View article: Cannabinoids Modulate Food Preference and Consumption in Drosophila Melanogaster
Cannabinoids Modulate Food Preference and Consumption in Drosophila Melanogaster Open
Cannabinoids have an important role in regulating feeding behaviors via cannabinoid receptors in mammals. Cannabinoids also exhibit potential therapeutic functions in Drosophila melanogaster , or fruit fly that lacks cannabinoid receptors.…
View article: Cannabinoids modulate food preference and consumption in<i>Drosophila melanogaster</i>
Cannabinoids modulate food preference and consumption in<i>Drosophila melanogaster</i> Open
Cannabinoids have an important role in regulating feeding behaviors via cannabinoid receptors in mammals. Cannabinoids also exhibit potential therapeutic functions in Drosophila melanogaster , or fruit fly that lacks cannabinoid receptors.…
View article: Microscope-type laser speckle contrast imaging for in vivo assessment of microcirculation
Microscope-type laser speckle contrast imaging for in vivo assessment of microcirculation Open
Laser speckle contrast imaging (LSCI) can be used to observe dynamic changes in the tissue microcirculation in vivo according to the dynamic interaction between red blood cells and coherent light. In this study, a dual-wavelength LSCI syst…
View article: The AMPK-PP2A axis in insect fat body is activated by 20-hydroxyecdysone to antagonize insulin/IGF signaling and restrict growth rate
The AMPK-PP2A axis in insect fat body is activated by 20-hydroxyecdysone to antagonize insulin/IGF signaling and restrict growth rate Open
Significance Final body size determination in animals remains a long-standing puzzle in the field of developmental biology. In insects, insulin/insulin-like growth factor signaling (IIS) and the steroid hormone 20-hydroxyecdysone (20E) are…
View article: A microtubule polymerase is required for microtubule orientation and dendrite pruning in <i>Drosophila</i>
A microtubule polymerase is required for microtubule orientation and dendrite pruning in <i>Drosophila</i> Open
View article: Protein phosphatase PP2A regulates microtubule orientation and dendrite pruning in <i>Drosophila</i>
Protein phosphatase PP2A regulates microtubule orientation and dendrite pruning in <i>Drosophila</i> Open
View article: Decision letter: Low FoxO expression in Drosophila somatosensory neurons protects dendrite growth under nutrient restriction
Decision letter: Low FoxO expression in Drosophila somatosensory neurons protects dendrite growth under nutrient restriction Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract During prolonged nutrient res…
View article: The membrane protein Raw regulates dendrite pruning via the secretory pathway
The membrane protein Raw regulates dendrite pruning via the secretory pathway Open
Neuronal pruning is essential for proper wiring of the nervous systems in invertebrates and vertebrates. Drosophila ddaC sensory neurons selectively prune their larval dendrites to sculpt the nervous system during early metamorphosis. Howe…
View article: Ultrahigh-resolution optical coherence tomography/angiography with an economic and compact supercontinuum laser
Ultrahigh-resolution optical coherence tomography/angiography with an economic and compact supercontinuum laser Open
In this study, a Q-switch pumped supercontinuum laser (QS-SCL) is used as a light source for in vivo imaging via ultrahigh-resolution optical coherence tomography and angiography (UHR-OCT/OCTA). For this purpose, an OCT system based…
View article: CRL4Mahj E3 ubiquitin ligase promotes neural stem cell reactivation
CRL4Mahj E3 ubiquitin ligase promotes neural stem cell reactivation Open
The ability of neural stem cells (NSCs) to transit between quiescence and proliferation is crucial for brain development and homeostasis. Drosophila Hippo pathway maintains NSC quiescence, but its regulation during brain development remain…