Duane Moogk
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View article: 261 Evidence for durable anti-tumor responses by TAC-T cells in preclinical models of solid tumors
261 Evidence for durable anti-tumor responses by TAC-T cells in preclinical models of solid tumors Open
Background T cell antigen coupler (TAC) is a chimeric receptor that redirects T cells (TAC-T) towards surface-expressed tumor antigens to create safe and durable anti-cancer immune responses. The TAC activates T cells by co-opting the endo…
View article: Development of a B-cell maturation antigen-specific T-cell antigen coupler receptor for multiple myeloma
Development of a B-cell maturation antigen-specific T-cell antigen coupler receptor for multiple myeloma Open
The modifications to the TAC scaffold described herein represent an important step in the evolution of this technology, which tolerates a range of expression levels without impacting therapeutic efficacy.
View article: 94 The T cell antigen coupler (TAC) redirects T cell oncolysis while limiting tonic signaling to create a safer engineered T cell product with a higher threshold for activation
94 The T cell antigen coupler (TAC) redirects T cell oncolysis while limiting tonic signaling to create a safer engineered T cell product with a higher threshold for activation Open
Background The T cell Antigen Couper (TAC) is a chimeric receptor that redirects the endogenous T cell receptor (TCR) against a tumor target via an extracellular antigen-binding domain to induce activation and oncolysis. TAC-engineered T c…
View article: Immunotherapy Bridge 2017 and Melanoma Bridge 2017: meeting abstracts
Immunotherapy Bridge 2017 and Melanoma Bridge 2017: meeting abstracts Open
Immunotherapy approaches targeting the PD-1 pathway have shown some clinical benefits in a fraction of patients with lung cancer, but expression of PD-L1 has proven to be an imperfect biomarker of efficacy.Recent studies have shown that tu…
View article: 2081
2081 Open
OBJECTIVES/SPECIFIC AIMS: To characterize the CD4+ T-cell response during CTLA-4 blockade immunotherapy with ipilimumab in patients with metastatic melanoma by correlating cytokine profiles with phenotypic changes in the intratumoral lymph…
View article: Constitutive Lck Activity Drives Sensitivity Differences between CD8+ Memory T Cell Subsets
Constitutive Lck Activity Drives Sensitivity Differences between CD8+ Memory T Cell Subsets Open
CD8+ T cells develop increased sensitivity following Ag experience, and differences in sensitivity exist between T cell memory subsets. How differential TCR signaling between memory subsets contributes to sensitivity differences is unclear…