Duncan Forster
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View article: Regional Vulnerability of Cardiac Chambers to Radiotherapy: A Multi-Omics Perspective
Regional Vulnerability of Cardiac Chambers to Radiotherapy: A Multi-Omics Perspective Open
The heart is highly vulnerable to radiotherapy (RT)-induced injury, leading to molecular and structural remodeling collectively termed radiation-induced cardiac toxicity (RICT). Although several biological pathways have been implicated, th…
View article: CCR2-driven monocyte recruitment is protective against radiotherapy-induced intestinal toxicity
CCR2-driven monocyte recruitment is protective against radiotherapy-induced intestinal toxicity Open
Radiotherapy (RT) is essential in treating abdominal and pelvic cancers but often damages the healthy tissues, particularly the intestines, leading to radiation-induced toxicities with limited treatment options. While the immune system is …
View article: P09.18.A EFFECTS OF HEMI-BRAIN IRRADIATION ON CEREBRAL BLOOD FLOW, VASCULAR INTEGRITY, AND RECOGNITION MEMORY IN NAÏVE MICE
P09.18.A EFFECTS OF HEMI-BRAIN IRRADIATION ON CEREBRAL BLOOD FLOW, VASCULAR INTEGRITY, AND RECOGNITION MEMORY IN NAÏVE MICE Open
BACKGROUND Despite playing a critical role in curative and palliative treatment of brain tumours, radiotherapy (RT) damages peritumoral normal brain tissue, which contributes to cognitive decline in up to 90 % of those who survive past 6 m…
View article: A global genetic interaction map of a human cell reveals conserved principles of genetic networks
A global genetic interaction map of a human cell reveals conserved principles of genetic networks Open
We generated a genome-scale, genetic interaction network from the analysis of more than 4 million double mutants in the haploid human cell line, HAP1. The network maps ∼90,000 genetic interactions, including thousands of extreme synthetic …
View article: Supplementary Figure S1 from Combined Oxygen-Enhanced MRI and Perfusion Imaging Detect Hypoxia Modification from Banoxantrone and Atovaquone and Track Their Differential Mechanisms of Action
Supplementary Figure S1 from Combined Oxygen-Enhanced MRI and Perfusion Imaging Detect Hypoxia Modification from Banoxantrone and Atovaquone and Track Their Differential Mechanisms of Action Open
Supplementary Figure S1 shows a summary of the cohorts of xenografts used in each experiment.
View article: Supplementary Figure S2 from Combined Oxygen-Enhanced MRI and Perfusion Imaging Detect Hypoxia Modification from Banoxantrone and Atovaquone and Track Their Differential Mechanisms of Action
Supplementary Figure S2 from Combined Oxygen-Enhanced MRI and Perfusion Imaging Detect Hypoxia Modification from Banoxantrone and Atovaquone and Track Their Differential Mechanisms of Action Open
Supplementary Figure S2: Confirmation that oxygen increases tumor R1.
View article: Supplementary Figure S4 from Combined Oxygen-Enhanced MRI and Perfusion Imaging Detect Hypoxia Modification from Banoxantrone and Atovaquone and Track Their Differential Mechanisms of Action
Supplementary Figure S4 from Combined Oxygen-Enhanced MRI and Perfusion Imaging Detect Hypoxia Modification from Banoxantrone and Atovaquone and Track Their Differential Mechanisms of Action Open
Supplementary Figure S4 confirms that there was no drug effect on cell number or viability.
View article: Supplementary Figure S3 from Combined Oxygen-Enhanced MRI and Perfusion Imaging Detect Hypoxia Modification from Banoxantrone and Atovaquone and Track Their Differential Mechanisms of Action
Supplementary Figure S3 from Combined Oxygen-Enhanced MRI and Perfusion Imaging Detect Hypoxia Modification from Banoxantrone and Atovaquone and Track Their Differential Mechanisms of Action Open
Supplementary Figure S3 shows the MRI analysis steps.
View article: Supplementary Figure S6 from Combined Oxygen-Enhanced MRI and Perfusion Imaging Detect Hypoxia Modification from Banoxantrone and Atovaquone and Track Their Differential Mechanisms of Action
Supplementary Figure S6 from Combined Oxygen-Enhanced MRI and Perfusion Imaging Detect Hypoxia Modification from Banoxantrone and Atovaquone and Track Their Differential Mechanisms of Action Open
Supplementary Figure S6 shows that banoxantrone induces tumor necrosis.
View article: Supplementary Figure S5 from Combined Oxygen-Enhanced MRI and Perfusion Imaging Detect Hypoxia Modification from Banoxantrone and Atovaquone and Track Their Differential Mechanisms of Action
Supplementary Figure S5 from Combined Oxygen-Enhanced MRI and Perfusion Imaging Detect Hypoxia Modification from Banoxantrone and Atovaquone and Track Their Differential Mechanisms of Action Open
Supplementary Figure S5 compares the natural history growth of Calu6 and U87 xenografts.
View article: CCR2-driven monocyte recruitment is protective against radiotherapy-induced intestinal toxicity
CCR2-driven monocyte recruitment is protective against radiotherapy-induced intestinal toxicity Open
Radiotherapy (RT) is essential in treating abdominal and pelvic cancers but often damages the healthy tissues, particularly the intestines, leading to radiation-induced toxicities with limited treatment options. While the immune system is …
View article: Figure 3 from Combined Oxygen-Enhanced MRI and Perfusion Imaging Detect Hypoxia Modification from Banoxantrone and Atovaquone and Track Their Differential Mechanisms of Action
Figure 3 from Combined Oxygen-Enhanced MRI and Perfusion Imaging Detect Hypoxia Modification from Banoxantrone and Atovaquone and Track Their Differential Mechanisms of Action Open
Atovaquone (ATQ) induces modification of tumor hypoxia in Calu6 xenografts. A, TMR [18F] FAZA uptake is increased from baseline at day 7 in control tumors (Cn; white bars) but was reduced in drug-treated tumors. B,…
View article: Supplementary Figure S3 from Combined Oxygen-Enhanced MRI and Perfusion Imaging Detect Hypoxia Modification from Banoxantrone and Atovaquone and Track Their Differential Mechanisms of Action
Supplementary Figure S3 from Combined Oxygen-Enhanced MRI and Perfusion Imaging Detect Hypoxia Modification from Banoxantrone and Atovaquone and Track Their Differential Mechanisms of Action Open
Supplementary Figure S3 shows the MRI analysis steps.
View article: Supplementary Figure S6 from Combined Oxygen-Enhanced MRI and Perfusion Imaging Detect Hypoxia Modification from Banoxantrone and Atovaquone and Track Their Differential Mechanisms of Action
Supplementary Figure S6 from Combined Oxygen-Enhanced MRI and Perfusion Imaging Detect Hypoxia Modification from Banoxantrone and Atovaquone and Track Their Differential Mechanisms of Action Open
Supplementary Figure S6 shows that banoxantrone induces tumor necrosis.
View article: Figure 5 from Combined Oxygen-Enhanced MRI and Perfusion Imaging Detect Hypoxia Modification from Banoxantrone and Atovaquone and Track Their Differential Mechanisms of Action
Figure 5 from Combined Oxygen-Enhanced MRI and Perfusion Imaging Detect Hypoxia Modification from Banoxantrone and Atovaquone and Track Their Differential Mechanisms of Action Open
MRI elucidates differential drug mechanism of action for banoxantrone and atovaquone. Banoxantrone did not cause growth inhibition in (A) Calu6 xenografts or (B) U87 xenografts. Atovaquone did not cause growth inhibition in (…
View article: Supplementary Figure S1 from Combined Oxygen-Enhanced MRI and Perfusion Imaging Detect Hypoxia Modification from Banoxantrone and Atovaquone and Track Their Differential Mechanisms of Action
Supplementary Figure S1 from Combined Oxygen-Enhanced MRI and Perfusion Imaging Detect Hypoxia Modification from Banoxantrone and Atovaquone and Track Their Differential Mechanisms of Action Open
Supplementary Figure S1 shows a summary of the cohorts of xenografts used in each experiment.
View article: Figure 4 from Combined Oxygen-Enhanced MRI and Perfusion Imaging Detect Hypoxia Modification from Banoxantrone and Atovaquone and Track Their Differential Mechanisms of Action
Figure 4 from Combined Oxygen-Enhanced MRI and Perfusion Imaging Detect Hypoxia Modification from Banoxantrone and Atovaquone and Track Their Differential Mechanisms of Action Open
Banoxantrone (BN) hypoxia modification is replicated in U87, a xenograft model with different growth and hypoxia characteristics. U87 xenografts were less hypoxic than Calu6 xenografts. The group average ΔR1 for size matched (
View article: Supplementary Figure S4 from Combined Oxygen-Enhanced MRI and Perfusion Imaging Detect Hypoxia Modification from Banoxantrone and Atovaquone and Track Their Differential Mechanisms of Action
Supplementary Figure S4 from Combined Oxygen-Enhanced MRI and Perfusion Imaging Detect Hypoxia Modification from Banoxantrone and Atovaquone and Track Their Differential Mechanisms of Action Open
Supplementary Figure S4 confirms that there was no drug effect on cell number or viability.
View article: Data from Combined Oxygen-Enhanced MRI and Perfusion Imaging Detect Hypoxia Modification from Banoxantrone and Atovaquone and Track Their Differential Mechanisms of Action
Data from Combined Oxygen-Enhanced MRI and Perfusion Imaging Detect Hypoxia Modification from Banoxantrone and Atovaquone and Track Their Differential Mechanisms of Action Open
Oxygen-enhanced MRI (OE-MRI) has shown promise for quantifying and spatially mapping tumor hypoxia, either alone or in combination with perfusion imaging. Previous studies have validated the technique in mouse models and in patients with c…
View article: Supplementary Figure S2 from Combined Oxygen-Enhanced MRI and Perfusion Imaging Detect Hypoxia Modification from Banoxantrone and Atovaquone and Track Their Differential Mechanisms of Action
Supplementary Figure S2 from Combined Oxygen-Enhanced MRI and Perfusion Imaging Detect Hypoxia Modification from Banoxantrone and Atovaquone and Track Their Differential Mechanisms of Action Open
Supplementary Figure S2: Confirmation that oxygen increases tumor R1.
View article: Supplementary Figure S5 from Combined Oxygen-Enhanced MRI and Perfusion Imaging Detect Hypoxia Modification from Banoxantrone and Atovaquone and Track Their Differential Mechanisms of Action
Supplementary Figure S5 from Combined Oxygen-Enhanced MRI and Perfusion Imaging Detect Hypoxia Modification from Banoxantrone and Atovaquone and Track Their Differential Mechanisms of Action Open
Supplementary Figure S5 compares the natural history growth of Calu6 and U87 xenografts.
View article: Figure 1 from Combined Oxygen-Enhanced MRI and Perfusion Imaging Detect Hypoxia Modification from Banoxantrone and Atovaquone and Track Their Differential Mechanisms of Action
Figure 1 from Combined Oxygen-Enhanced MRI and Perfusion Imaging Detect Hypoxia Modification from Banoxantrone and Atovaquone and Track Their Differential Mechanisms of Action Open
Determining drug mechanism of action in Calu6 cells in vitro. A, Increased retention of the fluorescent cytotoxic metabolite of banoxantrone, AQ4, as oxygen concentration decreased, with (B) example images shown for ce…
View article: Figure 2 from Combined Oxygen-Enhanced MRI and Perfusion Imaging Detect Hypoxia Modification from Banoxantrone and Atovaquone and Track Their Differential Mechanisms of Action
Figure 2 from Combined Oxygen-Enhanced MRI and Perfusion Imaging Detect Hypoxia Modification from Banoxantrone and Atovaquone and Track Their Differential Mechanisms of Action Open
Banoxantrone (BN) induces modification of tumor hypoxia in Calu6 xenografts. A, TMR of [18F] FAZA uptake is increased from baseline at day 1 and 3 in control tumors (Cn; white bars) but was reduced in drug-treated tumors.…
View article: Combined Oxygen-Enhanced MRI and Perfusion Imaging Detect Hypoxia Modification from Banoxantrone and Atovaquone and Track Their Differential Mechanisms of Action
Combined Oxygen-Enhanced MRI and Perfusion Imaging Detect Hypoxia Modification from Banoxantrone and Atovaquone and Track Their Differential Mechanisms of Action Open
Oxygen-enhanced MRI (OE-MRI) has shown promise for quantifying and spatially mapping tumor hypoxia, either alone or in combination with perfusion imaging. Previous studies have validated the technique in mouse models and in patients with c…
View article: BS01 Multi-omics approach to dissect the effect of radiotherapy on cardiac substructures
BS01 Multi-omics approach to dissect the effect of radiotherapy on cardiac substructures Open
Radiation therapy (RT) plays a pivotal role in cancer treatment, constituting a vital aspect of the therapeutic protocol for over half of cancer patients. Despite continuous advancements in RT technology improving the precision and accura…
View article: A systematic review of normal tissue neurovascular unit damage following brain irradiation—Factors affecting damage severity and timing of effects
A systematic review of normal tissue neurovascular unit damage following brain irradiation—Factors affecting damage severity and timing of effects Open
Background Radiotherapy is key in the treatment of primary and secondary brain tumors. However, normal tissue is inevitably irradiated, causing toxicity and contributing to cognitive dysfunction. The relative importance of vascular damage …
View article: To Transformers and Beyond: Large Language Models for the Genome
To Transformers and Beyond: Large Language Models for the Genome Open
In the rapidly evolving landscape of genomics, deep learning has emerged as a useful tool for tackling complex computational challenges. This review focuses on the transformative role of Large Language Models (LLMs), which are mostly based…
View article: Supplementary Figure 4 from [<sup>18</sup>F]-FLT Positron Emission Tomography Can Be Used to Image the Response of Sensitive Tumors to PI3-Kinase Inhibition with the Novel Agent GDC-0941
Supplementary Figure 4 from [<sup>18</sup>F]-FLT Positron Emission Tomography Can Be Used to Image the Response of Sensitive Tumors to PI3-Kinase Inhibition with the Novel Agent GDC-0941 Open
PDF file - 46 KB, Chronic dosing with GDC-0941 leads to an increase in MAP-kinase pathway signaling in sensitive tumors.
View article: Supplementary Figure 2 from [<sup>18</sup>F]-FLT Positron Emission Tomography Can Be Used to Image the Response of Sensitive Tumors to PI3-Kinase Inhibition with the Novel Agent GDC-0941
Supplementary Figure 2 from [<sup>18</sup>F]-FLT Positron Emission Tomography Can Be Used to Image the Response of Sensitive Tumors to PI3-Kinase Inhibition with the Novel Agent GDC-0941 Open
PDF file - 65 KB, Acute dosing with GDC-0941 leads to an increase in apoptotic signaling in in sensitive tumors.
View article: Supplementary Figure 1 from [<sup>18</sup>F]-FLT Positron Emission Tomography Can Be Used to Image the Response of Sensitive Tumors to PI3-Kinase Inhibition with the Novel Agent GDC-0941
Supplementary Figure 1 from [<sup>18</sup>F]-FLT Positron Emission Tomography Can Be Used to Image the Response of Sensitive Tumors to PI3-Kinase Inhibition with the Novel Agent GDC-0941 Open
PDF file - 74 KB, GDC-0941 inhibits hypoxic signaling in drug sensitive U87 tumors.