Duncan Graham
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View article: Unveiling the Unprecedented Optical Properties of Citrate‐Stabilized Hollow AgAu Nanoshells Under Photothermal Irradiation
Unveiling the Unprecedented Optical Properties of Citrate‐Stabilized Hollow AgAu Nanoshells Under Photothermal Irradiation Open
Metallic nanoshells heat efficiently on excitation of the localized surface plasmon resonance (LSPR). Whilst investigating the photothermal properties of citrate‐stabilized hollow gold nanoshells (HGNs) synthesized using a sacrificial silv…
View article: Functionalizing Injectable Hydrogels with Cobalt‐Based Metallacarboranes for Targeted Delivery in Triple‐Negative Breast Cancer
Functionalizing Injectable Hydrogels with Cobalt‐Based Metallacarboranes for Targeted Delivery in Triple‐Negative Breast Cancer Open
Cobalt‐based metallacarboranes have emerged as potential candidates for cancer treatment owing to their unique structural properties. In this study, a biocompatible delivery platform is developed by noncovalently incorporating cobalt metal…
View article: Ultrasensitive Alzheimer’s Disease Biomarker Detection with Nanopillar Photonic Crystal Biosensors
Ultrasensitive Alzheimer’s Disease Biomarker Detection with Nanopillar Photonic Crystal Biosensors Open
The recent development of drugs able to mitigate neurodegenerative diseases has created an urgent need for tests that can be readily used by practitioners. Detection directly in patients’ blood has recently emerged as a possibility, howeve…
View article: Ultrasensitive Alzheimer’s disease biomarker detection with nanopillar photonic crystal biosensors
Ultrasensitive Alzheimer’s disease biomarker detection with nanopillar photonic crystal biosensors Open
The recent development of drugs able to mitigate neurodegenerative diseases has created an urgent need for biomarker tests that can be readily used by practitioners. Although biomarker detection directly in patients’ blood is now possible,…
View article: Sensitive Detection and Identification Method of Erythrocyte-like Cells upon Doxorubicin Induced Differentiation with Vibrational Techniques
Sensitive Detection and Identification Method of Erythrocyte-like Cells upon Doxorubicin Induced Differentiation with Vibrational Techniques Open
Altered differentiation of blood cell precursors and their clonal expansion occurs in various types of leukemia. One treatment strategy is to induce differentiation into the mature form, which is capable of undergoing apoptosis. It has bee…
View article: A point-of-care diagnostic for drug-induced liver injury using surface-enhanced Raman scattering lateral flow immunoassay
A point-of-care diagnostic for drug-induced liver injury using surface-enhanced Raman scattering lateral flow immunoassay Open
View article: Unmixing Hyperspectral SRS Images in the Cell-Silent Region of the Raman Spectrum Using Phasor Analysis
Unmixing Hyperspectral SRS Images in the Cell-Silent Region of the Raman Spectrum Using Phasor Analysis Open
Hyperspectral stimulated Raman scattering (SRS) microscopy is rapidly becoming an established method for chemical and biomedical imaging due to the combination of high spatial resolution and chemical information contained within the three-…
View article: Sensitive detection and identification method of erythrocyte-like cells upon doxorubicin induced differentiation with vibrational techniques
Sensitive detection and identification method of erythrocyte-like cells upon doxorubicin induced differentiation with vibrational techniques Open
Altered differentiation of blood cell precursors and their clonal expansion occurs in various types of leukaemia. One treatment strategy is to induce differentiation into the mature form, which is capable of undergoing apoptosis. It has be…
View article: Ultrasensitive Alzheimer’s Disease Biomarker Detection with Nanopillar Photonic Crystal Biosensors
Ultrasensitive Alzheimer’s Disease Biomarker Detection with Nanopillar Photonic Crystal Biosensors Open
The recent development of drugs able to mitigate neurodegenerative diseases has created an urgent need for tests that can be readily used by practitioners. Detection directly in patients’ blood has recently emerged as a possibility, howeve…
View article: Ultrasensitive Alzheimer’s Disease Biomarker Detection with Nanopillar Photonic Crystal Biosensors
Ultrasensitive Alzheimer’s Disease Biomarker Detection with Nanopillar Photonic Crystal Biosensors Open
The recent development of drugs able to mitigate neurodegenerative diseases has created an urgent need for tests that can be readily used by practitioners. Detection directly in patients’ blood has recently emerged as a possibility, howeve…
View article: Ultrasensitive Alzheimer’s Disease Biomarker Detection with Nanopillar Photonic Crystal Biosensors
Ultrasensitive Alzheimer’s Disease Biomarker Detection with Nanopillar Photonic Crystal Biosensors Open
The recent development of drugs able to mitigate neurodegenerative diseases has created an urgent need for tests that can be readily used by practitioners. Detection directly in patients’ blood has recently emerged as a possibility, howeve…
View article: Surface Enhanced Raman Scattering for Biomolecular Sensing in Human Healthcare Monitoring
Surface Enhanced Raman Scattering for Biomolecular Sensing in Human Healthcare Monitoring Open
Since the 1980s, surface enhanced Raman scattering (SERS) has been used for the rapid and sensitive detection of biomolecules. Whether a label-free or labeled assay is adopted, SERS has demonstrated low limits of detection in a variety of …
View article: Unprecedented Cytotoxicity of Transition Metal Metallacarboranes on Triple Negative Breast Cancer Cells and a Vertebrate Cancer Model
Unprecedented Cytotoxicity of Transition Metal Metallacarboranes on Triple Negative Breast Cancer Cells and a Vertebrate Cancer Model Open
SUMMARY Metallacarboranes have long been the subject of attention in the context of medicinal chemistry because of their promising characteristics and unconventional interactions with biological entities. The metal centre has been shown to…
View article: A new point of care diagnostic for the sensitive and specific diagnosis of drug-induced liver injury using a surface enhanced Raman scattering lateral flow immunoassay (SERS-LFIA)
A new point of care diagnostic for the sensitive and specific diagnosis of drug-induced liver injury using a surface enhanced Raman scattering lateral flow immunoassay (SERS-LFIA) Open
Paracetamol overdose (POD) is common, with approximately 100,000 cases attending hospital emergency departments in the UK annually. Early treatment with the antidote N-acetylcysteine (NAC) is crucial for patients who are at risk of develop…
View article: Emerging applications of stimulated Raman scattering microscopy for medicinal chemistry and drug discovery
Emerging applications of stimulated Raman scattering microscopy for medicinal chemistry and drug discovery Open
Stimulated Raman scattering (SRS) microscopy provides unique opportunities for molecular imaging in preclinical drug evaluation.
View article: Surface-enhanced Raman spectroscopy: a half-century historical perspective
Surface-enhanced Raman spectroscopy: a half-century historical perspective Open
This review comprehensively presents the fifty-year journey of surface-enhanced Raman spectroscopy (SERS), covering its discovery, pivotal phases, innovative methods, and key inspirations from the pioneers and trailblazers.
View article: Advances in Super-resolution Stimulated Raman Scattering Microscopy
Advances in Super-resolution Stimulated Raman Scattering Microscopy Open
[Image: see text] Super-resolution optical imaging overcomes the diffraction limit in light microscopy to enable the visualization of previously invisible molecular details within a sample. The realization of super-resolution imaging based…
View article: Surface‐Enhanced Raman Scattering and Photothermal Effects on Optoplasmonic Nanofibers
Surface‐Enhanced Raman Scattering and Photothermal Effects on Optoplasmonic Nanofibers Open
When decorated with plasmonic nanoparticles, pulled optical nanofibers are compatible with plasmonic techniques enabling the ability to probe microenvironments with high spatial and temporal resolution. Although the nanofibers exhibit exce…
View article: Advancing SERS as a quantitative technique: challenges, considerations, and correlative approaches to aid validation
Advancing SERS as a quantitative technique: challenges, considerations, and correlative approaches to aid validation Open
Surface-enhanced Raman scattering (SERS) remains a significant area of research since it’s discovery 50 years ago. The surface-based technique has been used in a wide variety of fields, most prominently in chemical detection, cellular imag…
View article: Ultrasensitive Dual ELONA/SERS–RPA Multiplex Diagnosis of Antimicrobial Resistance
Ultrasensitive Dual ELONA/SERS–RPA Multiplex Diagnosis of Antimicrobial Resistance Open
Antimicrobial resistance (AMR) is a significant global health threat concern, necessitating healthcare practitioners to accurately prescribe the most effective antimicrobial agents with correct doses to combat resistant infections. This is…
View article: Label-Free Screening of Drug-Induced Liver Injury Using Stimulated Raman Scattering Microscopy and Spectral Phasor Analysis
Label-Free Screening of Drug-Induced Liver Injury Using Stimulated Raman Scattering Microscopy and Spectral Phasor Analysis Open
Hepatic toxicity is a leading cause of the termination of clinical trials and the withdrawal of therapeutics following regulatory approval. The detection of drug-induced liver injury (DILI) is therefore of importance to ensure patient safe…
View article: Issue Information
Issue Information Open
No abstract is available for this article.
View article: Alterations in lipid metabolism accompanied by changes in protein and carotenoid content as spectroscopic markers of human T cell activation
Alterations in lipid metabolism accompanied by changes in protein and carotenoid content as spectroscopic markers of human T cell activation Open
View article: Cytokeratin-18 is a sensitive biomarker of alanine transaminase increase in a placebo-controlled, randomized, crossover trial of therapeutic paracetamol dosing (PATH-BP biomarker substudy)
Cytokeratin-18 is a sensitive biomarker of alanine transaminase increase in a placebo-controlled, randomized, crossover trial of therapeutic paracetamol dosing (PATH-BP biomarker substudy) Open
Drug-induced liver injury (DILI) is a challenge in clinical medicine and drug development. Highly sensitive novel biomarkers have been identified for detecting DILI following a paracetamol overdose. The study objective was to evaluate biom…
View article: Hypertensive Pressure Mechanosensing Alone Triggers Lipid Droplet Accumulation and Transdifferentiation of Vascular Smooth Muscle Cells to Foam Cells (Adv. Sci. 9/2024)
Hypertensive Pressure Mechanosensing Alone Triggers Lipid Droplet Accumulation and Transdifferentiation of Vascular Smooth Muscle Cells to Foam Cells (Adv. Sci. 9/2024) Open
Vascular Smooth Muscle Cells Arterial vascular smooth muscle cells (VSMCs) play a central role in the onset and progression of atherosclerosis. In article 2308686, Thomas Iskratsch and co‐workers report that hypertensive pressure transform…
View article: Hydrogen storage capacity of freeze cast microporous monolithic composites
Hydrogen storage capacity of freeze cast microporous monolithic composites Open
3D adsorptive monoliths, with potential for incorporation into ullage of liquid storage tanks, providing reduced boil-off, increasing safety and efficiency.
View article: Issue Information
Issue Information Open
No abstract is available for this article.
View article: New insights into lipid and fatty acid metabolism from Raman spectroscopy
New insights into lipid and fatty acid metabolism from Raman spectroscopy Open
Raman microscopy can reveal metabolic signatures and heterogeneity at the single cell level.
View article: Live chicken egg embryos as an alternative <i>in vivo</i> tumour model for deep surface enhanced Raman spectroscopy
Live chicken egg embryos as an alternative <i>in vivo</i> tumour model for deep surface enhanced Raman spectroscopy Open
SERS and SESORS for the detection and localisation of AuNPs in a live chick embryo tumour model.
View article: Multiplex detection of the big five carbapenemase genes using solid-phase recombinase polymerase amplification
Multiplex detection of the big five carbapenemase genes using solid-phase recombinase polymerase amplification Open
The development of solid-phase recombinase polymerase amplification (RPA) assay against the big 5 carbapenemase genes. The assay result can be measured using both a benchtop microplate reader and portable Raman spectrometer.