Duncan Lambie
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View article: Facial and Trigeminal Viral Neuritis Mimicking Perineural Spread
Facial and Trigeminal Viral Neuritis Mimicking Perineural Spread Open
Cutaneous head and neck malignancies can display a phenomenon of tumour spread, called perineural spread (PNS), associated with reduced overall- and disease-specific survival. Benign conditions can present in a similar manner, of which vir…
View article: An Audit of Narrative Reports Compared to Structured Pathology Reporting for Cutaneous Squamous Cell Carcinoma
An Audit of Narrative Reports Compared to Structured Pathology Reporting for Cutaneous Squamous Cell Carcinoma Open
Background Australia introduced structured pathology reporting guidelines for non‐melanoma skin cancer (NMSC) including cutaneous squamous cell carcinoma (cSCC) in 2023 to encourage accurate histological assessment and recording of well re…
View article: When you don’t see horses, think of zebras: an unusual case of recurrent gastrointestinal bleeding
When you don’t see horses, think of zebras: an unusual case of recurrent gastrointestinal bleeding Open
View article: Automated scoring of tumor-infiltrating lymphocytes informs risk of death from thin melanoma: A nested case-case study
Automated scoring of tumor-infiltrating lymphocytes informs risk of death from thin melanoma: A nested case-case study Open
View article: A case of cutaneous malignant glomus tumor
A case of cutaneous malignant glomus tumor Open
Glomus tumors are well‐known but relatively rare vascular neoplasms, with their malignant counterparts still being rarer. There are very few reports of cutaneous malignant glomus tumors, and the current limited evidence suggests that they …
View article: A novel FET‐ETS family fusion (FUS::FLI1) in a case of Ewing sarcoma
A novel FET‐ETS family fusion (FUS::FLI1) in a case of Ewing sarcoma Open
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View article: Pleomorphic rhabdomyosarcoma: diagnostic considerations and case report
Pleomorphic rhabdomyosarcoma: diagnostic considerations and case report Open
View article: Pembrolizumab-induced toxic epidermal necrolysis: case report
Pembrolizumab-induced toxic epidermal necrolysis: case report Open
A 63-year-old man with metastatic lung adenocarcinoma presented with biopsy confirmed toxic epidermal necrolysis (TEN). Symptoms commenced following 3 cycles of carboplatin, pemetrexed and pembrolizumab, with the first cycle given ~9.5 wee…
View article: Genome-Scale DNA Methylation Analysis Identifies Repeat Element Alterations that Modulate the Genomic Stability of Melanocytic Nevi
Genome-Scale DNA Methylation Analysis Identifies Repeat Element Alterations that Modulate the Genomic Stability of Melanocytic Nevi Open
View article: Heterotopic ossification within the gallbladder – First reported Australian case
Heterotopic ossification within the gallbladder – First reported Australian case Open
In conclusion, we report the rare and unusual finding of heterotopic ossification of the gallbladder, and suspect that inflammation secondary to calculous debris initiated the ossification. Current technical limitations preclude diagnosis …
View article: Unexpected High Levels of BRN2/POU3F2 Expression in Human Dermal Melanocytic Nevi
Unexpected High Levels of BRN2/POU3F2 Expression in Human Dermal Melanocytic Nevi Open
View article: Cytokine/chemokine profiles in squamous cell carcinoma correlate with precancerous and cancerous disease stage
Cytokine/chemokine profiles in squamous cell carcinoma correlate with precancerous and cancerous disease stage Open
Actinic Keratosis (AK), Intraepidermal Carcinoma (IEC), and Squamous Cell Carcinoma (SCC) are generally considered to be advancing stages of the same disease spectrum. However, while AK often regress spontaneously, and IEC often regress in…
View article: FDG-PET Response Assessment in Patients with Locally Advanced Nodal Melanoma Undergoing High-Dose Neo-Adjuvant or Definitive Radiotherapy
FDG-PET Response Assessment in Patients with Locally Advanced Nodal Melanoma Undergoing High-Dose Neo-Adjuvant or Definitive Radiotherapy Open
View article: RNF8 is associated with radioresistance, nodal stage and extranodal spread in oral cavity squamous-cell carcinoma
RNF8 is associated with radioresistance, nodal stage and extranodal spread in oral cavity squamous-cell carcinoma Open
Background: Oral cavity cancer has an early metastatic profile and poor adjuvant therapy response when compared with other head and neck cancers, which is reflected in more aggressive clinical management. Accurate prognostic prediction is …
View article: 112 Skin micro-sampling device, MicrobiopsyTM is more sensitive to detect known melanoma and non-melanoma skin cancer biomarkers on volunteers
112 Skin micro-sampling device, MicrobiopsyTM is more sensitive to detect known melanoma and non-melanoma skin cancer biomarkers on volunteers Open
View article: An Ex Vivo Human Tumor Assay Shows Distinct Patterns of EGFR Trafficking in Squamous Cell Carcinoma Correlating to Therapeutic Outcomes
An Ex Vivo Human Tumor Assay Shows Distinct Patterns of EGFR Trafficking in Squamous Cell Carcinoma Correlating to Therapeutic Outcomes Open
EGFR overexpression is associated with squamous cell carcinoma development. Altered endocytosis and polarization of receptor tyrosine kinases, including EGFR, affect migration and invasion in three-dimensional culture. These studies have b…
View article: Whole-Exome Sequencing of Acquired Nevi Identifies Mechanisms for Development and Maintenance of Benign Neoplasms
Whole-Exome Sequencing of Acquired Nevi Identifies Mechanisms for Development and Maintenance of Benign Neoplasms Open
View article: 通过电子皮镜观察到在后天性痣亚型中常见 BRAF 和 NRAS 突变,表现出组成型 MAPK 通路活化
通过电子皮镜观察到在后天性痣亚型中常见 BRAF 和 NRAS 突变,表现出组成型 MAPK 通路活化 Open
大多数人的皮肤上都有几个褐斑,我们称之为黑素细胞痣或痣。痣对人体无害,但偶尔可能转化为潜在致死性肿瘤,也就是恶性黑色素瘤。在放大镜(电子皮镜)下,皮肤科专家通过外观确定了不同类型的痣。广义上:“球状”痣在早年出现,并且可能转化为黑色素瘤;“网状”痣在成年期出现,并且可能与未长痣部位出现的黑色素瘤有关;带“外围球状体”(PG) 的网状痣会生长,但非恶性。良性痣及癌性痣(恶性黑色素瘤)中都可能出现 BRAF 和 NRAS 基因突变(变异)。这些基因是在肿瘤形成中起重要作用的 M…
View article: RNA-seq reveals more consistent reference genes for gene expression studies in human non-melanoma skin cancers
RNA-seq reveals more consistent reference genes for gene expression studies in human non-melanoma skin cancers Open
Identification of appropriate reference genes (RGs) is critical to accurate data interpretation in quantitative real-time PCR (qPCR) experiments. In this study, we have utilised next generation RNA sequencing (RNA-seq) to analyse the trans…
View article: Peer Review #2 of "RNA-seq reveals more consistent reference genes for gene expression studies in human non-melanoma skin cancers (v0.1)"
Peer Review #2 of "RNA-seq reveals more consistent reference genes for gene expression studies in human non-melanoma skin cancers (v0.1)" Open
Identification of appropriate reference genes (RGs) is critical to accurate data interpretation in quantitative real-time PCR (qPCR) experiments.In this study, we have utilised next generation RNA sequencing (RNA-seq) to analyse the transc…
View article: Positive regulatory interactions between YAP and Hedgehog signalling in skin homeostasis and BCC development in mouse skin in vivo
Positive regulatory interactions between YAP and Hedgehog signalling in skin homeostasis and BCC development in mouse skin in vivo Open
Skin is a highly plastic tissue that undergoes tissue turnover throughout life, but also in response to injury. YAP and Hedgehog signalling play a central role in the control of epidermal stem/progenitor cells in the skin during embryonic …
View article: Genome-Wide Overexpression Screen Identifies Genes Able to Bypass p16-Mediated Senescence in Melanoma
Genome-Wide Overexpression Screen Identifies Genes Able to Bypass p16-Mediated Senescence in Melanoma Open
Malignant melanomas often arise from nevi, which result from initial oncogene-induced hyperproliferation of melanocytes that are maintained in a CDKN2A/p16-mediated senescent state. Thus, genes that can bypass this senescence barrier are l…
View article: Expression profiling of cutaneous squamous cell carcinoma with perineural invasion implicates the p53 pathway in the process
Expression profiling of cutaneous squamous cell carcinoma with perineural invasion implicates the p53 pathway in the process Open
View article: RNA-seq reveals more consistent reference genes for gene expression studies in human non-melanoma skin cancers
RNA-seq reveals more consistent reference genes for gene expression studies in human non-melanoma skin cancers Open
Identification of appropriate reference genes (RGs) is critical to accurate data interpretation in quantitative real-time PCR (qPCR) experiments. In this study, we have utilised next generation RNA-sequencing (RNA-seq) to analyse the trans…
View article: RNA-seq reveals more consistent reference genes for gene expression studies in human non-melanoma skin cancers
RNA-seq reveals more consistent reference genes for gene expression studies in human non-melanoma skin cancers Open
Identification of appropriate reference genes (RGs) is critical to accurate data interpretation in quantitative real-time PCR (qPCR) experiments. In this study, we have utilised next generation RNA-sequencing (RNA-seq) to analyse the trans…
View article: Multiparameter analysis of naevi and primary melanomas identifies a subset of naevi with elevated markers of transformation
Multiparameter analysis of naevi and primary melanomas identifies a subset of naevi with elevated markers of transformation Open
Summary Here we have carried out a multiparameter analysis using a panel of 28 immunohistochemical markers to identify markers of transformation from benign and dysplastic naevus to primary melanoma in three separate cohorts totalling 279 …
View article: Molecular markers to complement sentinel node status in predicting survival in patients with high-risk locally invasive melanoma
Molecular markers to complement sentinel node status in predicting survival in patients with high-risk locally invasive melanoma Open
Sentinel lymph node status is a major prognostic marker in locally invasive cutaneous melanoma. However, this procedure is not always feasible, requires advanced logistics and carries rare but significant morbidity. Previous studies have l…
View article: A pilot study to compare the detection of HPV-16 biomarkers in salivary oral rinses with tumour p16INK4a expression in head and neck squamous cell carcinoma patients
A pilot study to compare the detection of HPV-16 biomarkers in salivary oral rinses with tumour p16INK4a expression in head and neck squamous cell carcinoma patients Open
View article: Galectin-1 is associated with poor prognosis in patients with cutaneous head and neck cancer with perineural spread
Galectin-1 is associated with poor prognosis in patients with cutaneous head and neck cancer with perineural spread Open
View article: Additional file 3: Table S3. of A pilot study to compare the detection of HPV-16 biomarkers in salivary oral rinses with tumour p16INK4a expression in head and neck squamous cell carcinoma patients
Additional file 3: Table S3. of A pilot study to compare the detection of HPV-16 biomarkers in salivary oral rinses with tumour p16INK4a expression in head and neck squamous cell carcinoma patients Open
Summary of results for the detection of HPV-16-specific DNA and RNA in oral rinse of patients with p16INK4a-negative HNSCC (XLSX 38Â kb)