Duncan S. Sutherland
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View article: DNA Origami‐Guided Assembly of Gold Nanoparticles for Plasmonic Enhancement in Fiber Optic Surface Plasmon Resonance Sensing
DNA Origami‐Guided Assembly of Gold Nanoparticles for Plasmonic Enhancement in Fiber Optic Surface Plasmon Resonance Sensing Open
Surface plasmon resonance (SPR) biosensors, including fiber‐optic SPR (FO‐SPR), are powerful tools for biomolecular detection; however, their sensitivity and limits of detection can be further enhanced through innovative signal amplificati…
View article: Display of clustered antigen by follicular dendritic cells tunes B-cell receptor activation
Display of clustered antigen by follicular dendritic cells tunes B-cell receptor activation Open
To generate high-affinity antibodies against pathogens, B cells engage antigens displayed on the surface of follicular dendritic cells (FDCs) in secondary lymphoid tissues. Binding of cognate antigen by the B-cell receptor (BCR) causes Src…
View article: Nanoscale Precise Stamping of Biomolecule Patterns Using DNA Origami
Nanoscale Precise Stamping of Biomolecule Patterns Using DNA Origami Open
Understanding the importance of ligand patterning in biological processes requires precise control over molecular positioning and spacing. While DNA origami structures offer nanoscale precision in biomolecule arrangement, their biological …
View article: Thermally Robust Plasmonic Nanorings from Titanium Nitride
Thermally Robust Plasmonic Nanorings from Titanium Nitride Open
Plasmonic nanostructures are widely utilized in fields such as chemical sensing, photothermal therapy, and optoelectronics due to their ability to confine and enhance electromagnetic fields at the nanoscale. Among these, nanorings offer un…
View article: Thermoplasmonic Nanorings via Sputter Deposition
Thermoplasmonic Nanorings via Sputter Deposition Open
The fabrication of plasmonic nanostructures with precise geometries and scalable production remains a critical challenge for advancing light–matter interaction technologies in applications such as sensing, photonics, and thermal management…
View article: Thermoplasmonic Nanorings for Passive Solar‐Responsive Smart Windows in Energy‐Efficient Building Applications
Thermoplasmonic Nanorings for Passive Solar‐Responsive Smart Windows in Energy‐Efficient Building Applications Open
Reducing solar heat gain through windows is a major challenge in the pursuit of energy‐efficient buildings. Current smart window technologies aim to modulate near‐infrared (NIR) solar transmission suffering from limitations in transparency…
View article: Familial Alzheimer's disease mutation identifies novel role of SORLA in release of neurotrophic exosomes
Familial Alzheimer's disease mutation identifies novel role of SORLA in release of neurotrophic exosomes Open
INTRODUCTION Mutations in SORL1 , encoding the sorting receptor Sortilin‐related receptor with A‐type repeats (SORLA), are found in individuals with Alzheimer's disease (AD). We studied SORLA N1358S , carrying a mutation in its ligand bind…
View article: Nanoscale precise stamping of biomolecule patterns using DNA origami
Nanoscale precise stamping of biomolecule patterns using DNA origami Open
Understanding the importance of ligand patterning in biological processes requires precise control over molecular positioning and spacing. While DNA origami structures offer nanoscale precision in biomolecule arrangement, their biological …
View article: Familial Alzheimer disease mutation identifies novel role of SORLA in release of neurotrophic exosomes
Familial Alzheimer disease mutation identifies novel role of SORLA in release of neurotrophic exosomes Open
Sortilin-related receptor with A-type repeats (SORLA) is an intracellular sorting receptor that directs target proteins between endocytic and secretory compartments of cells. Mutations in SORL1 , encoding SORLA, are common in individuals s…
View article: Silicon oxide nanoparticles grown on graphite by codeposition of the atomic constituents
Silicon oxide nanoparticles grown on graphite by codeposition of the atomic constituents Open
Nanoscale silicate dust particles are the most abundant refractory component observed in the interstellar medium and thought to play a key role in catalysing the formation of complex organic molecules in the star forming regions of space. …
View article: Nanoscale Cellular Traction Force Quantification: CRISPR-Cas12a Supercharged DNA Tension Sensors in Nanoclustered Ligand Patterns
Nanoscale Cellular Traction Force Quantification: CRISPR-Cas12a Supercharged DNA Tension Sensors in Nanoclustered Ligand Patterns Open
High-throughput measurement of cellular traction forces at the nanoscale remains a significant challenge in mechanobiology, limiting our understanding of how cells interact with their microenvironment. Here, we present a novel technique fo…
View article: Serial intravital microscopy reveals temporal dynamics of autoreactive germinal centers in the spleen
Serial intravital microscopy reveals temporal dynamics of autoreactive germinal centers in the spleen Open
The spleen plays a key role in clearing blood-borne infections and is involved in autoimmune and hematological disorders. It undergoes extensive remodeling during inflammation and immune reactions, but its localization in the peritoneal ca…
View article: Distinct regulation of Tau Monomer and aggregate uptake and intracellular accumulation in human neurons
Distinct regulation of Tau Monomer and aggregate uptake and intracellular accumulation in human neurons Open
Background The prion-like spreading of Tau pathology is the leading cause of disease progression in various tauopathies. A critical step in propagating pathologic Tau in the brain is the transport from the extracellular environment and acc…
View article: Single-Molecule Multivalent Interactions Revealed by Plasmon-Enhanced Fluorescence
Single-Molecule Multivalent Interactions Revealed by Plasmon-Enhanced Fluorescence Open
Multivalency as an interaction principle is widely utilized in nature. It enables specific and strong binding by multiple weak interactions through enhanced avidity and is a core process in immune recognition and cellular signaling, which …
View article: Rate-Engineered Plasmon-Enhanced Fluorescence for Real-Time Microsecond Dynamics of Single Biomolecules
Rate-Engineered Plasmon-Enhanced Fluorescence for Real-Time Microsecond Dynamics of Single Biomolecules Open
Single-molecule fluorescence has revealed a wealth of biochemical processes but does not give access to submillisecond dynamics involved in transient interactions and molecular dynamics. Here we overcome this bottleneck and demonstrate rec…
View article: Nanofabrication of nanostructure lattices: from high-quality large patterns to precise hybrid units
Nanofabrication of nanostructure lattices: from high-quality large patterns to precise hybrid units Open
Sub-wavelength nanostructure lattices provide versatile platforms for light control and the basis for various novel phenomena and applications in physics, material science, chemistry, biology, and energy. The thriving study of nanostructur…
View article: Versatile Nanoring Fabrication Assisted by Hole-mask Colloidal Lithography
Versatile Nanoring Fabrication Assisted by Hole-mask Colloidal Lithography Open
Nanomaterials shaped as rings are interesting nanostructures with control of the materials properties at the nanoscale. Nanoring plasmonic resonators provide tunable optical resonances in the near-infrared with application in sensing. Fabr…
View article: Smart Biointerfaces via Click Chemistry-Enabled Nanopatterning of Multiple Bioligands and DNA Force Sensors
Smart Biointerfaces via Click Chemistry-Enabled Nanopatterning of Multiple Bioligands and DNA Force Sensors Open
Nanoscale biomolecular placement is crucial for advancing cellular signaling, sensor technology, and molecular interaction studies. Despite this, current methods fall short in enabling large-area nanopatterning of multiple biomolecules whi…
View article: Amyloid-β aggregates activate peripheral monocytes in mild cognitive impairment
Amyloid-β aggregates activate peripheral monocytes in mild cognitive impairment Open
The peripheral immune system is important in neurodegenerative diseases, both in protecting and inflaming the brain, but the underlying mechanisms remain elusive. Alzheimer’s Disease is commonly preceded by a prodromal period. Here, we rep…
View article: Kinetics and dynamics of single-molecule multivalent interactions revealed by plasmon-enhanced fluorescence
Kinetics and dynamics of single-molecule multivalent interactions revealed by plasmon-enhanced fluorescence Open
Multivalency as an interaction principle is widely utilized in nature. It enables specific and strong binding by multiple weak interactions through enhanced avidity and is a core process in immune recognition and cellular signaling and a c…
View article: Real-time microsecond dynamics of single biomolecules probed by plasmon-enhanced fluorescence
Real-time microsecond dynamics of single biomolecules probed by plasmon-enhanced fluorescence Open
Biomolecules exhibit dynamics on widely varying timescales, which are critical to their functioning in living systems. Particularly sub-millisecond dynamics, such as low-affinity ligand binding and interactions of individual binding sites …
View article: Microplate Format Protein Nanopatterning for High-Throughput Screening of Cellular Microenvironments
Microplate Format Protein Nanopatterning for High-Throughput Screening of Cellular Microenvironments Open
An advanced protein nanopatterned cell culture platform is engineered to emulate the extracellular matrix’s complexity, enabling precise nanoscale biomolecule copatterning to mimic environments analogous to native tissue for cellular assay…
View article: Engineering Substrate-Mediated Localized Surface Plasmons in Gold Nanodiscs
Engineering Substrate-Mediated Localized Surface Plasmons in Gold Nanodiscs Open
A variety of nanostructures capable of generating strong local electromagnetic fields (hot spots) in interaction with radiation have been under intensive investigation towards plasmonic applications in surface-enhanced Raman scattering (SE…
View article: Serial intravital 2-photon microscopy and analysis of the kidney using upright microscopes
Serial intravital 2-photon microscopy and analysis of the kidney using upright microscopes Open
Serial intravital 2-photon microscopy of the kidney and other abdominal organs is a powerful technique to assess tissue function and structure simultaneously and over time. Thus, serial intravital microscopy can capture dynamic tissue chan…
View article: Advanced bioengineering of female germ cells to preserve fertility
Advanced bioengineering of female germ cells to preserve fertility Open
Oogenesis and folliculogenesis are considered as complex and species-specific cellular differentiation processes, which depend on the in vivo ovarian follicular environment and endocrine cues. Considerable efforts have been devoted to driv…
View article: The Role of Nanoscale Distribution of Fibronectin in the Adhesion of <i>Staphylococcus aureus</i> Studied by Protein Patterning and DNA-PAINT
The Role of Nanoscale Distribution of Fibronectin in the Adhesion of <i>Staphylococcus aureus</i> Studied by Protein Patterning and DNA-PAINT Open
Staphylococcus aureus is a widespread and highly virulent pathogen that can cause superficial and invasive infections. Interactions between S. aureus surface receptors and the extracellular matrix protein fibronectin mediate the bacterial …
View article: Protein Ligand Nanopattern Size Selects for Cellular Adhesion via Hemidesmosomes over Focal Adhesions
Protein Ligand Nanopattern Size Selects for Cellular Adhesion via Hemidesmosomes over Focal Adhesions Open
Hemidesmosomes (HDs) are multiprotein complexes that firmly anchor epidermal cells to the basement membrane of skin through the interconnection of the cytoplasmic intermediate filaments with extracellular laminin 332 (Ln332). Considerably …
View article: Co-delivery of STAT3 siRNA and methotrexate in breast cancer cells
Co-delivery of STAT3 siRNA and methotrexate in breast cancer cells Open
Co-delivery of anticancer drugs and biologics can provide synergetic effects and outperform single delivery therapies. Here, a nanoparticle (NP) system for co-delivery of methotrexate (MTX) and STAT3 siRNA has been developed and tested in …