Duncan R. Smith
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Development and cross-amplification of novel SSR markers for population genetic analysis of Kitti’s hog-nosed bat (Craseonycteris thonglongyai) in Thailand Open
Kitti's hog-nosed bat or Craseonycteris thonglongyai is the only species in the family Craseonycteridae genus Craseonycteris and is considered as Endangered on the IUCN Red List of near-threatened vulnerable animals. This study aimed prima…
View article: Increased expression of chaperone proteins in response to DENV 2 infection of Huh-7 liver cells
Increased expression of chaperone proteins in response to DENV 2 infection of Huh-7 liver cells Open
The mosquito transmitted dengue virus (DENV; family Flaviviridae , genus Orthoflaviviru s, species Orthoflavivirus denguei ) is a significant public health problem in many tropical and subtropical countries around the world. Human infectio…
View article: Sphingomyelins in mosquito saliva reconfigure skin lipidome to promote viral protein levels and enhance transmission of flaviviruses
Sphingomyelins in mosquito saliva reconfigure skin lipidome to promote viral protein levels and enhance transmission of flaviviruses Open
Many flaviviruses with high pandemic potential are transmitted through mosquito bites. While mosquito saliva is essential for transmission and represents a promising pan-flaviviral target, there is a dearth of knowledge on salivary metabol…
View article: Comparative Analysis of Two Zika Virus Isolates in a Rhesus Macaque Pregnancy Model
Comparative Analysis of Two Zika Virus Isolates in a Rhesus Macaque Pregnancy Model Open
Zika virus (ZIKV) infection during pregnancy can cause a broad range of neurological birth defects, collectively named Congenital Zika Syndrome (CZS). We have previously shown that infection with the Puerto Rican isolate PRVABC59 (ZIKV-PR)…
View article: The interaction of Orthoflavivirus nonstructural proteins 3 and 5 with human fatty acid synthase
The interaction of Orthoflavivirus nonstructural proteins 3 and 5 with human fatty acid synthase Open
Mosquito-transmitted viruses of the genus Orthoflavivirus impose a significant public health burden in many tropical and sub-tropical countries around the world, yet there is still no therapeutic drug to treat infection by any of these vir…
View article: Evidence of RNA polymerase III recruitment and transcription at protein-coding gene promoters
Evidence of RNA polymerase III recruitment and transcription at protein-coding gene promoters Open
RNA polymerase (Pol) I, II, and III are most commonly described as having distinct roles in synthesizing ribosomal RNA (rRNA), messenger RNA (mRNA), and specific small noncoding (nc)RNAs, respectively. This delineation of transcriptional r…
View article: Strain Variation Can Significantly Modulate the miRNA Response to Zika Virus Infection
Strain Variation Can Significantly Modulate the miRNA Response to Zika Virus Infection Open
Zika virus (ZIKV) is a mosquito-transmitted virus that has emerged as a major public health concern due to its association with neurological disorders in humans, including microcephaly in fetuses. ZIKV infection has been shown to alter the…
View article: Mosquito surveillance on U.S military installations as part of a Japanese encephalitis virus detection program: 2016 to 2021
Mosquito surveillance on U.S military installations as part of a Japanese encephalitis virus detection program: 2016 to 2021 Open
Japanese encephalitis virus (JEV) continues to circulate throughout Southeast Asia and the Western Pacific where approximately 3 billion people in 24 countries are at risk of infection. Surveillance targeting the mosquito vectors of JEV wa…
View article: The vitamin D receptor agonist EB1089 can exert its antiviral activity independently of the vitamin D receptor
The vitamin D receptor agonist EB1089 can exert its antiviral activity independently of the vitamin D receptor Open
Vitamin D has been shown to have antiviral activity in a number of different systems. However, few studies have investigated whether the antiviral activity is exerted through the vitamin D receptor (VDR). In this study, we investigated whe…
View article: Mosquito surveillance on U.S military installations as part of a Japanese encephalitis virus detection program: 2016 to 2021
Mosquito surveillance on U.S military installations as part of a Japanese encephalitis virus detection program: 2016 to 2021 Open
Japanese encephalitis virus (JEV) continues to circulate throughout Southeast Asia and the Western Pacific where approximately 3 billion people in 24 countries are at risk of infection. Surveillance targeting the mosquito vectors of JEV wa…
View article: Resveratrol Enhances Cytotoxic Effects of Cisplatin by Inducing Cell Cycle Arrest and Apoptosis in Ovarian Adenocarcinoma SKOV-3 Cells through Activating the p38 MAPK and Suppressing AKT
Resveratrol Enhances Cytotoxic Effects of Cisplatin by Inducing Cell Cycle Arrest and Apoptosis in Ovarian Adenocarcinoma SKOV-3 Cells through Activating the p38 MAPK and Suppressing AKT Open
In the current study, we identified a mechanism of resveratrol (RES) underlying its anti-cancer properties against human ovarian adenocarcinoma SKOV-3 cells. We investigated its anti-proliferative and apoptosis-inducing effects in combinat…
View article: The anti-leukemic activity of a luteolin-apigenin enriched fraction from an edible and ethnomedicinal plant, Elsholtzia stachyodes, is exerted through an ER stress/autophagy/cell cycle arrest/ apoptotic cell death signaling axis
The anti-leukemic activity of a luteolin-apigenin enriched fraction from an edible and ethnomedicinal plant, Elsholtzia stachyodes, is exerted through an ER stress/autophagy/cell cycle arrest/ apoptotic cell death signaling axis Open
This study is the first to report E. stachyodes as a new source of luteolin and apigenin which are capable of triggering leukemic cell death. This could lead to a novel strategy against leukemia using ethnomedicinal plant extracts as an al…
View article: Alpinetin Suppresses Zika Virus-Induced Interleukin-1β Production and Secretion in Human Macrophages
Alpinetin Suppresses Zika Virus-Induced Interleukin-1β Production and Secretion in Human Macrophages Open
Zika virus (ZIKV) infection has been recognized to cause adverse sequelae in the developing fetus. Specially, this virus activates the excessive release of IL-1β causing inflammation and altered physiological functions in multiple organs. …
View article: Simultaneous Production of a Virus-Like Particle Linked to dsRNA to Enhance dsRNA Delivery for Yellow Head Virus Inhibition
Simultaneous Production of a Virus-Like Particle Linked to dsRNA to Enhance dsRNA Delivery for Yellow Head Virus Inhibition Open
A co-expressed Penaeus stylirostris densovirus (PstDNV) capsid and dsRNA specific to the yellow head virus (YHV) protease (CoEx cpPstDNV/dspro) has been shown to suppress YHV replication in the Pacific white-legged shrimp (Litopenaeus vann…
View article: Cell Type Variability in the Incorporation of Lipids in the Dengue Virus Virion
Cell Type Variability in the Incorporation of Lipids in the Dengue Virus Virion Open
A lipid bilayer produced from the host membrane makes up around 20% of the weight of the dengue virus (DENV) virion and is crucial for virus entry. Despite its significance, the virion’s lipid composition is still poorly understood. In tan…
View article: Isolation and Characterization of a Phapecoctavirus Infecting Multidrug-Resistant Acinetobacter baumannii in A549 Alveolar Epithelial Cells
Isolation and Characterization of a Phapecoctavirus Infecting Multidrug-Resistant Acinetobacter baumannii in A549 Alveolar Epithelial Cells Open
Multidrug-resistant Acinetobacter baumannii (MDR A. baumannii) is an emerging pathogen in the ESKAPE group. The global burden of antimicrobial resistance has led to renewed interest in alternative antimicrobial treatment strategies, includ…
View article: The Roles of Mitophagy and Autophagy in Ineffective Erythropoiesis in β-Thalassemia
The Roles of Mitophagy and Autophagy in Ineffective Erythropoiesis in β-Thalassemia Open
β-Thalassemia is one of the most common genetically inherited disorders worldwide, and it is characterized by defective β-globin chain synthesis leading to reduced or absent β-globin chains. The excess α-globin chains are the key factor le…