Duncan T. Wilcox
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View article: 0450 Performance of an AI Algorithm in Scoring Respiratory and Non-Respiratory Arousals Using Respiratory Inductance Plethysmography Signals
0450 Performance of an AI Algorithm in Scoring Respiratory and Non-Respiratory Arousals Using Respiratory Inductance Plethysmography Signals Open
Introduction Arousals are brief awakenings from sleep that can occur spontaneously or in response to stimuli, including respiratory disturbances, limb movements, or environmental factors. They impact sleep architecture and are key to diagn…
View article: Author Correction: Lower urinary dysfunction as a long-term effect of childhood vincristine treatment, with potential influences by sex and dose
Author Correction: Lower urinary dysfunction as a long-term effect of childhood vincristine treatment, with potential influences by sex and dose Open
View article: Urological Outcomes in Adult Females Born with Anorectal Malformation or Hirschsprung Disease
Urological Outcomes in Adult Females Born with Anorectal Malformation or Hirschsprung Disease Open
Introduction Women born with anorectal malformation (ARM) or Hirschsprung disease (HD) may have impaired urologic function resulting in sequelae in adulthood. This study assessed and compared self-reported urinary outcomes in adult females…
View article: Undescended testis: A roundtable discussion based on clinical scenarios – Part 2
Undescended testis: A roundtable discussion based on clinical scenarios – Part 2 Open
View article: Risk of acute kidney injury after lower urinary tract reconstruction with early NSAID therapy: A propensity matched retrospective analysis
Risk of acute kidney injury after lower urinary tract reconstruction with early NSAID therapy: A propensity matched retrospective analysis Open
These results support that postoperative NSAIDs were an unlikely source of AKI. However, AKI remained a risk following these surgeries, regardless of NSAID use, likely owing to underlying disease, longer operations, and fluid shifts.
View article: Lower urinary dysfunction as a long-term effect of childhood vincristine treatment, with potential influences by sex and dose
Lower urinary dysfunction as a long-term effect of childhood vincristine treatment, with potential influences by sex and dose Open
View article: Undescended testis: A roundtable discussion based on clinical scenarios – Part 1
Undescended testis: A roundtable discussion based on clinical scenarios – Part 1 Open
View article: Anorectal malformation in a 46,XY patient with a de novo stop-loss variant in PPP1R12A and associated difference in sexual development: A case report
Anorectal malformation in a 46,XY patient with a de novo stop-loss variant in PPP1R12A and associated difference in sexual development: A case report Open
Introduction: Here we report an infant with a 46,XY karyotype and novel de novo PPP1R12A stop-loss variant with a concomitant anorectal malformation (ARM) and difference in sex development (DSD). Case report: This is an infant born with am…
View article: Management of the urological tract in children with anorectal malformations – a contemporary review
Management of the urological tract in children with anorectal malformations – a contemporary review Open
Anorectal malformations (ARMs) consist of a broad spectrum of congenital anomalies that are associated with an equally wide variety of urological abnormalities, often with increasing incidence as the severity of the ARM increases. The impo…
View article: Anti-fibrotic effect of tocotrienols for bladder dysfunction due to partial bladder outlet obstruction
Anti-fibrotic effect of tocotrienols for bladder dysfunction due to partial bladder outlet obstruction Open
Purpose: To investigate potential beneficial effects of tocotrienols which have been suggested to inhibit hypoxia-inducible factor (HIF) pathway, on partial bladder outlet obstruction (PBOO)-induced bladder pathology. Materials and Methods…
View article: Do Adult Patients with Congenital Colorectal Conditions know their Diagnosis?
Do Adult Patients with Congenital Colorectal Conditions know their Diagnosis? Open
Purpose Limited research exists about the knowledge that adult patients have about their congenital colorectal diagnosis. Methods This was an IRB approved, prospective study of patients in the Adult Colorectal Research Registry who complet…
View article: Sexual dimorphic impacts of systemic vincristine on lower urinary tract function
Sexual dimorphic impacts of systemic vincristine on lower urinary tract function Open
Vincristine (VCR) is one of the most common chemotherapy agents used in pediatric oncology. Despite the well-known VCR-induced peripheral neuropathy, potential impacts of VCR on lower urinary tract (LUT) function remain poorly defined. We …
View article: Total urogenital mobilization via prone approach
Total urogenital mobilization via prone approach Open
Objective: A urogenital sinus (UGS) is a rare congenital condition defined by a common channel into which both the urinary and genital tracts drain. This malformation is often associated with other anomalies such as differences of sexual d…
View article: A prospective survey study of lower urinary tract dysfunction in childhood cancer survivors after vincristine and/or doxorubicin chemotherapy
A prospective survey study of lower urinary tract dysfunction in childhood cancer survivors after vincristine and/or doxorubicin chemotherapy Open
Background Two chemotherapeutic agents used widely in pediatric oncology are vincristine (VCR) and doxorubicin (DOX), which may cause neuropathy and myopathy, respectively. The study hypothesis is that neurotoxic effects of VCR and/or myot…
View article: Functional constipation induces bladder overactivity associated with upregulations of Htr2 and Trpv2 pathways
Functional constipation induces bladder overactivity associated with upregulations of Htr2 and Trpv2 pathways Open
View article: Design and development of the Pediatric Urology Recovery After Surgery Endeavor (PURSUE) multicentre pilot and exploratory study
Design and development of the Pediatric Urology Recovery After Surgery Endeavor (PURSUE) multicentre pilot and exploratory study Open
Introduction Lower urinary tract reconstruction in paediatric urology represents a physiologically stressful event that is associated with high complication rates, including readmissions and emergency room visits. Enhanced recovery after s…
View article: MP54-17 CONSTIPATION INDUCES DETRUSOR OVERACTIVITY MEDIATED BY AN INCREASED SENSITIVITY TO SEROTONIN IN MOUSE BLADDERS
MP54-17 CONSTIPATION INDUCES DETRUSOR OVERACTIVITY MEDIATED BY AN INCREASED SENSITIVITY TO SEROTONIN IN MOUSE BLADDERS Open
You have accessJournal of UrologyUrodynamics/Lower Urinary Tract Dysfunction/Female Pelvic Medicine: Basic Research & Pathophysiology (MP54)1 Apr 2020MP54-17 CONSTIPATION INDUCES DETRUSOR OVERACTIVITY MEDIATED BY AN INCREASED SENSITIVITY T…
View article: Doxorubicin induces detrusor smooth muscle impairments through myosin dysregulation, leading to a risk of lower urinary tract dysfunction
Doxorubicin induces detrusor smooth muscle impairments through myosin dysregulation, leading to a risk of lower urinary tract dysfunction Open
Cytotoxic chemotherapy is the foundation for the treatment of the wide variety of childhood malignancies; however, these therapies are known to have a variety of deleterious side effects. One common chemotherapy used in children, doxorubic…
View article: Inpatient interventions that may preclude outpatient open pyeloplasty in infants
Inpatient interventions that may preclude outpatient open pyeloplasty in infants Open
In appropriately selected patients, outpatient pyeloplasty appears to be feasible with an oral postoperative analgesia plan to be administered at home.
View article: Inpatient interventions that may preclude outpatient open pyeloplasty in infants
Inpatient interventions that may preclude outpatient open pyeloplasty in infants Open
Objective: In the majority of published series, children undergoing open pyeloplasty are admitted for at least one night. We hypothesized that it would be possible in the majority of infants to perform open pyeloplasty as an outpatient pro…
View article: Early life voiding dysfunction leads to lower urinary tract dysfunction through alteration of muscarinic and purinergic signaling in the bladder
Early life voiding dysfunction leads to lower urinary tract dysfunction through alteration of muscarinic and purinergic signaling in the bladder Open
Lower urinary tract dysfunction (LUTD) is a common problem in children and constitutes up to 40% of pediatric urology clinic visits. Improved diagnosis and interventions have been leading to better outcomes in many patients, whereas some c…
View article: MP38-14 CONSTIPATION INDUCES OVERACTIVE BLADDER THROUGH ALTERATIONS OF NICOTINIC AND PURINERGIC PATHWAYS IN MOUSE BLADDERS
MP38-14 CONSTIPATION INDUCES OVERACTIVE BLADDER THROUGH ALTERATIONS OF NICOTINIC AND PURINERGIC PATHWAYS IN MOUSE BLADDERS Open
You have accessJournal of UrologyUrodynamics/Lower Urinary Tract Dysfunction/Female Pelvic Medicine: Basic Research & Pathophysiology II1 Apr 2018MP38-14 CONSTIPATION INDUCES OVERACTIVE BLADDER THROUGH ALTERATIONS OF NICOTINIC AND PURINERG…
View article: PD48-09 DESIGN AND DEVELOPMENT OF THE PEDIATRIC UROLOGY RECOVERY AFTER SURGERY ENDEAVOR (PURSUE) MULTI-CENTER PILOT AND EXPLORATORY STUDY
PD48-09 DESIGN AND DEVELOPMENT OF THE PEDIATRIC UROLOGY RECOVERY AFTER SURGERY ENDEAVOR (PURSUE) MULTI-CENTER PILOT AND EXPLORATORY STUDY Open
You have accessJournal of UrologyTrauma/Reconstruction/Diversion: Transitional Urology & GU Congenitalism1 Apr 2018PD48-09 DESIGN AND DEVELOPMENT OF THE PEDIATRIC UROLOGY RECOVERY AFTER SURGERY ENDEAVOR (PURSUE) MULTI-CENTER PILOT AND EXPL…
View article: MP56-03 CHARACTERIZATION OF VOIDING PHENOTYPE IN MALE MICE TREATED WITH DOXORUBICIN
MP56-03 CHARACTERIZATION OF VOIDING PHENOTYPE IN MALE MICE TREATED WITH DOXORUBICIN Open
You have accessJournal of UrologyPediatrics: Dysfunctional Voiding & Enuresis1 Apr 2018MP56-03 CHARACTERIZATION OF VOIDING PHENOTYPE IN MALE MICE TREATED WITH DOXORUBICIN Nao Iguchi, Kevin Huang, Alonso Carrasco, Duncan Wilcox, Anna Malykh…
View article: Preventative effects of a HIF inhibitor, 17-DMAG, on partial bladder outlet obstruction-induced bladder dysfunction
Preventative effects of a HIF inhibitor, 17-DMAG, on partial bladder outlet obstruction-induced bladder dysfunction Open
Posterior urethral valves are the most common cause of partial bladder outlet obstruction (PBOO) in the pediatric population. Pathological changes in the bladder developed during PBOO are responsible for long-lasting voiding dysfunction in…
View article: Genitourinary and gastrointestinal co-morbidities in children: The role of neural circuits in regulation of visceral function
Genitourinary and gastrointestinal co-morbidities in children: The role of neural circuits in regulation of visceral function Open
View article: Inhibition of HIF Reduces Bladder Hypertrophy and Improves Bladder Function in Murine Model of Partial Bladder Outlet Obstruction
Inhibition of HIF Reduces Bladder Hypertrophy and Improves Bladder Function in Murine Model of Partial Bladder Outlet Obstruction Open
In vivo 17-DMAG treatment decreased partial bladder outlet obstruction induced pathophysiological changes in the bladder. HIF pathway inhibition has a potential clinical implication for the development of novel pharmacological therapies to…