Dunja Gorup
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View article: Detecting glioblastoma infiltration beyond conventional imaging tumour margins using MTE-NODDI
Detecting glioblastoma infiltration beyond conventional imaging tumour margins using MTE-NODDI Open
Glioblastoma (GBM) is the most common and aggressive brain tumour with stark resistance to available therapies, leading to relapse and a median survival of <15 months. A key cause of therapy resistance is diffuse infiltration of tumour …
View article: Reactivation of corticogenesis-related transcriptional factors BCL11B and SATB2 after ischemic lesion of the adult mouse brain
Reactivation of corticogenesis-related transcriptional factors BCL11B and SATB2 after ischemic lesion of the adult mouse brain Open
The aim of this study was to characterize expression of corticogenesis-related transcription factors BCL11B and SATB2 after brain ischemic lesion in the adult mice, and to analyze their correlation to the subsequent brain recovery. Ischemi…
View article: Data-driven spatio-temporal modelling of glioblastoma
Data-driven spatio-temporal modelling of glioblastoma Open
Mathematical oncology provides unique and invaluable insights into tumour growth on both the microscopic and macroscopic levels. This review presents state-of-the-art modelling techniques and focuses on their role in understanding glioblas…
View article: Imaging mass spectrometry differentiates the effects of doxorubicin formulations on non-targeted tissues
Imaging mass spectrometry differentiates the effects of doxorubicin formulations on non-targeted tissues Open
Imaging mass spectrometry indicated a wide range of chemical disturbances in a model of non-targeted organs of rats treated with different formulations of doxorubicin and enabled the differentiation of drug formulation-specific effects.
View article: Molecular mechanisms of microglia- and astrocyte-driven neurorestoration triggered by application of electromagnetic fields
Molecular mechanisms of microglia- and astrocyte-driven neurorestoration triggered by application of electromagnetic fields Open
The microglia-astrocyte crosstalk during EMF treatment is crucial for the initiation of neurorestoration. Elucidating the exact mechanisms of EMF actions upon microglia and astrocytes, and its role in neurorestoration could be a key step i…
View article: Tlr2 Deficiency is Associated with Enhanced Elements of Neuronal Repair and Caspase 3 Activation Following Brain Ischemia
Tlr2 Deficiency is Associated with Enhanced Elements of Neuronal Repair and Caspase 3 Activation Following Brain Ischemia Open
The aim of this study was to apply multimodal in vivo imaging to assess the influence of altered innate immunity on brain repair after ischemic lesion. Tlr2-deficient mice were compared to wild type controls, as they lack Tlr2-mediated pro…
View article: Stem cells and stroke—how glowing neurons illuminate new paths
Stem cells and stroke—how glowing neurons illuminate new paths Open
A reliable method of cell tracing is essential in evaluating potential therapeutic procedures based on stem cell transplantation. Here we present data collected using neural stem cells isolated from a transgenic mouse line Thy1-YFP. When t…
View article: Neural stem cells from mouse strain Thy1 YFP-16 are a valuable tool to monitor and evaluate neuronal differentiation and morphology
Neural stem cells from mouse strain Thy1 YFP-16 are a valuable tool to monitor and evaluate neuronal differentiation and morphology Open
View article: The effect of natriuretic peptides and bradykinin on development of brain oedema after ischemic stroke
The effect of natriuretic peptides and bradykinin on development of brain oedema after ischemic stroke Open
View article: Increased expression and colocalization of GAP43 and CASP3 after brain ischemic lesion in mouse
Increased expression and colocalization of GAP43 and CASP3 after brain ischemic lesion in mouse Open