Jay Dunlap
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View article: Core Clock Protein Subcellular Dynamics Coordinate Local and Global Circadian Control in Syncytia
Core Clock Protein Subcellular Dynamics Coordinate Local and Global Circadian Control in Syncytia Open
Circadian rhythms are pervasive among eukaryotes, and the underlying clocks share a common regulatory architecture - a negative feedback loop. A wealth of genetic and biochemical data underpin current perceptions of circadian oscillators b…
View article: A Daily Cycle of White Collar Complex Dephosphorylation Sustains Circadian Rhythmicity in <i>Neurospora</i>
A Daily Cycle of White Collar Complex Dephosphorylation Sustains Circadian Rhythmicity in <i>Neurospora</i> Open
As a photoreceptor, the transcription factor complex WCC acutely activates ∼5% of the genome in response to blue light, while as the circadian positive element in the dark WCC influences expression of about 40% of the transcriptome. Among …
View article: Celebrating the fifth edition of the International Symposium on Fungal Stress – ISFUS, a decade after its 2014 debut
Celebrating the fifth edition of the International Symposium on Fungal Stress – ISFUS, a decade after its 2014 debut Open
The Fifth International Symposium on Fungal Stress (ISFUS) brought together in Brazil many of the leaders in the field of fungal stress responses, from fourteen countries, for four days of outstanding science ranging from basic research to…
View article: A Compensated Clock: Temperature and Nutritional Compensation Mechanisms Across Circadian Systems
A Compensated Clock: Temperature and Nutritional Compensation Mechanisms Across Circadian Systems Open
Circadian rhythms are ∼24‐h biological oscillations that enable organisms to anticipate daily environmental cycles, so that they may designate appropriate day/night functions that align with these changes. The molecular clock in animals an…
View article: The auxotrophic formate (for) mutant of Neurospora crassa has significantly delayed growth but a normal circadian clock
The auxotrophic formate (for) mutant of Neurospora crassa has significantly delayed growth but a normal circadian clock Open
Some cell biological studies of Neurospora crassa have been limited by the rapid rates of hyphal growth and fusion. In this study, we investigated the causative mutation in the standard C24 allele of for (FGSC #9) and assayed the growth an…
View article: Acetylation of WCC is dispensable for the core circadian clock but differentially regulates acute light responses in Neurospora
Acetylation of WCC is dispensable for the core circadian clock but differentially regulates acute light responses in Neurospora Open
In the Neurospora circadian system, the White Collar Complex (WCC) formed by WC-1 and WC-2 drives expression of the frequency (frq) gene whose product FRQ feedbacks to inhibit transcriptional activity of WCC. Phosphorylation of WCC has bee…
View article: Transcriptional rewiring of an evolutionarily conserved circadian clock
Transcriptional rewiring of an evolutionarily conserved circadian clock Open
Circadian clocks temporally coordinate daily organismal biology over the 24-h cycle. Their molecular design, preserved between fungi and animals, is based on a core-oscillator composed of a one-step transcriptional-translational-negative-f…
View article: Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock
Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock Open
Circadian clocks are composed of transcription-translation negative feedback loops that pace rhythms of gene expression to the diurnal cycle. In the filamentous fungus Neurospora crassa, the proteins F requency ( F RQ), the F RQ-interactin…
View article: Author Response: Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock
Author Response: Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock Open
Full text Figures and data Peer review Side by side Abstract eLife assessment eLife digest Introduction Results Discussion Materials and methods Data availability References Article and author information Metrics Abstract Circadian clocks …
View article: Reviewer #2 (Public Review): Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock
Reviewer #2 (Public Review): Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock Open
Circadian clocks are composed of molecular oscillators that pace rhythms of gene expression to the diurnal cycle. Therein, transcriptional-translational negative feedback loops (TTFLs) generate oscillating levels of transcriptional repress…
View article: Author Response: Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock
Author Response: Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock Open
Circadian clocks are composed of molecular oscillators that pace rhythms of gene expression to the diurnal cycle. Therein, transcriptional-translational negative feedback loops (TTFLs) generate oscillating levels of transcriptional repress…
View article: Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock
Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock Open
Circadian clocks are composed of molecular oscillators that pace rhythms of gene expression to the diurnal cycle. Therein, transcriptional-translational negative feedback loops (TTFLs) generate oscillating levels of transcriptional repress…
View article: Reviewer #1 (Public Review): Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock
Reviewer #1 (Public Review): Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock Open
Circadian clocks are composed of molecular oscillators that pace rhythms of gene expression to the diurnal cycle. Therein, transcriptional-translational negative feedback loops (TTFLs) generate oscillating levels of transcriptional repress…