Explanipedia

Unanchored ubiquitin chains promote the non-canonical inflammasome via UBXN1 2222 Open

Jason G. Cahoon, Duomeng Yang, Tingting Geng, Chengliang Wang, Andrew G. Harrison , et al. · 2025

Description Ubiquitination is a major posttranslational covalent modification that regulates numerous cellular processes including inflammasome signaling. Cells also contain unanchored ubiquitin chains (polyUb) that bind protein targets no…

Mechanisms and therapeutic potential of pharmacological agents targeting inflammasomes Open

Haitao Li, Tiantian Liu, Xiaolei Shi, Hao Du, Chengzhi Cai , et al. · 2025

Recent high-impact research has significantly advanced our understanding of inflammasomes as therapeutic targets for inflammatory diseases. Breakthrough studies have revealed new mechanisms of inflammasome regulation and innovative inhibit…

UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling Open

Andrew G. Harrison, Duomeng Yang, Jason G. Cahoon, Tingting Geng, Ziming Cao , et al. · 2024

Unanchored ubiquitin chains promote the non-canonical inflammasome via UBXN1 Open

Duomeng Yang, Jason G. Cahoon, Tingting Geng, Chengliang Wang, Andrew G. Harrison , et al. · 2024

Ubiquitination is a major posttranslational covalent modification that regulates numerous cellular processes including inflammasome signaling. Cells also contain unanchored ubiquitin chains (polyUb) that bind protein targets non-covalently…

Endothelial α1-adrenergic receptor activation improves cardiac function in septic mice via PKC-ERK/p38MAPK signaling pathway Open

Tian Tian, Qing Yu, Duomeng Yang, Xue Zhang, Chanjuan Zhang , et al. · 2024

Cardiomyopathy is particularly common in septic patients. Our previous studies have shown that activation of the alpha 1 adrenergic receptor (α₁-AR) on cardiomyocytes inhibits sepsis-induced myocardial dysfunction. However, the …

UBXN3B is crucial for B lymphopoiesis Open

Tingting Geng, Duomeng Yang, Tao Lin, Andrew G. Harrison, Binsheng Wang , et al. · 2024

United States National Institutes of Health grants, R01AI132526 and R21AI155820.

UBXN9 governs GLUT4-mediated spatial confinement of RIG-I-like receptors and signaling Open

Penghua Wang, Andrew G. Harrison, Duomeng Yang, Jason G. Cahoon, Tingting Geng , et al. · 2024

The cytoplasmic RIG-I-like receptors (RLRs) recognize viral RNA and initiate innate antiviral immunity. RLR signaling also triggers glycolytic reprogramming through glucose transporters (GLUTs), whose role in antiviral immunity is elusive.…

UBR5 promotes antiviral immunity by disengaging the transcriptional brake on RIG-I like receptors Open

Duomeng Yang, Tingting Geng, Andrew G. Harrison, Jason G. Cahoon, Xing Jian , et al. · 2024

The Retinoic acid-Inducible Gene I (RIG-I) like receptors (RLRs) are the major viral RNA sensors essential for the initiation of antiviral immune responses. RLRs are subjected to stringent transcriptional and posttranslational regulations,…

Unanchored Ubiquitin Chains Promote the Non-Canonical Inflammasome via UBXN1 Open

Duomeng Yang, Jason G. Cahoon, Tingting Geng, Chengliang Wang, Andrew G. Harrison , et al. · 2024

Endothelial α1-Adrenergic Receptor Activation Improves Cardiac Function in Septic Mice via PKC-ERK/p38MAPK Signaling Pathway Open

Tian Tian, Duomeng Yang, Qing Yu, Xue Zhang, Chanjuan Zhang , et al. · 2024

Dexmedetomidine post-treatment exacerbates metabolic disturbances in septic cardiomyopathy via α2A-adrenoceptor Open

Yaqian Xu, Xue Zhang, Xiangxu Tang, Chanjuan Zhang, Jason G. Cahoon , et al. · 2023

Cardiomyopathy is a common complication and significantly increases the risk of death in septic patients. Our previous study demonstrated that post-treatment with dexmedetomidine (DEX) aggravates septic cardiomyopathy. However, the mechani…

The glucose transporter GLUT4 tethers RIG-I-like receptors to suppress antiviral immunity Open

Andrew G. Harrison, Duomeng Yang, Jason G. Cahoon, Tingting Geng, Timofey A. Karginov , et al. · 2023

The current dogma of RIG-I-like receptor (RLR) regulation states that dysregulated interferon (IFN) production is predominantly repressed by reversible posttranslational modifications (e.g., ubiquitination). However, RLR activation has pro…

The development of COVID-19 treatment Open

Yongliang Yuan, Baihai Jiao, Lili Qu, Duomeng Yang, Ruijuan Liu · 2023

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a pandemic named coronavirus disease 2019 (COVID-19) that has become the greatest worldwide public health threat of this century. Recent studies have unra…

UBXN3B is Crucial for B Lymphopoiesis Open

Tingting Geng, Duomeng Yang, Tao Lin, Andrew G. Harrison, Binsheng Wang , et al. · 2023

UBXN3B Controls Immunopathogenesis of Arthritogenic Alphaviruses by Maintaining Hematopoietic Homeostasis Open

Tingting Geng, Duomeng Yang, Tao Lin, Jason G. Cahoon, Penghua Wang · 2022

The human genome encodes 13 ubiquitin regulatory X (UBX) domain-containing proteins (UBXN) that might participate in diverse cellular processes. However, their in vivo physiological functions remain largely elusive.

The noncanonical inflammasome in health and disease Open

Jason G. Cahoon, Duomeng Yang, Penghua Wang · 2022

Innate immune signaling plays a significant role in the rapid cellular responses against foreign entities. An inflammasome is a large cytosolic polymer of a pattern recognition receptor with/without an adaptor protein, formed in response t…

Intrinsic cardiac adrenergic cells contribute to LPS-induced myocardial dysfunction Open

Duomeng Yang, Xiaomeng Dai, Yun Xing, Xiangxu Tang, Guang Yang , et al. · 2022

Intrinsic cardiac adrenergic (ICA) cells regulate both developing and adult cardiac physiological and pathological processes. However, the role of ICA cells in septic cardiomyopathy is unknown. Here we show that norepinephrine (NE) secreti…

Differential roles of RIG-I like receptors in SARS-CoV-2 infection Open

Duomeng Yang, Tingting Geng, Andrew G. Harrison, Penghua Wang · 2021

A critical role for MSR1 in vesicular stomatitis virus infection of the central nervous system Open

Duomeng Yang, Tao Lin, Cen Li, Andrew G. Harrison, Tingting Geng , et al. · 2021

An Essential Role of UBXN3B in B Lymphopoiesis Open

Tingting Geng, Duomeng Yang, Tao Lin, Andrew G. Harrison, Binsheng Wang , et al. · 2021

Hematopoiesis is finely regulated to enable timely production of the right numbers and types of mature immune cells to maintain tissue homeostasis. Dysregulated hematopoiesis may compromise antiviral immunity and/or exacerbate immunopathog…

Intrinsic cardiac adrenergic cells contribute to septic cardiomyopathy Open

Duomeng Yang, Xiaomeng Dai, Yun Xing, Xiangxu Tang, Guang Yang , et al. · 2021

Occurring independently of cardiac sympathetic nervous system, the intrinsic cardiac adrenergic (ICA) cells have been identified as an important regulator in both of developing and adult cardiac physiological and pathological processes. Ho…

Differential roles of RIG-I-like receptors in SARS-CoV-2 infection Open

Duomeng Yang, Tingting Geng, Andrew G. Harrison, Penghua Wang · 2021

The retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5) are the major viral RNA sensors that are essential for activation of antiviral immune responses. However, their roles in severe acute respi…

CXCL10 Signaling Contributes to the Pathogenesis of Arthritogenic Alphaviruses Open

Lin Tao, Tingting Geng, Andrew G. Harrison, Duomeng Yang, Anthony T. Vella , et al. · 2020

Emerging and re-emerging arthritogenic alphaviruses, such as Chikungunya virus (CHIKV) and O’nyong nyong virus, cause acute and chronic crippling arthralgia associated with inflammatory immune responses. Approximately 50% of CHIKV-infected…

A Critical Role for STING Signaling in Limiting Pathogenesis of Chikungunya Virus Open

Tingting Geng, Tao Lin, Duomeng Yang, Andrew G. Harrison, Anthony T. Vella , et al. · 2020

The stimulator of interferon gene (STING) pathway controls both DNA and RNA virus infection. STING is essential for induction of innate immune responses during DNA virus infection, while its mechanism against RNA virus remains largely elus…

Macrophage scavenger receptor 1 controls Chikungunya virus infection through autophagy in mice Open

Long Yang, Tingting Geng, Guang Yang, Jinzhu Ma, Leilei Wang , et al. · 2020

Macrophage scavenger receptor 1 (MSR1) mediates the endocytosis of modified low-density lipoproteins and plays an important antiviral role. However, the molecular mechanism underlying MSR1 antiviral actions remains elusive. We report that …

Effect of dobutamine on intrinsic myocardial function and myocardial apoptosis in septic rats with myocardial dysfunction Open

Xiangxu Tang, Ya-Qian Xu, Xiaomeng Dai, Yun Xing, Duomeng Yang , et al. · 2020

Background Dobutamine (DOB) has been recommended as the first-line inotrope for septic patients with low cardiac output, but its long-term impact on intrinsic myocardial dysfunction during sepsis remains unclear. This study investigated th…

A critical role for MSR1 in vesicular stomatitis virus infection of the central nervous system Open

Duomeng Yang, Tao Lin, Andrew G. Harrison, Tingting Geng, Huadong Wang , et al. · 2020

Macrophage scavenger receptor 1 (MSR1) plays an important role in host defense to bacterial infections, M2 macrophage polarization and lipid homeostasis. However, its physiological function in viral pathogenesis remains poorly defined. Her…

STING deficiency-associated aberrant CXCL10 expression contributes to pathogenesis of arthritogenic alphaviruses Open

Tao Lin, Tingting Geng, Andrew G. Harrison, Duomeng Yang, Anthony T. Vella , et al. · 2020

Arthritogenic alphaviruses such as Chikungunya virus and O’nyong nyong virus cause acute and chronic crippling arthralgia associated with inflammatory immune responses. However, the physiological functions of individual immune signaling pa…

MicroRNA181b Is Protective in Murine Models of Sepsis by Limiting Gut Permeability Open

Antonio J. Arciniegas, Jack Varon, Joseph A. DeCorte, Luis Fandino, S. Haemming , et al. · 2020

Macrophage scavenger receptor 1 controls Chikungunya virus infection through autophagy Open

Long Yang, Tingting Geng, Guang Yang, Jinzhu Ma, Leilei Wang , et al. · 2020

Macrophage scavenger receptor 1 (MSR1) mediates the endocytosis of modified low-density lipoproteins and plays an important antiviral role. However, the molecular mechanism underlying MSR1 antiviral actions remains elusive. Herein, we repo…

Duomeng Yang YOU? Author Swipe