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View article: A FRET-based high-throughput screening assay for the discovery of <i>Mycobacterium tuberculosis</i> DNA ADP-ribosylglycohydrolase DarG inhibitors
A FRET-based high-throughput screening assay for the discovery of <i>Mycobacterium tuberculosis</i> DNA ADP-ribosylglycohydrolase DarG inhibitors Open
DarTG2 is a conserved toxin-antitoxin ADP-ribosylation system that regulates bacterial survival and the anti-phage response found in many pathogenic bacteria, including Mycobacterium tuberculosis . While DNA ADP-ribosyltransferase (DarT2) …
View article: Identification of a series of pyrrolo-pyrimidine based SARS-CoV-2 Mac1 inhibitors that repress coronavirus replication
Identification of a series of pyrrolo-pyrimidine based SARS-CoV-2 Mac1 inhibitors that repress coronavirus replication Open
Coronaviruses (CoVs) can emerge from zoonotic sources and cause severe diseases in humans and animals. All CoVs encode for a macrodomain (Mac1) that binds to and removes ADP-ribose from target proteins. SARS-CoV-2 Mac1 promotes virus repli…
View article: Discovery of 2-amide-3-methylester thiophenes that target SARS-CoV-2 Mac1 and repress coronavirus replication, validating Mac1 as an anti-viral target
Discovery of 2-amide-3-methylester thiophenes that target SARS-CoV-2 Mac1 and repress coronavirus replication, validating Mac1 as an anti-viral target Open
The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has made it clear that further development of antiviral therapies will be needed to combat additional SARS-CoV-2 variants or novel CoVs. Her…