Duo‐Yao Cao
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View article: Palmitoylation: an emerging therapeutic target bridging physiology and disease
Palmitoylation: an emerging therapeutic target bridging physiology and disease Open
View article: Editorial: Hiding features in myeloid cells: metabolism preference in different disease models
Editorial: Hiding features in myeloid cells: metabolism preference in different disease models Open
View article: Peroxisome proliferator-activated receptor alpha is an essential factor in enhanced macrophage immune function induced by angiotensin-converting enzyme
Peroxisome proliferator-activated receptor alpha is an essential factor in enhanced macrophage immune function induced by angiotensin-converting enzyme Open
View article: Tumor derived cell‐free nucleic acid upregulates programmed death‐ligand 1 expression in neutrophil via intracellular Toll‐like receptor signaling
Tumor derived cell‐free nucleic acid upregulates programmed death‐ligand 1 expression in neutrophil via intracellular Toll‐like receptor signaling Open
View article: The role of forkhead box M1-methionine adenosyltransferase 2 A/2B axis in liver inflammation and fibrosis
The role of forkhead box M1-methionine adenosyltransferase 2 A/2B axis in liver inflammation and fibrosis Open
Methionine adenosyltransferase 2 A (MAT2A) and MAT2B are essential for hepatic stellate cells (HSCs) activation. Forkhead box M1 (FOXM1) transgenic mice develop liver inflammation and fibrosis. Here we examine if they crosstalk in male mic…
View article: Lactococcus lactis subsp. cremoris C60 Upregulates Macrophage Function by Modifying Metabolic Preference in Enhanced Anti-Tumor Immunity
Lactococcus lactis subsp. cremoris C60 Upregulates Macrophage Function by Modifying Metabolic Preference in Enhanced Anti-Tumor Immunity Open
Lactococcus lactis subsp. cremoris C60 is a probiotic strain of lactic acid bacteria (LAB) which induces various immune modifications in myeloid lineage cells. These modifications subsequently regulate T cell function, resulting in enhance…
View article: Classical and nonclassical effects of angiotensin-converting enzyme: How increased ACE enhances myeloid immune function
Classical and nonclassical effects of angiotensin-converting enzyme: How increased ACE enhances myeloid immune function Open
View article: Neutrophils Expressing Programmed Death-Ligand 1 Play an Indispensable Role in Effective Bacterial Elimination and Resolving Inflammation in Methicillin-Resistant Staphylococcus aureus Infection
Neutrophils Expressing Programmed Death-Ligand 1 Play an Indispensable Role in Effective Bacterial Elimination and Resolving Inflammation in Methicillin-Resistant Staphylococcus aureus Infection Open
Programmed death ligand 1 (PD-L1) is a co-inhibitory molecule expressed on the surface of various cell types and known for its suppressive effect on T cells through its interaction with PD-1. Neutrophils also express PD-L1, and its express…
View article: The role of γδT lymphocytes in atherosclerosis
The role of γδT lymphocytes in atherosclerosis Open
Atherosclerosis poses a significant threat to human health, impacting overall well-being and imposing substantial financial burdens. Current treatment strategies mainly focus on managing low-density lipids (LDL) and optimizing liver functi…
View article: Lactococcus lactis subsp. cremoris C60 Upregulates Macrophage Function by Modifying Metabolic Preference in Enhanced Anti‐Tumor Immunity
Lactococcus lactis subsp. cremoris C60 Upregulates Macrophage Function by Modifying Metabolic Preference in Enhanced Anti‐Tumor Immunity Open
Lactococcus lactis subsp. cremoris C60 is a probiotic strain of lactic acid bacteria (LAB) which induces various immune modifications in myeloid lineage cells. These modifications subsequently reg-ulate T cell function, resulting in enhanc…
View article: Neutrophils Expressing Programmed Death-Ligand 1 Play an Indispensable Role in Effective Bacterial Elimination and Resolving Inflammation in Methicillin-Resistant Staphylococcus aureus Infection
Neutrophils Expressing Programmed Death-Ligand 1 Play an Indispensable Role in Effective Bacterial Elimination and Resolving Inflammation in Methicillin-Resistant Staphylococcus aureus Infection Open
Programmed death ligand 1 (PD-L1) is a co-inhibitory molecule expressed on the surface of various cell types, known for its suppressive effect on T cells through interaction with PD-1. Neutrophils also express PD-L1, and its expression is …
View article: Probiotic lactic acid bacteria promote anti-tumor immunity through enhanced major histocompatibility complex class I-restricted antigen presentation machinery in dendritic cells
Probiotic lactic acid bacteria promote anti-tumor immunity through enhanced major histocompatibility complex class I-restricted antigen presentation machinery in dendritic cells Open
Lactic acid bacteria (LAB) possess the ability to argument T cell activity through functional modification of antigen presenting cells (APCs), such as dendritic cells (DCs) and macrophages. Nevertheless, the precise mechanism underlying LA…
View article: Hepatic prohibitin 1 and methionine adenosyltransferase α1 defend against primary and secondary liver cancer metastasis
Hepatic prohibitin 1 and methionine adenosyltransferase α1 defend against primary and secondary liver cancer metastasis Open
View article: Testicular ACE regulates sperm metabolism and fertilization through the transcription factor PPARγ
Testicular ACE regulates sperm metabolism and fertilization through the transcription factor PPARγ Open
View article: Myeloid cell ACE shapes cellular metabolism and function in PCSK-9 induced atherosclerosis
Myeloid cell ACE shapes cellular metabolism and function in PCSK-9 induced atherosclerosis Open
The pathogenesis of atherosclerosis is defined by impaired lipid handling by macrophages which increases intracellular lipid accumulation. This dysregulation of macrophages triggers the accumulation of apoptotic cells and chronic inflammat…
View article: Editorial: Role of angiotensin-converting enzyme in myeloid immune functions
Editorial: Role of angiotensin-converting enzyme in myeloid immune functions Open
EDITORIAL article Front. Physiol., 28 September 2023Sec. Cell Physiology Volume 14 - 2023 | https://doi.org/10.3389/fphys.2023.1297995
View article: Macrophage angiotensin-converting enzyme reduces atherosclerosis by increasing peroxisome proliferator-activated receptor α and fundamentally changing lipid metabolism
Macrophage angiotensin-converting enzyme reduces atherosclerosis by increasing peroxisome proliferator-activated receptor α and fundamentally changing lipid metabolism Open
Aims The metabolic failure of macrophages to adequately process lipid is central to the aetiology of atherosclerosis. Here, we examine the role of macrophage angiotensin-converting enzyme (ACE) in a mouse model of PCSK9-induced atheroscler…
View article: Gene Expression Profiling of Fibroepithelial Lesions of the Breast
Gene Expression Profiling of Fibroepithelial Lesions of the Breast Open
Fibroepithelial lesions of the breast (FELs) are a heterogeneous group of neoplasms exhibiting a histologic spectrum ranging from fibroadenomas (FAs) to malignant phyllodes tumors (PTs). Despite published histologic criteria for their clas…
View article: miR766-3p and miR124-3p Dictate Drug Resistance and Clinical Outcome in HNSCC
miR766-3p and miR124-3p Dictate Drug Resistance and Clinical Outcome in HNSCC Open
Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive disease with poor prognosis, which is mainly due to drug resistance. The biology determining the response to chemo-radiotherapy in HNSCC is poorly understood. Using clini…
View article: Overexpressed angiotensin-converting enzyme in neutrophils suppresses glomerular damage in crescentic glomerulonephritis
Overexpressed angiotensin-converting enzyme in neutrophils suppresses glomerular damage in crescentic glomerulonephritis Open
We studied immune complex (IC)-mediated crescentic glomerulonephritis in NeuACE mice that overexpress ACE only in neutrophils. Such mice show no significant defects in humoral immunity but strongly resist nephrotoxic serum nephritis (less …
View article: Tubular IL-1β Induces Salt Sensitivity in Diabetes by Activating Renal Macrophages
Tubular IL-1β Induces Salt Sensitivity in Diabetes by Activating Renal Macrophages Open
Background: Chronic renal inflammation has been widely recognized as a major promoter of several forms of high blood pressure including salt-sensitive hypertension. In diabetes, IL (interleukin)-6 induces salt sensitivity through a dysregu…
View article: The non-cardiovascular actions of ACE
The non-cardiovascular actions of ACE Open
View article: Creatine supplementation enhances immunological function of neutrophils by increasing cellular adenosine triphosphate
Creatine supplementation enhances immunological function of neutrophils by increasing cellular adenosine triphosphate Open
Creatine is an organic compound which is utilized in biological activities, especially for adenosine triphosphate (ATP) production in the phosphocreatine system. This is a well-known biochemical reaction that is generally recognized as bei…
View article: RASAL3 Is a Putative RasGAP Modulating Inflammatory Response by Neutrophils
RASAL3 Is a Putative RasGAP Modulating Inflammatory Response by Neutrophils Open
As first responder cells in host defense, neutrophils must be carefully regulated to prevent collateral tissue injury. However, the intracellular events that titrate the neutrophil’s response to inflammatory stimuli remain poorly understoo…
View article: An ACE inhibitor reduces bactericidal activity of human neutrophils in vitro and impairs mouse neutrophil activity in vivo
An ACE inhibitor reduces bactericidal activity of human neutrophils in vitro and impairs mouse neutrophil activity in vivo Open
ACE inhibitor treatment reduces human and mouse neutrophil function.
View article: Novel roles of the renal angiotensin-converting enzyme
Novel roles of the renal angiotensin-converting enzyme Open
View article: Renal Inflammation Induces Salt Sensitivity in Male db/db Mice through Dysregulation of ENaC
Renal Inflammation Induces Salt Sensitivity in Male db/db Mice through Dysregulation of ENaC Open
Significance Statement Men with diabetes have higher incidence of renal disease and hypertension than premenopausal women with diabetes. A mouse model investigated the mechanisms that predispose to salt-sensitive hypertension during diabet…
View article: Tumors exploit CXCR4 <sup>hi</sup> CD62L <sup>lo</sup> aged neutrophils to facilitate metastatic spread
Tumors exploit CXCR4 <sup>hi</sup> CD62L <sup>lo</sup> aged neutrophils to facilitate metastatic spread Open
Granulocytes are key players in cancer metastasis. While tumor-induced de novo expansion of immunosuppressive myeloid-derived suppressor cells (MDSCs) is well-described, the fate and contribution of terminally differentiated mature …
View article: Bacterial Lipoteichoic Acid Attenuates Toll-Like Receptor Dependent Dendritic Cells Activation and Inflammatory Response
Bacterial Lipoteichoic Acid Attenuates Toll-Like Receptor Dependent Dendritic Cells Activation and Inflammatory Response Open
Toll-like receptor (TLR) signaling is an indispensable factor in immune cells activation. Many TLR ligands have been identified, and were characterized the immunological functions such as inflammatory cytokine production in immune cells. H…
View article: Role of angiotensin-converting enzyme in myeloid cell immune responses
Role of angiotensin-converting enzyme in myeloid cell immune responses Open