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View article: Relative biological effectiveness and neural stem cell fate in carbon ion–irradiated human brain organoids
Relative biological effectiveness and neural stem cell fate in carbon ion–irradiated human brain organoids Open
View article: Radiation quality matters: morphological and biochemical responses of Brassica rapa microgreens to X-rays, C-ions, and Fe-ions
Radiation quality matters: morphological and biochemical responses of Brassica rapa microgreens to X-rays, C-ions, and Fe-ions Open
View article: Experimental assessment of novel PET detector components for online imaging of radioactive ion beams
Experimental assessment of novel PET detector components for online imaging of radioactive ion beams Open
Objective. This work aims to evaluate the ability of novel detector components to measure with submillimeter resolution in beam positron emission tomography (PET) signals produced by 10 C and 11 C radioactive ion beams stopped in PMMA targ…
View article: Characterization of a permanent magnetic dipolar system for the FOOT experiment
Characterization of a permanent magnetic dipolar system for the FOOT experiment Open
The FOOT (FragmentatiOn Of Target) experiment aims to measure double differential fragmentation cross-sections for applications in Particle Therapy and space radiation protection. A critical component of the apparatus is its magnetic spect…
View article: Image-guided treatment of mouse tumours with radioactive ion beams
Image-guided treatment of mouse tumours with radioactive ion beams Open
Charged particle therapy with protons or heavier ions is one of the most effective radiotherapy techniques, but uncertainties in the beam range can limit its efficacy. Radioactive ion beams are ideal for image-guided particle therapy becau…
View article: 2-Deoxy-D-Glucose and ES-936 sensitize cancer- but not normal cells to both low- and high LET irradiation
2-Deoxy-D-Glucose and ES-936 sensitize cancer- but not normal cells to both low- and high LET irradiation Open
Introduction Metabolic differences of normal- and cancer cells represent an important target for the development of novel cancer treatment strategies. Given that radiotherapy constitutes one of the primary treatment modalities for solid ca…
View article: Real-time motion modeling and treatment verification for irregular motion in carbon ion therapy: a feasibility study
Real-time motion modeling and treatment verification for irregular motion in carbon ion therapy: a feasibility study Open
Objective. Irregular motion impacts treatment accuracy and can be compensated by larger margins or online adaptive approaches. A seamless workflow for fast and accurate 4D-dose reconstruction allows dosimetric monitoring intra- and inter-f…
View article: DNA double-strand breaks in and beyond heavy-ion tracks: the role of Base Excision Repair and DNA-damage complexity
DNA double-strand breaks in and beyond heavy-ion tracks: the role of Base Excision Repair and DNA-damage complexity Open
Space radiation poses a threat to human health during space missions. Its biological effect largely depends on heavy ions. These induce highly clustered DNA damage along their tracks, thus impacting genomic integrity and cancer risk. δ-ele…
View article: Comprehensive Robustness Evaluation of Proton and Carbon-Ion Plans in Thoracic Cancer Treatment
Comprehensive Robustness Evaluation of Proton and Carbon-Ion Plans in Thoracic Cancer Treatment Open
View article: In vitro measurement of proton RBE: A multi-centric comparison using a harmonized setup
In vitro measurement of proton RBE: A multi-centric comparison using a harmonized setup Open
View article: Induction of Cytoplasmic dsDNA and cGAS-STING Immune Signaling After Exposure of Breast Cancer Cells to X-ray or High-Energetic Carbon Ions
Induction of Cytoplasmic dsDNA and cGAS-STING Immune Signaling After Exposure of Breast Cancer Cells to X-ray or High-Energetic Carbon Ions Open
View article: HyperSHArc: Single-Isocenter Stereotactic Radiosurgery of Multiple Brain Metastases Using Proton, Helium, and Carbon Ion Arc Therapy
HyperSHArc: Single-Isocenter Stereotactic Radiosurgery of Multiple Brain Metastases Using Proton, Helium, and Carbon Ion Arc Therapy Open
View article: Diagnostic and therapeutic care pathway of the Cardiac Network for Heart Failure
Diagnostic and therapeutic care pathway of the Cardiac Network for Heart Failure Open
The Cardiac Network for Heart Failure integrates patients into a dedicated clinical pathway to enhance care and improve quality of life, creating a personalized approach according to current guidelines. This study seeks to evaluate nurses’…
View article: Development and performance assessment of the BGO calorimeter module for the FOOT experiment
Development and performance assessment of the BGO calorimeter module for the FOOT experiment Open
FOOT (FragmentatiOn Of Target) is a nuclear physics experiment currently under construction that will measure differential cross sections for the production of secondary fragments induced by the interactions of proton and ion beams, up to …
View article: Feasibility study of 4D-online monitoring of density gradients induced by lung cancer treatment using carbon ions
Feasibility study of 4D-online monitoring of density gradients induced by lung cancer treatment using carbon ions Open
Tumor motion is a major challenge for scanned ion-beam therapy. In the case of lung tumors, strong under- and overdosage can be induced due to the high density gradients between the tumor- and bone tissues compared to lung tissues. This wo…
View article: Aberrant choroid plexus formation drives the development of treatment-related brain toxicity
Aberrant choroid plexus formation drives the development of treatment-related brain toxicity Open
View article: Evaluation of motion mitigation strategies for carbon ion therapy of abdominal tumors based on non-periodic imaging data
Evaluation of motion mitigation strategies for carbon ion therapy of abdominal tumors based on non-periodic imaging data Open
Objective. To identify suitable combination strategies for treatment planning and beam delivery in scanned carbon ion therapy of moving tumors. Approach . Carbon ion treatment plans for five abdominal tumors were optimized on four-dimensio…
View article: The HEARTS EU Project and Its Initial Results on Fragmented High-Energy Heavy-Ion Single-Event Effects Testing
The HEARTS EU Project and Its Initial Results on Fragmented High-Energy Heavy-Ion Single-Event Effects Testing Open
<p>We performed Single Event Effects (SEE) tests with well-characterized fully fragmented high-energy heavy-ion beams<br>and compare the results with those expected from conventional, mono-Linear Energy Transfer (LET)…
View article: Probing Spatiotemporal Effects of Intertrack Recombination with a New Implementation of Simultaneous Multiple Tracks in TRAX-CHEM
Probing Spatiotemporal Effects of Intertrack Recombination with a New Implementation of Simultaneous Multiple Tracks in TRAX-CHEM Open
Among the most investigated hypotheses for a radiobiological explanation of the mechanism behind the FLASH effect in ultra-high dose rate radiotherapy, intertrack recombination between particle tracks arriving at a close spatiotemporal dis…
View article: Cross Section Measurements of Large Angle Fragments Production in the Interaction of Carbon Ion Beams with Thin Targets
Cross Section Measurements of Large Angle Fragments Production in the Interaction of Carbon Ion Beams with Thin Targets Open
The fragmentation cross sections of carbon ion beams with kinetic energies of $115 - 353~\text{MeV/u}$ impinging on thin targets of graphite (C), polyvinyl-toluene (C$_9$H$_{10}$) and PMMA (C$_2$O$_5$H$_8$) have been measured at 90$^{\text…
View article: Radioresistant, Rare, Recurrent, and Radioinduced: 4Rs of Hadrontherapy for Patients Selections
Radioresistant, Rare, Recurrent, and Radioinduced: 4Rs of Hadrontherapy for Patients Selections Open
Biological characteristics of the tumor support the administration of HT in radioresistant, rare, recurrent, and radio-induced tumors and should be considered during multidisciplinary discussions.
View article: Morphological and Photosynthetic Pigment Screening of Four Microgreens Species Exposed to Heavy Ions
Morphological and Photosynthetic Pigment Screening of Four Microgreens Species Exposed to Heavy Ions Open
Numerous challenges are posed by the extra-terrestrial environment for space farming and various technological growth systems are being developed to allow for microgreens’ cultivation in space. Microgreens, with their unique nutrient profi…
View article: FLASH Bragg-Peak Irradiation With a Therapeutic Carbon Ion Beam: First In Vivo Results
FLASH Bragg-Peak Irradiation With a Therapeutic Carbon Ion Beam: First In Vivo Results Open
These results suggest that the UHDR irradiations can improve the safety and effectiveness of heavy ion therapy, and provide a crucial benchmark for current mechanistic FLASH models. However, additional experiments are needed to validate th…
View article: First image-guided treatment of a mouse tumor with radioactive ion beams
First image-guided treatment of a mouse tumor with radioactive ion beams Open
View article: First image-guided treatment of a mouse tumor with radioactive ion beams
First image-guided treatment of a mouse tumor with radioactive ion beams Open
Radioactive ion beams (RIB) are a key focus of current research in nuclear physics. Already long ago it was proposed that they could have applications in cancer therapy. In fact, while charged particle therapy is potentially the most effec…
View article: Real-time delivered dose assessment in carbon ion therapy of moving targets
Real-time delivered dose assessment in carbon ion therapy of moving targets Open
Objective . Real-time adaptive particle therapy is being investigated as a means to maximize the treatment delivery accuracy. To react to dosimetric errors, a system for fast and reliable verification of the agreement between planned and d…
View article: Opportunities and challenges of upright patient positioning in radiotherapy
Opportunities and challenges of upright patient positioning in radiotherapy Open
Objective. Upright positioning has seen a surge in interest as a means to reduce radiotherapy (RT) cost, improve patient comfort, and, in selected cases, benefit treatment quality. In particle therapy (PT) in particular, eliminating the ne…
View article: Induction of cytoplasmic dsDNA and cGAS-STING immune signaling after exposure of breast cancer cells to X-rays or high energetic carbon ions
Induction of cytoplasmic dsDNA and cGAS-STING immune signaling after exposure of breast cancer cells to X-rays or high energetic carbon ions Open
Radiotherapy can trigger activation of the cGAS-STING axis via cytoplasmic dsDNA fragment induction. The activation of cGAS–STING initiates innate immune signaling mediated by interferon type-I that can contribute to eradicate the malignan…
View article: Deep learning-based voxel sampling for particle therapy treatment planning
Deep learning-based voxel sampling for particle therapy treatment planning Open
Objective. Scanned particle therapy often requires complex treatment plans, robust optimization, as well as treatment adaptation. Plan optimization is especially complicated for heavy ions due to the variable relative biological effectiven…
View article: Upright to supine image registration and contour propagation for thoracic patients
Upright to supine image registration and contour propagation for thoracic patients Open
A renewed interest in upright therapy is currently driven by the availability of upright positioning and imaging systems. Aside from reduced cost, upright positioning possibly provides clinical advantages. The comparison between upright an…