Durga Prasad Beda
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View article: A novel RP-HPLC stability-indicating method for simultaneous estimation of Niraparib and Abiraterone in synthetic mixtures and combined tablet formulations
A novel RP-HPLC stability-indicating method for simultaneous estimation of Niraparib and Abiraterone in synthetic mixtures and combined tablet formulations Open
Niraparib and Abiraterone in a combined dosage form offer a fortunate regimen for treating cancers, mainly those resistant to conventional therapies cast in cancer treatment. The present study intends to develop a novel RP-HPLC method for …
View article: Innovative Non-Pharmacological Therapies for SARS-CoV-2 Infections: Advances, Challenges and Future Directions
Innovative Non-Pharmacological Therapies for SARS-CoV-2 Infections: Advances, Challenges and Future Directions Open
The COVID-19 pandemic has necessitated diverse therapeutic approaches, including drug-free therapies to complement pharmaceutical interventions. This review examines the current landscape, challenges and future perspectives of non-drug the…
View article: Spectrophotometric method development and validation for simultaneous quantification of Cefoperazone and Sulbactum sodium in bulk and marketed formulation: greenness profile evaluation
Spectrophotometric method development and validation for simultaneous quantification of Cefoperazone and Sulbactum sodium in bulk and marketed formulation: greenness profile evaluation Open
The antibiotics Cefoperazone Sodium and Sulbactam Sodium are widely employed in clinical medicine as means to combat many kinds of bacterial infections. The drugs Cefoperazone and Sulbactum shows wavelength at 229 m and 277 nm respectively…
View article: Role of tert-Butyl Hydroperoxide (TBHP) in Cross-Coupling Reactions
Role of tert-Butyl Hydroperoxide (TBHP) in Cross-Coupling Reactions Open
tert-Butyl hydroperoxide (tBuOOH, TBHP) is a common hydroperoxide used in a variety of oxidation processes. The primary reasons for TBHP’s increased usability are its low cost, environmental friendliness, high efficiency, and capacity to r…
View article: Implementation of quality by design and green chemistry principles to validate the stability indicating method on UHPLC for the simultaneous quantification of Glycopyrronium, Fluticasone, Vilanterol in inhaled formulation
Implementation of quality by design and green chemistry principles to validate the stability indicating method on UHPLC for the simultaneous quantification of Glycopyrronium, Fluticasone, Vilanterol in inhaled formulation Open
The combination of Glycopyrronium, Fluticasone, and Vilanterol is utilized to manage chronic obstructive pulmonary disease (COPD) and mitigate asthma symptoms. Glycopyrronium functions as an anticholinergic compound, Fluticasone serves as …
View article: <i>tert</i> ‐Butyl Hydroperoxide (TBHP): Recent Progress in C−H Functionalization and Heteroatom‐Heteroatom Bond Formations
<i>tert</i> ‐Butyl Hydroperoxide (TBHP): Recent Progress in C−H Functionalization and Heteroatom‐Heteroatom Bond Formations Open
tert‐ Butyl hydroperoxide (tBuOOH, TBHP) is a commonly used hydroperoxide in many oxidation processes. The primary factors contributing to the increasing usefulness of TBHP include its affordability, eco‐friendliness, exceptional efficacy,…
View article: Combined green analytical principles and quality by design for ultraperformance liquid chromatography analytical method development, the characterization and in-silico toxicity prediction of Ixazomib degradation products using mass spectrometry
Combined green analytical principles and quality by design for ultraperformance liquid chromatography analytical method development, the characterization and in-silico toxicity prediction of Ixazomib degradation products using mass spectrometry Open
Ixazomib citrate (IC) is the first oral selective proteosome inhibitor for treating multiple myeloma. IC is prone to degradation due to its oxidative deboronation and the amide bond, affecting patient health, drug quality, and efficacy. Th…
View article: Characterization of Prasugrel Degradation Profile by Several Oxidative Reagents using HPLC and LC-MS/MS Technique
Characterization of Prasugrel Degradation Profile by Several Oxidative Reagents using HPLC and LC-MS/MS Technique Open
Prasugrel, a derivative of thienopyridine functions as a prodrug that exerts irreversible inhibition on platelet ADP receptors by specifically targeting the P2Y12 receptor. In pharmaceuticals, the stability of the product plays a crucial r…
View article: Implementation of green analytical principles to develop and validate the HPLC method for the separation and identification of degradation products of Panobinostat, and its characterization by using LC-QTOF-MS/MS and its in-silico toxicity prediction using ADMET software
Implementation of green analytical principles to develop and validate the HPLC method for the separation and identification of degradation products of Panobinostat, and its characterization by using LC-QTOF-MS/MS and its in-silico toxicity prediction using ADMET software Open
Panobinostat (PAN) is an inhibitor of histone deacetylase (HDAC) that has been granted approval by the US Regulator for the purpose of treating chronic lymphocytic leukemia. Stress studies were conducted on PAN to assess its inherent stabi…