Explanipedia

Evaluation of non-invasive biomarkers of kidney allograft rejection in a prospective multicenter unselected cohort study (EU-TRAIN) Open

Valentin Goutaudier, Richard Danger, Rusan Catar, Maud Racapé, Aurélie Philippe , et al. · 2024

Non-invasive biomarkers are promising tools for improving kidney allograft rejection monitoring, but their clinical adoption requires more evidence in specifically designed studies. To address this unmet need, we designed the EU-TRAIN stud…

Vasoregulatory Autoantibodies and Clinical Outcome After Ischemic Stroke—PROSCIS‐B Open

Thomas Liman, Bob Siegerink, Sophie K. Piper, Rusan Catar, Guido Moll , et al. · 2023

Background Vasoregulatory autoantibodies including autoantibodies targeting G‐protein–coupled receptors might play a functional role in vascular diseases. We investigated the impact of vasoregulatory autoantibodies on clinical outcome afte…

Impact of everolimus plus calcineurin inhibitor on formation of non-HLA antibodies and graft outcomes in kidney transplant recipients: 12-month results from the ATHENA substudy Open

Aurélie Philippe, Wolfgang Arns, Vanessa Ditt, Ingeborg A. Hauser, Friedrich Thaiss , et al. · 2023

Background Non-human leukocyte antigen (non-HLA) antibodies including antibodies targeting Angiotensin II type 1 (AT1R) and Endothelin-1 type A (ETAR) receptors represent a topic of interest in kidney transplantation (KTx). This explorator…

Autoantibodies from patients with kidney allograft vasculopathy stimulate a proinflammatory switch in endothelial cells and monocytes mediated via GPCR-directed PAR1-TNF-α signaling Open

Guido Moll, Christian Luecht, Michael Adu Gyamfi, Dennyson Leandro M. Fonseca, Pinchao Wang , et al. · 2023

Non-HLA-directed regulatory autoantibodies (RABs) are known to target G-protein coupled receptors (GPCRs) and thereby contribute to kidney transplant vasculopathy and failure. However, the detailed underlying signaling mechanisms in human …

Everolimus plus reduced calcineurin inhibitor prevents de novo anti-HLA antibodies and humoral rejection in kidney transplant recipients: 12-month results from the ATHENA study Open

Wolfgang Arns, Aurélie Philippe, Vanessa Ditt, Ingeborg A. Hauser, Friedrich Thaiss , et al. · 2023

Background Studies prospectively monitoring de novo donor-specific antibodies (dnDSAs) and their clinical impact are sparse. This substudy of ATHENA was initiated to evaluate the effect of everolimus (EVR) or mycophenolic acid (MPA) in com…

Expanded Hemodialysis ameliorates uremia-induced impairment of vasculoprotective KLF2 and concomitant proinflammatory priming of endothelial cells through an ERK/AP1/cFOS-dependent mechanism Open

Hongfan Zhao, Dashan Wu, Michael Adu Gyamfi, Pinchao Wang, Christian Luecht , et al. · 2023

Aims Expanded hemodialysis (HDx) therapy with improved molecular cut-off dialyzers exerts beneficial effects on lowering uremia-associated chronic systemic microinflammation, a driver of endothelial dysfunction and cardiovascular disease (…

Molecular Effects of Auto-Antibodies on Angiotensin II Type 1 Receptor Signaling and Cell Proliferation Open

Aurélie Philippe, Gunnar Kleinau, Jason Jannis Gruner, Sumin Wu, Daniel Postpieszala , et al. · 2022

The angiotensin II (Ang II) type 1 receptor (AT1R) is involved in the regulation of blood pressure (through vasoconstriction) and water and ion homeostasis (mediated by interaction with the endogenous agonist). AT1R can also be activated b…

Molecular Effects of Auto-Antibodies on Angiotensin II Type 1 Receptor Signaling and Cell Proliferation Open

Aurélie Philippe, Gunnar Kleinau, Jason Jannis Gruner, Sumin Wu, Daniel Postpieszala , et al. · 2022

The angiotensin II (Ang II) type 1 receptor (AT₁R) is involved in the regulation of blood pressure (through vasoconstriction) and water and ion homeostasis (mediated by interaction with the endogenous agonist). AT₁R c…

Table of Contents Open

john sargent, José A. Moura-Neto, John T. Daugirdas, Robyn G. Langham, Kamyar Kalantar‐Zadeh , et al. · 2022

Autoantibodies Targeting AT1- and ETA-Receptors Link Endothelial Proliferation and Coagulation via Ets-1 Transcription Factor Open

Rusan Catar, Melanie Herse-Naether, Nan Zhu, Philine Wagner, Oskar Wischnewski , et al. · 2021

Scleroderma renal crisis (SRC) is an acute life-threatening manifestation of systemic sclerosis (SSc) caused by obliterative vasculopathy and thrombotic microangiopathy. Evidence suggests a pathogenic role of immunoglobulin G (IgG) targeti…

Expanded Hemodialysis Therapy Ameliorates Uremia-Induced Systemic Microinflammation and Endothelial Dysfunction by Modulating VEGF, TNF-α and AP-1 Signaling Open

Rusan Catar, Guido Moll, Julian Kamhieh‐Milz, Christian Luecht, Lei Chen , et al. · 2021

Systemic chronic microinflammation and altered cytokine signaling, with adjunct cardiovascular disease (CVD), endothelial maladaptation and dysfunction is common in dialysis patients suffering from end-stage renal disease and associated wi…

Association of non-HLA antibodies against endothelial targets and donor-specific HLA antibodies with antibody-mediated rejection and graft function in pediatric kidney transplant recipients Open

Alexander Fichtner, Caner Süsal, Britta Höcker, Susanne Rieger, Rüdiger Waldherr , et al. · 2021

High cut-off dialysis mitigates pro-calcific effects of plasma on vascular progenitor cells Open

Theres Schaub, Daniel Janke, Daniel Zickler, Claudia Lange, Matthias Girndt , et al. · 2021

Mortality of patients with end-stage renal disease tremendously exceeds that of the general population due to excess cardiovascular morbidity. Large middle-sized molecules (LMM) including pro-inflammatory cytokines are major drivers of ure…

Kidney re-transplantation in a child across the barrier of persisting angiotensin II type I receptor antibodies Open

Annika Gold, Alexander Fichtner, Daniela Choukair, Claus Peter Schmitt, Caner Süsal , et al. · 2020

Background Approximately 20% of antibody-mediated rejection (ABMR) episodes in the absence of donor-specific antibodies against human leucocyte antigens (HLA-DSA) in pediatric and adult kidney transplant recipients are associated with, and…

Effect of everolimus‐based drug regimens on CMV‐specific T‐cell functionality after renal transplantation: 12‐month ATHENA subcohort‐study results Open

Ingeborg A. Hauser, Stefanie Marx, Claudia Sommerer, Barbara Suwelack, Duska Dragun , et al. · 2020

Post‐transplant cytomegalovirus (CMV) infections and increased viral replication are associated with CMV‐specific T‐cell anergy. In the ATHENA‐study, de‐novo everolimus (EVR) with reduced‐exposure tacrolimus (TAC) or cyclosporine (CyA) sho…

Author response for "Effect of everolimus-based drug regimens on CMV-specific T-cell functionality after renal transplantation: 12-month ATHENA subcohort-study results" Open

Ingeborg A. Hauser, Stefanie Marx, Claudia Sommerer, Barbara Suwelack, Duska Dragun , et al. · 2020

The Banff 2019 Kidney Meeting Report (I): Updates on and clarification of criteria for T cell– and antibody-mediated rejection Open

Alexandre Loupy, Mark Haas, Candice Roufosse, Maarten Naesens, Benjamin Adam , et al. · 2020

Control of neutrophil influx during peritonitis by transcriptional cross‐regulation of chemokine CXCL1 by IL‐17 and IFN‐γ Open

Rusan Catar, Lei Chen, Simone Cuff, Ann Kift‐Morgan, Matthias Eberl , et al. · 2020

Neutrophil infiltration is a hallmark of peritoneal inflammation, but mechanisms regulating neutrophil recruitment in patients with peritoneal dialysis (PD)‐related peritonitis are not fully defined. We examined 104 samples of PD effluent …

Publisher Correction: mTORC1 and mTORC2 Differentially Regulate Cell Fate Programs to Coordinate Osteoblastic Differentiation in Mesenchymal Stromal Cells Open

Theres Schaub, Dennis Gürgen, Deborah Maus, Claudia Lange, Victor Tarabykin , et al. · 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

IgG stimulated β2 adrenergic receptor activation is attenuated in patients with ME/CFS Open

Jelka Hartwig, Franziska Sotzny, Sandra Bauer, Harald Heidecke, Gabriela Riemekasten , et al. · 2020

We provide evidence that IgG can activate β2 AdR. The β2 AdR activation by IgG is attenuated in ME/CFS patients. A dysregulation of β2 AdR function could explain many symptoms of ME/CFS.

mTORC1 and mTORC2 Differentially Regulate Cell Fate Programs to Coordinate Osteoblastic Differentiation in Mesenchymal Stromal Cells Open

Theres Schaub, Dennis Gürgen, Deborah Maus, Claudia Lange, Victor Tarabykin , et al. · 2019

Vascular regeneration depends on intact function of progenitors of vascular smooth muscle cells such as pericytes and their circulating counterparts, mesenchymal stromal cells (MSC). Deregulated MSC differentiation and maladaptive cell fat…

Diverse Responses of Autoantibodies to the Angiotensin II Type 1 Receptor in Primary Aldosteronism Open

Tracy Ann Williams, Diana Jaquin, Jacopo Burrello, Aurélie Philippe, Yuhong Yang , et al. · 2019

Primary aldosteronism is a common form of endocrine hypertension mainly caused by a unilateral aldosterone-producing adenoma (APA) or bilateral adrenal hyperplasia (BAH). AT1R-Abs (autoantibodies to the angiotensin II type 1 receptor) have…

Discovery and Validation of Novel Biomarkers for Detection of Epithelial Ovarian Cancer Open

Hagen Kulbe, Raik Otto, Silvia Darb‐Esfahani, Hedwig Lammert, Salem Abobaker , et al. · 2019

Detection of epithelial ovarian cancer (EOC) poses a critical medical challenge. However, novel biomarkers for diagnosis remain to be discovered. Therefore, innovative approaches are of the utmost importance for patient outcome. Here, we p…

Prophylactic inhibition of soluble epoxide hydrolase delays onset of nephritis and ameliorates kidney damage in NZB/W F1 mice Open

Jan Klocke, Arzu Ulu, Kaiyin Wu, Birgit Rudolph, Duska Dragun , et al. · 2019

FP761NON-HLA AGONISTIC ANTI-ANGIOTENSIN II TYPE 1 RECEPTOR ANTIBODIES INDUCE A DISTINCTIVE PHENOTYPE OF REJECTION IN KIDNEY TRANSPLANT RECIPIENTS: AN OBSERVATIONAL COHORT STUDY Open

Denis Viglietti, Carmen Lefaucheur, Aurélie Philippe, Olivier Aubert, Denis Glotz , et al. · 2019

A synthetic epoxyeicosatrienoic acid analogue prevents the initiation of ischemic acute kidney injury Open

Uwe Hoff, Gordana Bubalo, Mandy Fechner, Maximilian Blum, Ye Zhu , et al. · 2019

Aim Imbalances in cytochrome P450 (CYP)‐dependent eicosanoid formation may play a central role in ischemic acute kidney injury (AKI). We reported previously that inhibition of 20‐hydroxyeicosatetraenoic acid (20‐HETE) action ameliorated is…

Non-HLA agonistic anti-angiotensin II type 1 receptor antibodies induce a distinctive phenotype of antibody-mediated rejection in kidney transplant recipients Open

Carmen Lefaucheur, Denis Viglietti, Yassine Bouatou, Aurélie Philippe, Danièle Pievani , et al. · 2019

An open-label, randomized trial indicates that everolimus with tacrolimus or cyclosporine is comparable to standard immunosuppression in de novo kidney transplant patients Open

Claudia Sommerer, Barbara Suwelack, Duska Dragun, Peter Schenker, Ingeborg A. Hauser , et al. · 2019

GPCR-specific autoantibody signatures are associated with physiological and pathological immune homeostasis Open

Otávio Cabral-Marques, Alexandre H. C. Marques, Lasse M. Giil, Roberta De Vito, Judith Rademacher , et al. · 2018

Prevalence of Steatosis Hepatis in the Eurotransplant Region: Impact on Graft Acceptance Rates Open

Simon Moosburner, Joseph M. G. V. Gassner, Maximilian Nösser, Julian Pohl, David Wyrwal , et al. · 2018

Due to the shortage of liver allografts and the rising prevalence of fatty liver disease in the general population, steatotic liver grafts are considered for transplantation. This condition is an important risk factor for the outcome after…

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