Explanipedia

Maternal Coronavirus Disease 2019 Test Positivity and Neonatal Intensive Care Unit Outcomes for Infants Born Extremely Preterm Open

Emily A. Messick, Somnath Saha, Jonathan L. Slaughter, Matthew J. Kielt, Kristen Benninger , et al. · 2025

Comparison of metrics of neonatal intensive care unit antibiotic use Open

Alvaro Zevallos Barboza, Sagori Mukhopadhyay, Karen M. Puopolo, Di Shu, Jeffrey S. Gerber , et al. · 2025

Objective: To compare temporal trends, variation, and correlations between antibiotic use metrics across U.S. neonatal intensive care units (NICUs) and assess associations with mortality. Methods: We conducted a retrospective cohort study …

Hospital-onset bacteremia in the neonatal intensive care unit: strategies for risk adjustment Open

Erica C. Prochaska, Shaoming Xiao, Elizabeth Colantuoni, Nora Elhaissouni, Reese H. Clark , et al. · 2025

Objective: To quantify the impact of patient- and unit-level risk adjustment on infant hospital-onset bacteremia (HOB) standardized infection ratio (SIR) ranking. Design: A retrospective, multicenter cohort study. Setting and participants:…

Targeted Maternal Chagas Disease Screening Among Individuals Born in a Chagas-Endemic Country Open

Álvaro Proaño, Neil C. Shah, Sneider Alexander Gutierrez Guarnizo, Monica Miranda‐Schaeubinger, Michael Z. Levy , et al. · 2024

This cohort study examines the prevalence of Chagas disease among Hispanic pregnant women delivering in Philadelphia, Pennsylvania.

Antibiotics for culture-negative neonatal early-onset sepsis: measuring the unmeasurable Open

Dustin D. Flannery, Matthew B Green · 2024

Hospital-Onset Bacteremia Among Neonatal Intensive Care Unit Patients Open

Erica C. Prochaska, Shaoming Xiao, Elizabeth Colantuoni, Reese H. Clark, Julia Johnson , et al. · 2024

Importance The Centers for Disease Control and Prevention plans to introduce hospital-onset bacteremia (HOB) as a health care–associated infection measure. The epidemiology and clinical characteristics of HOB among infants admitted to the …

459 Common vaginal microbes modify Group B Streptococcus growth at epithelial barriers: potential mechanisms governing colonization Open

Briana Ferguson, Dylan Curry, Elliot S. Friedman, Jennifer A. McCoy, Paul J. Planet , et al. · 2024

EBNEO Commentary: Safety and immunogenicity of GBS vaccine in pregnancy and determination of a serocorrelate for infant protection Open

Dustin D. Flannery, Karen M. Puopolo · 2023

COMMENTARYGroup B Streptococcus (GBS) causes approximately 150 000 stillbirths and infant deaths annually worldwide. 1Infants who are exposed to maternal GBS colonisation are at risk of sepsis and meningitis, which when not fatal, are asso…

Antibiotic Use Among Infants Admitted to Neonatal Intensive Care Units Open

Dustin D. Flannery, Alvaro Zevallos Barboza, Sagori Mukhopadhyay, Kelly C. Wade, Jeffrey S. Gerber , et al. · 2023

This cross-sectional study examines antibiotic exposure, days of therapy, types of antibiotics, and changes in use patterns among newborns in neonatal intensive care units (NICUs) across the US from 2009 to 2021.

<span>EBNEO</span> Commentary: Respiratory syncytial virus vaccine in pregnancy for infant protection Open

Álvaro Proaño, Dustin D. Flannery · 2023

Worldwide, respiratory syncytial virus (RSV) is the leading cause of infant hospitalisation and an important cause of death in children.1, 2 RSV leads to 3.2 million annual hospitalisations and 100 000 deaths annually.2 Maternal RSV vaccin…

Association of postnatal age with neonatal hospital-onset bacteremia in a multicenter, retrospective cohort Open

Erica C. Prochaska, Shaoming Xiao, Elizabeth Colantuoni, Sagori Mukhopadhyay, Dustin D. Flannery , et al. · 2023

Background: Prevention of hospital-onset bacteremia (HOB) in all settings is a healthcare priority. The CDC is developing a neonatal-specific HOB quality metric, but the epidemiology of neonatal HOB is poorly understood. Our objective was …

Critical care among newborns with and without a COVID-19 diagnosis, May 2020–February 2022 Open

Bailey Wallace, Daniel Chang, Emily O’Malley Olsen, Dustin D. Flannery, Van T. Tong , et al. · 2023

Measles Serostatus Among Parturient Patients at 2 Philadelphia Hospitals in 2021 Open

Dustin D. Flannery, Alvaro Zevallos Barboza, Kelly C. Wade, Madeline R. Pfeifer, Jeffrey S. Gerber , et al. · 2023

This observational study explores whether rubella serostatus, which is routinely assessed during pregnancy, can serve as a proxy for measles serostatus in parturient persons.

Synthetic patch infection after congenital diaphragmatic hernia repair: A case series Open

Sabrina Flohr, Sierra D. Land, Holly L. Hedrick, Natalie E. Rintoul, Sanjeev Swami , et al. · 2023

Large congenital diaphragmatic hernia (CDH) defects that cannot be closed primarily often require reinforced repair. Synthetic patch is a widely used method of prosthetic patch closure. Infections associated with synthetic patch repair are…

Maternal and Newborn Hospital Outcomes of Perinatal SARS-CoV-2 Infection: A National Registry Open

Mark L. Hudak, Dustin D. Flannery, Kimberly Barnette, Trace Getzlaff, Shiva Gautam , et al. · 2023

OBJECTIVES The American Academy of Pediatrics National Registry for the Surveillance and Epidemiology of Perinatal coronavirus disease 2019 (COVID-19) (NPC-19) was developed to provide information on the effects of perinatal severe acute r…

Diagnostic Performance and Patient Outcomes With C-Reactive Protein Use in Early-Onset Sepsis Evaluations Open

Miren B. Dhudasia, W.E. Benitz, Dustin D. Flannery, Lori Christ, David M. Rub , et al. · 2022

Late-Onset Sepsis Among Very Preterm Infants Open

Dustin D. Flannery, Erika M. Edwards, Sarah A. Coggins, Jeffrey D. Horbar, Karen M. Puopolo · 2022

OBJECTIVES To determine the epidemiology, microbiology, and associated outcomes of late-onset sepsis among very preterm infants using a large and nationally representative cohort of NICUs across the United States. METHODS Prospective obser…

Comparison of Maternal and Neonatal Antibody Levels After COVID-19 Vaccination vs SARS-CoV-2 Infection Open

Dustin D. Flannery, Sigrid Gouma, Miren B. Dhudasia, Sagori Mukhopadhyay, Madeline R. Pfeifer , et al. · 2022

Importance Pregnant persons are at an increased risk of severe COVID-19 from SARS-CoV-2 infection, and COVID-19 vaccination is currently recommended during pregnancy. Objective To ascertain the association of vaccine type, time from vaccin…

Serratia Infection Epidemiology Among Very Preterm Infants in the Neonatal Intensive Care Unit Open

Sarah A. Coggins, Erika M. Edwards, Dustin D. Flannery, Jeffrey S. Gerber, Jeffrey D. Horbar , et al. · 2022

Background: Serratia spp. are opportunistic, multidrug resistant, Gram-negative pathogens, previously described among preterm infants in case reports or outbreaks of infection. We describe Serratia late-onset infection (LOI) in very preter…

Perinatal COVID-19 maternal and neonatal outcomes at two academic birth hospitals Open

Dustin D. Flannery, Alvaro Zevallos Barboza, Madeline R. Pfeifer, Mark L. Hudak, Kimberly Barnette , et al. · 2022

Assessment of SARS-CoV-2 serostatus and hypertensive disorders of pregnancy Open

Jourdan E. Triebwasser, Miren B. Dhudasia, Sagori Mukhopadhyay, Dustin D. Flannery, Sigrid Gouma , et al. · 2022

Neighborhood Characteristics and Racial Disparities in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Seropositivity in Pregnancy Open

Heather H. Burris, Anne Mullin, Miren B. Dhudasia, Dustin D. Flannery, Sagori Mukhopadhyay , et al. · 2022

OBJECTIVE: To quantify the extent to which neighborhood characteristics contribute to racial and ethnic disparities in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seropositivity in pregnancy. METHODS: This cohort study inc…

Early childhood antibiotic utilization for infants discharged from the neonatal intensive care unit Open

Dustin D. Flannery, Molly Passarella, Sagori Mukhopadhyay, Miren B. Dhudasia, Jeffrey S. Gerber , et al. · 2022

Group B <i>Streptococcus</i> Infection in Extremely Preterm Neonates and Neurodevelopmental Outcomes at 2 Years Open

Karen M. Puopolo, Sagori Mukhopadhyay, Nellie I. Hansen, Dustin D. Flannery, Rachel G. Greenberg , et al. · 2022

Background This study was performed to determine the incidence of group B Streptococcus (GBS) disease among extremely preterm infants and assess to risk of death or neurodevelopmental impairment (NDI) at a corrected age of 18–26 months. Me…

Time to positivity of blood cultures in neonatal late-onset bacteraemia Open

Sagori Mukhopadhyay, Sara M. Briker, Dustin D. Flannery, Miren B. Dhudasia, Sarah A. Coggins , et al. · 2022

Objective To determine the time to positivity (TTP) of blood cultures among infants with late-onset bacteraemia and predictors of TTP >36 hours. Design Retrospective cohort study. Setting 16 birth centres in two healthcare systems. Patient…

Delivery Characteristics and the Risk of Early-Onset Neonatal Sepsis Open

Dustin D. Flannery, Sagori Mukhopadhyay, Knashawn H. Morales, Miren B. Dhudasia, Molly Passarella , et al. · 2022

BACKGROUND AND OBJECTIVES Multiple strategies are used to identify newborn infants at high risk of culture-confirmed early-onset sepsis (EOS). Delivery characteristics have been used to identify preterm infants at lowest risk of infection …

Assessment of SARS-CoV-2 serostatus and hypertensive disorders of pregnancy Open

Jourdan E. Triebwasser, Miren B. Dhudasia, Sagori Mukhopadhyay, Dustin D. Flannery, Madeline R. Pfeifer , et al. · 2021

181. Potential Benefit of Masking and other COVID-19 Infection Prevention Measures on Late-Onset Infections in the NICU Open

Charlene R. Bultmann, Jaclyn Wiggins, Sagori Mukhopadhyay, Dustin D. Flannery, Mark R. Conaway , et al. · 2021

Background Incidence of blood stream infections (BSI) among NICU admissions remains high, with associated mortality and morbidity. Due to COVID-19, there are increased infection prevention (IP) measures in NICUs including universal masking…

Neonatal multidrug-resistant gram-negative infection: epidemiology, mechanisms of resistance, and management Open

Dustin D. Flannery, Kathleen Chiotos, Jeffrey S. Gerber, Karen M. Puopolo · 2021

Disparities in SARS-CoV-2 positivity among pregnant patients with limited English proficiency Open

Diana Montoya‐Williams, Anne Mullin, Sara C. Handley, Dustin D. Flannery, Scott A. Lorch , et al. · 2021

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