Dustin L. Higashi
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View article: An inflammatory paradox: strategies inflammophilic oral pathobionts employ to exploit innate immunity via neutrophil manipulation
An inflammatory paradox: strategies inflammophilic oral pathobionts employ to exploit innate immunity via neutrophil manipulation Open
Inflammatory dysbiotic diseases present an intriguing biological paradox. Like most other infectious disease processes, the alarm bells of the host are potently activated by tissue-destructive pathobionts, triggering a cascade of physiolog…
View article: Complete genome sequence of <i>Parvimonas micra</i> strain JM503A, a genetically tractable dental abscess clinical isolate
Complete genome sequence of <i>Parvimonas micra</i> strain JM503A, a genetically tractable dental abscess clinical isolate Open
Parvimonas micra is a pathobiont of humans that is often found in abundance at sites of mucosal inflammation as well as within malignant tumors. Here, we report the complete genome sequence of P. micra strain JM503A, which is a genetically…
View article: Mass spectrometry and split luciferase complementation assays reveal the MecA protein interactome of <i>Streptococcus mutans</i>
Mass spectrometry and split luciferase complementation assays reveal the MecA protein interactome of <i>Streptococcus mutans</i> Open
MecA is a highly conserved adaptor protein encoded by prokaryotes from the Bacillota phylum. MecA mutants exhibit similar pleiotropic defects in a variety of organisms, although most of these phenotypes currently lack a mechanistic basis. …
View article: Mass spectrometry and split luciferase complementation assays reveal the MecA protein interactome of<i>Streptococcus mutans</i>
Mass spectrometry and split luciferase complementation assays reveal the MecA protein interactome of<i>Streptococcus mutans</i> Open
MecA is a highly conserved adaptor protein encoded by prokaryotes from the Bacillota phylum. MecA mutants exhibit similar pleiotropic defects in a variety of organisms, although most of these phenotypes currently lack a mechanistic basis. …
View article: Who is in the driver's seat? <scp> <i>Parvimonas micra</i> </scp> : An understudied pathobiont at the crossroads of dysbiotic disease and cancer
Who is in the driver's seat? <span> <i>Parvimonas micra</i> </span> : An understudied pathobiont at the crossroads of dysbiotic disease and cancer Open
Recent advances in our understanding of microbiome composition at sites of inflammatory dysbiosis have triggered a substantial interest in a variety of historically understudied bacteria, especially among fastidious obligate anaerobes. A p…
View article: Development of the First Tractable Genetic System for Parvimonas micra, a Ubiquitous Pathobiont in Human Dysbiotic Disease
Development of the First Tractable Genetic System for Parvimonas micra, a Ubiquitous Pathobiont in Human Dysbiotic Disease Open
Parvimonas micra is among the most highly enriched species at numerous sites of mucosal dysbiotic disease and is closely associated with numerous cancers. Despite this, little is known about P. micra pathobiology, which is directly attribu…
View article: Development of the First Tractable Genetic System for <i>Parvimonas micra</i>, a Ubiquitous Pathobiont in Human Dysbiotic Disease
Development of the First Tractable Genetic System for <i>Parvimonas micra</i>, a Ubiquitous Pathobiont in Human Dysbiotic Disease Open
Parvimonas micra is a Gram-positive obligate anaerobe and a typical member of the human microbiome. P. micra is among the most highly enriched species at numerous sites of mucosal dysbiotic disease and is closely associated with the develo…
View article: The transcription regulator BrsR serves as a network hub of natural competence protein–protein interactions in <i>Streptococcus mutans</i>
The transcription regulator BrsR serves as a network hub of natural competence protein–protein interactions in <i>Streptococcus mutans</i> Open
Significance Streptococcus mutans is one of the primary species associated with human dental caries, which affects the vast majority of adults worldwide. Like most streptococci, S. mutans is naturally competent and employs this ability to …
View article: Group A Streptococcus-Induced Activation of Human Plasminogen Is Required for Keratinocyte Wound Retraction and Rapid Clot Dissolution
Group A Streptococcus-Induced Activation of Human Plasminogen Is Required for Keratinocyte Wound Retraction and Rapid Clot Dissolution Open
Invasive outcomes of Group A Streptococcus (GAS) infections that involve damage to skin and other tissues are initiated when these bacteria colonize and disseminate via an open wound to gain access to blood and deeper tissues. Two critical…
View article: CD46 is phosphorylated at tyrosine 354 upon infection of epithelial cells by Neisseria gonorrhoeae
CD46 is phosphorylated at tyrosine 354 upon infection of epithelial cells by Neisseria gonorrhoeae Open
The Neisseria type IV pilus promotes bacterial adhesion to host cells. The pilus binds CD46, a complement-regulatory glycoprotein present on nucleated human cells (Källström et al., 1997). CD46 mutants with truncated cytoplasmic tails fail…