Thanh D. Nguyen
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View article: Influence of combined posterior and medial-lateral mid-air trunk perturbations on knee biomechanics during single-leg landing
Influence of combined posterior and medial-lateral mid-air trunk perturbations on knee biomechanics during single-leg landing Open
Objectives To determine the effect of combined posterior and medial-lateral mid-air trunk perturbation on biomechanical variables associated with ACL loading during single-leg landings. Design Controlled laboratory investigation with a rep…
View article: Smoking predicts brain atrophy in 10,134 healthy individuals and is potentially influenced by body mass index
Smoking predicts brain atrophy in 10,134 healthy individuals and is potentially influenced by body mass index Open
View article: Synthetic Generation and Latent Projection Denoising of Rim Lesions in Multiple Sclerosis
Synthetic Generation and Latent Projection Denoising of Rim Lesions in Multiple Sclerosis Open
Quantitative susceptibility maps from magnetic resonance images can provide both prognostic and diagnostic information in multiple sclerosis, a neurodegenerative disease characterized by the formation of lesions in white matter brain tissu…
View article: Quantifying the Impact of Ocrelizumab on Paramagnetic Rim Lesions in Multiple Sclerosis
Quantifying the Impact of Ocrelizumab on Paramagnetic Rim Lesions in Multiple Sclerosis Open
Paramagnetic rim lesions (PRLs) are a subset of chronic active multiple sclerosis (MS) lesions, characterized by a rim of iron-laden macrophages and microglia encircling a demyelinated core. These lesions signify persistent inflammatory ac…
View article: 0602 Noninvasive MRI-Based Parenchymal CSF (pCSF) Mapping Shows Increased Glymphatic Fluid Volume in Untreated OSA
0602 Noninvasive MRI-Based Parenchymal CSF (pCSF) Mapping Shows Increased Glymphatic Fluid Volume in Untreated OSA Open
Introduction Obstructive sleep apnea (OSA) is one of the most prevalent sleep disorders, affecting an estimated 936 million adults globally. When left untreated, OSA increases the risk for co-morbidities including cardiovascular and metabo…
View article: Validating the Utility of Supervised Clustering Algorithm for Precise [<sup>11</sup>C]DPA-713 PET Brain Image Quantification
Validating the Utility of Supervised Clustering Algorithm for Precise [<sup>11</sup>C]DPA-713 PET Brain Image Quantification Open
The reliance of quantitative PET imaging on the arterial input function makes brain PET challenging to perform in certain populations, limiting the sample size. To address this challenge, a supervised clustering algorithm (SVCA) has been i…
View article: Predicting cognition using estimated structural and functional connectivity networks and artificial intelligence in multiple sclerosis
Predicting cognition using estimated structural and functional connectivity networks and artificial intelligence in multiple sclerosis Open
Our prior work demonstrated that estimated structural and functional connectomes (eSC and eFC) generated using multiple sclerosis (MS) lesion masks and artificial intelligence (AI) models can predict disability as effectively as SC and FC …
View article: Predicting cognition using estimated structural and functional connectivity networks and artificial intelligence in multiple sclerosis
Predicting cognition using estimated structural and functional connectivity networks and artificial intelligence in multiple sclerosis Open
Background Our prior work demonstrated that estimated structural and functional connectomes (eSC and eFC) generated using multiple sclerosis (MS) lesion masks and artificial intelligence (AI) models can predict disability as effectively as…
View article: The effect of arm swings on lower limb kinetics during single-leg forward, vertical, and backward hopping
The effect of arm swings on lower limb kinetics during single-leg forward, vertical, and backward hopping Open
Single-leg forward hopping was commonly used to evaluate knee function and quadricep strength deficits following anterior cruciate ligament (ACL) injuries. Achieving similar hopping performance between legs was insufficient to support symm…
View article: TSPO-PET Reveals Higher Inflammation in White Matter Disrupted by Paramagnetic Rim Lesions in Multiple Sclerosis
TSPO-PET Reveals Higher Inflammation in White Matter Disrupted by Paramagnetic Rim Lesions in Multiple Sclerosis Open
Objective To explore whether the inflammatory activity is higher in white matter (WM) tracts disrupted by paramagnetic rim lesions (PRLs) and if inflammation in PRL-disrupted WM tracts is associated with disability in people with multiple …
View article: Brain glymphatic fluid mapping in Alzheimer’s disease: a human MRI and PET study
Brain glymphatic fluid mapping in Alzheimer’s disease: a human MRI and PET study Open
Glymphatic system has been identified as a fluid exchange network in brain parenchymal for removal of toxic metabolites in Alzheimer’s disease. However, a clinically feasible, accurate, and non-invasive imaging technique for mapping global…
View article: Quantitative susceptibility mapping is more sensitive and specific than phase imaging in detecting chronic active multiple sclerosis lesion rims: pathological validation
Quantitative susceptibility mapping is more sensitive and specific than phase imaging in detecting chronic active multiple sclerosis lesion rims: pathological validation Open
Quantitative susceptibility mapping and phase imaging are used to identify multiple sclerosis lesions with paramagnetic rims that slowly expand over time and are associated with earlier progression to disability, decreased brain volume and…
View article: Renal Atrophy Relates to Brain Volume Loss on 7,149 MRI Scans
Renal Atrophy Relates to Brain Volume Loss on 7,149 MRI Scans Open
Background Renal atrophy may reflect an end organ consequence of chronic vascular disease. Renal volume loss may therefore provide a window into brain aging and Alzheimer disease risk. Method We obtained whole‐body 1.5T MRI scans on 7,149 …
View article: Psoas Muscle Sarcopenia Predicts Brain Volume Loss on MRI in 7,149 Individuals
Psoas Muscle Sarcopenia Predicts Brain Volume Loss on MRI in 7,149 Individuals Open
Background Sarcopenia has been linked to brain atrophy and there is lack of information on specific muscle groups that may contribute to this link. The psoas muscles are sensitive to sarcopenia and thus may sensitively relate to brain agin…
View article: Differential Patterns of Brain and Body Aging on MR Imaging
Differential Patterns of Brain and Body Aging on MR Imaging Open
Background Comparative information on how whole‐body organs are linked with age and the brain is lacking. Method Overall, 7,149 healthy participants from four sites (Mean age 53.06 ± 12.95 years, 18‐97 years; 48% women; 52% men; 38% non‐wh…
View article: Differential Patterns of Brain and Body Aging on MR Imaging
Differential Patterns of Brain and Body Aging on MR Imaging Open
Background Comparative information on how whole‐body organs are linked with age and the brain is lacking. Method Overall, 7,149 healthy participants from four sites (Mean age 53.06 ± 12.95 years, 18‐97 years; 48% women; 52% men; 38% non‐wh…
View article: Psoas Muscle Sarcopenia Predicts Brain Volume Loss on MRI in 7,149 Individuals
Psoas Muscle Sarcopenia Predicts Brain Volume Loss on MRI in 7,149 Individuals Open
Background Sarcopenia has been linked to brain atrophy and there is lack of information on specific muscle groups that may contribute to this link. The psoas muscles are sensitive to sarcopenia and thus may sensitively relate to brain agin…
View article: Renal Atrophy Relates to Brain Volume Loss on 7,149 MRI Scans
Renal Atrophy Relates to Brain Volume Loss on 7,149 MRI Scans Open
Background Renal atrophy may reflect an end organ consequence of chronic vascular disease. Renal volume loss may therefore provide a window into brain aging and Alzheimer disease risk. Method We obtained whole‐body 1.5T MRI scans on 7,149 …
View article: <scp>Microstructure‐Informed Myelin Mapping</scp> (<scp>MIMM</scp>) from routine multi‐echo gradient echo data using multiscale physics modeling of iron and myelin effects and <scp>QSM</scp>
<span>Microstructure‐Informed Myelin Mapping</span> (<span>MIMM</span>) from routine multi‐echo gradient echo data using multiscale physics modeling of iron and myelin effects and <span>QSM</span> Open
Purpose Myelin quantification is used in the study of demyelination in neurodegenerative diseases. A novel noninvasive MRI method, Microstructure‐Informed Myelin Mapping (MIMM), is proposed to quantify the myelin volume fraction (MVF) from…
View article: Sensitivity assessment of QSM+qBOLD (or QQ) in detecting elevated oxygen extraction fraction (OEF) in physiological change
Sensitivity assessment of QSM+qBOLD (or QQ) in detecting elevated oxygen extraction fraction (OEF) in physiological change Open
The study investigated the sensitivity of a novel MRI-based OEF mapping, quantitative susceptibility mapping plus quantitative blood oxygen level-dependent imaging (QSM+qBOLD or QQ), to physiological changes, particularly increased oxygen …
View article: MRI quantification of liver fibrosis using diamagnetic susceptibility: An ex-vivo feasibility study
MRI quantification of liver fibrosis using diamagnetic susceptibility: An ex-vivo feasibility study Open
In chronic liver disease, liver fibrosis develops as excessive deposition of extracellular matrix macromolecules, predominantly collagens, progressively form fibrous scars that disrupt the hepatic architecture, and fibrosis, iron, and fat …
View article: Single‐Administration Self‐Boosting Microneedle Patch for the Treatment of Obesity (Adv. Therap. 9/2024)
Single‐Administration Self‐Boosting Microneedle Patch for the Treatment of Obesity (Adv. Therap. 9/2024) Open
View article: Levinson’s theorem for two-dimensional scattering systems: It was a surprise, it is now topological!
Levinson’s theorem for two-dimensional scattering systems: It was a surprise, it is now topological! Open
We prove a general Levinson’s theorem for Schrödinger operators in two dimensions with threshold obstructions at zero energy. Our results confirm and simplify earlier seminal results of Bollé, Gesztesy et al., while providing an explicit t…
View article: Deep learning improved autofocus for motion artifact reduction and its application in quantitative susceptibility mapping
Deep learning improved autofocus for motion artifact reduction and its application in quantitative susceptibility mapping Open
Purpose: To develop a pipeline for motion artifact correction in mGRE and quantitative susceptibility mapping (QSM). Methods: Deep learning is integrated with autofocus to improve motion artifact suppression, which is applied QSM of patien…
View article: Intense exercise increases dopamine transporter and neuromelanin concentrations in the substantia nigra in Parkinson’s disease
Intense exercise increases dopamine transporter and neuromelanin concentrations in the substantia nigra in Parkinson’s disease Open
View article: Multi-Echo Complex Quantitative Susceptibility Mapping and Quantitative Blood Oxygen Level-Dependent Magnitude (mcQSM + qBOLD or mcQQ) for Oxygen Extraction Fraction (OEF) Mapping
Multi-Echo Complex Quantitative Susceptibility Mapping and Quantitative Blood Oxygen Level-Dependent Magnitude (mcQSM + qBOLD or mcQQ) for Oxygen Extraction Fraction (OEF) Mapping Open
Oxygen extraction fraction (OEF), the fraction of oxygen that tissue extracts from blood, is an essential biomarker used to directly assess tissue viability and function in neurologic disorders. In ischemic stroke, for example, increased O…
View article: Parenchymal CSF fraction is a measure of brain glymphatic clearance and positively associated with amyloid beta deposition on PET
Parenchymal CSF fraction is a measure of brain glymphatic clearance and positively associated with amyloid beta deposition on PET Open
INTRODUCTION Mapping of microscopic changes in the perivascular space (PVS) of the cerebral cortex, beyond magnetic resonance‐visible PVS in white matter, may enhance our ability to diagnose Alzheimer's disease (AD) early. METHODS We used …
View article: Maximum spherical mean value filtering for whole‐brain QSM
Maximum spherical mean value filtering for whole‐brain QSM Open
Purpose To develop a tissue field‐filtering algorithm, called maximum spherical mean value (mSMV), for reducing shadow artifacts in QSM of the brain without requiring brain‐tissue erosion. Theory and Methods Residual background field is a …
View article: RimSet: Quantitatively Identifying and Characterizing Chronic Active Multiple Sclerosis Lesion on Quantitative Susceptibility Maps
RimSet: Quantitatively Identifying and Characterizing Chronic Active Multiple Sclerosis Lesion on Quantitative Susceptibility Maps Open
Background: Rim+ lesions in multiple sclerosis (MS), detectable via Quantitative Susceptibility Mapping (QSM), correlate with increased disability. Existing literature lacks quantitative analysis of these lesions. We introduce RimSet for q…
View article: Multi-Echo Complex Quantitative Susceptibility Mapping and Quantitative Blood Oxygen Level Dependent Magnitude (mcQSM+qBOLD or mcQQ) for Oxygen Extraction Fraction (OEF) Mapping
Multi-Echo Complex Quantitative Susceptibility Mapping and Quantitative Blood Oxygen Level Dependent Magnitude (mcQSM+qBOLD or mcQQ) for Oxygen Extraction Fraction (OEF) Mapping Open
Oxygen extraction fraction (OEF), the fraction of oxygen that tissue extracts from blood, is an es-sential biomarker for directly assessing tissue viability and function in neurologic disorders. For quantitative mapping of OEF, an integrat…