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View article: Gelatin and hydroxyapatite concentration improves rheological properties of 3D-printed HA/Gel/CMC bone scaffolds
Gelatin and hydroxyapatite concentration improves rheological properties of 3D-printed HA/Gel/CMC bone scaffolds Open
This study investigates the rheological properties and stability of hydroxyapatite (HA)/gelatin (Gel)/carboxymethyl cellulose (CMC) hydrogel inks to establish ideal printing conditions for 3D printing of bone scaffolds. The effects of 10 a…
View article: Gallic Acid Loaded Alginate‐Gelatin Beads for Potential Bone Tissue Engineering Applications
Gallic Acid Loaded Alginate‐Gelatin Beads for Potential Bone Tissue Engineering Applications Open
In this study, alginate/gelatin (AL/GEL) spherical beads are prepared and encapsulated with 1 wt % of needle‐shaped gallic acid (GA) crystals to develop a drug delivery system. The % encapsulation efficiency of GA into AL/GEL beads, its re…
View article: Development of Bioactive 3D Printed MC/Al/Gel/HA Scaffolds with Enhanced Printability, Flexibility and Mechanical Strength
Development of Bioactive 3D Printed MC/Al/Gel/HA Scaffolds with Enhanced Printability, Flexibility and Mechanical Strength Open
Achieving high shape fidelity is critical for the fabrication of functional 3D printed bone scaffolds. This study aimed to develop a printable and bioactive hydrogel scaffold suitable for bone tissue engineering by incorporating methylcell…
View article: nano-HA and Gel improves mechanical performance and biomineralization of 3D-printed nano-HA/Gel/CMC bone scaffolds
nano-HA and Gel improves mechanical performance and biomineralization of 3D-printed nano-HA/Gel/CMC bone scaffolds Open
In 3D printing scaffolds for bone tissue engineering applications, obtaining high degree of printability and shape fidelity while maintaining sufficient mechanical support are important obstacles. To address this issue, in this study, carb…
View article: Highly Flexible Methyl Cellulose/Gelatin Hydrogels for Potential Cartilage Tissue Engineering Applications
Highly Flexible Methyl Cellulose/Gelatin Hydrogels for Potential Cartilage Tissue Engineering Applications Open
Cartilage damage resulting from trauma demonstrates a poor capacity for repair due to its avascular nature. Cartilage tissue engineering offers a unique therapeutic option for cartilage recovery. In this study, methylcellulose (MC)/gelatin…
View article: Molecular Weight‐Dependent Boron Release Effect in <scp>PVA</scp>/Chitosan Cryogels and In Vitro Mineralization Evaluations by Osteoblast Cells
Molecular Weight‐Dependent Boron Release Effect in <span>PVA</span>/Chitosan Cryogels and In Vitro Mineralization Evaluations by Osteoblast Cells Open
Cryogels were fabricated by combining polyvinyl alcohol (PVA) and chitosan of varying molecular weights (Mw). In this study, the effects of chitosan Mw, types of boron‐containing molecules on network formation, and boron release rate in re…
View article: CMC/Gel/GO 3D-printed cardiac patches: GO and CMC improve flexibility and promote H9C2 cell proliferation, while EDC/NHS enhances stability
CMC/Gel/GO 3D-printed cardiac patches: GO and CMC improve flexibility and promote H9C2 cell proliferation, while EDC/NHS enhances stability Open
In this research, carboxymethyl cellulose (CMC)/gelatin (Gel)/graphene oxide (GO)-based scaffolds were produced by using extrusion-based 3D printing for cardiac tissue regeneration. Rheological studies were conducted to evaluate the printa…
View article: Ionic medicine: Exploiting metallic ions to stimulate skeletal muscle tissue regeneration
Ionic medicine: Exploiting metallic ions to stimulate skeletal muscle tissue regeneration Open
The regeneration of healthy and functional skeletal muscle at sites of injuries and defects remains a challenge. Mimicking the natural environment surrounding skeletal muscle cells and the application of electrical and mechanical stimuli a…
View article: Chitosan‐enhanced sensitivity of mercaptoundecanoic acid (MUA)‐ capped gold nanorod based localized surface plasmon resonance (LSPR) biosensor for detection of alpha‐synuclein oligomer biomarker in parkinson’s disease
Chitosan‐enhanced sensitivity of mercaptoundecanoic acid (MUA)‐ capped gold nanorod based localized surface plasmon resonance (LSPR) biosensor for detection of alpha‐synuclein oligomer biomarker in parkinson’s disease Open
Alpha‐synuclein oligomers play a crucial role in the early diagnosis of Parkinson's disease (PD). In this study, a mercaptoundecanoic acid (MUA)‐capped gold nanorod (GNR)‐coated and chitosan (CH)‐immobilized fiber optic probe has shown con…
View article: Assessing the properties of biodegradable magnesium alloy AZ31 protected by a polymer layer on a plasma electrolytic oxidized (PEO) surface
Assessing the properties of biodegradable magnesium alloy AZ31 protected by a polymer layer on a plasma electrolytic oxidized (PEO) surface Open
In the present work we consider the AZ31 Mg alloy for applications as medical implants with bone contact. The alloy has the advantages that it combines a high strength with light weight. Most importantly, it eventually dissolves in the bod…
View article: Investigating the Effect of Processing and Material Parameters of Alginate Dialdehyde-Gelatin (ADA-GEL)-Based Hydrogels on Stiffness by XGB Machine Learning Model
Investigating the Effect of Processing and Material Parameters of Alginate Dialdehyde-Gelatin (ADA-GEL)-Based Hydrogels on Stiffness by XGB Machine Learning Model Open
To address the limitations of alginate and gelatin as separate hydrogels, partially oxidized alginate, alginate dialdehyde (ADA), is usually combined with gelatin to prepare ADA-GEL hydrogels. These hydrogels offer tunable properties, cont…
View article: Investigation of effect of processing parameters of 3D printed NHS/EDC crosslinked carboxy methyl cellulose/gelatin hydrogels with machine learning techniques
Investigation of effect of processing parameters of 3D printed NHS/EDC crosslinked carboxy methyl cellulose/gelatin hydrogels with machine learning techniques Open
This study focuses on the effects of preparing conditions of gelatin/carboxymethyl cellulose (CMC) composites on their mechanical properties of gelatin/carboxymethyl cellulose (CMC) by extreme gradient boosting (XGB) machine learning algor…
View article: Exploring the effect of chlorhexidine concentration on the biocorrosion behavior of <scp>Ti6Al4V</scp> for dental implants
Exploring the effect of chlorhexidine concentration on the biocorrosion behavior of <span>Ti6Al4V</span> for dental implants Open
Corrosion of dental implants is one of the most critical factors in the failure of implant treatments. Generally, corrosion depends on the type of material used in implants and the chemical composition of the oral environment. Due to the a…
View article: Cobalt Oxide-Decorated on Carbon Derived from Onion Skin Biomass for Li-Ion Storage Application
Cobalt Oxide-Decorated on Carbon Derived from Onion Skin Biomass for Li-Ion Storage Application Open
Onion waste, particularly onion skin, is a widely generated waste material, and harnessing its potential for energy storage aligns with sustainable development goals. Despite the high specific surface area exhibited by biocarbon derived fr…
View article: XGB Modeling Reveals Improvement of Compressive Strength of Cement-Based Composites with Addition of HPMC and Chitosan
XGB Modeling Reveals Improvement of Compressive Strength of Cement-Based Composites with Addition of HPMC and Chitosan Open
This study investigates the improvement in the compressive strength of cellulose/cement-based composites. Methyl cellulose (MC), carboxymethyl cellulose (CMC), and hydroxypropyl cellulose (HPMC) are separately used as the cellulose phase w…
View article: Machine learning models to predict the relationship between printing parameters and tensile strength of 3D Poly (lactic acid) scaffolds for tissue engineering applications
Machine learning models to predict the relationship between printing parameters and tensile strength of 3D Poly (lactic acid) scaffolds for tissue engineering applications Open
3D printing is an effective method to prepare 3D scaffolds for tissue engineering applications. However, optimization of printing conditions to obtain suitable mechanical properties for various tissue engineering applications is costly and…
View article: CNT incorporation improves the resolution and stability of porous 3D printed PLGA/HA/CNT scaffolds for bone regeneration
CNT incorporation improves the resolution and stability of porous 3D printed PLGA/HA/CNT scaffolds for bone regeneration Open
In this study, 3D printed porous poly(lactide-co-glycolide) (PLGA) and its nanocomposites with 5 wt. % hydroxyapatite (HA) and 0.5, 1 and 2 wt. % carboxyl-functionalized multi-walled carbon nanotube (CNT) scaffolds were fabricated by using…
View article: Processing and characterization of aligned electrospun gelatin/polycaprolactone nanofiber mats incorporating borate glass (13-93B3) microparticles
Processing and characterization of aligned electrospun gelatin/polycaprolactone nanofiber mats incorporating borate glass (13-93B3) microparticles Open
Aligned biodegradable fibers incorporating bioactive glass particles are being highly investigated for tissue engineering applications. In this study, 5, 7 and 10 wt% melt-derived 1393B3 borate glass (BG) microparticles (average size: 3.15…
View article: Incorporating the Antioxidant Fullerenol into Calcium Phosphate Bone Cements Increases Cellular Osteogenesis without Compromising Physical Cement Characteristics
Incorporating the Antioxidant Fullerenol into Calcium Phosphate Bone Cements Increases Cellular Osteogenesis without Compromising Physical Cement Characteristics Open
Herein, fullerenol (Ful), a highly water‐soluble derivative of C 60 fullerene with demonstrated antioxidant activity, is incorporated into calcium phosphate cements (CPCs) to enhance their osteogenic ability. CPCs with added carboxymethyl …
View article: Is 3D Printing Promising for Osteochondral Tissue Regeneration?
Is 3D Printing Promising for Osteochondral Tissue Regeneration? Open
Osteochondral tissue regeneration is quite difficult to achieve due to the complexity of its organization. In the design of these complex multilayer structures, a fabrication method, 3D printing, started to be employed, especially by using…
View article: Effect of Boron-Doped Mesoporous Bioactive Glass Nanoparticles on C2C12 Cell Viability and Differentiation: Potential for Muscle Tissue Application
Effect of Boron-Doped Mesoporous Bioactive Glass Nanoparticles on C2C12 Cell Viability and Differentiation: Potential for Muscle Tissue Application Open
Mesoporous bioactive glasses (MBGs) exhibit a high surface area and a highly ordered mesoporous structure. MBGs have potential for both hard and soft tissue engineering applications. MBGs may be doped with biologically active ions to tailo…
View article: Borate Bioactive Glasses (BBG): Bone Regeneration, Wound Healing Applications, and Future Directions
Borate Bioactive Glasses (BBG): Bone Regeneration, Wound Healing Applications, and Future Directions Open
Since the early 2000s, borate bioactive glasses (BBGs) have been extensively investigated for biomedical applications. The research so far indicates that BBGs frequently exhibit superior bioactivity and bone healing capacity compared to si…
View article: Action Mechanisms of Curcumin in Alzheimer’s Disease and Its Brain Targeted Delivery
Action Mechanisms of Curcumin in Alzheimer’s Disease and Its Brain Targeted Delivery Open
AD is a chronic neurodegenerative disease. Many different signaling pathways, such as Wnt/β-catenin, Notch, ROS/JNK, and PI3K/Akt/mTOR are involved in Alzheimer’s disease and crosstalk between themselves. A promising treatment involves the…
View article: Effect of Concentration of Citric Acid on The Rheological Properties of Methylcellulose Hydrogels
Effect of Concentration of Citric Acid on The Rheological Properties of Methylcellulose Hydrogels Open
Objectives:In this study, the influence of sodium citrate dehydrates (SC) salts on the rheological properties of a thermoresponsive hydrogel was investigated.Materials and Methods:The hydrogel was prepared by combining 8 w/v % methylcellul…
View article: Production of Graphene Oxide/Poly (Lactic Acid)-Based Nanofibers for Neural Regeneration
Production of Graphene Oxide/Poly (Lactic Acid)-Based Nanofibers for Neural Regeneration Open
Objectives:Peripheral nerve injury is a serious health problem and it significantly affects the patients’ quality of life. Short gap of the peripheral nerve damage recover very slowly and if the gap between transected nerve ends is large, …
View article: Rheological and Mechanical Properties of Thermoresponsive Methylcellulose/Calcium Phosphate-Based Injectable Bone Substitutes
Rheological and Mechanical Properties of Thermoresponsive Methylcellulose/Calcium Phosphate-Based Injectable Bone Substitutes Open
In this study, a novel injectable bone substitute (IBS) was prepared by incorporating a bioceramic powder in a polymeric solution comprising of methylcellulose (MC), gelatin and citric acid. Methylcellulose was utilized as the polymeric ma…
View article: Graphene Oxide/Polymer‐Based Biomaterials
Graphene Oxide/Polymer‐Based Biomaterials Open
Since its discovery in 2004, derivatives of graphene have been developed and heavily investigated in the field of tissue engineering. Among the most extensively studied forms of graphene, graphene oxide (GO), and GO/polymer‐based nanocompo…