Jonathan D. W. Clarke
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View article: An analysis of contractile and protrusive cell behaviors at the superficial surface of the zebrafish neural plate
An analysis of contractile and protrusive cell behaviors at the superficial surface of the zebrafish neural plate Open
Background The forces underlying convergence and internalization of the teleost neural plate remain unknown. To help understand this morphogenesis, we analyzed collective and individual cell behaviors at the superficial surface of the neur…
View article: Telencephalic eversion in embryos and early larvae of four teleost species
Telencephalic eversion in embryos and early larvae of four teleost species Open
The telencephalon of ray‐finned fishes undergoes eversion, which is very different to the evagination that occurs in most other vertebrates. Ventricle morphogenesis is key to build an everted telencephalon. Thus, here we use the apical mar…
View article: An analysis of contractile and protrusive cell behaviours at the superficial surface of the zebrafish neural plate
An analysis of contractile and protrusive cell behaviours at the superficial surface of the zebrafish neural plate Open
The motive forces underlying convergence and internalisation of the teleost neural plate remain unknown. To help understand this crucial morphogenetic movement we have analysed collective and individual cell behaviours at the superficial s…
View article: Telencephalic eversion in embryos and early larvae of four teleost species
Telencephalic eversion in embryos and early larvae of four teleost species Open
1. Abstract The telencephalon of ray-finned fishes undergoes eversion, which is very different to the evagination that occurs in most other vertebrates. Ventricle morphogenesis is key in order to build an everted telencephalon. Thus, here …
View article: Coordinated assembly and release of adhesions builds apical junctional belts during <i>de novo</i> polarisation of an epithelial tube
Coordinated assembly and release of adhesions builds apical junctional belts during <i>de novo</i> polarisation of an epithelial tube Open
Using the zebrafish neural tube as a model, we uncover the in vivo mechanisms allowing the generation of two opposing apical epithelial surfaces within the centre of an initially unpolarised, solid organ. We show that Mpp5a and Rab11a play…
View article: Actin-based protrusions lead microtubules during stereotyped axon initiation in spinal neurons<i>in vivo</i>
Actin-based protrusions lead microtubules during stereotyped axon initiation in spinal neurons<i>in vivo</i> Open
In vitro , developing neurons progress through well-defined stages to form an axon and multiple dendrites. In vivo , neurons are derived from progenitors within a polarised neuroepithelium and it is not clear how axon initiation observed i…
View article: Cadherins regulate nuclear topography and function of developing ocular motor circuitry
Cadherins regulate nuclear topography and function of developing ocular motor circuitry Open
In the vertebrate central nervous system, groups of functionally related neurons, including cranial motor neurons of the brainstem, are frequently organised as nuclei. The molecular mechanisms governing the emergence of nuclear topography …
View article: Author response: Cadherins regulate nuclear topography and function of developing ocular motor circuitry
Author response: Cadherins regulate nuclear topography and function of developing ocular motor circuitry Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract In the vertebrate central nervous system, …
View article: Cadherins regulate nuclear topography and function of developing ocular motor circuitry
Cadherins regulate nuclear topography and function of developing ocular motor circuitry Open
In the vertebrate central nervous system, groups of functionally-related neurons, including cranial motor neurons of the brainstem, are frequently organised as nuclei. The molecular mechanisms governing the emergence of nuclear topography …
View article: Coordinated assembly and release of adhesions builds apical junctional belts during<i>de novo</i>polarisation of an epithelial tube
Coordinated assembly and release of adhesions builds apical junctional belts during<i>de novo</i>polarisation of an epithelial tube Open
Using the zebrafish neural tube as a model, we uncover the in vivo mechanisms allowing the generation of two opposing apical epithelial surfaces within the centre of an initially unpolarised, solid organ. We show that NOK/Pals1/Mpp5a and R…
View article: Basal Protrusions Mediate Spatiotemporal Patterns of Spinal Neuron Differentiation
Basal Protrusions Mediate Spatiotemporal Patterns of Spinal Neuron Differentiation Open
During early spinal cord development, neurons of particular subtypes differentiate with a sparse periodic pattern while later neurons differentiate in the intervening space to eventually produce continuous columns of similar neurons. The m…
View article: Generation of the squamous epithelial roof of the 4th ventricle
Generation of the squamous epithelial roof of the 4th ventricle Open
We use the transparency of zebrafish embryos to reveal the de novo generation of a simple squamous epithelium and identify the cellular architecture in the epithelial transition zone that ties this squamous epithelium to the columnar neuro…
View article: Cdh2 coordinates Myosin-II dependent internalisation of the zebrafish neural plate
Cdh2 coordinates Myosin-II dependent internalisation of the zebrafish neural plate Open
Tissue internalisation is a key morphogenetic mechanism by which embryonic tissues generate complex internal organs and a number of studies of epithelia have outlined a general view of tissue internalisation. Here we have used quantitative…
View article: Cdh2 coordinates Myosin-II dependent internalisation of the zebrafish neural plate
Cdh2 coordinates Myosin-II dependent internalisation of the zebrafish neural plate Open
Tissue internalisation is a key morphogenetic mechanism by which embryonic tissues generate complex internal organs and a number of studies of epithelia have outlined a general view of tissue internalisation. Here we have used quantitative…
View article: Generation of the squamous epithelial roof of the 4<sup>th</sup>ventricle
Generation of the squamous epithelial roof of the 4<sup>th</sup>ventricle Open
Summary We use the transparency of zebrafish embryos to reveal the de novo generation of a simple squamous epithelium and identify the cellular architecture in the epithelial transition zone that ties this squamous epithelium to the column…
View article: OC08.02: Ultrasound diagnosis of molar pregnancy
OC08.02: Ultrasound diagnosis of molar pregnancy Open
The aim of this study was to establish what proportion of histologically diagnosed molar pregnancies is identified by ultrasound pre-operatively. This was a retrospective observational study conducted in the Early Pregnancy Unit (EPU) at K…
View article: Extracellular matrix couples the convergence movements of mesoderm and neural plate during the early stages of neurulation
Extracellular matrix couples the convergence movements of mesoderm and neural plate during the early stages of neurulation Open
Background : During the initial stages zebrafish neurulation, neural plate cells undergo highly coordinated movements before they assemble into a multicellular solid neural rod. We have previously identified that the underlying mesoderm is…
View article: Reversible Optogenetic Control of Subcellular Protein Localization in a Live Vertebrate Embryo
Reversible Optogenetic Control of Subcellular Protein Localization in a Live Vertebrate Embryo Open
We demonstrate the utility of the phytochrome system to rapidly and reversibly recruit proteins to specific subcellular regions within specific cells in a living vertebrate embryo. Light-induced heterodimerization using the phytochrome sys…