Edwin D.W. Moore
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View article: Phosphorylation of RyR2 simultaneously expands the dyad and rearranges the tetramers
Phosphorylation of RyR2 simultaneously expands the dyad and rearranges the tetramers Open
We have previously demonstrated that type II ryanodine receptors (RyR2) tetramers can be rapidly rearranged in response to a phosphorylation cocktail. The cocktail modified downstream targets indiscriminately, making it impossible to deter…
View article: hiPSC-derived cardiomyocytes as a model to study the role of small-conductance Ca2+-activated K+ (SK) ion channel variants associated with atrial fibrillation
hiPSC-derived cardiomyocytes as a model to study the role of small-conductance Ca2+-activated K+ (SK) ion channel variants associated with atrial fibrillation Open
Atrial fibrillation (AF), the most common arrhythmia, has been associated with different electrophysiological, molecular, and structural alterations in atrial cardiomyocytes. Therefore, more studies are required to elucidate the genetic an…
View article: Data for: PHOSPHORYLATION OF RyR2 SIMULTANEOUSLY EXPANDS THE DYAD AND REARRANGES THE TETRAMERS
Data for: PHOSPHORYLATION OF RyR2 SIMULTANEOUSLY EXPANDS THE DYAD AND REARRANGES THE TETRAMERS Open
This is data that was used to generate the figures and tables for the Journal of General Physiology paper:PHOSPHORYLATION OF RyR2 SIMULTANEOUSLY EXPANDS THE DYAD AND REARRANGES THE TETRAMERS The uploaded data was used to generate all the f…
View article: Data for: PHOSPHORYLATION OF RyR2 SIMULTANEOUSLY EXPANDS THE DYAD AND REARRANGES THE TETRAMERS
Data for: PHOSPHORYLATION OF RyR2 SIMULTANEOUSLY EXPANDS THE DYAD AND REARRANGES THE TETRAMERS Open
This is data that was used to generate the figures and tables for the Journal of General Physiology paper:PHOSPHORYLATION OF RyR2 SIMULTANEOUSLY EXPANDS THE DYAD AND REARRANGES THE TETRAMERS The uploaded data was used to generate all the f…
View article: 3D structured illumination microscope using a spinning disk [Invited]
3D structured illumination microscope using a spinning disk [Invited] Open
Three-dimensional (3D) structured illumination microscopy (SIM) improves spatial resolution by a factor of two in both lateral and axial directions. However, the adoption of 3D SIM is limited by low imaging speed, susceptibility to out-of-…
View article: Cardiomyocyte ryanodine receptor clusters expand and coalesce after application of isoproterenol
Cardiomyocyte ryanodine receptor clusters expand and coalesce after application of isoproterenol Open
Earlier work has shown that ventricular ryanodine receptors (RyR2) within a cluster rearrange on phosphorylation as well as with a number of other stimuli. Using dSTORM, we investigated the effects of 300 nmol/liter isoproterenol on RyR2 c…
View article: CARDIOMYOCYTE RYANODINE RECEPTOR CLUSTERS EXPAND AND COALESCE AFTER APPLICATION OF ISOPROTERENOL
CARDIOMYOCYTE RYANODINE RECEPTOR CLUSTERS EXPAND AND COALESCE AFTER APPLICATION OF ISOPROTERENOL Open
This is data that was used to generate the figures and tables for the Journal of General Physiology paper CARDIOMYOCYTE RYANODINE RECEPTOR CLUSTERS EXPAND AND COALESCE AFTER APPLICATION OF ISOPROTERENOL The data is in two parts: i) Blink d…
View article: CARDIOMYOCYTE RYANODINE RECEPTOR CLUSTERS EXPAND AND COALESCE AFTER APPLICATION OF ISOPROTERENOL
CARDIOMYOCYTE RYANODINE RECEPTOR CLUSTERS EXPAND AND COALESCE AFTER APPLICATION OF ISOPROTERENOL Open
This is data that was used to generate the figures and tables for the Journal of General Physiology paper CARDIOMYOCYTE RYANODINE RECEPTOR CLUSTERS EXPAND AND COALESCE AFTER APPLICATION OF ISOPROTERENOL The data is in two parts: i) Blink d…
View article: PHOSPHORYLATION OF RyR2 SIMULTANEOUSLY EXPANDS THE DYAD AND REARRANGES THE TETRAMERS
PHOSPHORYLATION OF RyR2 SIMULTANEOUSLY EXPANDS THE DYAD AND REARRANGES THE TETRAMERS Open
We have previously demonstrated that type II ryanodine receptors (RyR2) tetramers can be rapidly rearranged in response to a phosphorylation cocktail. The cocktail modified downstream targets indiscriminately making it impossible to determ…
View article: Graphene-Based Materials in Dental Applications: Antibacterial, Biocompatible, and Bone Regenerative Properties
Graphene-Based Materials in Dental Applications: Antibacterial, Biocompatible, and Bone Regenerative Properties Open
Graphene-based materials have been shown to have advantageous properties in biomedical and dental applications due to their high mechanical, physiochemical, antibacterial, and stem cell differentiating properties. Although graphene-based m…
View article: Cardiac ryanodine receptor distribution is dynamic and changed by auxiliary proteins and post-translational modification
Cardiac ryanodine receptor distribution is dynamic and changed by auxiliary proteins and post-translational modification Open
The effects of the immunophilins, FKBP12 and FKBP12.6, and phosphorylation on type II ryanodine receptor (RyR2) arrangement and function were examined using correlation microscopy (line scan confocal imaging of Ca2+ sparks and dual-tilt el…
View article: Ca2+ signaling machinery is present at intercellular junctions and structures associated with junction turnover in rat Sertoli cells†
Ca2+ signaling machinery is present at intercellular junctions and structures associated with junction turnover in rat Sertoli cells† Open
The endoplasmic reticulum (ER) in Sertoli cells is a component of unique adhesion junctions (ectoplasmic specializations-ESs) and is closely associated with structures termed tubulobulbar complexes (TBCs) that internalize intercellular jun…
View article: Sub:Cellular Network Analysis of Ryanodine Receptor Positioning in Control and Phosphorylated States
Sub:Cellular Network Analysis of Ryanodine Receptor Positioning in Control and Phosphorylated States Open
Type 2 ryanodine receptors (RyR2) are large (mass=2.2MegaDalton) proteins expressed in heart cells that mediate the release of calcium ions (Ca 2+ ) that, in turn, modulate contraction of the heart.In this work, we analyze the sub-cellular…
View article: Cardiac Ryanodine Receptor (Ryr2)-mediated Calcium Signals Specifically Promote Glucose Oxidation via Pyruvate Dehydrogenase
Cardiac Ryanodine Receptor (Ryr2)-mediated Calcium Signals Specifically Promote Glucose Oxidation via Pyruvate Dehydrogenase Open
Cardiac ryanodine receptor (Ryr2) Ca2+ release channels and cellular metabolism are both disrupted in heart disease. Recently, we demonstrated that total loss of Ryr2 leads to cardiomyocyte contractile dysfunction, arrhythmia, and reduced …