Dylan C. Sieck
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View article: Histamine is a molecular transducer of adaptation to endurance exercise training in humans
Histamine is a molecular transducer of adaptation to endurance exercise training in humans Open
Histamine appears to be intimately involved with skeletal muscle responses during and following exercise. Blocking histamine’s actions during endurance exercise training by taking common over-the-counter antihistamines resulted in diminish…
View article: The effect of local passive heating on skeletal muscle histamine concentration: implications for exercise-induced histamine release
The effect of local passive heating on skeletal muscle histamine concentration: implications for exercise-induced histamine release Open
The “exercise signal” that triggers histamine release within active skeletal muscle during aerobic exercise is unknown. By mimicking the magnitude and time course of increasing skeletal muscle temperature observed during aerobic exercise, …
View article: Use of a Non-Invasive Pulmonary Gas-Exchange Analyzer to Improve the Pretest Probability of Pulmonary Embolism in a Patient Classified as "Low Risk"
Use of a Non-Invasive Pulmonary Gas-Exchange Analyzer to Improve the Pretest Probability of Pulmonary Embolism in a Patient Classified as "Low Risk" Open
View article: Hemodynamics of postexercise versus post-hot water immersion recovery
Hemodynamics of postexercise versus post-hot water immersion recovery Open
Hot water immersion resulted in a postintervention hypotension similar to that observed following exercise matched for time and core temperature rise, but with greater reductions in brachial retrograde shear. Heating was associated with lo…
View article: Improving gas exchange and exercise tolerance in mild COPD patients
Improving gas exchange and exercise tolerance in mild COPD patients Open
In their recent study, Phillips et al. (2021) focused on patients with mild chronic obstructive pulmonary disease (COPD) who have an exaggerated ventilatory response to exercise contributing to exertional dyspnoea, resulting in exercise in…
View article: Histamine and Cardiovascular Adaptation to Endurance Exercise
Histamine and Cardiovascular Adaptation to Endurance Exercise Open
Adaptations associated with repeated aerobic exercise come in many forms and act synergistically to increase the amount of oxygen an individual can consume during exercise. Moderate intensity aerobic exercise causes increased histamine con…
View article: Effect of Time of Day on Sustained Postexercise Vasodilation Following Small Muscle-Mass Exercise in Humans
Effect of Time of Day on Sustained Postexercise Vasodilation Following Small Muscle-Mass Exercise in Humans Open
These data suggest previous studies which identified diurnal variations in postexercise vasodilation responses are likely reflecting central rather than peripheral modulation of cardiovascular responses.
View article: Histamine-Receptor Antagonists Slow 10-km Cycling Performance in Competitive Cyclists
Histamine-Receptor Antagonists Slow 10-km Cycling Performance in Competitive Cyclists Open
Histamine is released within skeletal muscle during exercise. In humans, antihistamines have no effect on speed, power output, or time-to-completion of short-duration high-intensity exercise. In mice, blocking histamine’s actions decreases…
View article: Update: evidence of a broad histamine footprint on the human exercise transcriptome
Update: evidence of a broad histamine footprint on the human exercise transcriptome Open
View article: Effects of histamine-receptor blockade and exercise on blood-glucose concentration
Effects of histamine-receptor blockade and exercise on blood-glucose concentration Open
View article: Mast cell degranulation and de novo histamine formation contribute to sustained postexercise vasodilation in humans
Mast cell degranulation and de novo histamine formation contribute to sustained postexercise vasodilation in humans Open
In humans, acute aerobic exercise elicits a sustained postexercise vasodilation within previously active skeletal muscle. This response is dependent on activation of histamine H 1 and H 2 receptors, but the source of intramuscular histamin…
View article: A single dose of histamine-receptor antagonists before downhill running alters markers of muscle damage and delayed-onset muscle soreness
A single dose of histamine-receptor antagonists before downhill running alters markers of muscle damage and delayed-onset muscle soreness Open
Histamine contributes to elevations in skeletal muscle blood flow following exercise, which raises the possibility that histamine is an important mediator of the inflammatory response to exercise. We examined the influence of antihistamine…
View article: Post-exercise syncope: Wingate syncope test and visual-cognitive function
Post-exercise syncope: Wingate syncope test and visual-cognitive function Open
Adequate cerebral perfusion is necessary to maintain consciousness in upright humans. Following maximal anaerobic exercise, cerebral perfusion can become compromised and result in syncope. It is unknown whether post-exercise reductions in …
View article: Evidence of a broad histamine footprint on the human exercise transcriptome
Evidence of a broad histamine footprint on the human exercise transcriptome Open
Key points Histamine is a primordial signalling molecule, capable of activating cells in an autocrine or paracrine fashion via specific cell surface receptors, in a variety of pathways that probably predate its more recent role in innate a…
View article: Effect of antioxidants on histamine receptor activation and sustained postexercise vasodilatation in humans
Effect of antioxidants on histamine receptor activation and sustained postexercise vasodilatation in humans Open
New Findings What is the central question of this study? Is exercise‐induced oxidative stress the upstream exercise‐related signalling mechanism that leads to sustained postexercise vasodilatation via activation of H 1 and H 2 histamine re…
View article: Neurovascular control following small muscle-mass exercise in humans
Neurovascular control following small muscle-mass exercise in humans Open
Sustained postexercise vasodilation, which may be mediated at both a neural and vascular level, is seen in previously active skeletal muscle vascular beds following both large and small muscle-mass exercise. Blunted sympathetic vascular tr…