Dylan C. Souder
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View article: Neuron-specific isoform of PGC-1α regulates neuronal metabolism and brain aging
Neuron-specific isoform of PGC-1α regulates neuronal metabolism and brain aging Open
The brain is a high-energy tissue, and although aging is associated with dysfunctional inflammatory and neuron-specific functional pathways, a direct connection to metabolism is not established. Here, we show that isoforms of mitochondrial…
View article: Lehigh Valley Procedure: Combined Pulmonary Vein Isolation and Accessory Pathway Ablation for Atrial Fibrillation in Wolff-Parkinson-White Syndrome
Lehigh Valley Procedure: Combined Pulmonary Vein Isolation and Accessory Pathway Ablation for Atrial Fibrillation in Wolff-Parkinson-White Syndrome Open
Wolff-Parkinson-White (WPW) syndrome is a congenital condition characterized by the presence of an accessory pathway (AP) that can lead to tachyarrhythmias such as atrial fibrillation (AF). Patients with WPW are at an increased risk of dev…
View article: Mitochondrial regulator PGC-1a in neuronal metabolism and brain aging
Mitochondrial regulator PGC-1a in neuronal metabolism and brain aging Open
The brain is a high energy tissue, and the cell types of which it is comprised are distinct in function and in metabolic requirements. The transcriptional co-activator PGC-1a is a master regulator of mitochondrial function and is highly ex…
View article: Neuron-Specific Mechanisms Control the Mitochondrial Regulator PGC-1a
Neuron-Specific Mechanisms Control the Mitochondrial Regulator PGC-1a Open
Mitochondrial dysfunction has been proposed as a hallmark of the aging process. Specifically, as a function of aging, mitochondria appear to have decreased enzyme activity and respiratory capacity and increase reactive oxygen species produ…
View article: Rhesus monkeys as a translational model for late‐onset Alzheimer's disease
Rhesus monkeys as a translational model for late‐onset Alzheimer's disease Open
Age is a major risk factor for late‐onset Alzheimer's disease (AD) but seldom features in laboratory models of the disease. Furthermore, heterogeneity in size and density of AD plaques observed in individuals are not recapitulated in trans…
View article: An expanding GSK3 network: implications for aging research
An expanding GSK3 network: implications for aging research Open
View article: GSK3β Regulates Brain Energy Metabolism
GSK3β Regulates Brain Energy Metabolism Open