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View article: 7480 Isolated IgG4-Related Infundibulo-Hypophysitis
7480 Isolated IgG4-Related Infundibulo-Hypophysitis Open
Disclosure: M. Allen: None. R.T. Beck: None. N.T. Zwagerman: None. R.J. Ryzka: None. D. Coss: None. A. Fisco: None. A.G. Ioachimescu: None. Background: 130 cases of IgG4-related hypophysitis (IgG4-RH) have been reported, usually in context…
View article: Isolated IgG4-related Infundibulo-hypophysitis
Isolated IgG4-related Infundibulo-hypophysitis Open
A 72-year-old man presented with several months of weakness, poor appetite, and depressed moods. Laboratory tests indicated central hypocortisolism, hypothyroidism and hypogonadism, and mild hyperprolactinemia. Imaging indicated a homogeno…
View article: The diverging role of O-GlcNAc Transferase in corticotroph and somatotroph adenomas
The diverging role of O-GlcNAc Transferase in corticotroph and somatotroph adenomas Open
Purpose Molecular mechanisms involved in the pathogenesis and tumor progression of pituitary adenomas (PA) remain incompletely understood. Corticotroph and somatotroph PA associate a high clinical burden, and despite improved surgical outc…
View article: Noninvasive Autopsy-Validated Tumor Probability Maps Identify Glioma Invasion Beyond Contrast Enhancement
Noninvasive Autopsy-Validated Tumor Probability Maps Identify Glioma Invasion Beyond Contrast Enhancement Open
BACKGROUND AND OBJECTIVES: This study identified a clinically significant subset of patients with glioma with tumor outside of contrast enhancement present at autopsy and subsequently developed a method for detecting nonenhancing tumor usi…
View article: Consecutive resections of double pituitary adenoma for resolution of Cushing disease: illustrative case
Consecutive resections of double pituitary adenoma for resolution of Cushing disease: illustrative case Open
BACKGROUND Double pituitary adenomas are rare presentations of two distinct adenohypophyseal lesions seen in <1% of surgical cases. Increased rates of recurrence or persistence are reported in the resection of Cushing microadenomas and are…
View article: NIMG-28. DIFFUSION DIFFERENCES IN LOW TO HIGH GRADE GLIOMA TRANSFORMATION
NIMG-28. DIFFUSION DIFFERENCES IN LOW TO HIGH GRADE GLIOMA TRANSFORMATION Open
PURPOSE Apparent diffusion coefficient (ADC) maps offer tremendous insight into cellularity and local tissue environment. Proliferation of tumor cells results in increased local cellularity and cell density, thus impairing the free diffusi…
View article: NIMG-41. ASSOCIATION BETWEEN PERFUSION IMAGING METRICS AND RADIO-PATHOMIC MAPS OF TUMOR PROBABILITY WITHIN AND BEYOND THE CONTRAST-ENHANCING VOLUME IN GLIOMA PATIENTS
NIMG-41. ASSOCIATION BETWEEN PERFUSION IMAGING METRICS AND RADIO-PATHOMIC MAPS OF TUMOR PROBABILITY WITHIN AND BEYOND THE CONTRAST-ENHANCING VOLUME IN GLIOMA PATIENTS Open
Perfusion MRI, using both contrast-based techniques such as dynamic susceptibility imaging (DSC) and non-contrast-based techniques like arterial spin labeling (ASL) have been used to monitor blood flow as a marker of angiogenic glioma pres…
View article: STEM-10. SOX2 POSITIVE, PRESUMED TUMOR INVASION MEASURED WELL BEYOND CONTRAST ENHANCEMENT AND FLAIR HYPERINTENSITY IN BOTH TREATED AND UNTREATED GLIOBLASTOMA PATIENTS ASSESSED AT AUTOPSY
STEM-10. SOX2 POSITIVE, PRESUMED TUMOR INVASION MEASURED WELL BEYOND CONTRAST ENHANCEMENT AND FLAIR HYPERINTENSITY IN BOTH TREATED AND UNTREATED GLIOBLASTOMA PATIENTS ASSESSED AT AUTOPSY Open
In the treatment of glioblastoma (GBM), MRI is used to determine location and extent of cancer. It is poorly understood how far tumor invasion may exist outside of contrast enhancement (CE) and FLAIR hyperintensity (FL). This study identif…
View article: NIMG-43. A 57-YEAR-OLD MALE WITH PRIMARY GLIOBLASTOMA TREATED WITH LASER INTERSTITIAL THERMAL THERAPY: IMAGING AND AUTOPSY FINDINGS
NIMG-43. A 57-YEAR-OLD MALE WITH PRIMARY GLIOBLASTOMA TREATED WITH LASER INTERSTITIAL THERMAL THERAPY: IMAGING AND AUTOPSY FINDINGS Open
INTRODUCTION: Glioblastoma (GBM) is an aggressive primary brain cancer with significant resistance to the current therapeutic approach of chemotherapy and radiotherapy, jointly known as chemoradiation (CRT). Magnetic hyperthermia therapy (…
View article: NIMG-44. RADIOMIC FEATURES OF CONTRAST ENHANCED T1 MRI SEQUENCES PREDICT SURVIVAL IN PRIMARY GLIOBLASTOMA PATIENTS WHO UNDERWENT ADJUVANT RADIATION THERAPY
NIMG-44. RADIOMIC FEATURES OF CONTRAST ENHANCED T1 MRI SEQUENCES PREDICT SURVIVAL IN PRIMARY GLIOBLASTOMA PATIENTS WHO UNDERWENT ADJUVANT RADIATION THERAPY Open
PURPOSE Glioblastoma (GBM) is an aggressive primary brain tumor that is monitored through magnetic resonance imaging (MRI). Radiomic analysis offers valuable insight into better understanding the imaging features of these tumors. We tested…
View article: NIMG-31. AXONS INTERSECTING TUMOR ENHANCEMENT (AXITE) RADIOMICS: A NOVEL PREDICTOR FOR OVERALL SURVIVAL IN GLIOBLASTOMA
NIMG-31. AXONS INTERSECTING TUMOR ENHANCEMENT (AXITE) RADIOMICS: A NOVEL PREDICTOR FOR OVERALL SURVIVAL IN GLIOBLASTOMA Open
AIM The diffuse infiltration of glioblastoma (GBM) along the intricate network of white matter (WM) tracts poses a major challenge. Our aim is to investigate the potential of axons intersecting tumor enhancement (AXITE)-derived radiomic fe…
View article: NIMG-11. AUTOPSY-BASED RADIO-PATHOMIC MAPS OF TISSUE COMPOSITION DELINEATE IDH1 STATS IN GLIOMAS
NIMG-11. AUTOPSY-BASED RADIO-PATHOMIC MAPS OF TISSUE COMPOSITION DELINEATE IDH1 STATS IN GLIOMAS Open
Isocitrate dehydrogenase 1 (IDH1) mutation status is used as an important prognostic marker for gliomas, where IDH1-wildtype patients see shorter survival than patients with an IDH1 mutation. This study uses radio-pathomic maps of cell, ex…
View article: NIMG-35. RADIO-PATHOMIC MAPS OF TUMOR PROBABILITY IDENTIFY GLIOBLASTOMA INVASION BEYOND 5-ALA GUIDED RESECTION MARGINS THAT EVENTUALLY EXHIBIT TUMOR RECURRENCE
NIMG-35. RADIO-PATHOMIC MAPS OF TUMOR PROBABILITY IDENTIFY GLIOBLASTOMA INVASION BEYOND 5-ALA GUIDED RESECTION MARGINS THAT EVENTUALLY EXHIBIT TUMOR RECURRENCE Open
Current standard of care for glioblastoma includes surgery followed by chemotherapy and radiation, with extent of resection strongly correlated with survival. There is a need to improve the detection of tumor invasion beyond traditional im…
View article: NIMG-14. AUTOPSY-BASED RADIO-PATHOMIC MAPS REVEAL DEMOGRAPHIC FACTORS IMPACT THE PRESENCE OF TUMOR OUTSIDE CONTRAST ENHANCEMENT IN GLIOMA PATIENTS
NIMG-14. AUTOPSY-BASED RADIO-PATHOMIC MAPS REVEAL DEMOGRAPHIC FACTORS IMPACT THE PRESENCE OF TUMOR OUTSIDE CONTRAST ENHANCEMENT IN GLIOMA PATIENTS Open
Gliomas are vastly heterogenous tumors with wide-ranging pathological signatures; as such, there is a pressing need to understand how individualized factors affect tumor growth patterns to develop treatment plans and improve prognosis. Thi…
View article: NIMG-68. TEMPORAL CHANGES IN TUMOR COMPOSITION DIFFER ACROSS TUMOR GRADE IN GLIOMA
NIMG-68. TEMPORAL CHANGES IN TUMOR COMPOSITION DIFFER ACROSS TUMOR GRADE IN GLIOMA Open
Gliomas are the most common primary adult brain tumor in the United States and their biological heterogeneity makes it difficult to assess and treat tumor progression over time. This study used conventional MRI tumor segmentations to deter…
View article: SAT618 Uncovering The Role Of O-glcnacylation In Pituitary Adenoma Pathogenesis: Insights From Corticotroph Tumors
SAT618 Uncovering The Role Of O-glcnacylation In Pituitary Adenoma Pathogenesis: Insights From Corticotroph Tumors Open
Disclosure: L.J. Massman: None. R. Gonzalez: None. B. Laing: None. D. Coss: None. A.G. Ioachimescu: None. N. Zwagerman: None. S. Olivier-Van Stichelen: None. Functioning corticotroph pituitary adenomas are associated with high mortality, m…
View article: NCOG-18. OVERALL SURVIVAL VARIATION DUE TO THE TIMING OF POST-SURGICAL RADIATION IN HIGH-GRADE GLIOMAS
NCOG-18. OVERALL SURVIVAL VARIATION DUE TO THE TIMING OF POST-SURGICAL RADIATION IN HIGH-GRADE GLIOMAS Open
PURPOSE Grade III and IV astrocytomas and glioblastomas are recognized as high-grade gliomas with aggressive heterogenous natures that carry with them a low overall survival (OS). Standard treatment currently involves surgical resection fo…
View article: NIMG-18. A GROUND TRUTH COMPARISON OF PATHOLOGICALLY CONFIRMED GLIOBLASTOMA MARGINS TO CONTRAST ENHANCEMENT AT AUTOPSY
NIMG-18. A GROUND TRUTH COMPARISON OF PATHOLOGICALLY CONFIRMED GLIOBLASTOMA MARGINS TO CONTRAST ENHANCEMENT AT AUTOPSY Open
PURPOSE Glioblastoma is one of the most common and deadly adult brain tumors. Current standard treatment is surgical resection followed by radiation and concomitant chemotherapy (chemoRT). Glioblastoma progression is monitored using MRI, p…
View article: NIMG-63. PRE-SURGICAL RADIO-PATHOMIC MAPS OF TUMOR CELLULARITY PREDICT EARLY RECURRENCE IN GLIOBLASTOMA PATIENTS
NIMG-63. PRE-SURGICAL RADIO-PATHOMIC MAPS OF TUMOR CELLULARITY PREDICT EARLY RECURRENCE IN GLIOBLASTOMA PATIENTS Open
PURPOSE Glioblastoma time to recurrence following initial surgery is difficult to predict as it differs widely between patients. This is important as those who recur early have a poorer prognosis and shorter survival time. This study aimed…
View article: PATH-39. A 44-YEAR-OLD FEMALE WITH DICER1-MUTANT PRIMARY INTRACRANIAL SARCOMA WITH IMAGING NEAR END OF LIFE
PATH-39. A 44-YEAR-OLD FEMALE WITH DICER1-MUTANT PRIMARY INTRACRANIAL SARCOMA WITH IMAGING NEAR END OF LIFE Open
DICER1-mutant intracranial sarcomas were recently defined by WHO in the 2021 CNS tumor classifications. Currently there is a lack of literature describing the clinical nature of this disease. Here we present a case of primary intracranial …