Dylan Curtin
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View article: Default mode and motor networks facilitate early learning of implicit motor sequences: a multimodal MR spectroscopy and fMRI study
Default mode and motor networks facilitate early learning of implicit motor sequences: a multimodal MR spectroscopy and fMRI study Open
Learning new motor skills is a fundamental process that involves the sequencing of actions. Skill develops with practice and time and manifests as performance that is fast and accurate. Although we know that learning can occur through an i…
View article: Default mode and motor networks facilitate early learning of implicit motor sequences: a multimodal MR spectroscopy and fMRI study
Default mode and motor networks facilitate early learning of implicit motor sequences: a multimodal MR spectroscopy and fMRI study Open
Learning new motor skills is a fundamental process that involves the sequencing of actions. Skill develops with practice and time, and manifests as performance that is fast and accurate. Although we know that learning can occur through an …
View article: Exercise‐induced cortical disinhibition mediates the relationship between fitness and memory in older adults
Exercise‐induced cortical disinhibition mediates the relationship between fitness and memory in older adults Open
Regular exercise benefits learning and memory in older adults, but the neural mechanisms mediating these effects remain unclear. Evidence in young adults indicates that acute exercise creates a favourable environment for synaptic plasticit…
View article: Dopamine D2 Receptor Modulates Exercise Related Effect on Cortical Excitation/Inhibition and Motor Skill Acquisition
Dopamine D2 Receptor Modulates Exercise Related Effect on Cortical Excitation/Inhibition and Motor Skill Acquisition Open
Exercise is known to benefit motor skill learning in health and neurological disease. Evidence from brain stimulation, genotyping, and Parkinson's disease studies converge to suggest that the dopamine D2 receptor, and shifts in the cortica…
View article: High-intensity acute exercise impacts motor learning in healthy older adults
High-intensity acute exercise impacts motor learning in healthy older adults Open
Healthy aging is associated with changes in motor sequence learning, with some studies indicating decline in motor skill learning in older age. Acute cardiorespiratory exercise has emerged as a potential intervention to improve motor learn…
View article: Ageing attenuates exercise‐enhanced motor cortical plasticity
Ageing attenuates exercise‐enhanced motor cortical plasticity Open
Cardiorespiratory exercise is known to modulate motor cortical plasticity in young adults, but the influence of ageing on this relationship is unknown. Here, we compared the effects of a single session of cardiorespiratory exercise on moto…
View article: The effect of dopamine D2 receptor blockade on human motor skill learning
The effect of dopamine D2 receptor blockade on human motor skill learning Open
Rationale: Dopamine signalling supports motor skill learning in a variety of ways, including through an effect on cortical and striatal plasticity. One neuromodulator that has been consistently linked to motor skill learning is dopamine. H…
View article: Ageing attenuates exercise-enhanced motor cortical plasticity
Ageing attenuates exercise-enhanced motor cortical plasticity Open
Cardiorespiratory exercise is known to modulate motor cortical plasticity in young adults, but the influence of ageing on this relationship is unknown. Here, we compared the effects of a single session of cardiorespiratory exercise on moto…
View article: High-intensity acute exercise impacts motor learning in healthy older adults
High-intensity acute exercise impacts motor learning in healthy older adults Open
Healthy aging is associated with a decline in motor sequence learning. Acute cardiorespiratory exercise has emerged as a potential intervention to improve motor learning, however research in healthy older adults is limited. The current stu…
View article: D2 receptor blockade eliminates exercise-induced changes in cortical inhibition and excitation
D2 receptor blockade eliminates exercise-induced changes in cortical inhibition and excitation Open
Our results provide causal evidence that D2 receptor blockade eliminates exercise-induced changes in excitatory and inhibitory cortical networks, and have implications for how exercise should be prescribed in diseases of dopaminergic dysfu…
View article: A single bout of moderate-intensity aerobic exercise improves motor learning in premanifest and early Huntington’s disease
A single bout of moderate-intensity aerobic exercise improves motor learning in premanifest and early Huntington’s disease Open
Introduction Cardiorespiratory exercise has emerged as a promising candidate to modify disease progression in Huntington’s disease (HD). In animal models, exercise has been found to alter biomarkers of neuroplasticity and delay evidence of…
View article: Motor Cortex Plasticity Response to Acute Cardiorespiratory Exercise and Intermittent Theta-Burst Stimulation is Attenuated in Premanifest and Early Huntington’s Disease
Motor Cortex Plasticity Response to Acute Cardiorespiratory Exercise and Intermittent Theta-Burst Stimulation is Attenuated in Premanifest and Early Huntington’s Disease Open
Huntington’s disease (HD) mouse models suggest that cardiovascular exercise may enhance neuroplasticity and delay disease signs, however, the effects of exercise on neuroplasticity in people with HD are unknown. Using a repeated-measures e…
View article: What's off‐key in the brain of musicians with focal task‐specific dystonia?
What's off‐key in the brain of musicians with focal task‐specific dystonia? Open
The brain's ability to change in response to practice and experience subserves a number of important adaptive functions, such as learning and memory. Yet, this plasticity can also become maladaptive and produce pathological outcomes. A rar…