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View article: Antibody-mediated control of anellovirus infection: evidence from people who inject drugs
Antibody-mediated control of anellovirus infection: evidence from people who inject drugs Open
Infections with viruses belonging to the family Anelloviridae are widespread among humans. Although generally considered a commensal, there is evidence to suggest that these infections may be controlled by host immune responses. However, t…
View article: MICBG406A polymorphism reduces risk of mechanical ventilation and death during viral acute lung injury
MICBG406A polymorphism reduces risk of mechanical ventilation and death during viral acute lung injury Open
MHC class I polypeptide-related sequence B (MICB) is a ligand for NKG2D. We have shown NK cells are central to lung transplant acute lung injury (ALI) via NKG2D activation, and increased MICB in bronchoalveolar lavage predicts ALI severity…
View article: High-affinity CD16A polymorphism associated with reduced risk ofsevere COVID-19
High-affinity CD16A polymorphism associated with reduced risk ofsevere COVID-19 Open
CD16A is an activating Fc receptor on NK cells that mediates antibody-dependent cellular cytotoxicity (ADCC), a key mechanism in antiviral immunity. However, the role of NK cell-mediated ADCC in SARS-CoV-2 infection remains unclear, partic…
View article: Long-Read Nanopore-Based Sequencing of Anelloviruses
Long-Read Nanopore-Based Sequencing of Anelloviruses Open
Routinely used metagenomic next-generation sequencing (mNGS) techniques often fail to detect low-level viremia (<104 copies/mL) and appear biased towards viruses with linear genomes. These limitations hinder the capacity to comprehensively…
View article: A hepatitis B virus (HBV) sequence variation graph improves alignment and sample-specific consensus sequence construction
A hepatitis B virus (HBV) sequence variation graph improves alignment and sample-specific consensus sequence construction Open
Nearly 300 million individuals live with chronic hepatitis B virus (HBV) infection (CHB), for which no curative therapy is available. As viral diversity is associated with pathogenesis and immunological control of infection, improved metho…
View article: Genetic Susceptibility to Astrovirus Diarrhea in Bangladeshi Infants
Genetic Susceptibility to Astrovirus Diarrhea in Bangladeshi Infants Open
Background Astroviral infections commonly cause acute nonbacterial gastroenteritis in children globally. However, these infections often go undiagnosed outside of research settings. There is no treatment available for astrovirus, and Astro…
View article: Genetic Susceptibility to Astrovirus Diarrhea in Bangladeshi Infants
Genetic Susceptibility to Astrovirus Diarrhea in Bangladeshi Infants Open
Astroviral infections commonly cause acute nonbacterial gastroenteritis in children globally. However, these infections often go undiagnosed outside of research settings. There is no treatment available for astrovirus, and Astroviridae str…
View article: A hepatitis B virus (HBV) sequence variation graph improves sequence alignment and sample-specific consensus sequence construction for genetic analysis of HBV
A hepatitis B virus (HBV) sequence variation graph improves sequence alignment and sample-specific consensus sequence construction for genetic analysis of HBV Open
Hepatitis B virus (HBV) remains a global public health concern, with over 250 million individuals living with chronic HBV infection (CHB) and no curative therapy currently available. Viral diversity is associated with CHB pathogenesis and …
View article: Pathogen exposure misclassification can bias association signals in GWAS of infectious diseases when using population-based common controls
Pathogen exposure misclassification can bias association signals in GWAS of infectious diseases when using population-based common controls Open
Genome-wide association studies (GWAS) have been performed to identify host genetic factors for a range of phenotypes, including for infectious diseases. The use of population-based common controls from biobanks and extensive consortiums i…
View article: Simulated hepatitis B virus (HBV) sequencing data and HBV sequence variation graph materials
Simulated hepatitis B virus (HBV) sequencing data and HBV sequence variation graph materials Open
Simulated HBV sequencing data (InSilicoSeq, HiSeq error model) and a sequence variation graph constructed using HBV genome sequences described in https://doi.org/10.1099/jgv.0.001387
View article: Simulated hepatitis B virus (HBV) sequencing data and HBV sequence variation graph materials
Simulated hepatitis B virus (HBV) sequencing data and HBV sequence variation graph materials Open
Simulated HBV sequencing data (InSilicoSeq, HiSeq error model) and a sequence variation graph constructed using HBV genome sequences described in https://doi.org/10.1099/jgv.0.001387
View article: Genome-Wide Association Study of Campylobacter <i>-</i> Positive Diarrhea Identifies Genes Involved in Toxin Processing and Inflammatory Response
Genome-Wide Association Study of Campylobacter <i>-</i> Positive Diarrhea Identifies Genes Involved in Toxin Processing and Inflammatory Response Open
Children in low-to-middle-income countries often suffer from multiple enteric infections in their first few years of life, many of which have the potential for long-lasting effects. These children are already likely to be malnourished and …
View article: Host Genome-Wide Association Study of Infant Susceptibility to<i>Shigella</i>-Associated Diarrhea
Host Genome-Wide Association Study of Infant Susceptibility to<i>Shigella</i>-Associated Diarrhea Open
Shigella is a leading cause of moderate-to-severe diarrhea globally and the causative agent of shigellosis and bacillary dysentery. Associated with 80 to 165 million cases of diarrhea and >13% of diarrheal deaths, in many regions, Shigella…
View article: The ocular tissue-specificity of differentially expressed age-related macular degeneration associated genes
The ocular tissue-specificity of differentially expressed age-related macular degeneration associated genes Open
Purpose Age-related macular degeneration (AMD) is a leading cause of blindness in the developed world. One of the most genetically well-characterized degenerative diseases, genome-wide association studies (GWAS) have identified 52 independ…