Dylan Deska‐Gauthier
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View article: Widespread innervation of motoneurons by spinal V3 neurons globally amplifies locomotor output in mice
Widespread innervation of motoneurons by spinal V3 neurons globally amplifies locomotor output in mice Open
While considerable progress has been made in understanding the neuronal circuits that underlie the patterning of locomotor behaviors, less is known about the circuits that amplify motoneuron output to adjust muscle force. Here, we demonstr…
View article: Clinical, Molecular and Genetic Features of Spinal Meningiomas
Clinical, Molecular and Genetic Features of Spinal Meningiomas Open
Spinal meningiomas comprise 25-46% of all primary spinal tumors. While the majority are benign and slow growing, when left untreated, they can result in significant neurological decline. Emerging clinical, imaging, and molecular data has b…
View article: Widespread innervation of motoneurons by spinal V3 neurons globally amplifies locomotor output in mice
Widespread innervation of motoneurons by spinal V3 neurons globally amplifies locomotor output in mice Open
While considerable progress has been made in understanding the neuronal circuits that underlie the patterning of locomotor behaviours such as walking, less is known about the circuits that amplify motoneuron output to enable adaptable incr…
View article: Widespread Innervation of Motoneurons by Spinal V3 Neurons Globally Amplifies Locomotor Output in Mice
Widespread Innervation of Motoneurons by Spinal V3 Neurons Globally Amplifies Locomotor Output in Mice Open
View article: Embryonic temporal-spatial delineation of excitatory spinal V3 interneuron diversity
Embryonic temporal-spatial delineation of excitatory spinal V3 interneuron diversity Open
Spinal neural circuits that execute movement are composed of cardinal classes of neurons that emerged from distinct progenitor lineages. Each cardinal class contains multiple neuronal subtypes characterized by distinct molecular, anatomica…
View article: Distinct roles of spinal commissural interneurons in transmission of contralateral sensory information
Distinct roles of spinal commissural interneurons in transmission of contralateral sensory information Open
Crossed reflexes are mediated by commissural pathways transmitting sensory information to the contralateral side of the body, but the underlying network is not fully understood. Commissural pathways coordinating the activities of spinal lo…
View article: Neuroplasticity and regeneration after spinal cord injury
Neuroplasticity and regeneration after spinal cord injury Open
Spinal cord injury (SCI) is a debilitating condition with significant personal, societal, and economic burden. The highest proportion of traumatic injuries occur at the cervical level, which results in severe sensorimotor and autonomic def…
View article: The role of V3 neurons in speed-dependent interlimb coordination during locomotion in mice
The role of V3 neurons in speed-dependent interlimb coordination during locomotion in mice Open
Speed-dependent interlimb coordination allows animals to maintain stable locomotion under different circumstances. The V3 neurons are known to be involved in interlimb coordination. We previously modeled the locomotor spinal circuitry cont…
View article: Author response: The role of V3 neurons in speed-dependent interlimb coordination during locomotion in mice
Author response: The role of V3 neurons in speed-dependent interlimb coordination during locomotion in mice Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Speed-dependent interl…
View article: The role of V3 neurons in speed-dependent interlimb coordination during locomotion in mice
The role of V3 neurons in speed-dependent interlimb coordination during locomotion in mice Open
Speed-dependent interlimb coordination allows animals to maintain stable locomotion under different circumstances. We have previously demonstrated that a subset of spinal V3 neurons contributes to stable locomotion by mediating mutual exci…
View article: The Temporal Mechanisms Guiding Interneuron Differentiation in the Spinal Cord
The Temporal Mechanisms Guiding Interneuron Differentiation in the Spinal Cord Open
Neurogenesis timing is an essential developmental mechanism for neuronal diversity and organization throughout the central nervous system. In the mouse spinal cord, growing evidence is beginning to reveal that neurogenesis timing acts in t…
View article: Organized cannabinoid receptor distribution in neurons revealed by super-resolution fluorescence imaging
Organized cannabinoid receptor distribution in neurons revealed by super-resolution fluorescence imaging Open
View article: The Temporal Neurogenesis Patterning of Spinal p3–V3 Interneurons into Divergent Subpopulation Assemblies
The Temporal Neurogenesis Patterning of Spinal p3–V3 Interneurons into Divergent Subpopulation Assemblies Open
Neuronal diversity provides the spinal cord with the functional flexibility required to perform complex motor tasks. Spinal neurons arise during early embryonic development with the establishment of spatially and molecularly discrete proge…
View article: Spinal V3 Interneurons and Left–Right Coordination in Mammalian Locomotion
Spinal V3 Interneurons and Left–Right Coordination in Mammalian Locomotion Open
Commissural interneurons (CINs) mediate interactions between rhythm-generating locomotor circuits located on each side of the spinal cord and are necessary for left-right limb coordination during locomotion. While glutamatergic V3 CINs hav…
View article: Combining tensile testing and structural analysis at the single collagen fibril level
Combining tensile testing and structural analysis at the single collagen fibril level Open
View article: In tendons, differing physiological requirements lead to functionally distinct nanostructures
In tendons, differing physiological requirements lead to functionally distinct nanostructures Open
View article: Post-rupture imaging data.xls
Post-rupture imaging data.xls Open
COLUMN A – Animal number (1 or 2) COLUMN B – Tendon type: common digital extensor (e) or superficial digital flexor (f) COLUMN C – Fibril number COLUMN D – Rupture location, at the glue or in the middle of the segment COLUMN E – Average dr…
View article: Cantilever spec sheet.xls
Cantilever spec sheet.xls Open
COLUMN A – Cantilever number COLUMN B – Cantilever manufacturer COLUMN C – Cantilever model COLUMN D – Cantilever type COLUMN E – Cantilever material COLUMN F – Cantilever length in micrometers COLUMN G – Tip height in micrometers COLUMN H…
View article: SHG pol-stacks.zip
SHG pol-stacks.zip Open
Raw SHG forward intensity pol-stacks containing 25 grey scales images in TIFF format. Each file is named using the first three columns of File 1, for example: animal 1, common digital extensor tendon, fibril 1 is 1e1. The pol-stack of the …
View article: Tensile data.xls
Tensile data.xls Open
COLUMN A – Animal number (1 or 2) COLUMN B – Tendon type: common digital extensor (e) or superficial digital flexor (f) COLUMN C – Fibril number COLUMN D – Length in micrometers of prepared fibril segment before pull-to-rupture COLUMN E – …
View article: AFM images.zip
AFM images.zip Open
Representative raw AFM images of the dried ruptured fibrils in their original Bruker nanoscope file format. The images were acquired using the Peak Force Quantitative Nanomechanical Mapping mode and can be opened using the freeware Gwyddio…
View article: Stress strain curves.zip
Stress strain curves.zip Open
Stress-strain curve for each fibril as a two column tabulated text file. The first column is the strain in percent and the second column is the stress in Mega Pascal measured as the tension divided by the dried fibril segment cross-section…
View article: Fluorescence images.zip
Fluorescence images.zip Open
Raw fluorescence images in .lsm format (Carl Zeiss) containing two channels: brighfield and fluorescence. Images can be opened using ImageJ (https://imagej.nih.gov/ij/). Each file is named using the first three columns of File 1, for examp…
View article: <i><scp>S</scp>im1</i> is required for the migration and axonal projections of V3 interneurons in the developing mouse spinal cord
<i><span>S</span>im1</i> is required for the migration and axonal projections of V3 interneurons in the developing mouse spinal cord Open
V3 spinal interneurons (INs) are a group of excitatory INs that play a crucial role in producing balanced and stable gaits in vertebrate animals. In the developing mouse spinal cord, V3 INs arise from the most ventral progenitor domain and…