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View article: Picomolar bivalent inhibitors of protein kinase CK2 active against β-coronavirus replication
Picomolar bivalent inhibitors of protein kinase CK2 active against β-coronavirus replication Open
The protein casein kinase 2 (CK2) has been shown to be upregulated in SARS-CoV-2 infections. However, few inhibitors have been tested for antiviral activity against coronaviruses. In this study, highly potent and selective bivalent inhibit…
View article: Binding‐Site Switch for Protein Kinase CK2 Inhibitors
Binding‐Site Switch for Protein Kinase CK2 Inhibitors Open
The serine/threonine protein kinase CK2, a tetramer composed of a regulatory dimer (CK2β 2 ) bound to two catalytic subunits CK2α, is a well‐established therapeutic target for various pathologies, including cancer and viral infections. Sev…
View article: Linkers in fragment-based drug design: an overview of the literature
Linkers in fragment-based drug design: an overview of the literature Open
The authors believe that fragment linking offers key advantages for compound design, particularly for the design of bivalent inhibitors linking two distinct pockets of the same or different subunits. On the other hand, more studies are nee…
View article: Comparison of viscoelastic property characterization of plastisol phantoms with magnetic resonance elastography and high-frequency rheometry
Comparison of viscoelastic property characterization of plastisol phantoms with magnetic resonance elastography and high-frequency rheometry Open
This study aims at evaluating Magnetic Resonance Elastography (MRE) as a reliable technique for the characterization of viscoelastic properties of soft tissues. Three phantoms with different concentrations of plastisol and softener were pr…