Dylan L. Mariuzza
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View article: 936 Tumor-specific antibodies elicited by engineered bacteria promote bladder cancer immunotherapy
936 Tumor-specific antibodies elicited by engineered bacteria promote bladder cancer immunotherapy Open
View article: Tumor-specific antibodies elicited by engineered bacteria promote bladder cancer immunotherapy
Tumor-specific antibodies elicited by engineered bacteria promote bladder cancer immunotherapy Open
The intratumoral microbiome has recently emerged as a new hallmark of cancer, with implications for response or resistance to therapy. While bacteria can either promote or inhibit cancer growth, intratumoral bacteria can also be engineered…
View article: Programmable bacteria synergize with PD-1 blockade to overcome cancer cell–intrinsic immune resistance mechanisms
Programmable bacteria synergize with PD-1 blockade to overcome cancer cell–intrinsic immune resistance mechanisms Open
Interferon-γ (IFN-γ) is a potent cytokine critical for response to immunotherapy, yet conventional methods to systemically deliver this cytokine have been hindered by severe dose-limiting toxicities. Here, we engineered a strain of probiot…
View article: Reciprocal transmission of activating and inhibitory signals and cell fate in regenerating T cells
Reciprocal transmission of activating and inhibitory signals and cell fate in regenerating T cells Open
The ability of activated progenitor T cells to self-renew while producing differentiated effector cell descendants may underlie immunological memory and persistent responses to ongoing infection. The nature of stem-like T cells responding …
View article: A reservoir of stem-like CD8 <sup>+</sup> T cells in the tumor-draining lymph node preserves the ongoing antitumor immune response
A reservoir of stem-like CD8 <sup>+</sup> T cells in the tumor-draining lymph node preserves the ongoing antitumor immune response Open
Tumor-specific CD8 + T cells in stable tumor-draining lymph node reservoir are clonally and developmentally related to those in tumors.
View article: A mouse model for the study of anti-tumor T cell responses in Kras-driven lung adenocarcinoma
A mouse model for the study of anti-tumor T cell responses in Kras-driven lung adenocarcinoma Open
View article: A reservoir of stem-like CD8 T cells in the tumor-draining lymph node maintains the ongoing anti-tumor immune response
A reservoir of stem-like CD8 T cells in the tumor-draining lymph node maintains the ongoing anti-tumor immune response Open
“Stem-like” TCF1 + CD8 + T cells (T SL ) are necessary for long-term maintenance of T cell responses and the efficacy of immunotherapy but, as tumors contain signals that should drive T-cell terminal-differentiation, how these cells are ma…
View article: A Novel Mouse Model for the Study of Anti-Tumor T Cell Responses in Kras Driven Lung Adenocarcinoma
A Novel Mouse Model for the Study of Anti-Tumor T Cell Responses in Kras Driven Lung Adenocarcinoma Open