Dylan Sosa
YOU?
Author Swipe
View article: Sex-biased duplicates are rapidly generated during <i>Drosophila</i> tRNA repertoire evolution
Sex-biased duplicates are rapidly generated during <i>Drosophila</i> tRNA repertoire evolution Open
Eukaryotic genomes encode hundreds of transfer RNA genes ostensibly to ensure efficient translation. How these seemingly redundant tRNA copies arise and are naturally selected in metazoan genomes and populations remains largely unexplored,…
View article: Evolutionarily new genes in humans with disease phenotypes reveal functional enrichment patterns shaped by adaptive innovation and sexual selection
Evolutionarily new genes in humans with disease phenotypes reveal functional enrichment patterns shaped by adaptive innovation and sexual selection Open
New genes (or young genes) are genetic novelties pivotal in mammalian evolution. However, their phenotypic impacts and evolutionary patterns over time remain elusive in humans owing to the technical and ethical complexities of functional s…
View article: The three-dimensional genome drives the evolution of asymmetric gene duplicates via enhancer capture-divergence
The three-dimensional genome drives the evolution of asymmetric gene duplicates via enhancer capture-divergence Open
Previous evolutionary models of duplicate gene evolution have overlooked the pivotal role of genome architecture. Here, we show that proximity-based regulatory recruitment by distally duplicated genes is an efficient mechanism for modulati…
View article: Human selenocysteine synthase, SEPSECS, has evolved to optimize binding of a tRNA-based substrate
Human selenocysteine synthase, SEPSECS, has evolved to optimize binding of a tRNA-based substrate Open
The evolution of the genetic code to incorporate selenocysteine (Sec) enabled the development of a selenoproteome in all domains of life. O-phosphoseryl-tRNASec selenium transferase (SepSecS) catalyzes the terminal reaction of Sec synthesi…
View article: The Rapid Evolution of De Novo Proteins in Structure and Complex
The Rapid Evolution of De Novo Proteins in Structure and Complex Open
Recent studies in the rice genome-wide have established that de novo genes, evolving from noncoding sequences, enhance protein diversity through a stepwise process. However, the pattern and rate of their evolution in protein structure over…
View article: One million years of solitude: the rapid evolution of de novo protein structure and complex
One million years of solitude: the rapid evolution of de novo protein structure and complex Open
Recent studies have established that de novo genes, evolving from non-coding sequences, enhance protein diversity through a stepwise process. However, the pattern and rate of their structural evolution over time remain unclear. Here, we ad…
View article: Evolutionarily new genes in humans with disease phenotypes reveal functional enrichment patterns shaped by adaptive innovation and sexual selection.
Evolutionarily new genes in humans with disease phenotypes reveal functional enrichment patterns shaped by adaptive innovation and sexual selection. Open
New genes (or young genes) are genetic novelties pivotal in mammalian evolution. However, their phenotypic impacts and evolutionary patterns over time remain elusive in humans due to the technical and ethical complexities of functional stu…
View article: Human Gene Age Dating Reveals an Early and Rapid Evolutionary Construction of the Adaptive Immune System
Human Gene Age Dating Reveals an Early and Rapid Evolutionary Construction of the Adaptive Immune System Open
T cells are a type of white blood cell that play a critical role in the immune response against foreign pathogens through a process called T cell adaptive immunity (TCAI). However, the evolution of the genes and nucleotide sequences involv…
View article: New gene evolution with subcellular expression patterns detected in PacBio-sequenced genomes of<i>Drosophila</i>genus
New gene evolution with subcellular expression patterns detected in PacBio-sequenced genomes of<i>Drosophila</i>genus Open
Previous studies described gene age distributions in the focal species of Drosophila melanogaster . Using third-generation PacBio technology to sequence Drosophila species we investigated gene age distribution in the two subgenera of Droso…
View article: Rapid Cis–Trans Coevolution Driven by a Novel Gene Retroposed from a Eukaryotic Conserved CCR4–NOT Component in Drosophila
Rapid Cis–Trans Coevolution Driven by a Novel Gene Retroposed from a Eukaryotic Conserved CCR4–NOT Component in Drosophila Open
Young, or newly evolved, genes arise ubiquitously across the tree of life, and they can rapidly acquire novel functions that influence a diverse array of biological processes. Previous work identified a young regulatory duplicate gene in D…
View article: Species-specific partial gene duplication in <i>Arabidopsis thaliana</i> evolved novel phenotypic effects on morphological traits under strong positive selection
Species-specific partial gene duplication in <i>Arabidopsis thaliana</i> evolved novel phenotypic effects on morphological traits under strong positive selection Open
Gene duplication is increasingly recognized as an important mechanism for the origination of new genes, as revealed by comparative genomic analysis. However, how new duplicate genes contribute to phenotypic evolution remains largely unknow…
View article: Species-specific gene duplication in<i>Arabidopsis thaliana</i>evolved novel phenotypic effects on morphological traits under strong positive selection
Species-specific gene duplication in<i>Arabidopsis thaliana</i>evolved novel phenotypic effects on morphological traits under strong positive selection Open
Gene duplication is increasingly recognized as an important mechanism for the origination of new genes, as revealed by comparative genomic analysis. However, the ways in which new duplicate genes contribute to phenotypic evolution remain l…
View article: Retraction Note: Vibrio parahaemolyticus RhsP represents a widespread group of pro-effectors for type VI secretion systems
Retraction Note: Vibrio parahaemolyticus RhsP represents a widespread group of pro-effectors for type VI secretion systems Open
This paper has been retracted.