Dylan T. Jones
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View article: Editor’s Note: Effects of Transferrin Receptor Blockade on Cancer Cell Proliferation and Hypoxia-Inducible Factor Function and Their Differential Regulation by Ascorbate
Editor’s Note: Effects of Transferrin Receptor Blockade on Cancer Cell Proliferation and Hypoxia-Inducible Factor Function and Their Differential Regulation by Ascorbate Open
View article: Assessing the relative impacts of satellite ozone and its precursor observations to improve global tropospheric ozone analysis using multiple chemical reanalysis systems
Assessing the relative impacts of satellite ozone and its precursor observations to improve global tropospheric ozone analysis using multiple chemical reanalysis systems Open
Chemical reanalysis products have been produced by integrating various satellite observational data to provide comprehensive information on atmospheric composition. Five global chemical reanalysis datasets were used to evaluate the relativ…
View article: Assessment of regional and interannual variations in tropospheric ozone in chemical reanalyses
Assessment of regional and interannual variations in tropospheric ozone in chemical reanalyses Open
We evaluate regional and interannual variations in tropospheric ozone in five chemical reanalyses, consisting of the Copernicus Atmosphere Monitoring Service reanalysis (CAMSRA), the second-generation Tropospheric Chemistry Reanalysis (TCR…
View article: Assessing the relative impacts of satellite ozone and its precursor observations to improve global tropospheric ozone analysis using multiple chemical reanalysis systems
Assessing the relative impacts of satellite ozone and its precursor observations to improve global tropospheric ozone analysis using multiple chemical reanalysis systems Open
Chemical reanalysis products have been produced by integrating various satellite observational data to provide comprehensive information on atmospheric composition. Five global chemical reanalysis datasets were used to evaluate the relativ…
View article: Supplementary Figure 7 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers
Supplementary Figure 7 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers Open
Significant differential abundance analysis of lipids as a heat map. A. MDA-MB-468 and B. PC3 spheroids were treated for 4 days with inhibitors against metabolic enzymes PDHK, ACC, FASN and DGAT, and kinases PI3K, AKT and mTOR at two diffe…
View article: Supplementary Figure 8 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers
Supplementary Figure 8 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers Open
Analysis of saturated, mono-unsaturated and poly-unsaturated phospholipids in MDA-MB-468 and PC3 spheroids. Levels of PC, PE, PI, PS, and SM in MDA-MB-468 and PC3 spheroids treated with inhibitors against metabolic enzymes PDHK, ACC, FASN …
View article: Supplementary Figure 3 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers
Supplementary Figure 3 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers Open
GI50 calculation of spheroids treated with inhibitors. (A) MDA-MB-468 on day 8 and (B) PC3 spheroids on day 12 treated with inhibitors against metabolic enzymes PDHK, ACC, FASN and DGAT, and signalling enzymes PI3K, Akt and mTOR. Between 5…
View article: Supplementary Figure 3 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers
Supplementary Figure 3 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers Open
GI50 calculation of spheroids treated with inhibitors. (A) MDA-MB-468 on day 8 and (B) PC3 spheroids on day 12 treated with inhibitors against metabolic enzymes PDHK, ACC, FASN and DGAT, and signalling enzymes PI3K, Akt and mTOR. Between 5…
View article: Supplementary Figure 5 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers
Supplementary Figure 5 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers Open
Clustered heat map analysis of lipids in MDA-MB-468 and PC3 spheroids treated for 4 days with A. FASN and B. DGAT inhibitor at different concentrations. All Lipids were compared against DMSO control. Side covariates indicate lipid families…
View article: Supplementary Figure 6 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers
Supplementary Figure 6 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers Open
Clustered heat map analysis of lipids in MDA-MB-468 and PC3 spheroids treated for 4 days with A. ACC and B. PDHK inhibitor at different concentrations. All Lipids were compared against DMSO control. Side covariates indicate lipid families,…
View article: Supplementary Figure 7 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers
Supplementary Figure 7 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers Open
Significant differential abundance analysis of lipids as a heat map. A. MDA-MB-468 and B. PC3 spheroids were treated for 4 days with inhibitors against metabolic enzymes PDHK, ACC, FASN and DGAT, and kinases PI3K, AKT and mTOR at two diffe…
View article: Supplementary Figure 8 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers
Supplementary Figure 8 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers Open
Analysis of saturated, mono-unsaturated and poly-unsaturated phospholipids in MDA-MB-468 and PC3 spheroids. Levels of PC, PE, PI, PS, and SM in MDA-MB-468 and PC3 spheroids treated with inhibitors against metabolic enzymes PDHK, ACC, FASN …
View article: Supplementary Figure 2 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers
Supplementary Figure 2 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers Open
Two dimensional CyQuant cell proliferation assay of (A) MDA-MB-468 and (B) PC3 cells following 3 days of treatment under normoxic and hypoxic conditions with inhibitors against metabolic enzymes PDHK, ACC, FASN and DGAT, and signalling enz…
View article: Data from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers
Data from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers Open
Tumor cells exhibit altered lipid metabolism compared with normal cells. Cell signaling kinases are important for regulating lipid synthesis and energy storage. How upstream kinases regulate lipid content, versus direct targeting of lipid-…
View article: Supplementary Figure 2 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers
Supplementary Figure 2 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers Open
Two dimensional CyQuant cell proliferation assay of (A) MDA-MB-468 and (B) PC3 cells following 3 days of treatment under normoxic and hypoxic conditions with inhibitors against metabolic enzymes PDHK, ACC, FASN and DGAT, and signalling enz…
View article: Supplementary Figure 1 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers
Supplementary Figure 1 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers Open
Chemical structure of drugs that inhibit metabolic enzymes FASN (AZ22), ACC (AZ52), DGAT (AZ17), PDHK (AZ30), and cell signalling kinase enzymes PI3K (AZ46), AKT (AZ28) and mTOR (AZ64).
View article: Data from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers
Data from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers Open
Tumor cells exhibit altered lipid metabolism compared with normal cells. Cell signaling kinases are important for regulating lipid synthesis and energy storage. How upstream kinases regulate lipid content, versus direct targeting of lipid-…
View article: Supplementary Figure 1 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers
Supplementary Figure 1 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers Open
Chemical structure of drugs that inhibit metabolic enzymes FASN (AZ22), ACC (AZ52), DGAT (AZ17), PDHK (AZ30), and cell signalling kinase enzymes PI3K (AZ46), AKT (AZ28) and mTOR (AZ64).
View article: Supplementary Figure 4 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers
Supplementary Figure 4 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers Open
Clustered heat map analysis of lipids in MDA-MB-468 and PC3 spheroids treated for 4 days with A. AKT, B. PI3K and C. mTOR inhibitor at different concentrations. All Lipids were compared against DMSO control. Side covariates indicate lipid …
View article: Supplementary Figure 5 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers
Supplementary Figure 5 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers Open
Clustered heat map analysis of lipids in MDA-MB-468 and PC3 spheroids treated for 4 days with A. FASN and B. DGAT inhibitor at different concentrations. All Lipids were compared against DMSO control. Side covariates indicate lipid families…
View article: Supplementary Figure 6 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers
Supplementary Figure 6 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers Open
Clustered heat map analysis of lipids in MDA-MB-468 and PC3 spheroids treated for 4 days with A. ACC and B. PDHK inhibitor at different concentrations. All Lipids were compared against DMSO control. Side covariates indicate lipid families,…
View article: Supplementary Figure 4 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers
Supplementary Figure 4 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers Open
Clustered heat map analysis of lipids in MDA-MB-468 and PC3 spheroids treated for 4 days with A. AKT, B. PI3K and C. mTOR inhibitor at different concentrations. All Lipids were compared against DMSO control. Side covariates indicate lipid …
View article: Repurposing FDA-approved drugs as inhibitors of therapy-induced invadopodia activity in glioblastoma cells
Repurposing FDA-approved drugs as inhibitors of therapy-induced invadopodia activity in glioblastoma cells Open
Glioblastoma (GBM) is the most prevalent primary central nervous system tumour in adults. The lethality of GBM lies in its highly invasive, infiltrative, and neurologically destructive nature resulting in treatment failure, tumour recurren…
View article: Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer
Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer Open
Significance The hypoxic microenvironment in solid tumors is known to reduce the efficacy of anticancer treatments in many cancer types, including breast cancer. This study shows hypoxia induces an amino acid transporter, SNAT2, which then…
View article: 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers
3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers Open
Tumor cells exhibit altered lipid metabolism compared with normal cells. Cell signaling kinases are important for regulating lipid synthesis and energy storage. How upstream kinases regulate lipid content, versus direct targeting of lipid-…
View article: Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine-resistance in breast cancer
Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine-resistance in breast cancer Open
Tumor hypoxia is associated with poor patient outcomes in estrogen receptor-α (ERα) positive breast cancer. Hypoxia is known to affect tumor growth by reprogramming metabolism and regulating amino acid (AA) uptake. Here we show that the gl…
View article: Disrupting Hypoxia-Induced Bicarbonate Transport Acidifies Tumor Cells and Suppresses Tumor Growth
Disrupting Hypoxia-Induced Bicarbonate Transport Acidifies Tumor Cells and Suppresses Tumor Growth Open
Tumor hypoxia is associated clinically with therapeutic resistance and poor patient outcomes. One feature of tumor hypoxia is activated expression of carbonic anhydrase IX (CA9), a regulator of pH and tumor growth. In this study, we invest…
View article: Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments
Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments Open
View article: Additional file 11: Movies 1â 8. of Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments
Additional file 11: Movies 1â 8. of Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments Open
Movies showing 3D reconstructions of ultrasound images of tumours after 27Â days of doxycycline treatment. (ZIP 17982 kb)
View article: Estrogen receptor-α directly regulates the hypoxia-inducible factor 1 pathway associated with antiestrogen response in breast cancer
Estrogen receptor-α directly regulates the hypoxia-inducible factor 1 pathway associated with antiestrogen response in breast cancer Open
Significance About 1.7 million new cases of breast cancer occur every year, 70% of which are estrogen receptor-α (ERα) positive. Antiestrogen therapy to block ERα function is the most important approach in treatment of ERα + patients. Howe…