Dylan Wint
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View article: Gene-Specific Effects on Brain Volume and Cognition of <i>TMEM106B</i> in Frontotemporal Lobar Degeneration
Gene-Specific Effects on Brain Volume and Cognition of <i>TMEM106B</i> in Frontotemporal Lobar Degeneration Open
We identified associations of TMEM106B with gray matter volume and cognition in the presence of GRN and C9orf72 pathogenic variants. The association of TMEM106B with outcomes of interest in presymptomatic GRN and C9orf72 pathogenic variant…
View article: Association of CSF α-Synuclein Seeding Amplification Assay Results With Clinical Features of Possible and Probable Dementia With Lewy Bodies
Association of CSF α-Synuclein Seeding Amplification Assay Results With Clinical Features of Possible and Probable Dementia With Lewy Bodies Open
This study provided Class III evidence that CSF αSyn-SAA distinguishes patients with clinically diagnosed DLB from normal controls.
View article: Gene specific effects on brain volume and cognition of <i>TMEM106B</i> in frontotemporal lobar degeneration
Gene specific effects on brain volume and cognition of <i>TMEM106B</i> in frontotemporal lobar degeneration Open
Background and Objectives TMEM106B has been proposed as a modifier of disease risk in FTLD-TDP, particularly in GRN mutation carriers. Furthermore, TMEM106B has been investigated as a disease modifier in the context of healthy aging and ac…
View article: ATN Cerebrospinal Fluid Biomarkers in Dementia with Lewy Bodies: Initial Results from the United States Dementia with Lewy Bodies Consortium
ATN Cerebrospinal Fluid Biomarkers in Dementia with Lewy Bodies: Initial Results from the United States Dementia with Lewy Bodies Consortium Open
Background Neuropathological hallmarks of AD, amyloid plaques and neurofibrillary tangles, have been described in dementia with Lewy bodies (DLB). Less is known about changes in pre‐mortem cerebrospinal fluid (CSF) amyloid and tau biomarke…
View article: Identification of Hippocampal and Amygdala Subfields Predictive of MoCA Scores in Patients with Dementia with Lewy Bodies
Identification of Hippocampal and Amygdala Subfields Predictive of MoCA Scores in Patients with Dementia with Lewy Bodies Open
Background Hippocampal and amygdala subfields variably affect cognitive impairment in neurodegenerative diseases. Subfields of these regions can be well segmented using modern neuroimaging tools but their role in neurodegenerative disease …
View article: Nevada exploratory Alzheimer’s disease research center: Advancing dementia care in rural communities
Nevada exploratory Alzheimer’s disease research center: Advancing dementia care in rural communities Open
Background People with MCI and AD living in rural areas represent an understudied and underserved population in the broader AD landscape. Very little works have been done on rural cohorts by NIA‐designated Alzheimer’s Disease Research Cent…
Does Informant-Based Reporting of Cognitive Decline Correlate with Age-Adjusted Hippocampal Volume in Mild Cognitive Impairment and Alzheimer’s Disease? Open
Background: Informant-based measures are effective screening tools for cognitive impairment. The Alzheimer’s Questionnaire (AQ) is a subjective, informant-based measure that detects amnestic mild cognitive impairment (aMCI) and Alzheimer’s…
Informant‐based report of cognitive decline correlates with age‐adjusted hippocampal volume in mild cognitive impairment and Alzheimer's dementia? Open
Background Informant‐based measures can be effective screening tools for cognitive impairment. The Alzheimer’s Questionnaire (AQ; Sabbagh et al., 2010) is a subjective, informant‐based measure that captures five cognitive domains associate…
Screening for Adverse Drug Reactions in Dementia Patients on Cholinesterase Inhibitor Therapy Open
Dementia is a clinical syndrome of a progressive functional decline and cognitive impairment.1 Globally an estimated 46.6 million people live with dementia, and this number is projected to rise to 152 million people by 2050.2, 3 Despite th…