Alfonso Fasano
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View article: Consensus expert recommendations for management of dysphagia during hospital admission in Parkinson's disease
Consensus expert recommendations for management of dysphagia during hospital admission in Parkinson's disease Open
Dysphagia is a common and often underrecognized symptom in patients with Parkinson's disease (PD) that is frequently overlooked during hospitalization. Dysphagia may be present without overt clinical signs, complicating timely identificati…
View article: Consensus expert recommendations for referral of Parkinson’s disease patients for deep brain stimulation surgery
Consensus expert recommendations for referral of Parkinson’s disease patients for deep brain stimulation surgery Open
Deep brain Stimulation (DBS) surgery effectively alleviates troublesome motor symptoms of Parkinson's disease (PD) such as tremor, rigidity, bradykinesia, motor fluctuations and dyskinesia. It also improves some non-motor symptoms and qual…
View article: Dystonia Scales for Children: Challenges and Obstacles in <scp>DBS</scp> Practice
Dystonia Scales for Children: Challenges and Obstacles in <span>DBS</span> Practice Open
Background Dystonia in pediatric patients often coexists with other movement disorders and neurodevelopmental issues. Current rating scales for evaluating pediatric deep brain stimulation (DBS) candidates are not universally applicable and…
View article: Clinical and Radiological Evolution of Idiopathic Normal Pressure Hydrocephalus: A Critical Review
Clinical and Radiological Evolution of Idiopathic Normal Pressure Hydrocephalus: A Critical Review Open
Background The pathophysiology of idiopathic normal pressure hydrocephalus (iNPH) remains poorly understood. While it is commonly accepted that iNPH has an insidious onset, little is known about its preclinical and early stages and its dev…
View article: Status dystonicus is a distinct state characterized by pallidal beta-band activity
Status dystonicus is a distinct state characterized by pallidal beta-band activity Open
Status dystonicus (SD) is a poorly known neurological emergency requiring urgent interventions, including deep brain stimulation (DBS) targeting the globus pallidus interna (GPi). The sensing capabilities of DBS electrodes provide an oppor…
View article: Analyzing the ‘Bradykinesia Complex’ in Parkinson's Disease
Analyzing the ‘Bradykinesia Complex’ in Parkinson's Disease Open
Background Bradykinesia is the hallmark sign of parkinsonism. We recently proposed redefining bradykinesia as a complex of motor abnormalities, each reflecting separate pathophysiological elements. Objective To analyze the ‘bradykinesia co…
View article: Long-Term Personalized Adaptive Deep Brain Stimulation in Parkinson Disease
Long-Term Personalized Adaptive Deep Brain Stimulation in Parkinson Disease Open
Importance Adaptive deep brain stimulation (aDBS) automatically adjusts stimulation amplitude in response to changes in relevant neural activity in people with Parkinson disease (PD). Whether long-term at-home aDBS is safe and delivers eff…
View article: Anticholinergic Burden and Botulinum Toxin Needs after Deep Brain Stimulation in Adult and Pediatric Patients with Dystonia
Anticholinergic Burden and Botulinum Toxin Needs after Deep Brain Stimulation in Adult and Pediatric Patients with Dystonia Open
Background Anticholinergic medications and botulinum neurotoxin injections are established treatments for dystonia, yet they carry potential side effects and practical challenges. Deep brain stimulation (DBS) is offered in case of poor res…
View article: Diagnostic Accuracy of CSF Tap-Test Parameters in Predicting Shunt Responsiveness in Normal Pressure Hydrocephalus: A Cohort Study
Diagnostic Accuracy of CSF Tap-Test Parameters in Predicting Shunt Responsiveness in Normal Pressure Hydrocephalus: A Cohort Study Open
Background The cerebrospinal fluid tap test (CSF-TT) is widely used as an ancillary test to select patients with idiopathic Normal Pressure Hydrocephalus (iNPH) for surgical management; however, its diagnostic utility remains unclear. We e…
View article: Novel neuropathological observations in an adult with Dravet syndrome
Novel neuropathological observations in an adult with Dravet syndrome Open
Dravet syndrome (DS) is a developmental and epileptic encephalopathy associated with pathogenic variants in the SCN1A gene. The neuropathological features of adult DS remain poorly understood. We report the postmortem findings of a 55‐year…
View article: Levodopa‐Carbidopa Intestinal Gel Improves Dyskinesia in Parkinson's Disease: Post Hoc Analysis from the <scp>COSMOS</scp> Study
Levodopa‐Carbidopa Intestinal Gel Improves Dyskinesia in Parkinson's Disease: Post Hoc Analysis from the <span>COSMOS</span> Study Open
Background Dyskinesia is a debilitating complication of dopaminergic therapy in advanced Parkinson's disease. Objectives To evaluate the effect of levodopa‐carbidopa intestinal gel ( LCIG ) on dyskinesia burden. Methods This is a post hoc …
View article: Low/High Multi‐Frequency Stimulation of the Subthalamic Nucleus Improves Verbal Fluency Maintaining Motor Control in Parkinson's Disease
Low/High Multi‐Frequency Stimulation of the Subthalamic Nucleus Improves Verbal Fluency Maintaining Motor Control in Parkinson's Disease Open
Background High frequency deep brain stimulation of the subthalamic nucleus (STN‐DBS) is a well‐established therapy for Parkinson's disease (PD) motor symptoms, however, its effect on non‐motor symptoms is controversial. Low frequency DBS …
View article: F.3 fMRI-based deep brain stimulation programming: a blinded, crossover clinical trial
F.3 fMRI-based deep brain stimulation programming: a blinded, crossover clinical trial Open
Background: Deep brain stimulation (DBS) in Parkinson’s disease (PD) requires extensive trial-and-error programming, often taking over a year to optimize. An objective, rapid biomarker of stimulation success is needed. Our team developed a…
View article: Status Dystonicus in Children: Is it more Common than we Realize?
Status Dystonicus in Children: Is it more Common than we Realize? Open
Background Status dystonicus (SD) is the most severe form of dystonia, affecting predominantly children. SD is thought to be rare, but the incidence is unknown. Objective We aimed to: (1) assess the number of admissions involving SD (2) de…
View article: Bilateral Focused Ultrasound Thalamotomy for Essential Tremor: Clinical Outcomes Compared to Bilateral <scp>Deep Brain Stimulation</scp> and Probabilistic Lesion Mapping
Bilateral Focused Ultrasound Thalamotomy for Essential Tremor: Clinical Outcomes Compared to Bilateral <span>Deep Brain Stimulation</span> and Probabilistic Lesion Mapping Open
Background The efficacy and adverse events (AEs) of bilateral magnetic resonance‐guided focused ultrasound (MRgFUS) thalamotomies for essential tremor (ET) have not been compared to those of deep brain stimulation (DBS). Furthermore, it is…