Francesco Benedetti
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View article: Brain morphology mediators of the link between childhood trauma and bipolar disorder: a large-scale international analysis
Brain morphology mediators of the link between childhood trauma and bipolar disorder: a large-scale international analysis Open
Childhood trauma is a risk factor for bipolar disorder, but the biological mechanisms of this association remain incompletely defined. Gray matter differences observed after trauma exposure overlap with those reported in bipolar disorder, …
View article: Topological data analysis communities reveal gene-environment-brain subtypes of major depression in UK Biobank and multi-site cohorts
Topological data analysis communities reveal gene-environment-brain subtypes of major depression in UK Biobank and multi-site cohorts Open
Major depressive disorder (MDD) exhibits substantial clinical heterogeneity complicating prognosis definition and treatment selection. Characterizing MDD subtypes through distinct clinical manifestations could enhance personalized therapeu…
View article: Transdiagnostic alterations in white matter microstructure associated with suicidal thoughts and behaviours in the ENIGMA Suicidal Thoughts and Behaviours consortium
Transdiagnostic alterations in white matter microstructure associated with suicidal thoughts and behaviours in the ENIGMA Suicidal Thoughts and Behaviours consortium Open
View article: Polygenic liability to C-reactive protein defines immunometabolic depression phenotypes and influences antidepressant therapeutic outcomes
Polygenic liability to C-reactive protein defines immunometabolic depression phenotypes and influences antidepressant therapeutic outcomes Open
Inflammation has been implicated in the pathophysiology of major depressive disorder (MDD), with elevated serum C-reactive protein (CRP) and CRP polygenic scores (PGSs) previously associated with atypical symptoms and treatment outcomes. H…
View article: Schizophrenia Genetics Modulates Clinical Depressive Features
Schizophrenia Genetics Modulates Clinical Depressive Features Open
Schizophrenia (SCZ) genetic liability, quantified by polygenic scores (PGS), may influence clinical phenotypes in major depressive disorder (MDD). We investigated the effect of the SCZ‐PGS derived from the latest SCZ genome‐wide associatio…
View article: Gene–environment–brain topology reveals clinical subtypes of depression in UK Biobank
Gene–environment–brain topology reveals clinical subtypes of depression in UK Biobank Open
Major depressive disorder (MDD) is a leading cause of disability worldwide, affecting over 300 million people and posing a significant burden on healthcare systems. The heterogeneity of MDD can be attributed to diverse etiologic mechanisms…
View article: Classification of major depressive disorder using vertex-wise brain sulcal depth, curvature, and thickness with a deep and a shallow learning model
Classification of major depressive disorder using vertex-wise brain sulcal depth, curvature, and thickness with a deep and a shallow learning model Open
Major depressive disorder (MDD) is a complex psychiatric disorder that affects the lives of hundreds of millions of individuals around the globe. Even today, researchers debate if morphological alterations in the brain are linked to MDD, l…
View article: Executive control in Obsessive-Compulsive Disorder: A worldwide mega-analysis of task-based functional neuroimaging data of the ENIGMA-OCD consortium
Executive control in Obsessive-Compulsive Disorder: A worldwide mega-analysis of task-based functional neuroimaging data of the ENIGMA-OCD consortium Open
Objective Obsessive-compulsive disorder (OCD) is associated with impaired executive function and altered activity in associated neural circuits, contributing to reduced goal-directed behavior. To investigate neural activation during execut…
View article: Biotypes of deeply phenotyped depressed patients reflect signatures of adverse childhood experience and depressive cognitive biases
Biotypes of deeply phenotyped depressed patients reflect signatures of adverse childhood experience and depressive cognitive biases Open
Background Negative Cognitive Styles (NCS) are key features of depression contributing to severe clinical outcomes by sustaining negative affect. However, depression is clinically heterogeneous, reflecting complex neurobiological and envir…
View article: Regional, functional and transcriptomic decoding of multidimensional brain structure alterations in obsessive-compulsive disorder
Regional, functional and transcriptomic decoding of multidimensional brain structure alterations in obsessive-compulsive disorder Open
Studies of brain morphology in mental illness often incompletely characterize structural variation, focusing on a few neuroimaging phenotypes. Here we present a comprehensive morphological characterization in obsessive-compulsive disorder …
View article: Moving toward precision and personalized treatment strategies in psychiatry
Moving toward precision and personalized treatment strategies in psychiatry Open
Precision psychiatry aims to improve routine clinical practice by integrating biological, clinical, and environmental data. Many studies have been performed in different areas of research on major depressive disorder, bipolar disorder, and…
View article: Sex-Specific Inflammatory Profiles Affect Neuropsychiatric Issues in COVID-19 Survivors
Sex-Specific Inflammatory Profiles Affect Neuropsychiatric Issues in COVID-19 Survivors Open
Post-COVID syndrome has unveiled intricate connections between inflammation, depressive psychopathology, and cognitive impairment. This study investigates these relationships in 101 COVID-19 survivors, focusing on sex-specific variations. …
View article: Insulin Resistance and Suicidal Behaviors: Insights into Mood Disorders
Insulin Resistance and Suicidal Behaviors: Insights into Mood Disorders Open
Introduction Compared to the general population, mood disorders (MD) patients show an increased risk of developing type II diabetes and obesity, which are associated with changes in brain correlates and a worse clinical outcome [1] . Accor…
View article: Dissecting heterogeneity in cortical thickness abnormalities in major depressive disorder: a large-scale ENIGMA MDD normative modelling study
Dissecting heterogeneity in cortical thickness abnormalities in major depressive disorder: a large-scale ENIGMA MDD normative modelling study Open
Importance Major depressive disorder (MDD) is highly heterogeneous, with marked individual differences in clinical presentation and neurobiology, which may obscure identification of structural brain abnormalities in MDD. To explore this, w…
View article: Cardiovascular Risk Predicts White Matter Hyperintensities, Brain Atrophy and Treatment Resistance in Major Depressive Disorder: Role of Genetic Liability
Cardiovascular Risk Predicts White Matter Hyperintensities, Brain Atrophy and Treatment Resistance in Major Depressive Disorder: Role of Genetic Liability Open
Introduction Depressive disorders are a leading cause of global disease burden, particularly with the challenge of treatment‐resistant depression (TRD). Research points to a complex bidirectional relationship between cardiovascular (CV) ri…
View article: EFFICACY OF LOW-DOSE INTERLEUKIN 2 AS ADD-ON IN THE TREATMENT OF UNIPOLAR AND BIPOLAR DEPRESSION
EFFICACY OF LOW-DOSE INTERLEUKIN 2 AS ADD-ON IN THE TREATMENT OF UNIPOLAR AND BIPOLAR DEPRESSION Open
Background Immune-inflammatory mechanisms are promising targets for antidepressant pharmacology [1-3]. Based on reported immune cell abnormalities, we defined an antidepressant potentiation treatment with add-on low-dose interleukin 2 (IL-…
View article: PERIPHERAL BLOOD CELLS UNVEIL NEURAL AND SEX-RELATED SUBTYPES OF DEPRESSION: AN UNSUPERVISED MACHINE LEARNING APPROACH
PERIPHERAL BLOOD CELLS UNVEIL NEURAL AND SEX-RELATED SUBTYPES OF DEPRESSION: AN UNSUPERVISED MACHINE LEARNING APPROACH Open
Background Heterogeneity in depression results from interactions of multiple biological and environmental factors. For instance, exposure to early-adverse events amplifies the cross-talk between inflammation and brain activity, resulting i…
View article: HISTORY OF PERIPARTUM DEPRESSION MODERATES THE ASSOCIATION BETWEEN ESTRADIOL PRS AND BASAL GANGLIA VOLUMES IN MAJOR DEPRESSIVE DISORDER
HISTORY OF PERIPARTUM DEPRESSION MODERATES THE ASSOCIATION BETWEEN ESTRADIOL PRS AND BASAL GANGLIA VOLUMES IN MAJOR DEPRESSIVE DISORDER Open
Background Past studies have identified associations among brain structural alterations in major depressive disorder patients (MDD) and cases of peripartum depression (PPD) [1,2]. Furthermore, previous findings have identified an effect of…
View article: STRUCTURAL NEUROIMAGING UNCOVERS DIFFERENT CARDIOMETABOLIC RISK PROFILES IN DEPRESSION: A DATA-DRIVEN APPROACH ON UK BIOBANK
STRUCTURAL NEUROIMAGING UNCOVERS DIFFERENT CARDIOMETABOLIC RISK PROFILES IN DEPRESSION: A DATA-DRIVEN APPROACH ON UK BIOBANK Open
Background Major depressive disorder (MDD) is a heterogeneous psychiatric condition associated with a high risk of mortality considering both high rates of suicide [1] and of severe comorbid cardiometabolic dysfunctions [2]. Environmental …
View article: Specific symptomatology profile associated with treatment resistant depression: A multicentric study from the Group for the Study of Resistant Depression with a focus on sex
Specific symptomatology profile associated with treatment resistant depression: A multicentric study from the Group for the Study of Resistant Depression with a focus on sex Open
A specific baseline symptom profile characterized by higher sadness, reduced sleep and anhedonic features may be indicative of poor treatment outcome. Females showed a distinctive baseline profile associated with poor response.
View article: A generalizable normative deep autoencoder for brain morphological anomaly detection: application to the multi-site StratiBip dataset on bipolar disorder in an external validation framework
A generalizable normative deep autoencoder for brain morphological anomaly detection: application to the multi-site StratiBip dataset on bipolar disorder in an external validation framework Open
The heterogeneity of psychiatric disorders makes researching disorder-specific neurobiological markers an ill-posed problem. Here, we face the need for disease stratification models by presenting a generalizable multivariate normative mode…
View article: Predicting Antidepressant Treatment Response From Cortical Structure on <scp>MRI</scp>: A Mega‐Analysis From the <scp>ENIGMA</scp>‐<scp>MDD</scp> Working Group
Predicting Antidepressant Treatment Response From Cortical Structure on <span>MRI</span>: A Mega‐Analysis From the <span>ENIGMA</span>‐<span>MDD</span> Working Group Open
Accurately predicting individual antidepressant treatment response could expedite the lengthy trial‐and‐error process of finding an effective treatment for major depressive disorder (MDD). We tested and compared machine learning‐based meth…
View article: Association between a large change between the minimum and maximum monthly values of solar insolation and a history of suicide attempts in bipolar I disorder
Association between a large change between the minimum and maximum monthly values of solar insolation and a history of suicide attempts in bipolar I disorder Open
View article: Assessment of <scp>ComBat</scp> Harmonization Performance on Structural <scp>Magnetic Resonance Imaging</scp> Measurements
Assessment of <span>ComBat</span> Harmonization Performance on Structural <span>Magnetic Resonance Imaging</span> Measurements Open
Data aggregation across multiple research centers is gaining importance in the context of MRI research, driving diverse high‐dimensional datasets to form large‐scale heterogeneous sample, increasing statistical power and relevance of machi…
View article: Disentangling the Genetic Landscape of Peripartum Depression: A Multi-Polygenic Machine Learning Approach on an Italian Sample
Disentangling the Genetic Landscape of Peripartum Depression: A Multi-Polygenic Machine Learning Approach on an Italian Sample Open
Background: The genetic determinants of peripartum depression (PPD) are not fully understood. Using a multi-polygenic score approach, we characterized the relationship between genome-wide information and the history of PPD in patients with…
View article: Abnormal choroid plexus, hippocampus, and lateral ventricles volumes as markers of treatment‐resistant major depressive disorder
Abnormal choroid plexus, hippocampus, and lateral ventricles volumes as markers of treatment‐resistant major depressive disorder Open
Aim One‐third of patients with major depressive disorder (MDD) do not achieve full remission and have high relapse rates even after treatment, leading to increased medical costs and reduced quality of life and health status. The possible s…
View article: Rational sub-nanometer manipulation of polymer morphology for efficient chemical separations
Rational sub-nanometer manipulation of polymer morphology for efficient chemical separations Open
The ability to control polymer morphology on the sub-nanometer length scale has broad implications for chemical separations. To achieve such control on easily processable systems, this proposal focuses on the synthesis and characterization…
View article: Transdiagnostic alterations in white matter microstructure associated with suicidal thoughts and behaviours in the ENIGMA Suicidal Thoughts and Behaviours consortium
Transdiagnostic alterations in white matter microstructure associated with suicidal thoughts and behaviours in the ENIGMA Suicidal Thoughts and Behaviours consortium Open
Previous studies have suggested that alterations in white matter (WM) microstructure are implicated in suicidal thoughts and behaviours (STBs). However, findings of diffusion tensor imaging (DTI) studies have been inconsistent. In this lar…
View article: White matter microstructure in obesity and bipolar disorders: an ENIGMA bipolar disorder working group study in 2186 individuals
White matter microstructure in obesity and bipolar disorders: an ENIGMA bipolar disorder working group study in 2186 individuals Open
View article: Inflammation and depression: A study protocol to dissect pathogenetic mechanisms in the onset, comorbidity and treatment response
Inflammation and depression: A study protocol to dissect pathogenetic mechanisms in the onset, comorbidity and treatment response Open