Catherine Leblanc
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View article: Building Climate Adaptation Capacity: A Pedagogical Model for Training Civil Engineers
Building Climate Adaptation Capacity: A Pedagogical Model for Training Civil Engineers Open
Civil engineers play a central role in climate change adaptation, as they are responsible for designing and managing infrastructure that supports societal resilience. However, professional education has not kept pace with the growing deman…
View article: Comparison of short and long-read metabarcoding sequencing: challenges and solutions for plastid read removal and microbial community exploration of seaweed samples
Comparison of short and long-read metabarcoding sequencing: challenges and solutions for plastid read removal and microbial community exploration of seaweed samples Open
View article: A Practical Comparison of Short‐ and Long‐Read Metabarcoding Sequencing: Challenges and Solutions for Plastid Read Removal and Microbial Community Exploration of Seaweed Samples
A Practical Comparison of Short‐ and Long‐Read Metabarcoding Sequencing: Challenges and Solutions for Plastid Read Removal and Microbial Community Exploration of Seaweed Samples Open
Short‐read metabarcoding analysis is the gold standard for accessing partial 16S and ITS genes with high read quality. With the advent of long‐read sequencing, the amplification of full‐length target genes is possible, but with low read ac…
View article: Evolutionary history and association with seaweeds shape the genomes and metabolisms of marine bacteria
Evolutionary history and association with seaweeds shape the genomes and metabolisms of marine bacteria Open
Seaweeds harbor a rich diversity of bacteria, providing them with metabolic resources and a surface for attachment and biofilm development. The host’s unique environment potentially shapes the bacterial genomes and promotes adaptations for…
View article: A duo of fungi and complex and dynamic bacterial community networks contribute to shape the <i>Ascophyllum nodosum</i> holobiont
A duo of fungi and complex and dynamic bacterial community networks contribute to shape the <i>Ascophyllum nodosum</i> holobiont Open
The brown alga Ascophyllum nodosum and its microbiota form a dynamic functional entity named holobiont. Some microbial partners may play a role in seaweed health through bioactive compounds crucial for normal morphology, development, and p…
View article: Multi-omics analysis of the correlation between surface microbiome and metabolome in <i>Saccharina latissima</i> (Laminariales, Phaeophyceae)
Multi-omics analysis of the correlation between surface microbiome and metabolome in <i>Saccharina latissima</i> (Laminariales, Phaeophyceae) Open
The microbiome of Saccharina latissima, an important brown macroalgal species in Europe, significantly influences its health, fitness, and pathogens resistance. Yet, comprehensive studies on the diversity and function of microbial communit…
View article: Microbial DNA extraction from the brown seaweed Ascophyllum nodosum v1
Microbial DNA extraction from the brown seaweed Ascophyllum nodosum v1 Open
This protocol is the result of optimizing microbial DNA extraction from the brown alga Ascophyllum nodosum. This protocol includes three different DNA purification steps to remove polysaccharide contaminants and other potential PCR inhibit…
View article: Evolutionary genomics of the emergence of brown algae as key components of coastal ecosystems
Evolutionary genomics of the emergence of brown algae as key components of coastal ecosystems Open
View article: Progress and future directions for seaweed holobiont research
Progress and future directions for seaweed holobiont research Open
Summary In the marine environment, seaweeds (i.e. marine macroalgae) provide a wide range of ecological services and economic benefits. Like land plants, seaweeds do not provide these services in isolation, rather they rely on their associ…
View article: Plant and algal lipidomes: Analysis, composition, and their societal significance
Plant and algal lipidomes: Analysis, composition, and their societal significance Open
View article: A review on the chemical ecology of the Fucaceae holobionts: from fundamental knowledge to applications
A review on the chemical ecology of the Fucaceae holobionts: from fundamental knowledge to applications Open
In recent years, the use of brown seaweeds (Phaeophyceae) and especially Fucaceae, has increased for a variety of applications including food additives, nutraceuticals, cosmetics, and agriculture, mainly because most edible brown algae con…
View article: Evolutionary genomics of the emergence of brown algae as key components of coastal ecosystems
Evolutionary genomics of the emergence of brown algae as key components of coastal ecosystems Open
SUMMARY Brown seaweeds are keystone species of coastal ecosystems, often forming extensive underwater forests, that are under considerable threat from climate change. Despite their ecological and evolutionary importance, this phylogenetic …
View article: Importance of quorum sensing crosstalk in the brown alga Saccharina latissima epimicrobiome
Importance of quorum sensing crosstalk in the brown alga Saccharina latissima epimicrobiome Open
Brown macroalgae are colonized by diverse microorganisms influencing the physiology of their host. However, cell-cell interactions within the surface microbiome (epimicrobiome) are largely unexplored, despite the significance of specific c…
View article: Empirical evidence for metabolic drift in plant and algal lipid biosynthesis pathways
Empirical evidence for metabolic drift in plant and algal lipid biosynthesis pathways Open
Metabolic pathway drift has been formulated as a general principle to help in the interpretation of comparative analyses between biosynthesis pathways. Indeed, such analyses often indicate substantial differences, even in widespread pathwa…
View article: Exploring uranium bioaccumulation in the brown alga Ascophyllum nodosum: insights from multi-scale spectroscopy and imaging
Exploring uranium bioaccumulation in the brown alga Ascophyllum nodosum: insights from multi-scale spectroscopy and imaging Open
Legacy radioactive waste can be defined as the radioactive waste produced during the infancy of the civil nuclear industry’s development in the mid-20th Century, a time when, unfortunately, waste storage and treatment were not well planned…
View article: Evolutionary Genomics of the Emergence of Brown Algae as Key Components of Coastal Ecosystems
Evolutionary Genomics of the Emergence of Brown Algae as Key Components of Coastal Ecosystems Open
View article: Corrigendum: Identification of novel anti-amoebic pharmacophores from kinase inhibitor chemotypes
Corrigendum: Identification of novel anti-amoebic pharmacophores from kinase inhibitor chemotypes Open
[This corrects the article DOI: 10.3389/fmicb.2023.1149145.].
View article: Aldehyde perception induces specific molecular responses in <i>Laminaria digitata</i> and affects algal consumption by a specialist grazer
Aldehyde perception induces specific molecular responses in <i>Laminaria digitata</i> and affects algal consumption by a specialist grazer Open
SUMMARY In the marine environment, distance signaling based on water‐borne cues occurs during interactions between macroalgae and herbivores. In the brown alga Laminaria digitata from North‐Atlantic Brittany, oligoalginates elicitation or …
View article: Inferring and comparing metabolism across heterogeneous sets of annotated genomes using AuCoMe
Inferring and comparing metabolism across heterogeneous sets of annotated genomes using AuCoMe Open
Comparative analysis of genome-scale metabolic networks (GSMNs) may yield important information on the biology, evolution, and adaptation of species. However, it is impeded by the high heterogeneity of the quality and completeness of struc…
View article: Identification of novel anti-amoebic pharmacophores from kinase inhibitor chemotypes
Identification of novel anti-amoebic pharmacophores from kinase inhibitor chemotypes Open
Acanthamoeba species, Naegleria fowleri , and Balamuthia mandrillaris are opportunistic pathogens that cause a range of brain, skin, eye, and disseminated diseases in humans and animals. These pathogenic free-living amoebae (pFLA) are comm…
View article: Supplementary Data from Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRAS<sup>G12C</sup>
Supplementary Data from Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRAS<sup>G12C</sup> Open
Supplementary Data from Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C
View article: Data from Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRAS<sup>G12C</sup>
Data from Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRAS<sup>G12C</sup> Open
Covalent inhibitors of KRASG12C have shown antitumor activity against advanced/metastatic KRASG12C-mutated cancers, though resistance emerges and additional strategies are needed to improve outcomes. JDQ443 is …
View article: Supplementary Data from Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRAS<sup>G12C</sup>
Supplementary Data from Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRAS<sup>G12C</sup> Open
Supplementary Data from Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C
View article: Data from Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRAS<sup>G12C</sup>
Data from Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRAS<sup>G12C</sup> Open
Covalent inhibitors of KRASG12C have shown antitumor activity against advanced/metastatic KRASG12C-mutated cancers, though resistance emerges and additional strategies are needed to improve outcomes. JDQ443 is …
View article: Supplementary Data from Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRAS<sup>G12C</sup>
Supplementary Data from Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRAS<sup>G12C</sup> Open
Supplementary Data from Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C
View article: Supplementary Data from Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRAS<sup>G12C</sup>
Supplementary Data from Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRAS<sup>G12C</sup> Open
Supplementary Data from Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C
View article: Supplementary Data from Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRAS<sup>G12C</sup>
Supplementary Data from Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRAS<sup>G12C</sup> Open
Supplementary Data from Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C
View article: Supplementary Data from Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRAS<sup>G12C</sup>
Supplementary Data from Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRAS<sup>G12C</sup> Open
Supplementary Data from Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C
View article: Supplementary Table S2 from FGF401, A First-In-Class Highly Selective and Potent FGFR4 Inhibitor for the Treatment of FGF19-Driven Hepatocellular Cancer
Supplementary Table S2 from FGF401, A First-In-Class Highly Selective and Potent FGFR4 Inhibitor for the Treatment of FGF19-Driven Hepatocellular Cancer Open
Pharmacologic profiling of FGF401 in cancer cell lines
View article: Supplementary Table S4 from FGF401, A First-In-Class Highly Selective and Potent FGFR4 Inhibitor for the Treatment of FGF19-Driven Hepatocellular Cancer
Supplementary Table S4 from FGF401, A First-In-Class Highly Selective and Potent FGFR4 Inhibitor for the Treatment of FGF19-Driven Hepatocellular Cancer Open
Activity of FGF401 in PDXs