Enrique Hong
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View article: Neuropilin-1: A Conserved Entry Receptor for SARS-CoV-2 and a Potential Therapeutic Target
Neuropilin-1: A Conserved Entry Receptor for SARS-CoV-2 and a Potential Therapeutic Target Open
Background/Objectives: Neuropilin-1 (NRP1) is a key co-receptor for SARS-CoV-2, complementing the ACE2 receptor. Several investigations have documented highly conserved sequences in this receptor, supporting the implication of NRP1 as a ke…
View article: Role of phospholipase Cη1 in lateral habenula astrocytes in depressive-like behavior in mice
Role of phospholipase Cη1 in lateral habenula astrocytes in depressive-like behavior in mice Open
Phospholipase C (PLC) enzymes play crucial roles in intracellular calcium-signaling transduction. Several brain PLC subtypes have been extensively studied, implicating them in psychiatric disorders such as depression, epilepsy and schizoph…
View article: Relationship Between Red Blood Cell Indices and Myxomatous Mitral Valve Disease in Small‐Breed Dogs: A Retrospective Study
Relationship Between Red Blood Cell Indices and Myxomatous Mitral Valve Disease in Small‐Breed Dogs: A Retrospective Study Open
Background Red blood cell (RBC) indices provide information on the size and haemoglobin content of erythrocytes. The RBC distribution width (RDW) is an index of size variability of the circulating RBC population. The correlation between va…
View article: Evaluation of an Antisense Oligonucleotide Targeting CAG Repeats: A Patient-Customized Therapy Study for Huntington’s Disease
Evaluation of an Antisense Oligonucleotide Targeting CAG Repeats: A Patient-Customized Therapy Study for Huntington’s Disease Open
Huntington’s disease is a genetic disorder characterized by progressive neuronal cell damage in some areas of the brain; symptoms are commonly associated with chorea, rigidity and dystonia. The symptoms in Huntington’s Disease are caused b…
View article: siRNA Targeting ECE-1 Partially Reverses Pulmonary Arterial HypertensionassociatedDamage in a Monocrotaline Model
siRNA Targeting ECE-1 Partially Reverses Pulmonary Arterial HypertensionassociatedDamage in a Monocrotaline Model Open
Aims: The aim of this study was to develop a possible treatment for pulmonary arterial hypertension. Background: Pulmonary arterial hypertension (PAH) is a rare disease characterised by a pulmonary arterial pressure greater than 20 mmHg. O…
View article: Effect of Supplementation with Omega-3 Polyunsaturated Fatty Acids on Metabolic Modulators in Skeletal Muscle of Rats with an Obesogenic High-Fat Diet
Effect of Supplementation with Omega-3 Polyunsaturated Fatty Acids on Metabolic Modulators in Skeletal Muscle of Rats with an Obesogenic High-Fat Diet Open
Previous studies provided evidence of the benefits of omega-3 polyunsaturated fatty acids (ω-3 PUFA) on the cardiovascular system and inflammation. However, its possible effect on skeletal muscle is unknown. This study aimed to evaluate wh…
View article: Attenuation of Pulmonary Damage Associated with COPD in a Cadmium-Exposed Model Due to the Administration of a siRNA Targeting PAD4
Attenuation of Pulmonary Damage Associated with COPD in a Cadmium-Exposed Model Due to the Administration of a siRNA Targeting PAD4 Open
Chronic obstructive pulmonary disease (COPD), characterised by persistent airflow limitation during breathing, is considered to be the third leading cause of death worldwide. Among the mechanisms involved in this pathology is the excessive…
View article: The Roles of MicroRNAs in Asthma and Emerging Insights into the Effects of Vitamin D3 Supplementation
The Roles of MicroRNAs in Asthma and Emerging Insights into the Effects of Vitamin D3 Supplementation Open
Asthma is one of the most common chronic non-communicable diseases worldwide, characterized by variable airflow limitation secondary to airway narrowing, airway wall thickening, and increased mucus resulting from chronic inflammation and a…
View article: Influence of Angiotensin II on <i>α</i><sub>1</sub>-Adrenergic Receptors Function in Rat Aorta and Expression in Vascular Smooth Muscle Cells
Influence of Angiotensin II on <i>&#945;</i><sub>1</sub>-Adrenergic Receptors Function in Rat Aorta and Expression in Vascular Smooth Muscle Cells Open
Angiotensin II (Ang II) is the main mediator of the Renin-Angiotensin-System acting on AT1 and other AT receptors. It is regarded as a pleiotropic agent that induces many actions, including functioning as a growth factor, and as a contract…
View article: siRNA Targeting PDE5A Partially Restores Vascular Damage Due to Type 1 Diabetes in a Streptozotocin-Induced Rat Model
siRNA Targeting PDE5A Partially Restores Vascular Damage Due to Type 1 Diabetes in a Streptozotocin-Induced Rat Model Open
Diabetes mellitus is a metabolic disease that can produce different alterations such as endothelial dysfunction, which is defined as a decrease in the vasodilator responses of the mechanisms involved such as the nitric oxide (NO) pathway. …
View article: Promoter methylation status of RORC, IL17A, and TNFA in peripheral blood leukocytes in adolescents with obesity-related asthma
Promoter methylation status of RORC, IL17A, and TNFA in peripheral blood leukocytes in adolescents with obesity-related asthma Open
A higher Th17-immune response characterises obesity and obesity-related asthma phenotype. Nevertheless, obesity-related asthma has a more significant Th17-immune response than obesity alone. Retinoid-related orphan receptor C (RORC) is the…
View article: Retinol-binding protein 4 and plasminogen activator inhibitor-1 as potential prognostic biomarkers of non-allergic asthma caused by obesity in adolescents
Retinol-binding protein 4 and plasminogen activator inhibitor-1 as potential prognostic biomarkers of non-allergic asthma caused by obesity in adolescents Open
Background: Non-allergic asthma caused by obesity is a complication of the low-grade chronic inflammation inherent in obesity. Consequently, the serum concentrations of adipokines such as retinol-binding protein 4 (RBP4) and plasminogen ac…
View article: Antihyperglycemic effect of Indorenate on 5-HT receptors
Antihyperglycemic effect of Indorenate on 5-HT receptors Open
Indorenate is a central hypertensive agent, exerting its action by 5-HT1A central receptor stimulation, but also possessing a 5-HT2 peripheral receptor stimulation. Since less than 1% of the oral administered dose penetrates into the CNS, …
View article: Antihyperglycemic effect of Quipazine in rats by 5-HT2 receptor stimulation
Antihyperglycemic effect of Quipazine in rats by 5-HT2 receptor stimulation Open
BACKGROUND: Serotonin, also known as 5-hidroxytriptamine is a monoamine found in both, central and peripheral nervous system. Recently, it has been suggested that serotonin has a modulating effect over glucose metabolism, being 5 HT2A the …
View article: Effect of TR3370, a quipazine analog, over glycemia in healthy and streptozotocin hyperglicemic rats
Effect of TR3370, a quipazine analog, over glycemia in healthy and streptozotocin hyperglicemic rats Open
BACKGROUND:Recent research suggests that administration of serotonin or 5-hydroxytryptamine (5-HT) its precursors or agonists of ttheir receptors can modulate glycemia in rodents; being 5 HT2A the main receptors involved in glycemia reduct…
View article: Role of GSK3&lt;i&gt;β&lt;/i&gt; and PP2A on Regulation of Tau Phosphorylation in Hippocampus and Memory Impairment in ICV-STZ Animal Model of Alzheimer’s Disease
Role of GSK3<i>β</i> and PP2A on Regulation of Tau Phosphorylation in Hippocampus and Memory Impairment in ICV-STZ Animal Model of Alzheimer’s Disease Open
Intracerebroventricular administration (ICV) of streptozotocin (STZ) in rats has been associated to desensitization of the insulin receptor (IR) and biochemical changes similar to those occurring in Alzheimer's disease (AD) or older brains…
View article: Fenofibrate plus Metformin Produces Cardioprotection in a Type 2 Diabetes and Acute Myocardial Infarction Model
Fenofibrate plus Metformin Produces Cardioprotection in a Type 2 Diabetes and Acute Myocardial Infarction Model Open
We investigated whether fenofibrate, metformin, and their combination generate cardioprotection in a rat model of type 2 diabetes (T2D) and acute myocardial infarction (AMI). Streptozotocin-induced diabetic- (DB-) rats received 14 days of …