Clare Bryant
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View article: An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice
An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice Open
Impaired mitochondrial bioenergetics in macrophages promotes hyperinflammatory cytokine responses, but whether inherited mtDNA mutations drive similar phenotypes is unknown. Here, we profiled macrophages harbouring a heteroplasmic mitochon…
View article: The Salmonella pathogenicity island 1 injectisome reprograms host cell translation to evade the inflammatory response
The Salmonella pathogenicity island 1 injectisome reprograms host cell translation to evade the inflammatory response Open
View article: Antibacterial properties and underlying mechanisms of Mo <sub>2</sub> TiC <sub>2</sub> T <sub> <i>x</i> </sub> and Mo <sub>2</sub> Ti <sub>2</sub> C <sub>3</sub> T <sub> <i>x</i> </sub> MXenes targeting <i>Escherichia coli</i> (Gram-negative bacterium)
Antibacterial properties and underlying mechanisms of Mo <sub>2</sub> TiC <sub>2</sub> T <sub> <i>x</i> </sub> and Mo <sub>2</sub> Ti <sub>2</sub> C <sub>3</sub> T <sub> <i>x</i> </sub> MXenes targeting <i>Escherichia coli</i> (Gram-negative bacterium) Open
Mo-based DTM MXenes (Mo 2 TiC 2 T x and Mo 2 Ti 2 C 3 T x ) exhibit strong antibacterial performance through nanoknives and oxidative stress, offering a promising pathway to mitigate antibiotic-resistant Gram-negative bacteria.
View article: Pattern recognition receptors in GtoPdb v.2025.3
Pattern recognition receptors in GtoPdb v.2025.3 Open
Pattern Recognition Receptors (PRRs, [118]) (nomenclature as agreed by NC-IUPHAR sub-committee on Pattern Recognition Receptors, [21]) participate in the innate immune response to microbial agents, the stimulation of which leads to activat…
View article: Astrocytic RNA editing regulates the host immune response to alpha-synuclein
Astrocytic RNA editing regulates the host immune response to alpha-synuclein Open
RNA editing is a posttranscriptional mechanism that targets changes in RNA transcripts to modulate innate immune responses. We report the role of astrocyte-specific, ADAR1-mediated RNA editing in neuroinflammation in Parkinson’s disease (P…
View article: Pattern recognition receptors in GtoPdb v.2025.1
Pattern recognition receptors in GtoPdb v.2025.1 Open
Pattern Recognition Receptors (PRRs, [118]) (nomenclature as agreed by NC-IUPHAR sub-committee on Pattern Recognition Receptors, [21]) participate in the innate immune response to microbial agents, the stimulation of which leads to activat…
View article: Gut microbiota-derived hexa-acylated lipopolysaccharides enhance cancer immunotherapy responses
Gut microbiota-derived hexa-acylated lipopolysaccharides enhance cancer immunotherapy responses Open
View article: Role of inflammasomes in acute respiratory distress syndrome
Role of inflammasomes in acute respiratory distress syndrome Open
Acute respiratory distress syndrome (ARDS) is present in >10% of all people admitted to critical care and is associated with severe morbidity and mortality. Despite more than half a century since its first description, no efficacious pharm…
View article: An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and <i>in vivo</i>
An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and <i>in vivo</i> Open
Impaired mitochondrial bioenergetics in macrophages can drive hyperinflammatory cytokine responses 1–6 , but whether this may also be caused by inherited mtDNA mutations is unknown. Here, we address this question using a multi-omic approac…
View article: ASC specks as a single-molecule fluid biomarker of inflammation in neurodegenerative diseases
ASC specks as a single-molecule fluid biomarker of inflammation in neurodegenerative diseases Open
View article: 1271 Hexa-acylated lipopolysaccharides from the gut microbiota enhance cancer immunotherapy responses
1271 Hexa-acylated lipopolysaccharides from the gut microbiota enhance cancer immunotherapy responses Open
View article: 432 A drop of insight: single cell functional profiling for immuno-oncology
432 A drop of insight: single cell functional profiling for immuno-oncology Open
View article: Targeting DNA-PK is a highly conserved poxvirus innate immune evasion mechanism
Targeting DNA-PK is a highly conserved poxvirus innate immune evasion mechanism Open
The sensing of viral nucleic acid by pattern recognition receptors (PRRs) is essential for initiation of a type-I interferon response against infection. Intracellular DNA sensing PRRs are responsible for initiating innate immune responses …
View article: Rethinking Toll-like receptor signalling
Rethinking Toll-like receptor signalling Open
Since the discovery of Toll and Toll-like receptors (TLRs) in the 90s, an extensive body of research has been performed to determine how Pattern Recognition Receptors (PRRs) recognise 'ligands' and signal. The families of PRRs now include …
View article: Modelling molecular differences in the innate immune system responses of chickens and ducks to highly pathogenic avian influenza virus
Modelling molecular differences in the innate immune system responses of chickens and ducks to highly pathogenic avian influenza virus Open
Highly pathogenic avian influenza virus (HPAIV) presents a global threat to chicken livestock; chickens infected by HPAIV tend to show severe symptoms and high mortality rates. In 2022, the largest recorded outbreak of HPAIV in Europe resu…
View article: Hexa-acylated lipopolysaccharides from the gut microbiota enhance cancer immunotherapy responses
Hexa-acylated lipopolysaccharides from the gut microbiota enhance cancer immunotherapy responses Open
Immune checkpoint inhibitors (ICI), such as anti-PD-1, have revolutionized cancer treatment, but they are only effective for a minority of patients. The gut microbiome plays a crucial role in modulating immunotherapy treatment responses, a…
View article: Author response: The delayed kinetics of Myddosome formation explains why amyloid-beta aggregates trigger Toll-like receptor 4 less efficiently than lipopolysaccharide
Author response: The delayed kinetics of Myddosome formation explains why amyloid-beta aggregates trigger Toll-like receptor 4 less efficiently than lipopolysaccharide Open
View article: The delayed kinetics of Myddosome formation explains why amyloid-beta aggregates trigger Toll-like receptor 4 less efficiently than lipopolysaccharide
The delayed kinetics of Myddosome formation explains why amyloid-beta aggregates trigger Toll-like receptor 4 less efficiently than lipopolysaccharide Open
The Myddosome is a key innate immune signalling platform. It forms at the cell surface and contains MyD88 and IRAK proteins which ultimately coordinate the production of pro-inflammatory cytokines. Toll-like receptor 4 (TLR4) signals via t…
View article: Enhanced CD95 and interleukin 18 signalling accompany T cell receptor Vβ21.3+ activation in multi-inflammatory syndrome in children
Enhanced CD95 and interleukin 18 signalling accompany T cell receptor Vβ21.3+ activation in multi-inflammatory syndrome in children Open
View article: An ovine model for investigation of the microenvironment of the male mammary gland
An ovine model for investigation of the microenvironment of the male mammary gland Open
The specific biology of the male breast remains relatively unexplored in spite of the increasing global prevalence of male breast cancer. Delineation of the microenvironment of the male breast is restricted by the low availability of human…
View article: The delayed kinetics of Myddosome formation explains why Aβ aggregates trigger TLR4 less efficiently than LPS
The delayed kinetics of Myddosome formation explains why Aβ aggregates trigger TLR4 less efficiently than LPS Open
The Myddosome is a key innate immune signalling platform. It forms at the cell surface and contains MyD88 and IRAK proteins which ultimately coordinate the production of pro-inflammatory cytokines. Toll-like receptor 4 signals via the Mydd…
View article: Author response: The delayed kinetics of Myddosome formation explains why Aβ aggregates trigger TLR4 less efficiently than LPS
Author response: The delayed kinetics of Myddosome formation explains why Aβ aggregates trigger TLR4 less efficiently than LPS Open
The Myddosome is a key innate immune signalling platform. It forms at the cell surface and contains MyD88 and IRAK proteins which ultimately coordinate the production of pro-inflammatory cytokines. Toll-like receptor 4 signals via the Mydd…
View article: Reviewer #1 (Public Review): The delayed kinetics of Myddosome formation explains why Aβ aggregates trigger TLR4 less efficiently than LPS
Reviewer #1 (Public Review): The delayed kinetics of Myddosome formation explains why Aβ aggregates trigger TLR4 less efficiently than LPS Open
The Myddosome is a key innate immune signalling platform. It forms at the cell surface and contains MyD88 and IRAK proteins which ultimately coordinate the production of pro-inflammatory cytokines. Toll-like receptor 4 signals via the Mydd…
View article: A programmable and automated optical electrowetting-on-dielectric (oEWOD) driven platform for massively parallel and sequential processing of single cell assay operations
A programmable and automated optical electrowetting-on-dielectric (oEWOD) driven platform for massively parallel and sequential processing of single cell assay operations Open
Recently, there has been an increasing emphasis on single cell profiling for high-throughput screening workflows in drug discovery and life sciences research. However, the biology underpinning these screens is often complex and is insuffic…
View article: Astrocytic RNA editing regulates the host immune response to alpha-synuclein
Astrocytic RNA editing regulates the host immune response to alpha-synuclein Open
RNA editing is a post transcriptional mechanism that targets changes in RNA transcripts to modulate innate immune responses. We report the role of astrocyte specific, ADAR1 mediated RNA editing in neuroinflammation in Parkinson’s disease. …
View article: Arachidonic acid inhibition of the NLRP3 inflammasome is a mechanism to explain the anti-inflammatory effects of fasting
Arachidonic acid inhibition of the NLRP3 inflammasome is a mechanism to explain the anti-inflammatory effects of fasting Open
View article: Activity of<i>Salmonella</i>SPI-1 inhibits the TLR4-dependent transcriptional but not translational response during macrophage infection
Activity of<i>Salmonella</i>SPI-1 inhibits the TLR4-dependent transcriptional but not translational response during macrophage infection Open
Changes in gene expression during bacterial infection are the combined result of altered transcription and translation, with the latter comparatively understudied. Gram-negative bacteria rapidly trigger cytokine gene transcription in macro…
View article: The delayed kinetics of Myddosome formation explains why amyloid-beta aggregates trigger Toll-like receptor 4 less efficiently than lipopolysaccharide
The delayed kinetics of Myddosome formation explains why amyloid-beta aggregates trigger Toll-like receptor 4 less efficiently than lipopolysaccharide Open
The Myddosome is a key innate immune signalling platform. It forms at the cell surface and contains MyD88 and IRAK proteins which ultimately coordinate the production of pro-inflammatory cytokines. Toll-like receptor 4 (TLR4) signals via t…
View article: The delayed kinetics of Myddosome formation explains why Aβ aggregates trigger TLR4 less efficiently than LPS
The delayed kinetics of Myddosome formation explains why Aβ aggregates trigger TLR4 less efficiently than LPS Open
The Myddosome is a key innate immune signalling platform. It forms at the cell surface and contains MyD88 and IRAK proteins which ultimately coordinate the production of pro-inflammatory cytokines. Toll-like receptor 4 signals via the Mydd…
View article: A programmable and automated optical electrowetting-on-dielectric (oEWOD) driven platform for massively parallel and sequential processing of single cell assay operations
A programmable and automated optical electrowetting-on-dielectric (oEWOD) driven platform for massively parallel and sequential processing of single cell assay operations Open
We describe a platform that uses droplet microfluidics and optical electrowetting-on-dielectric (oEWOD) to perform sequential and multiplexed single cell assays in massively parallelised workflows to enable complex cell profiling during sc…