Eugenio De Corso
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View article: Real-life evaluation of the effectiveness of biologics for chronic rhinosinusitis with nasal polyps in Europe: a Delphi study to define key variables for the INVENT registry
Real-life evaluation of the effectiveness of biologics for chronic rhinosinusitis with nasal polyps in Europe: a Delphi study to define key variables for the INVENT registry Open
Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is a persistent inflammatory condition often associated with type 2 inflammation. While biologics are a promising treatment for patients with uncontrolled CRSwNP, real-world evid…
View article: Optimising care for chronic rhinosinusitis with nasal polyps and asthma in multimorbid patients: a multidisciplinary Delphi consensus
Optimising care for chronic rhinosinusitis with nasal polyps and asthma in multimorbid patients: a multidisciplinary Delphi consensus Open
This consensus highlights the value of a multidisciplinary approach for multimorbid CRSwNP and asthma patients, advocating for endotype-driven therapies and standardised pathways in clinical practice.
View article: Do Onodi Cells Influence the Onset of Sphenoiditis? A Multicentric Cross-Sectional Study
Do Onodi Cells Influence the Onset of Sphenoiditis? A Multicentric Cross-Sectional Study Open
Background: Sphenoiditis poses diagnostic and treatment challenges due to its complex anatomy and potential for serious complications. Anatomic variations, such as Onodi cells, could play a role in the onset and spreading of inflammation. …
View article: Small Airways Disease as a Novel Target for Mepolizumab in Asthma—The SASAM Prospective Real-Life Study
Small Airways Disease as a Novel Target for Mepolizumab in Asthma—The SASAM Prospective Real-Life Study Open
Mepolizumab represents an effective strategy for severe eosinophilic asthma. Small airways disease (SAD) defines a peculiar asthma phenotype related to worse disease control. Limited and indirect findings are currently available on the eff…
View article: Benralizumab and the integrated management of co‐morbid severe eosinophilic asthma with chronic rhinosinusitis with nasal polyps
Benralizumab and the integrated management of co‐morbid severe eosinophilic asthma with chronic rhinosinusitis with nasal polyps Open
Background Type 2 (T2) inflammation, characterized by blood and airway eosinophilia, underlies severe eosinophilic asthma (SEA) and chronic rhinosinusitis with nasal polyps (CRSwNP). In line with the Global Airways theory, SEA and CRSwNP f…
View article: Dupilumab Monthly Dose De‐Escalation Maintains Efficacy in <scp>CRSwNP</scp> : A Two‐Year Real‐World Study
Dupilumab Monthly Dose De‐Escalation Maintains Efficacy in <span>CRSwNP</span> : A Two‐Year Real‐World Study Open
Objective The aim of this study was to evaluate if dupilumab interval dose de‐escalation to every 4 weeks negatively impacts treatment outcomes in real‐life practice for severe uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP)…
View article: Pocket guide: biologics in upper and lower airways in adults
Pocket guide: biologics in upper and lower airways in adults Open
The introduction of biologics for the treatment of severe upper and lower (type 2) airway inflammation has been a gamechanger in the management of these diseases. Biologics are injectable medications targeting different molecules relevant …
View article: Remission in chronic rhinosinusitis with nasal polyps
Remission in chronic rhinosinusitis with nasal polyps Open
Remission has recently been proposed as the new goal of care in CRSwNP or Nasal Polyp Syndrome by the European Forum for Research and Education in Allergy and Airway Diseases / European Position Paper on Rhinosinusitis and Nasal Polyps (EU…
View article: Raising the bar in respiratory care by EUFOREA: report of the European Union Parliament Symposium, April 2024
Raising the bar in respiratory care by EUFOREA: report of the European Union Parliament Symposium, April 2024 Open
In April 2024, the European Summit “ Raising the bar in respiratory care” was organized by the European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA) in the European Parliament and hosted by Members of the Europ…
View article: The Impact and Burden of Chronic Rhinosinusitis with Nasal Polyps on Patients and Their Family Caregivers: A Nationally Representative Survey
The Impact and Burden of Chronic Rhinosinusitis with Nasal Polyps on Patients and Their Family Caregivers: A Nationally Representative Survey Open
Background: Chronic rhinosinusitis with nasal polyps (CRSwNPs) is a chronic inflammatory disease associated with frustrating symptoms, particularly nasal obstruction and loss of smell. We conducted a patient survey on the significant burde…
View article: Proposal of a New Composite Score (DAMADECO) to Simultaneously Evaluate Asthma and CRSwNP Severity in Comorbid Patients
Proposal of a New Composite Score (DAMADECO) to Simultaneously Evaluate Asthma and CRSwNP Severity in Comorbid Patients Open
Background: Asthma and chronic rhinosinusitis with nasal polyps (CRSwNP) are chronic respiratory conditions that frequently coexist. However, an integrated assessment tool for both conditions is currently lacking. This study aimed to devel…
View article: Role of body mass index as a predictor of dupilumab efficacy in patients with severe chronic rhinosinusitis with nasal polyps
Role of body mass index as a predictor of dupilumab efficacy in patients with severe chronic rhinosinusitis with nasal polyps Open
Our study confirmed the efficacy of dupilumab in each BMI subgroup. However, the efficacy seems to follow different timing with respect to patients' BMI. Our data suggest that patients with a compromised metabolic state present more severe…
View article: Blood and local nasal eosinophilia in chronic rhinosinusitis with nasal polyps: prevalence and correlation with severity of disease
Blood and local nasal eosinophilia in chronic rhinosinusitis with nasal polyps: prevalence and correlation with severity of disease Open
We demonstrated that blood eosinophil count and nasal cytology may represent useful tools in routine clinical practice to define Type 2 inflammation and that their levels are usually higher in patients with comorbidities. We also showed th…
View article: Oral Metastasis From Colorectal Adenocarcinoma: Report of a New Case and a Scoping Review
Oral Metastasis From Colorectal Adenocarcinoma: Report of a New Case and a Scoping Review Open
Objectives: This study is aimed at describing an unusual case of oral metastasis from colorectal adenocarcinoma and at performing a scoping review analyzing the available literature on such cases. Materials and Methods: We present a rare c…
View article: The Role of IL-5 in Type 2 Inflammatory Diseases
The Role of IL-5 in Type 2 Inflammatory Diseases Open
Type 2 inflammation is involved in severe asthma (SA), chronic rhinosinusitis with nasal polyps (CRSwNP), and eosinophilic granulomatosis with polyangiitis (EGPA). The pathogenesis of these diseases involves various immune system cells and…
View article: Algorithm for the Management of Primary Diffuse Chronic Rhinosinusitis
Algorithm for the Management of Primary Diffuse Chronic Rhinosinusitis Open
status: Published
View article: Pre-asthma: a useful concept? A EUFOREA paper. Part 2—late onset eosinophilic asthma
Pre-asthma: a useful concept? A EUFOREA paper. Part 2—late onset eosinophilic asthma Open
The concept of pre-diabetes has led to provision of measures to reduce disease progression through identification of subjects at risk of diabetes. We previously considered the idea of pre-asthma in relation to allergic asthma and considere…
View article: Sinonasal Outcomes Obtained after 2 Years of Treatment with Benralizumab in Patients with Severe Eosinophilic Asthma and CRSwNP: A “Real-Life” Observational Study
Sinonasal Outcomes Obtained after 2 Years of Treatment with Benralizumab in Patients with Severe Eosinophilic Asthma and CRSwNP: A “Real-Life” Observational Study Open
Background/Objectives: Benralizumab is a monoclonal antibody that targets the interleukin-5 receptor (IL-5Rα), leading to the rapid depletion of blood eosinophils. RCTs have demonstrated efficacy in patients with severe eosinophilic asthma…
View article: Dupilumab Improves Facial Pain and Reduces Rescue Treatments in Patients with CRSwNP and Recalcitrant Frontal Sinusitis
Dupilumab Improves Facial Pain and Reduces Rescue Treatments in Patients with CRSwNP and Recalcitrant Frontal Sinusitis Open
Recalcitrant frontal sinusitis in patients with chronic rhinosinusitis and nasal polyps (CRSwNP) has a negative impact on their quality of life due to frontal pain and a high risk of sinus occlusion, thus necessitating antibiotics, systemi…
View article: Dupilumab improves symptoms and reduces rescue treatments in patients with CRSwNP and recalcitrant frontal sinusitis
Dupilumab improves symptoms and reduces rescue treatments in patients with CRSwNP and recalcitrant frontal sinusitis Open
Background . Recalcitrant frontal sinusitis in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) have a negative impact on quality of life due to frontal pain and a high risk of sinus occlusion, thus necessitating repeated co…
View article: Pre-asthma: a useful concept? A EUFOREA paper. Part 2—late onset eosinophilic asthma
Pre-asthma: a useful concept? A EUFOREA paper. Part 2—late onset eosinophilic asthma Open
The concept of pre-diabetes has led to provision of measures to reduce disease progression through identification of subjects at risk of diabetes. We previously considered the idea of pre-asthma in relation to allergic asthma and considere…
View article: Management of patients with chronic rhinosinusitis with nasal polyps (CRSwNP): Results from a survey among allergists and clinical immunologists of the North-west and Center Italy Inter-Regional Sections of SIAAIC and otorhinolaryngologists of National IAR
Management of patients with chronic rhinosinusitis with nasal polyps (CRSwNP): Results from a survey among allergists and clinical immunologists of the North-west and Center Italy Inter-Regional Sections of SIAAIC and otorhinolaryngologists of National IAR Open
Chronic rhinosinusitis with nasal polyps (CRSwNP) is one of the most common medical conditions worldwide, characterised by chronic inflammation of the paranasal sinuses lasting for >12 weeks and the presence of nasal polyps. Its estimated …