Deepa Mathew
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View article: Presynaptic Changes in Mouse Rod Photoreceptors During Early Retinitis Pigmentosa
Presynaptic Changes in Mouse Rod Photoreceptors During Early Retinitis Pigmentosa Open
Rod degeneration induces molecular changes in the P23H/Gnat2-/- mouse rods that suggest synaptic plasticity and strengthening of rod-rod bipolar cell synaptic transmission in early RP.
View article: Downregulation of Transducin Delays Photoreceptor Degeneration in P23H Rhodopsin Retinitis Pigmentosa
Downregulation of Transducin Delays Photoreceptor Degeneration in P23H Rhodopsin Retinitis Pigmentosa Open
In inherited blinding diseases, such as Retinitis Pigmentosa (RP), photoreceptors progressively degenerate, eventually leading to blindness. Unfortunately, effective treatments to prevent or delay vision loss do not exist for most RPs. Dar…
View article: Never Say Never Again……. An Unusual Cause of Respiratory Distress in a Toddler
Never Say Never Again……. An Unusual Cause of Respiratory Distress in a Toddler Open
Most cases of Congenital Diaphragmatic Hernia (CDH) are usually diagnosed during the fetal anatomy scan in the second or third trimester.The late-presenting CDH represents a considerable diagnostic challenge.We describe the presentation in…
View article: Impact of Covid-19 lockdown on the emotional health of schoolchildren in an urban Indian setting
Impact of Covid-19 lockdown on the emotional health of schoolchildren in an urban Indian setting Open
Background Public health measures taken to prevent the spread of the Covid-19 pandemic can potentially impact the mental health of children. We assessed the prevalence and risk factors for childhood depression during the Covid-19 lockdown.…
View article: OR18-3 Case Series of 16 Patients With 17β-Hydroxysteroid Dehydrogenase Type 3 Deficiency at Five Children's Hospitals in the United States
OR18-3 Case Series of 16 Patients With 17β-Hydroxysteroid Dehydrogenase Type 3 Deficiency at Five Children's Hospitals in the United States Open
Objectives The 17β-hydroxysteroid dehydrogenase type 3 (17βHSD3) enzyme, expressed in the testes, converts androstenedione to testosterone. Deficiency of 17βHSD3 causes a 46,XY difference of sex development (DSD). Until recently, just 12 c…
View article: Dapagliflozin protects neural and vascular dysfunction of the retina in diabetes
Dapagliflozin protects neural and vascular dysfunction of the retina in diabetes Open
Introduction Dapagliflozin, a sodium-glucose transporter inhibitor, effectively reduces blood glucose and is indicated for individuals with kidney diseases and cardiovascular disorders. In this study, we further expand the therapeutic bene…
View article: Tourism industry: The cash cow industry for fostering the economic development of India
Tourism industry: The cash cow industry for fostering the economic development of India Open
Tourism feeds the economies of many countries in the world. The scope of tourism industry extents to areas such as hospitality, transportation, travel facilitation and attractions and entertainments of various kinds. As per the report of U…
View article: Circadian rhythm disruption results in visual dysfunction
Circadian rhythm disruption results in visual dysfunction Open
Artificial light has been increasingly in use for the past 70 years. The aberrant light exposure and round‐the‐clock nature of work lead to the disruption of biological clock. Circadian rhythm disruption (CRD) contributes to multiple metab…
View article: Patient perceptions about virtual clinical consultations during current COVID-19 pandemic: A multi-city survey across India
Patient perceptions about virtual clinical consultations during current COVID-19 pandemic: A multi-city survey across India Open
Introduction: COVID-19 has prevented many patients from accessing health care through traditional face-to-face clinic visits. Consequently, online consultations have gained popularity. Aim: To explore patient perceptions regarding virtual …
View article: 411 Patient perspectives regarding online consultations during the COVID-19 pandemic
411 Patient perspectives regarding online consultations during the COVID-19 pandemic Open
Background Introduction: COVID-19 and the associated lockdown has prevented patients from accessing healthcare professionals through the traditional face-to-face clinic visits. Modes of consultation have therefore adapted to overcome this …
View article: 101 The impact of 100 days of covid-19 lock-down on the emotional health of school children in an urban indian setting
101 The impact of 100 days of covid-19 lock-down on the emotional health of school children in an urban indian setting Open
Background In response to the WHO recommended measures of physical and social distancing to mitigate person-to-person transmission, most countries decided to close schools as part of a physical distancing policy to slow transmission of COV…
View article: Retinal Phenotyping of Ferrochelatase Mutant Mice Reveals Protoporphyrin Accumulation and Reduced Neovascular Response
Retinal Phenotyping of Ferrochelatase Mutant Mice Reveals Protoporphyrin Accumulation and Reduced Neovascular Response Open
Even with a buildup of PPIX in the retinal vessels in Fechm1Pas homozygotes, the vasculature remains normal. Notably, stimulus-induced ex vivo angiogenesis was decreased in Fechm1Pas mutants, consistent with reduced pathologic angiogenesis…
View article: Circadian Rhythm Disruption Results in Visual Dysfunction
Circadian Rhythm Disruption Results in Visual Dysfunction Open
Circadian rhythm disruption (CRD) contributes to the development of multiple metabolic and neurodegenerative diseases. However, its effect on vision is not understood. We evaluated the impact of CRD on retinal morphology, physiology, and v…
View article: The impact of 100 days of Covid-19 lock-down on the emotional health of school children in Chennai, India
The impact of 100 days of Covid-19 lock-down on the emotional health of school children in Chennai, India Open
Introduction: Public health measures taken to prevent the spread of the COVID-19 pandemic can potentially impact the mental health of children.Aims: To assess the prevalence and risk factors of childhood depression during the Covid-19 lock…
View article: Metformin Corrects Abnormal Circadian Rhythm and Kir4.1 Channels in Diabetes
Metformin Corrects Abnormal Circadian Rhythm and Kir4.1 Channels in Diabetes Open
Our findings demonstrate that metformin corrects abnormal circadian rhythm and Kir4.1 channels in db/db mouse a model of type 2 diabetes. Metformin could represent a critical pharmacological agent for preventing Müller cell dysfunction obs…
View article: SUN-159 17-beta Hydroxysteroid Dehydrogenase 3 Deficiency in 1 Month Old Infant
SUN-159 17-beta Hydroxysteroid Dehydrogenase 3 Deficiency in 1 Month Old Infant Open
Background: 17-beta hydroxysteroid dehydrogenase 3 deficiency is a rare autosomal recessive disorder caused by mutations in HSD17B3 encoding the enzyme which converts androstenedione to testosterone. It is characterized in 46, XY males by …
View article: SUN-651 Murine Cecal Ligation and Puncture (CLP) Perturbs Phosphorylation of Insulin Receptor Substrate 2 (IRS-2)
SUN-651 Murine Cecal Ligation and Puncture (CLP) Perturbs Phosphorylation of Insulin Receptor Substrate 2 (IRS-2) Open
Hyperglycemia is a characteristic finding in sepsis, and its presence worsens outcome (1). Patients with sepsis need larger doses of insulin to reduce glucose levels. This abnormality has been termed “insulin resistance” but the molecular …
View article: Strong Geodetic Domination of Graphs
Strong Geodetic Domination of Graphs Open
The problem to find a where all points of the graph are covered by a unique fixed geodesic between the pair of points in is called the strong geodetic problem. Here the domination concept is combined with strong geodetic concept resulting …
View article: Vision Dysfunction in Circadian Clock Gene Bmal Mice
Vision Dysfunction in Circadian Clock Gene Bmal Mice Open
Background and Hypothesis: The circadian rhythm disruption due to shift work results in a range of disorders such as metabolic disturbances, obesity, cardiovascular diseases, and insulin resistance. Interestingly, the core clock gene Brain…
View article: The Role of C Reactive Protein in Fever without Focus among Children Aged Between 1 – 3 Years
The Role of C Reactive Protein in Fever without Focus among Children Aged Between 1 – 3 Years Open
Background:The incidence of invasive pneumococcal disease in children has come down because of polysaccharide vaccine.The increased incidence of bacteremia among young children may be due to part of maturational immune deficiency in the pr…
View article: Diabetes Alters Diurnal Rhythm of Electroretinogram in db/db Mice
Diabetes Alters Diurnal Rhythm of Electroretinogram in db/db Mice Open
Diabetic retinopathy (DR) is the most common complications of diabetes and a leading cause of blindness in the United States. The retinal neuronal changes precede the vascular dysfunction observed in DR. The electroretinogram (ERG) determi…
View article: Diabetes Alters Diurnal Rhythm of Electroretinogram in db/db Mice.
Diabetes Alters Diurnal Rhythm of Electroretinogram in db/db Mice. Open
Diabetic retinopathy (DR) is the most common complications of diabetes and a leading cause of blindness in the United States. The retinal neuronal changes precede the vascular dysfunction observed in DR. The electroretinogram (ERG) determi…
View article: Inhibition of IRS-1 Alters Retinal Circadian Clock
Inhibition of IRS-1 Alters Retinal Circadian Clock Open
Background and Hypothesis: Life on Earth has adapted to a 24-hour cycle of light and darkness. Circadian physiology coordinates temporal metabolism, hormone cycling, and sleep using clock genes. It is documented that dysregulation of clock…