Guillaume E. Desanti
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Toll-like receptor 4 and macrophage scavenger receptor 1 crosstalk regulates phagocytosis of a fungal pathogen Open
The opportunistic fungal pathogen Cryptococcus neoformans causes lethal infections in immunocompromised patients. Macrophages are central to the host response to cryptococci; however, it is unclear how C. neoformans is recognised and phago…
Reciprocal regulation of TLR4, TLR3 and Macrophage Scavenger Receptor 1 regulates nonopsonic phagocytosis of the fungal pathogen<i>Cryptococcus neoformans</i> Open
The opportunistic fungal pathogen Cryptococcus neoformans causes lethal infections in immunocompromised patients. Macrophages are central to the host response to cryptococci; however, it is unclear how C. neoformans is recognized and phago…
View article: Correction: An in vitro method for inducing titan cells reveals novel features of yeast-to-titan switching in the human fungal pathogen Cryptococcus gattii
Correction: An in vitro method for inducing titan cells reveals novel features of yeast-to-titan switching in the human fungal pathogen Cryptococcus gattii Open
[This corrects the article DOI: 10.1371/journal.ppat.1010321.].
View article: An in vitro method for inducing titan cells reveals novel features of yeast-to-titan switching in the human fungal pathogen Cryptococcus gattii
An in vitro method for inducing titan cells reveals novel features of yeast-to-titan switching in the human fungal pathogen Cryptococcus gattii Open
Cryptococcosis is a potentially lethal fungal infection of humans caused by organisms within the Cryptococcus neoformans/gattii species complex. Whilst C . neoformans is a relatively common pathogen of immunocompromised individuals, C . ga…
View article: An <i>in vitro</i> method for inducing titan cells reveals novel features of yeast-to-titan switching in the human fungal pathogen <i>Cryptococcus gattii</i>
An <i>in vitro</i> method for inducing titan cells reveals novel features of yeast-to-titan switching in the human fungal pathogen <i>Cryptococcus gattii</i> Open
Cryptococcosis is a potentially lethal fungal infection of humans caused by organisms within the Cryptococcus neoformans/gattii species complex. Whilst C. neoformans is a relatively common pathogen of immunocompromised individuals, C. gatt…
Host-derived Reactive Nitrogen Species mediate the<i>Cryptococcus neoformans</i>yeast-to-titan switch via fungal-derived superoxide Open
In the host lung, the human fungal pathogen Cryptococcus neoformans undergoes a morphological switch from small haploid yeast to large polyploid titan cell, contributing to C. neoformans virulence. Titan cells are less readily phagocytosed…
The Gp1ba-Cre transgenic mouse: a new model to delineate platelet and leukocyte functions Open
Conditional knockout (KO) mouse models are invaluable for elucidating the physiological roles of platelets. The Platelet factor 4-Cre recombinase (Pf4-Cre) transgenic mouse is the current model of choice for generating megakaryocyte/platel…
TNFα depleting therapy improves fertility and animal welfare in TNFα-driven transgenic models of polyarthritis when administered in their routine breeding Open
Transgenic tumour necrosis factor alpha (TNFα)-driven models of polyarthritis such as the TNF ΔARE mouse have proven to be invaluable in delineating aspects of inflammatory disease pathophysiology in humans. Unfortunately, the onset of joi…