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View article: Lactulose, Rifaximin, and Survival in Hepatic Encephalopathy: A Cohort Study of 120 Patients
Lactulose, Rifaximin, and Survival in Hepatic Encephalopathy: A Cohort Study of 120 Patients Open
Background: Hepatic encephalopathy (HE) is a severe neuropsychiatric complication of advanced liver disease, driven primarily by ammonia accumulation due to impaired hepatic detoxification and portosystemic shunting. Lactulose is a corners…
View article: From Gut to Lungs: The Hidden Respiratory Impacts of IBD: A Systematic Review of the Literature
From Gut to Lungs: The Hidden Respiratory Impacts of IBD: A Systematic Review of the Literature Open
Pulmonary complications are an important yet underappreciated aspect of inflammatory bowel disease (IBD), which includes Crohn’s disease (CD) and ulcerative colitis (UC). These conditions often manifest with extraintestinal symptoms that c…
View article: Smart Microbiomes: How AI Is Revolutionizing Personalized Medicine
Smart Microbiomes: How AI Is Revolutionizing Personalized Medicine Open
Background: Recent studies have shown that gut microbiota have important roles in different human diseases. There has been an ever-increasing application of high-throughput technologies for the characterization of microbial ecosystems. Thi…
View article: Ethanol-Induced Dysbiosis and Systemic Impact: A Meta-Analytical Synthesis of Human and Animal Research
Ethanol-Induced Dysbiosis and Systemic Impact: A Meta-Analytical Synthesis of Human and Animal Research Open
Background: Chronic ethanol consumption is a major global health concern traditionally associated with liver disease. Ethanol disrupts gut microbial communities, compromises intestinal barrier function, and contributes to hepatic, metaboli…
View article: Hydatid Cyst in Pregnancy—A Diagnostic and Therapeutic Dilemma: Study Case Report
Hydatid Cyst in Pregnancy—A Diagnostic and Therapeutic Dilemma: Study Case Report Open
Background: Hydatid disease, caused by the larval form of Echinococcus granulosus, is a rare but potentially life-threatening condition during pregnancy, with an estimated incidence of 1 in 20,000 to 30,000 gestations. Physiological immuno…
View article: Therapeutic Efficacy of Silymarin, Vitamin E, and Essential Phospholipid Combination Therapy on Hepatic Steatosis, Fibrosis, and Metabolic Parameters in MASLD Patients: A Prospective Clinical Study
Therapeutic Efficacy of Silymarin, Vitamin E, and Essential Phospholipid Combination Therapy on Hepatic Steatosis, Fibrosis, and Metabolic Parameters in MASLD Patients: A Prospective Clinical Study Open
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease globally, and current estimates indicate an increase in incidence and prevalence in the general population. The design of the pros…
View article: Linking gut permeability to liver steatosis: Noninvasive biomarker evaluation in MASLD patients – a prospective cross-sectional study
Linking gut permeability to liver steatosis: Noninvasive biomarker evaluation in MASLD patients – a prospective cross-sectional study Open
Recent research highlights a potential link between metabolic dysfunction–associated steatotic liver disease (MASLD) and intestinal barrier dysfunction. Increased intestinal permeability (IP) may facilitate the translocation of bacteria, e…
View article: Intestinal permeability assessed by serum zonulin in liver cirrhosis: A systematic review and meta-analysis
Intestinal permeability assessed by serum zonulin in liver cirrhosis: A systematic review and meta-analysis Open
Background: In recent years, increased intestinal permeability has been considered a hallmark of liver cirrhosis (LC), thereby exposing the liver to many bacteria and microbial components of a leaky gut, such as zonulin which is a recogniz…
View article: Rehabilitation for Chronic Constipation: Integrative Approaches to Diagnosis and Treatment
Rehabilitation for Chronic Constipation: Integrative Approaches to Diagnosis and Treatment Open
Background: Chronic constipation is a well-recognized complication which is caused by hard and/or infrequent defecation. According to estimates, constipation presents as a chronic illness affecting 16% of adults globally, who deal with ins…
View article: Effectiveness of 8-week Treatment with Glecaprevir/Pibrentasvir in Treatment-naïve or -experienced HCV Patients: Results from an Observational Retrospective Study in Real-life Settings (ODYSSEY)
Effectiveness of 8-week Treatment with Glecaprevir/Pibrentasvir in Treatment-naïve or -experienced HCV Patients: Results from an Observational Retrospective Study in Real-life Settings (ODYSSEY) Open
Background and Aims: Pan-genotypic ribavirin-free oral direct-acting antivirals, including the glecaprevir/pibrentasvir combination, are recommended for the treatment of most patients with chronic hepatitis C virus (HCV) infection. In Roma…
View article: Intestinal Insights: The Gut Microbiome’s Role in Atherosclerotic Disease: A Narrative Review
Intestinal Insights: The Gut Microbiome’s Role in Atherosclerotic Disease: A Narrative Review Open
Recent advances have highlighted the gut microbiota as a significant contributor to the development and progression of atherosclerosis, which is an inflammatory cardiovascular disease (CVD) characterized by plaque buildup within arterial w…
View article: Healing from Within: How Gut Microbiota Predicts IBD Treatment Success—A Systematic Review
Healing from Within: How Gut Microbiota Predicts IBD Treatment Success—A Systematic Review Open
Recent research indicates that the microbiome has a significant impact on the progression of inflammatory bowel disease (IBD) and that creating therapies that change its composition could positively impact the outcomes of IBD treatment. Th…
View article: Introducing Colorectal Cancer Screening in Romania – Preliminary Results from the Regional Pilot Programs (ROCCAS)
Introducing Colorectal Cancer Screening in Romania – Preliminary Results from the Regional Pilot Programs (ROCCAS) Open
Background and Aims: Colorectal cancer (CRC) is the third cause of cancer-related death worldwide. Screening programs can reduce CRC mortality rates by up to 60%. In line with the European Union recommendations, Romania started the first f…
View article: Endotoxin Inflammatory Action on Cells by Dysregulated-Immunological-Barrier-Linked ROS-Apoptosis Mechanisms in Gut–Liver Axis
Endotoxin Inflammatory Action on Cells by Dysregulated-Immunological-Barrier-Linked ROS-Apoptosis Mechanisms in Gut–Liver Axis Open
Our study highlighted the immune changes by pro-inflammatory biomarkers in the gut–liver-axis-linked ROS-cell death mechanisms in chronic and acute inflammations when gut cells are exposed to endotoxins in patients with hepatic cirrhosis o…
View article: Safety, Efficacy and Persistence of Advanced Therapies in Inflammatory Bowel Disease: Results from ORIGINS. A Retrospective Observational Study
Safety, Efficacy and Persistence of Advanced Therapies in Inflammatory Bowel Disease: Results from ORIGINS. A Retrospective Observational Study Open
Background and Aims: Real-world assessments of efficacy and safety of advanced therapies used for inflammatory bowel disease (IBD) patients are limited. We aimed to report safety, efficacy and treatment persistence of new molecules (inflix…
View article: Calprotectin, Biomarker of Depression in Patients with Inflammatory Bowel Disease?
Calprotectin, Biomarker of Depression in Patients with Inflammatory Bowel Disease? Open
Background and Objectives: Calprotectin is a marker for intestinal inflammation. Recent research suggests a link between inflammation and depression. This study assessed the association between the levels of calprotectin in patients from S…
View article: Tissue and Circulating MicroRNA-31, MicroRNA-200b, and MicroRNA-200c Reflects Disease Activity in Crohn‘s Disease Patients: Results from the BIOMIR Study
Tissue and Circulating MicroRNA-31, MicroRNA-200b, and MicroRNA-200c Reflects Disease Activity in Crohn‘s Disease Patients: Results from the BIOMIR Study Open
Background and Aims: MicroRNAs (miR) have altered expression in multiple autoimmune disorders including inflammatory bowel disease. The aim of the study was to assess the tissue and circulating miR-31, miR-200b, and miR-200c expression lev…
View article: Depression in Central and Eastern Europe: How Much It Costs? Cost of Depression in Romania
Depression in Central and Eastern Europe: How Much It Costs? Cost of Depression in Romania Open
Objective: The present study aims to estimate the public cost of depression in Romania during a seven-year time span to complement existing papers with data from Central and Eastern Europe and to identify and propose measures that allow ef…
View article: TCF7L2, CASC8, and GREM1 polymorphism and colorectal cancer in south-eastern Romanian population
TCF7L2, CASC8, and GREM1 polymorphism and colorectal cancer in south-eastern Romanian population Open
Colorectal cancer (CRC) is a heterogeneous disease with an increasing trend and with multiple epigenetic alterations and different molecular features, a major cause of mortality and morbidity. The Wnt/β-Catenin pathway is involved in multi…
View article: KRAS, NRAS, BRAF, PIK3CA, and AKT1 signatures in colorectal cancer patients in south-eastern Romania
KRAS, NRAS, BRAF, PIK3CA, and AKT1 signatures in colorectal cancer patients in south-eastern Romania Open
Somatic mutations in the oncogenes of the epidermal growth factor receptor signaling pathway play vital roles in colorectal carcinogenesis and have been closely linked with clinical resistance to monoclonal therapy. In this study, we have …
View article: Design, Characterization, and Anticancer and Antimicrobial Activities of Mucoadhesive Oral Patches Loaded with Usnea barbata (L.) F. H. Wigg Ethanol Extract F-UBE-HPMC
Design, Characterization, and Anticancer and Antimicrobial Activities of Mucoadhesive Oral Patches Loaded with Usnea barbata (L.) F. H. Wigg Ethanol Extract F-UBE-HPMC Open
The oral cavity’s common pathologies are tooth decay, periodontal disease, and oral cancer; oral squamous cell carcinoma (OSCC) is the most frequent oral malignancy, with a high mortality rate. Our study aims to formulate, develop, charact…
View article: Intestinal Permeability and Depression in Patients with Inflammatory Bowel Disease
Intestinal Permeability and Depression in Patients with Inflammatory Bowel Disease Open
Depression is a global health problem that requires an early and accurate diagnosis to ensure quick access to appropriate treatment. Among multiple psychopathological paths, recent attention has focused on analysing the brain–gut–microbiot…
View article: Influence of type II diabetes mellitus on postoperative complications following colorectal cancer surgery
Influence of type II diabetes mellitus on postoperative complications following colorectal cancer surgery Open
Diabetes mellitus (DM) promotes colorectal cancer (CRC) carcinogenesis through complex processes and is considered as an independent risk factor for cancer in general and for CRC in particular. Diabetic patients have complications in the p…
View article: Association of TCF7L2, CASC8 and GREM1 Polymorphisms in Patients with Colorectal Cancer and Type II Diabetes Mellitus
Association of TCF7L2, CASC8 and GREM1 Polymorphisms in Patients with Colorectal Cancer and Type II Diabetes Mellitus Open
Background: The aim of the study is to explore the association between the TCF7L2 rs7903146, CASC8 rs6983267 and GREM1 rs16969681 polymorphisms in patients diagnosed with type 2 diabetes mellitus (T2DM) and colorectal cancer. Methods: Sixt…
View article: Extended Lymphadenectomy for Proximal Transverse Colon Cancer: Is There a Place for Standardization?
Extended Lymphadenectomy for Proximal Transverse Colon Cancer: Is There a Place for Standardization? Open
Background and Objectives: Complete mesocolon excision and high vascular ligation have become a standard procedure in the treatment of colon cancer. The transverse colon has certain embryological and anatomical particularities which requir…
View article: Romanian Guidelines for the Diagnosis and Treatment of GERD-induced Respiratory Manifestations
Romanian Guidelines for the Diagnosis and Treatment of GERD-induced Respiratory Manifestations Open
Background and Aims: Gastroesophageal reflux disease (GERD) is a common condition present in daily practice with a wide range of clinical phenotypes. In this line, respiratory conditions may be associated with GERD. The Romanian Societies …
View article: P006 MiR-192 is associated with stricturing phenotype in Crohn’s disease
P006 MiR-192 is associated with stricturing phenotype in Crohn’s disease Open
Background MicroRNAs (miRNAs) are small, non-coding short (ribonucleic acid) RNAs that have a role in the regulation of genes and protein expression. MiRNAs have altered expression in multiple autoimmune disorders including inflammatory bo…
View article: P037 MicroRNA-31 and microRNA-200 family reflect disease activity in Crohn’s disease: results from the BIOMIR study
P037 MicroRNA-31 and microRNA-200 family reflect disease activity in Crohn’s disease: results from the BIOMIR study Open
Background Accurate assessment of disease activity in inflammatory bowel disease (IBD) is of paramount importance in decisions regarding treatment strategies. To apply a treat-to-target strategy, a tight assessment of activity is mandatory…
View article: Risk Factors for Extraintestinal Manifestations in Inflammatory Bowel Diseases - Data from the Romanian National Registry
Risk Factors for Extraintestinal Manifestations in Inflammatory Bowel Diseases - Data from the Romanian National Registry Open
Background and Aims: Identifying the risk factors for extraintestinal manifestations (EIMs) in inflammatory bowel diseases (IBD) may optimize the therapeutic decision. We aimed to assess the prevalence of EIMs in IBD patients in Romania an…
View article: Romanian Guidelines for Nonpharmacological Therapy of IBS
Romanian Guidelines for Nonpharmacological Therapy of IBS Open
Background and Aims: The nonpharmacological therapy in irritable bowel syndrome (IBS) is expanding rapidly. Practitioners and medical educators need to be aware of progress and changes in knowledge of this topic. The Romanian Society of Ne…