Daniel Ebner
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View article: Figure 2 from Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models
Figure 2 from Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models Open
ART558 treatment leads to increased residual IR-induced DNA damage foci. A, γH2AX and 53BP1 foci in HCT116 and H460 cells treated with 3 μmol/L ART558 and 4 Gy IR, assessed at the indicated times points after IR. B, Represent…
View article: RADONC-GPT: AN AUTONOMOUS SYSTEM FOR DATA-DRIVEN RADIATION ONCOLOGY TASKS
RADONC-GPT: AN AUTONOMOUS SYSTEM FOR DATA-DRIVEN RADIATION ONCOLOGY TASKS Open
View article: Supplementary Figure S5 from Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models
Supplementary Figure S5 from Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models Open
Accompanies Figure 4 (Characterization of ART899 as a specific and potent Polθ inhibitor with improved stability)
View article: Figure 3 from Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models
Figure 3 from Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models Open
ART558-mediated radiosensitization under hypoxic conditions. A, Clonogenic survival of H460 cells irradiated upon hypoxia (0.5% and <0.1% oxygen). For OERs, see Supplementary Fig. S4. The 6 Gy data points are replotted in a bar grap…
View article: Supplementary Figure S4 from Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models
Supplementary Figure S4 from Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models Open
Accompanies Figure 3 (Effect of ART558 under hypoxic conditions)
View article: Supplementary Figure S1 from Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models
Supplementary Figure S1 from Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models Open
Distribution of POLQ mRNA levels across cell lines from CCLE
View article: Supplementary Table S1 from Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models
Supplementary Table S1 from Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models Open
Luciferase-based MMEJ assay in a panel of cancer cell lines.
View article: Figure 5 from Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models
Figure 5 from Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models Open
Polθ inhibitor ART899 combined with radiation causes significant tumor growth delay in vivo and is well tolerated. A, ART899 plasma concentration following oral dosage of ART899 at 50 or 150 mg/kg. Mouse plasma samples (n<…
View article: Supplementary Figure S6 from Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models
Supplementary Figure S6 from Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models Open
Accompanies Figure 5 (ART899 combined with radiation causes significant tumor growth delay in vivo and is well tolerated)
View article: Supplementary Figure S3 from Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models
Supplementary Figure S3 from Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models Open
Accompanies Figure 2 (ART558 treatment leads to increased residual IR-induced DNA damage foci)
View article: Focused Assessment With Sonography in Trauma (FAST) as a Prognostic Tool in Blunt Abdominal Trauma: A Prospective Observational Study
Focused Assessment With Sonography in Trauma (FAST) as a Prognostic Tool in Blunt Abdominal Trauma: A Prospective Observational Study Open
View article: Protocol for pooled FACS-based CRISPR knockout screening in human iPSC-derived microglia
Protocol for pooled FACS-based CRISPR knockout screening in human iPSC-derived microglia Open
View article: The Src family kinase inhibitor drug Dasatinib and glucocorticoids display synergistic activity against tongue squamous cell carcinoma and reduce MET kinase activity
The Src family kinase inhibitor drug Dasatinib and glucocorticoids display synergistic activity against tongue squamous cell carcinoma and reduce MET kinase activity Open
This work is the first to show a strong synergistic activity of Dasatinib in combination with clinically used glucocorticoids in solid tumors. Furthermore, the tyrosine kinase MET and its effector protein Gab1 are newly identified glucocor…
View article: Drug Combinations Targeting FAK and MEK Overcomes Tumor Heterogeneity in Glioblastoma
Drug Combinations Targeting FAK and MEK Overcomes Tumor Heterogeneity in Glioblastoma Open
Background/Objectives: Glioblastoma (GBM) is an aggressive brain tumor with limited treatment options and poor prognosis, largely owing to its heterogeneity and the involvement of multiple intracellular signaling pathways that contribute t…
View article: A comprehensive pharmacological survey across heterogeneous patient-derived GBM stem cell models
A comprehensive pharmacological survey across heterogeneous patient-derived GBM stem cell models Open
Despite substantial drug discovery investments, the lack of any significant therapeutic advancement in the treatment of glioblastoma (GBM) over the past two decades calls for more innovation in the identification of effective treatments. T…
View article: Drug combinations targeting FAK and MEK overcomes tumour heterogeneity in glioblastoma
Drug combinations targeting FAK and MEK overcomes tumour heterogeneity in glioblastoma Open
Glioblastoma (GBM) is an aggressive brain tumour with limited treatment options and poor prognosis, largely due to its heterogeneity and the involvement of multiple intracellular signalling pathways that contribute to drug resistance. Stan…
View article: The Src family kinase inhibitor drug Dasatinib and glucocorticoids display synergistic activity against tongue squamous cell carcinoma and reduce MET kinase activity
The Src family kinase inhibitor drug Dasatinib and glucocorticoids display synergistic activity against tongue squamous cell carcinoma and reduce MET kinase activity Open
Background Tongue squamous cell carcinoma (TSCC) is an aggressive cancer associated with a poor prognosis and limited treatment options, necessitating new drug targets to improve therapeutic outcomes. Our current work focuses on protein ty…
View article: A High‐Throughput Drug Repurposing Strategy to Treat <scp>TBX2</scp> and/or <scp>TBX3</scp> Dependent Cancers
A High‐Throughput Drug Repurposing Strategy to Treat <span>TBX2</span> and/or <span>TBX3</span> Dependent Cancers Open
Background The highly homologous T‐box transcription factors TBX2 and TBX3 are critical for embryonic development, and their overexpression in postnatal tissues contributes to a wide range of malignancies, including melanoma and rhabdomyos…
View article: Improving the representativeness of UK’s national COVID-19 Infection Survey through spatio-temporal regression and post-stratification
Improving the representativeness of UK’s national COVID-19 Infection Survey through spatio-temporal regression and post-stratification Open
View article: Targeting NKG2D ligands in glioblastoma with a bispecific T-cell engager is augmented with conventional therapy and enhances oncolytic virotherapy of glioma stem-like cells
Targeting NKG2D ligands in glioblastoma with a bispecific T-cell engager is augmented with conventional therapy and enhances oncolytic virotherapy of glioma stem-like cells Open
Background Glioblastoma (GBM) almost invariably becomes resistant towards conventional treatment of radiotherapy and temozolomide (TMZ) chemotherapy, partly due to subpopulations of intrinsically resistant glioma stem-like cells (GSC). The…
View article: Optimized protocol for CRISPR knockout of human iPSC-derived macrophages
Optimized protocol for CRISPR knockout of human iPSC-derived macrophages Open
View article: Genome‐wide CRISPR knockout screening to identify key regulators of phagocytosis in induced pluripotent stem cell derived microglia
Genome‐wide CRISPR knockout screening to identify key regulators of phagocytosis in induced pluripotent stem cell derived microglia Open
Background A whole genome knockout CRISPR screen in human induced pluripotent stem cell (hiPSC) derived microglia was undertaken to identify regulators of phagocytosis. The secondary objective was to cross reference these genes to Alzheime…
View article: Author Correction: C16orf72/HAPSTR1/TAPR1 functions with BRCA1/Senataxin to modulate replication-associated R-loops and confer resistance to PARP disruption
Author Correction: C16orf72/HAPSTR1/TAPR1 functions with BRCA1/Senataxin to modulate replication-associated R-loops and confer resistance to PARP disruption Open
View article: Persistence of SARS-CoV-2 antibodies over 18 months following infection: UK Biobank COVID-19 Serology Study
Persistence of SARS-CoV-2 antibodies over 18 months following infection: UK Biobank COVID-19 Serology Study Open
Background Little is known about the persistence of antibodies after the first year following SARS-CoV-2 infection. We aimed to determine the proportion of individuals that maintain detectable levels of SARS-CoV-2 antibodies over an 18-mon…
View article: Selective ROCK Inhibitor Enhances Blood Flow Recovery after Hindlimb Ischemia
Selective ROCK Inhibitor Enhances Blood Flow Recovery after Hindlimb Ischemia Open
The impairment in microvascular network formation could delay the restoration of blood flow after acute limb ischemia. A high-content screen of a GSK-published kinase inhibitor library identified a set of ROCK inhibitor hits enhancing endo…
View article: C16orf72/HAPSTR1/TAPR1 functions with BRCA1/Senataxin to modulate replication-associated R-loops and confer resistance to PARP disruption
C16orf72/HAPSTR1/TAPR1 functions with BRCA1/Senataxin to modulate replication-associated R-loops and confer resistance to PARP disruption Open
View article: Longitudinal characterization of TK6 cells sequentially adapted to animal product-free, chemically defined culture medium: considerations for genotoxicity studies
Longitudinal characterization of TK6 cells sequentially adapted to animal product-free, chemically defined culture medium: considerations for genotoxicity studies Open
Introduction: In vitro approaches are an essential tool in screening for toxicity of new chemicals, products and therapeutics. To increase the reproducibility and human relevance of these in vitro assessments, it is advocated to remove ani…
View article: Chemogenomic library design strategies for precision oncology, applied to phenotypic profiling of glioblastoma patient cells
Chemogenomic library design strategies for precision oncology, applied to phenotypic profiling of glioblastoma patient cells Open
View article: COVID-19 vaccination, risk-compensatory behaviours, and contacts in the UK
COVID-19 vaccination, risk-compensatory behaviours, and contacts in the UK Open
The physiological effects of vaccination against SARS-CoV-2 (COVID-19) are well documented, yet the behavioural effects not well known. Risk compensation suggests that gains in personal safety, as a result of vaccination, are offset by inc…
View article: Protection against SARS-CoV-2 Omicron BA.4/5 variant following booster vaccination or breakthrough infection in the UK
Protection against SARS-CoV-2 Omicron BA.4/5 variant following booster vaccination or breakthrough infection in the UK Open