Alexander E. Ehret
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View article: In vitro characterization of endothelial damage from rapid multiaxial mechanical loading
In vitro characterization of endothelial damage from rapid multiaxial mechanical loading Open
Lining the innermost surfaces of blood vessels, endothelial cells form a monolayer which regulates transport from and to the blood. Under physiological conditions, endothelial cells are exposed to various mechanical stimuli including hydro…
View article: Characterization of murine excisional wounds based on atomic force microscopy indentation
Characterization of murine excisional wounds based on atomic force microscopy indentation Open
Murine excisional skin wounds represent a widely applied model to investigate factors influencing the healing process. Among those, mechanical factors are receiving increasing attention, for instance concerning the role of fibroblasts' act…
View article: A consistent Lagrangian theory for phase separation in chemoelastic polymeric media at large deformations
A consistent Lagrangian theory for phase separation in chemoelastic polymeric media at large deformations Open
Large volume and shape changes may occur in polymer solutions and gels subject to mechanical loads or solvent loss. These deformations can lead to local alterations in composition, affecting or even triggering the phase separation into pol…
View article: Quantification of Stretch-Induced Stimuli Altering the Mechanome of Dermal Fibroblasts
Quantification of Stretch-Induced Stimuli Altering the Mechanome of Dermal Fibroblasts Open
Deformation is a key determinant of skin pathophysiology, as seen in skin growth during pregnancy and tissue expansion and in pathological processes such as excessive scarring in wounds under tension. However, the mechanisms underlying der…
View article: Length scales in the tear resistance of soft tissues and elastomers: a comparative study based on computational models
Length scales in the tear resistance of soft tissues and elastomers: a comparative study based on computational models Open
Fracture toughness describes a material’s ability to resist failure in the presence of defects. In case of soft biological tissues, a reliable determination and interpretation of the fracture properties is essential to estimate the risk of…
View article: Collagen hydrogels with similar polymer content but different microstructure — A comparative analysis of mechanical response
Collagen hydrogels with similar polymer content but different microstructure — A comparative analysis of mechanical response Open
Understanding the mechanical properties of collagen hydrogels is essential for successful applications in tissue engineering and 3D cell culture. This study compares the mechanical behavior of two collagen hydrogel sheets with similar coll…
View article: Length scales in the tear resistance of soft tissues and elastomers: a comparative study based on computational models
Length scales in the tear resistance of soft tissues and elastomers: a comparative study based on computational models Open
Fracture toughness describes a material’s ability to resist failure in the presence of defects. In case of soft biological tissues, a reliable determination and interpretation of the fracture properties is essential to estimate the risk of…
View article: A quadriphasic mechanical model of the human dermis
A quadriphasic mechanical model of the human dermis Open
The present study investigates the multiphasic nature of the mechanical behavior of human dermis. Motivated by experimental observations and by consideration of its composition, a quadriphasic model of the dermis is proposed, distinguishin…
View article: Sustained Physiological Stretch Induces Abdominal Skin Growth in Pregnancy
Sustained Physiological Stretch Induces Abdominal Skin Growth in Pregnancy Open
Supraphysiological stretches are exploited in skin expanders to induce tissue growth for autologous implants. As pregnancy is associated with large levels of sustained stretch, we investigated whether skin growth occurs in pregnancy. There…
View article: Discrete network models of endothelial cells and their interactions with the substrate
Discrete network models of endothelial cells and their interactions with the substrate Open
Endothelial cell monolayers line the inner surfaces of blood and lymphatic vessels. They are continuously exposed to different mechanical loads, which may trigger mechanobiological signals and hence play a role in both physiological and pa…
View article: Univariate Gauss quadrature for structural modelling of tissues and materials with distributed fibres
Univariate Gauss quadrature for structural modelling of tissues and materials with distributed fibres Open
This work presents a method for computing the averaged free energy and constitutive relations in hyperelastic material models with distributed fibres, as they apply to soft fibre-reinforced materials and biological tissues. While these mod…
View article: Variations on Ogden’s model: close and distant relatives
Variations on Ogden’s model: close and distant relatives Open
The power law in terms of stretch, the truncated series representation and the Valanis–Landel hypothesis are distinguished features of Ogden’s strain-energy density function. While they represent a set of special constitutive choices, they…
View article: Tailoring the multiscale architecture of electrospun membranes to promote 3D cellular infiltration
Tailoring the multiscale architecture of electrospun membranes to promote 3D cellular infiltration Open
Controlling the architecture of engineered scaffolds is of outmost importance to induce a targeted cell response and ultimately achieve successful tissue regeneration upon implantation. Robust, reliable and reproducible methods to control …
View article: Random auxetics from buckling fibre networks
Random auxetics from buckling fibre networks Open
Auxetic materials have gained increasing interest in the last decades, fostered by auspicious applications in various fields. While the design of new auxetics has largely focused on meta-materials with deterministic, periodically arranged …