Stephen E. Epstein
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View article: Marfan Cardiovascular Disease Without the Marfan Syndrome
Marfan Cardiovascular Disease Without the Marfan Syndrome Open
Dr. William C. Roberts: Herein we will discuss findings in a man with a fusiform aneurysm of the proximal ascending aorta, aortic-valve regurgitation, mitral-valve regurgitation, an anomalously arising left main coronary artery, and surviv…
View article: Combined Mitral and Aortic Regurgitation in Ankylosing Spondylitis
Combined Mitral and Aortic Regurgitation in Ankylosing Spondylitis Open
Clinical and cardiac morphologic features are described in a man with combined aortic and mitral regurgitation associated with ankylosing spondylitis. Although aortic regurgitation is a recognized accompaniment of ankylosing spondylitis, t…
View article: Effectiveness of face mask mandates in 4 suburban US communities during the SARS-CoV2 Omicron surge
Effectiveness of face mask mandates in 4 suburban US communities during the SARS-CoV2 Omicron surge Open
Objectives: To evaluate the effectiveness of face mask mandates in four suburban communities in the metropolitan Boston area during the SARS-CoV2 Omicron surge.Background: Face mask mandates have been implemented by local, state and nation…
View article: Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction
Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction Open
Myocardial infarction (MI), a leading cause of death around the world, displays a complex pattern of inheritance1,2. When MI occurs early in life, the role of inheritance is substantially greater1. Previously, rare mutations in low-density…
View article: Aging-Induced Collateral Dysfunction: Impaired Responsiveness of Collaterals and Susceptibility to Apoptosis via Dysfunctional eNOS signaling
Aging-Induced Collateral Dysfunction: Impaired Responsiveness of Collaterals and Susceptibility to Apoptosis via Dysfunctional eNOS signaling Open
Despite positive animal studies, clinical angiogenesis trials have been disappointing, possibly due to risk factors present in humans but usually unexplored in animals. We recently demonstrated aging causes impaired collateral remodeling a…
View article: Motivations and Disincentives in Studying the Languages of the Asia-Pacific Region in Aotearoa New Zealand
Motivations and Disincentives in Studying the Languages of the Asia-Pacific Region in Aotearoa New Zealand Open
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View article: High‐Sensitivity Troponin I Levels and Coronary Artery Disease Severity, Progression, and Long‐Term Outcomes
High‐Sensitivity Troponin I Levels and Coronary Artery Disease Severity, Progression, and Long‐Term Outcomes Open
Background The associations between high‐sensitivity troponin I (hsTnI) levels and coronary artery disease (CAD) severity and progression remain unclear. We investigated whether there is an association between hsTnI and angiographic severi…
View article: An Aggregate Biomarker Risk Score Predicts High Risk of Near‐Term Myocardial Infarction and Death: Findings From BARI 2D (Bypass Angioplasty Revascularization Investigation 2 Diabetes)
An Aggregate Biomarker Risk Score Predicts High Risk of Near‐Term Myocardial Infarction and Death: Findings From BARI 2D (Bypass Angioplasty Revascularization Investigation 2 Diabetes) Open
Background In a previous study, we found that a biomarker risk score ( BRS ) comprised of C‐reactive protein, fibrin‐degradation products, and heat shock protein‐70 predicts risk of myocardial infarction and death in coronary artery diseas…
View article: Pathway-Specific Aggregate Biomarker Risk Score Is Associated With Burden of Coronary Artery Disease and Predicts Near-Term Risk of Myocardial Infarction and Death
Pathway-Specific Aggregate Biomarker Risk Score Is Associated With Burden of Coronary Artery Disease and Predicts Near-Term Risk of Myocardial Infarction and Death Open
Background— Inflammation, coagulation, and cell stress contribute to atherosclerosis and its adverse events. A biomarker risk score (BRS) based on the circulating levels of biomarkers C-reactive protein, fibrin degradation products, and he…
View article: Intravenously Delivered Mesenchymal Stem Cells
Intravenously Delivered Mesenchymal Stem Cells Open
Rationale: Virtually all mesenchymal stem cell (MSC) studies assume that therapeutic effects accrue from local myocardial effects of engrafted MSCs. Because few intravenously administered MSCs engraft in the myocardium, studies have mainly…
View article: Systolic Blood Pressure and Risk of Type 2 Diabetes: A Mendelian Randomization Study
Systolic Blood Pressure and Risk of Type 2 Diabetes: A Mendelian Randomization Study Open
Observational studies have shown that elevated systolic blood pressure (SBP) is associated with future onset of type 2 diabetes, but whether this association is causal is not known. We applied the Mendelian randomization framework to evalu…
View article: Developing New Treatments for Heart Failure
Developing New Treatments for Heart Failure Open
Compared with heart failure (HF) care 20 to 30 years ago, there has been tremendous advancement in therapy for ambulatory HF with reduced ejection fraction with the use of agents that block maladaptive neurohormonal pathways. However, duri…
View article: A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease
A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease Open
Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is largely based on genome-wide association study (GWAS) analysis of common SNPs. Leveraging phased haplotypes from the 1000 Genomes Project, we report …
View article: Genetic analysis for a shared biological basis between migraine and coronary artery disease
Genetic analysis for a shared biological basis between migraine and coronary artery disease Open
The results suggest that shared biological processes contribute to risk of migraine and CAD, but surprisingly this commonality is restricted to migraine without aura and the impact is in opposite directions. Understanding the mechanisms un…
View article: Systems Genetics Analysis of Genome-Wide Association Study Reveals Novel Associations Between Key Biological Processes and Coronary Artery Disease
Systems Genetics Analysis of Genome-Wide Association Study Reveals Novel Associations Between Key Biological Processes and Coronary Artery Disease Open
Objective— Genome-wide association studies have identified multiple genetic variants affecting the risk of coronary artery disease (CAD). However, individually these explain only a small fraction of the heritability of CAD and for most, th…