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View article: Review Article: Extending the Frontiers of Intestinal Ultrasound Knowledge, Performance and Expansion
Review Article: Extending the Frontiers of Intestinal Ultrasound Knowledge, Performance and Expansion Open
Background Intestinal ultrasonography (IUS) is increasingly utilised for diagnosing and monitoring IBD. Despite its cost‐effectiveness, patient tolerance and suitability for serial bedside assessments, broad adoption has been limited by kn…
View article: Kinetics of intestinal ultrasound and shear-wave elastography to assess early response in ulcerative colitis patients treated with filgotinib
Kinetics of intestinal ultrasound and shear-wave elastography to assess early response in ulcerative colitis patients treated with filgotinib Open
Background and Aims A reduction of bowel wall thickness (BWT) on intestinal ultrasound (IUS) predicts endoscopic response in ulcerative colitis (UC). Advanced techniques such as shear-wave elastography (SWE) might enhance response assessme…
View article: Submucosal hyper-echogenicity on intestinal ultrasound is associated with fat deposition and predicts treatment non-response in patients with ulcerative colitis
Submucosal hyper-echogenicity on intestinal ultrasound is associated with fat deposition and predicts treatment non-response in patients with ulcerative colitis Open
Background and Aims The submucosa is the most responsive bowel wall layer on intestinal ultrasound (IUS) when assessing treatment response in ulcerative colitis (UC). Submucosal thickening with hyper-echogenicity is observed. This study ai…
View article: Transmural healing in ulcerative colitis patients improves long-term outcomes compared to endoscopic healing alone
Transmural healing in ulcerative colitis patients improves long-term outcomes compared to endoscopic healing alone Open
Background & Aims Endoscopic healing (EH) is recognized as a long-term treatment goal for patients with ulcerative colitis (UC). We investigated whether transmural healing (TH) in UC as assessed by intestinal ultrasound (IUS) is associated…
View article: The EXTENT Study: Results From an International Expert Delphi Consensus to Define Ultrasonographic Parameters for Measuring Bowel Damage in Crohn’s Disease
The EXTENT Study: Results From an International Expert Delphi Consensus to Define Ultrasonographic Parameters for Measuring Bowel Damage in Crohn’s Disease Open
This study supports intestinal ultrasonography as a promising tool for assessing bowel damage in Crohn's disease, providing an alternative to magnetic resonance imaging/computed tomography and colonoscopy. Implementing intestinal ultrasono…
View article: Intestinal Ultrasound and Its Advanced Modalities in Characterizing Strictures in Crohn's Disease
Intestinal Ultrasound and Its Advanced Modalities in Characterizing Strictures in Crohn's Disease Open
A combination of IUS and CEUS is accurate to differentiate between inflammatory and chronic strictures in CD. The Stricture Score Amsterdam needs external validation and confirmation in its potential as a diagnostic decision aid when choos…
View article: Quantified motility in Crohn’s disease to evaluate stricture composition using cine-MRI
Quantified motility in Crohn’s disease to evaluate stricture composition using cine-MRI Open
Objectives The histopathological composition of a stricture impacts clinical treatment choice. Therefore, imaging biomarkers that can distinguish a predominantly inflammatory from a chronic (i.e., non-inflammatory) stricture are highly rel…
View article: P1096 The predictive value of intestinal ultrasound for treatment response in Inflammatory Bowel Disease: a systematic review and pooled data analysis
P1096 The predictive value of intestinal ultrasound for treatment response in Inflammatory Bowel Disease: a systematic review and pooled data analysis Open
Background Intestinal ultrasound (IUS) is a promising tool in predicting treatment response in Inflammatory Bowel Disease (IBD). We aimed to systematically review current literature on the predictive value of IUS for treatment response. Me…
View article: P1186 Transperineal ultrasound is accurate in detecting perianal complications in Crohn’s disease: a systematic review and meta-analysis
P1186 Transperineal ultrasound is accurate in detecting perianal complications in Crohn’s disease: a systematic review and meta-analysis Open
Background Perianal complications such as fistulas and abscesses are common in Crohn’s disease (CD) and contribute to significant morbidity. Transperineal ultrasonography (TPUS) has emerged as a non-invasive and accurate method for periana…
View article: P0503 Submucosal hyperechogenicity on intestinal ultrasound is associated with fat deposition and is a predictor of endoscopic non-response to anti-inflammatory treatment in Ulcerative Colitis
P0503 Submucosal hyperechogenicity on intestinal ultrasound is associated with fat deposition and is a predictor of endoscopic non-response to anti-inflammatory treatment in Ulcerative Colitis Open
Background The submucosa is the most responsive wall layer in the monitoring of treatment response in ulcerative colitis (UC) with intestinal ultrasound (IUS).1 However, persistent submucosal thickening, often seen in combination with hype…
View article: Clinical relevance of calprotectin in patients with perianal fistulas in Crohn's disease and cryptoglandular fistulas
Clinical relevance of calprotectin in patients with perianal fistulas in Crohn's disease and cryptoglandular fistulas Open
Background and Aims Previous literature suggests that faecal calprotectin (FC) discriminates Crohn's disease perianal fistulas from cryptoglandular fistulas, irrespective of luminal disease. This study aims to prospectively validate this a…
View article: Diagnostic Accuracy of Intestinal Ultrasound in the Detection of Intra-Abdominal Complications in Crohn’s Disease: A Systematic Review and Meta-Analysis
Diagnostic Accuracy of Intestinal Ultrasound in the Detection of Intra-Abdominal Complications in Crohn’s Disease: A Systematic Review and Meta-Analysis Open
Background Crohn’s disease [CD] is frequently associated with the development of strictures and penetrating complications. Intestinal ultrasound [IUS] is a non-invasive imaging modality ideal for point-of-care assessment. In this systemati…
View article: P243 Multi-modality intestinal ultrasound is accurate and reproducible to distinguish inflammatory from chronic fibrotic strictures in Crohn’s disease – results from the STRICTURE study
P243 Multi-modality intestinal ultrasound is accurate and reproducible to distinguish inflammatory from chronic fibrotic strictures in Crohn’s disease – results from the STRICTURE study Open
Background In 30%-50% of patients with Crohn’s disease (CD) stenotic complications occur1. There is currently no imaging modality to identify stricture composition, which would allow early targeted (anti-inflammatory vs surgical) treatment…
View article: P127 Sphingosine-1-Phosphate Receptor Blockade with Etrasimod alters Lymphocyte Trafficking in Crohn's Disease: Insights from High-Dimensional Phenotypic Mapping
P127 Sphingosine-1-Phosphate Receptor Blockade with Etrasimod alters Lymphocyte Trafficking in Crohn's Disease: Insights from High-Dimensional Phenotypic Mapping Open
Background The blockade of lymphocyte trafficking from the lymph nodes (LNs) towards the intestinal mucosa is an effective approach for the treatment of ulcerative colitis (UC). Etrasimod is an oral, once-daily (QD), selective sphingosine …
View article: Early Intestinal Ultrasound Predicts Clinical and Endoscopic Treatment Response and Demonstrates Drug-Specific Kinetics in Moderate-to-Severe Ulcerative Colitis
Early Intestinal Ultrasound Predicts Clinical and Endoscopic Treatment Response and Demonstrates Drug-Specific Kinetics in Moderate-to-Severe Ulcerative Colitis Open
Background Intestinal ultrasound (IUS) is an emerging modality in monitoring disease activity in ulcerative colitis (UC). Here, we aimed to identify early IUS predictors of treatment response as evaluated by endoscopy and assessed the kine…
View article: Assessing Disease Activity in Pediatric Crohn’s Disease Using Ultrasound
Assessing Disease Activity in Pediatric Crohn’s Disease Using Ultrasound Open
Objectives: Currently, there is no consensus on how to score Crohn disease (CD) activity assessed by intestinal ultrasound (IUS) in children. This study aimed to design an easy‐to‐use IUS score for disease activity in pediatric CD. Methods…
View article: P187 Intestinal ultrasound is accurate for detecting intra-abdominal complications in Crohn’s disease: a meta-analysis
P187 Intestinal ultrasound is accurate for detecting intra-abdominal complications in Crohn’s disease: a meta-analysis Open
Background The clinical course of Crohn’s disease (CD) is associated with development of complications including strictures and penetrating lesions such as fistulas and abscesses. Close disease monitoring and optimizing therapy can prevent…
View article: P355 Motility in small bowel strictures in Crohn’s Disease measured with cine-MRI
P355 Motility in small bowel strictures in Crohn’s Disease measured with cine-MRI Open
Background Strictures develop in over half of Crohn’s Disease (CD) patients and can lead to complaints of bowel obstruction, requiring treatment. A study showed that strictures and pre-stricture small bowel (SB) have lower motility measure…
View article: P166 Calprotectin in patients with perianal fistula: the CANALS study
P166 Calprotectin in patients with perianal fistula: the CANALS study Open
Background Previous studies suggest that faecal calprotectin can be used to discriminate Crohn’s disease (CD) perianal fistulas from cryptoglandular (CG) perianal fistulas. The aim of this research was to prospectively validate these findi…
View article: P314 Microscopic appendicitis in ulcerative colitis: Feasibility of ultrasonographic diagnosis
P314 Microscopic appendicitis in ulcerative colitis: Feasibility of ultrasonographic diagnosis Open
Background Increasing evidence suggests appendectomy as potential alternative treatment in patients with ulcerative colitis (UC), especially in those with histological appendiceal inflammation (AI). Intestinal ultrasound (IUS) is a non-inv…
View article: Editorial: routine use of intestinal ultrasound in ulcerative colitis—are we missing the appendix? Authors' reply
Editorial: routine use of intestinal ultrasound in ulcerative colitis—are we missing the appendix? Authors' reply Open
LINKED CONTENT This article is linked to Reijntjes et al papers. To view these articles, visit https://doi.org/10.1111/apt.17267 and https://doi.org/10.1111/apt.17302
View article: Intestinal ultrasound detects an increased diameter and submucosal layer thickness in the appendix of patients with ulcerative colitis compared to healthy controls – a prospective cohort study
Intestinal ultrasound detects an increased diameter and submucosal layer thickness in the appendix of patients with ulcerative colitis compared to healthy controls – a prospective cohort study Open
Summary Background Increasing evidence suggests that appendicectomy as alternative treatment for ulcerative colitis (UC), especially in patients with histopathological appendiceal inflammation. Intestinal ultrasound (IUS) is a non‐invasive…
View article: Intestinal Ultrasound to Assess Ulcerative Colitis Disease Activity in Children: External Validation and Comparison of 2 Intestinal Ultrasound Activity Indices
Intestinal Ultrasound to Assess Ulcerative Colitis Disease Activity in Children: External Validation and Comparison of 2 Intestinal Ultrasound Activity Indices Open
Background There is currently no consensus on the definition of an abnormal intestinal ultrasound (IUS) for children with ulcerative colitis (UC). This cross-sectional study aimed to externally validate and compare 2 existing IUS indices i…
View article: Fecal Calprotectin, Chitinase 3-Like-1, S100A12 and Osteoprotegerin as Markers of Disease Activity in Children with Crohn’s Disease
Fecal Calprotectin, Chitinase 3-Like-1, S100A12 and Osteoprotegerin as Markers of Disease Activity in Children with Crohn’s Disease Open
Fecal calprotectin (FC), chitinase 3-like-1 protein (CHI3L1), S100A12 and osteoprotegerin (OPG) are biomarkers of intestinal inflammation. This cross-sectional study aimed to evaluate these biomarkers in a cohort of children with Crohn’s d…
View article: Intestinal Ultrasound Early on in Treatment Follow-up Predicts Endoscopic Response to Anti-TNFα Treatment in Crohn’s Disease
Intestinal Ultrasound Early on in Treatment Follow-up Predicts Endoscopic Response to Anti-TNFα Treatment in Crohn’s Disease Open
Background To assess treatment response, objective measures are superior to clinical improvement in Crohn’s disease [CD]. Intestinal ultrasound [IUS] is an attractive, non-invasive alternative to endoscopy, demonstrating early transmural c…
View article: The Role of the Lymphatic System in the Pathogenesis and Treatment of Inflammatory Bowel Disease
The Role of the Lymphatic System in the Pathogenesis and Treatment of Inflammatory Bowel Disease Open
Although the number of therapeutic options for the treatment of inflammatory bowel disease (IBD) has increased in recent years, patients suffer from decreased quality of life due to non-response or loss of response to the currently availab…
View article: DOP11 Early intestinal ultrasound predicts endoscopic response to anti-inflammatory treatment and shows drug-specific response to biologicals and tofacitinib in Ulcerative Colitis
DOP11 Early intestinal ultrasound predicts endoscopic response to anti-inflammatory treatment and shows drug-specific response to biologicals and tofacitinib in Ulcerative Colitis Open
Background Objective evaluation of treatment response is the gold standard in ulcerative colitis (UC). In this setting, intestinal ultrasound (IUS) is a non-invasive alternative to endoscopy. Recent studies showed change in IUS parameters …
View article: P179 Distinct ultrasound characteristics of the appendix in patients with ulcerative colitis: a prospective, cross-sectional cohort study
P179 Distinct ultrasound characteristics of the appendix in patients with ulcerative colitis: a prospective, cross-sectional cohort study Open
Background Increasing evidence suggests a role for the vermiform appendix in onset and relapse of ulcerative colitis (UC). Consequently, appendectomy is increasingly being seen as a potential alternative treatment. As a recent study sugges…