Erica Franceschini
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View article: Concomitant Autoimmune Liver Disease and Hepatic Actinomycosis: A Diagnostic Challenge—Brief Report and Review of the Literature
Concomitant Autoimmune Liver Disease and Hepatic Actinomycosis: A Diagnostic Challenge—Brief Report and Review of the Literature Open
Hepatic actinomycosis (HA) and IgG4-related inflammatory pseudotumors are rare and often overlooked causes of liver mass, which can easily be misdiagnosed as primary liver cancer or metastasis. Diagnosis is arduous due to unspecified clini…
View article: Streptococcus pneumoniae bacteremia: comparison of incidence, epidemiology, and clinical outcome in a pre- and post-COVID-19 period
Streptococcus pneumoniae bacteremia: comparison of incidence, epidemiology, and clinical outcome in a pre- and post-COVID-19 period Open
The COVID-19 pandemic has impacted the epidemiology and clinical severity of SPB. In our study, less than 10% of the high-risk population was vaccinated, while the older population (age ≥ 80 years) had a significantly higher 30-day mortali…
View article: Use of isavuconazole in critically ill patients in intensive care units: a prospective, observational, multicentre, cohort study
Use of isavuconazole in critically ill patients in intensive care units: a prospective, observational, multicentre, cohort study Open
Objectives In this multicentre, prospective study, we aimed to describe the use of isavuconazole in critically ill adult patients in ICU, in terms of patient characteristics, infection characteristics and outcomes. Methods Prospective, obs…
View article: Proactive antimicrobial stewardship with real-time microbiological alerts improves management of bloodstream infections
Proactive antimicrobial stewardship with real-time microbiological alerts improves management of bloodstream infections Open
Introduction This study aims to assess the impact of proactive Infectious Disease Specialist (IDS) interventions, in addition to standard antimicrobial stewardship (AMS) practices, triggered by real-time microbiological alerts, on improvin…
View article: Update on infection prevention in the ICU
Update on infection prevention in the ICU Open
Purpose of review Healthcare-associated infections (HAIs) remain a critical challenge in intensive care units (ICUs) due to the high prevalence of invasive procedures, vulnerable patient populations, and the increasing threat of antimicrob…
View article: Impact of vancomycin resistance on attributable mortality among <i>Enterococcus faecium</i> bloodstream infections: propensity score analysis of a large, multicentre retrospective study
Impact of vancomycin resistance on attributable mortality among <i>Enterococcus faecium</i> bloodstream infections: propensity score analysis of a large, multicentre retrospective study Open
Background Conflicting results exist about mortality risk of infections caused by vancomycin-susceptible Enterococcus faecium (VSEfm) and vancomycin-resistant Enterococcus faecium (VREfm). Our aim was to compare risk factors and clinical o…
View article: Carbapenemase type and mortality in blood-stream infections caused by carbapenemase-producing enterobacterales: a multicenter retrospective cohort study
Carbapenemase type and mortality in blood-stream infections caused by carbapenemase-producing enterobacterales: a multicenter retrospective cohort study Open
Background Previous studies analyzing differences in mortality associated with carbapenemase type in patients with a variety of infections caused by carbapenemase-producing Enterobacterales (CPE) have produced conflicting results. Methods …
View article: Streptococcus pneumoniae bacteremia: comparison of incidence, epidemiology, and clinical outcome in a pre- and post-COVID-19 period
Streptococcus pneumoniae bacteremia: comparison of incidence, epidemiology, and clinical outcome in a pre- and post-COVID-19 period Open
Objectives: Streptococcus pneumoniae is a leading cause of severe bacterial infections, including pneumonia, meningitis, and bacteremia. We aimed to evaluate the differences in clinical, epidemiological and outcome manifestations of patien…
View article: Central Nervous System Infections Caused by Bacillus Calmette–Guerin: Case Report and Narrative Literature Review
Central Nervous System Infections Caused by Bacillus Calmette–Guerin: Case Report and Narrative Literature Review Open
Bacillus Calmette–Guerin (BCG) central nervous system (CNS) infections are one of the rarest complications following BCG exposure. A 77-year-old male, with bladder cancer previously treated with BCG instillation, presented with fever, conf…
View article: Postoperative risk of infection with klebsiella in adults – a retrospective case–control study
Postoperative risk of infection with klebsiella in adults – a retrospective case–control study Open
A multi-variable model incorporating klebsiella colonization status and clinical factors can accurately predict klebsiella infections in elective surgery patients. This model can select high-risk patients, enhancing the efficiency of phase…
View article: P09. Clinical characteristics and outcomes of <i>Pseudomonas aeruginosa</i> community isolates from lower respiratory tract in intensive versus non- intensive care units: a 6-years retrospective cohort study
P09. Clinical characteristics and outcomes of <i>Pseudomonas aeruginosa</i> community isolates from lower respiratory tract in intensive versus non- intensive care units: a 6-years retrospective cohort study Open
Introduction Data about differences between patients infected or colonized with Pseudomonas aeruginosa (PA) isolate from lower respiratory tract at time of hospital admission are limited. This study aims to: compare susceptibility pattern,…
View article: P25. Characteristics, treatment options, and predictors of clinical failure among Pseudomonas aeruginosa infection with microbiologically confirmed intermediate or resistant carbapenem susceptibility profile: a multicenter clinical experience on behalf of CASPER (CArbapenem-reSistant <i>Pseudomonas aERuginosa</i> during and after the COVID-19 pandemic) study group
P25. Characteristics, treatment options, and predictors of clinical failure among Pseudomonas aeruginosa infection with microbiologically confirmed intermediate or resistant carbapenem susceptibility profile: a multicenter clinical experience on behalf of CASPER (CArbapenem-reSistant <i>Pseudomonas aERuginosa</i> during and after the COVID-19 pandemic) study group Open
Background This study aims to assess the risk factors for clinical failure in carbapenem-intermediate-resistant Pseudomonas aeruginosa (CiRPA) infections, focusing on susceptibility profiles, prior treatments, and the effectiveness of curr…
View article: P12. Retrospective comparative study of cefazolin and oxacillin in MSSA infections in patients with end-stage renal failure and dialysis
P12. Retrospective comparative study of cefazolin and oxacillin in MSSA infections in patients with end-stage renal failure and dialysis Open
Background Methicillin-sensible S. aureus bloodstream infections (MSSA BSIs) have high morbidity and mortality, especially in end stage renal disease (ESRD) and in patients on dialysis. While oxacillin is the first-line treatment, cefazoli…
View article: P16. Post-surgical infections in liver transplantation performed using robotic surgery: preliminary results of a case-control study
P16. Post-surgical infections in liver transplantation performed using robotic surgery: preliminary results of a case-control study Open
Background Minimally invasive robotic surgery is a safe and effective approach for the resection of primary and metastatic liver tumors, as well as for living donor liver transplantation. However, only a limited number of centers worldwide…
View article: Comparison of Patients With or Without COVID-19 and Without Hematological Diseases Treated for Invasive Pulmonary Aspergillosis: A 5-Year Retrospective Cohort Study with Propensity-Based Adjustment
Comparison of Patients With or Without COVID-19 and Without Hematological Diseases Treated for Invasive Pulmonary Aspergillosis: A 5-Year Retrospective Cohort Study with Propensity-Based Adjustment Open
Background Our aim was to compare epidemiological, clinical and treatment characteristics, and outcomes between patients with diagnoses of coronavirus disease 2019–associated pulmonary aspergillosis (CAPA) or putative invasive pulmonary as…
View article: Genomic and epidemiological evidence for the emergence of a <i>L. infantum/L. donovani</i> hybrid with unusual epidemiology in northern Italy
Genomic and epidemiological evidence for the emergence of a <i>L. infantum/L. donovani</i> hybrid with unusual epidemiology in northern Italy Open
Leishmania ( L .) infantum is one of the main causative agents of animal and human leishmaniasis across many endemic areas in South America, Europe, North Africa, and Asia. Despite its clinical significance, little is known about the genet…
View article: Severe acute respiratory syndrome coronavirus 2 infection in patients with hematological malignancies in the Omicron era: Respiratory failure, need for mechanical ventilation and mortality in seronegative and seropositive patients
Severe acute respiratory syndrome coronavirus 2 infection in patients with hematological malignancies in the Omicron era: Respiratory failure, need for mechanical ventilation and mortality in seronegative and seropositive patients Open
Background Patients with hematological malignancies (HM) have a high risk of severe coronavirus disease 2019 (COVID‐19), also in the Omicron period. Material and methods Retrospective single‐center study including HM patients with severe a…
View article: A rare case of necrotizing fasciitis of the leg in an intravenous drug user caused by <i>Prevotella denticola</i>
A rare case of necrotizing fasciitis of the leg in an intravenous drug user caused by <i>Prevotella denticola</i> Open
In IDUs the risk of deep skin and soft tissue infections is high and may be aggravated by contamination with oral microorganisms. The choice of empirical antibiotic treatment should include agents active against oral cavity anaerobes, such…
View article: Development and validation of a prediction score for failure to casirivimab/imdevimab in hospitalized patients with COVID-19 pneumonia
Development and validation of a prediction score for failure to casirivimab/imdevimab in hospitalized patients with COVID-19 pneumonia Open
Introduction Casirivimab and imdevimab (CAS/IMV) are two non-competing, high-affinity human IgG1 anti-SARS-CoV-2 monoclonal antibodies, that showed a survival benefit in seronegative hospitalized patients with COVID-19. This study aimed to…
View article: Intravenous fosfomycin in combination regimens as a treatment option for difficult-to-treat infections due to multi-drug-resistant Gram-negative organisms: A real-life experience
Intravenous fosfomycin in combination regimens as a treatment option for difficult-to-treat infections due to multi-drug-resistant Gram-negative organisms: A real-life experience Open
View article: Advances and Challenges in Sepsis Management: Modern Tools and Future Directions
Advances and Challenges in Sepsis Management: Modern Tools and Future Directions Open
Sepsis, a critical condition marked by systemic inflammation, profoundly impacts both innate and adaptive immunity, often resulting in lymphopenia. This immune alteration can spare regulatory T cells (Tregs) but significantly affects other…
View article: Long-Term Suppressive Therapeutic-Drug-Monitoring-Guided Dalbavancin Therapy for Cardiovascular Prosthetic Infections
Long-Term Suppressive Therapeutic-Drug-Monitoring-Guided Dalbavancin Therapy for Cardiovascular Prosthetic Infections Open
Dalbavancin represents a promising treatment for cardiovascular prosthetic infections due to its prolonged half-life, bactericidal activity, large spectrum of activity, and excellent biofilm penetration. However, the use of dalbavancin in …
View article: Association between Pulmonary Aspergillosis and Cytomegalovirus Reactivation in Critically Ill COVID-19 Patients: A Prospective Observational Cohort Study
Association between Pulmonary Aspergillosis and Cytomegalovirus Reactivation in Critically Ill COVID-19 Patients: A Prospective Observational Cohort Study Open
COVID-19-associated invasive pulmonary aspergillosis (CAPA) is common and is associated with poor outcomes in critically ill patients. This prospective observational study aimed to explore the association between CAPA development and the i…
View article: Vancomycin resistant enterococcus risk factors for hospital colonization in hematological patients: a matched case-control study
Vancomycin resistant enterococcus risk factors for hospital colonization in hematological patients: a matched case-control study Open
Background Vancomycin-resistant enterococcus (VRE) was the fastest growing pathogen in Europe in 2022 (+ 21%) but its clinical relevance is still unclear. We aim to identify risk factors for acquired VRE rectal colonization in hematologica…
View article: Association between Pulmonary Aspergillosis and Cytomegalovirus Reactivation in Critically ill COVID-19 Patients: A Prospective Observational Cohort Study
Association between Pulmonary Aspergillosis and Cytomegalovirus Reactivation in Critically ill COVID-19 Patients: A Prospective Observational Cohort Study Open
Introduction and Aims: COVID-19-associated invasive pulmonary aspergillosis (CAPA) is common and is associated with poor outcomes in critically ill patients. This prospective observational study aimed to explore the association between CAP…
View article: Death After Liver Transplantation: Mining Interpretable Risk Factors for Survival Prediction
Death After Liver Transplantation: Mining Interpretable Risk Factors for Survival Prediction Open
This study introduces a novel approach to mine risk factors for short-term death after liver transplantation (LT). The method outputs intelligible survival models by combining Cox's regression with a genetic programming technique known as …
View article: Low-molecular-weight heparin for the prevention of clinical worsening in severe non-critically ill COVID-19 patients: a joint analysis of two randomized controlled trials
Low-molecular-weight heparin for the prevention of clinical worsening in severe non-critically ill COVID-19 patients: a joint analysis of two randomized controlled trials Open
View article: Genomic and epidemiological evidence for the emergence of a putative<i>L. donovani/L. infantum</i>hybrid with unusual epidemiology in Northern Italy
Genomic and epidemiological evidence for the emergence of a putative<i>L. donovani/L. infantum</i>hybrid with unusual epidemiology in Northern Italy Open
Leishmania (L.) infantum is the main causative agent of animal and human leishmaniasis in the Mediterranean basin. Despite its clinical significance, little is known on the genetic diversity of L. infantum parasites circulating in Italy. H…
View article: COVID-19 omicron variant outbreak in a hematopoietic stem cell transplant unit
COVID-19 omicron variant outbreak in a hematopoietic stem cell transplant unit Open
View article: Prolonged RT-PCR test positivity in hemodialysis patients with COVID-19
Prolonged RT-PCR test positivity in hemodialysis patients with COVID-19 Open